http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김원구(Won-Ku Kim),권순홍(Soon-Hong Kwon),정성원(Sung-Won Chung),권순구(Soon-Gu Kwon),박종민(Jong-Min Park),최원식(Won-Sik Choi) 한국기계가공학회 2007 한국기계가공학회 춘추계학술대회 논문집 Vol.2007 No.-
The wear characteristics in supre-A dental material have been investigated. The wear tests were performed by using pin-on-disk wear tester at room temperature. Vickers hardness and fracture toughness measurement of dental materials were preformed. Microscopic observations on worn surfaces of specimens were conducted by SEM. The friction coefficient of supper-A material was investigated according to weight and slinging velocity.
한국인의 갑상선 유두암에서 종양 특이 생존율과 무병 생존율에 영향을 미치는 예후 인자
김원구 ( Won Gu Kim ),김원배 ( Won Bae Kim ),김태용 ( Tae Yong Kim ),김의영 ( Eui Young Kim ),류진숙 ( Jin Sook Ryu ),공경엽 ( Gyungyub Gong ),이정현 ( Jung Hyun Lee ),윤종호 ( Jong Ho Yoon ),김정민 ( Jung Min Kim ),홍석준 ( Suck 대한갑상선학회 2008 International Journal of Thyroidology Vol.1 No.1
Background and Objectives: There are few reports about various prognostic factors associated with cancer specific survival (CSS) and disease-free survival (DFS) of patients with papillary thyroid carcinoma (PTC) in Korea. This study was performed to evaluate the clinicopathologic factors determining CCS and DFS of PTC patients in Korea. Materials and Methods: The author applied the data from a retrospective analysis of 463 patients who underwent first thyroid surgery due to PTC in Asan medical center between 1996 and 1998. CSS and DFS were calculated by Kaplan-Meier method and various prognostic factors applied for Cox-proportional hazards model. Results: Sixteen out of 463 patients (3%) were died from PTC in median 93 months of follow up. Sixty-six out of 441 patients (15%) without distant metastasis had recurrence. Distant metastasis and age were significantly associated with more cancer specific death (HR=60.4, p<0.001 and HR=19.5, p=0.006). Gross and microscopic extrathyroidal extension were independent prognostic factors predicting poor CSS (HR=9.6, p=0.04 and HR=52.9, p<0.001, respectively) and DFS (HR=3.2, p<0.001 and HR=12.1, p<0.001, respectively). Cervical lymph node metastasis and male gender were associated with more clinical recurrences without regard to CSS. Conclusion: Independent prognostic factors correlated with CSS were distant metastasis, age and extrathyroidal extension, whereas extrathyroidal extension, cervical lymph node metastasis and gender were significantly associated with clinical recurrence.
갑상선여포암과 휘틀세포암에서 수술 전 세침흡인 세포검사 결과
김원구 ( Won Gu Kim ),임지혜 ( Ji Hye Yim ),김의영 ( Eui Young Kim ),김태용 ( Tae Yong Kim ),공경엽 ( Gyungyup Gong ),윤종호 ( Jong Ho Yoon ),홍석준 ( Suck Joon Hong ),김원배 ( Won Bae Kim ),송영기 ( Young Kee Shong ) 대한갑상선학회 2010 International Journal of Thyroidology Vol.3 No.2
Background and Objectives: Follicular thyroid carcinoma (FTC) and hurthle cell carcinoma (HCC) are relatively uncommon in iodine sufficient area, and there were few reports about these tumors. This study aimed to evaluate the preoperative diagnosis of FTC and HCC in Korea. Materials and Methods: This retrospective study enrolled 208 patients with FTC and 46 patients with HCC who underwent initial thyroid surgery between 1995 and 2006 in Asan Medical Center, Seoul, Korea. Results: There was no significant difference between FTC and HCC in basal clinicopathological parameters, except age and lymphovascular invasion (LVI). Patients with HCC were older (p=0.008), and had more LVI (p=0.008). Preoperative fine needle aspiration cytology (FNAC) diagnoses of FTC patients were follicular neoplasm (FN) in 84 cases (40%), hurthle cell neoplasm (HN) in 4 cases (2%), other malignancy in 26 cases (13%), and benign or indeterminate results in 89 cases (43%). FNAC diagnosis of HCC patients were 21 cases (46%) of HN, 8 cases (17%) of FN, 6 cases (13%) of other malignancy, and 11 (24%) cases of benign or indeterminate results. Conclusion: The results of FNAC were somewhat helpful for decision of thyroidectomy for the patients suspected FTC and HCC. However, clinical suspicion is also important for diagnosis of FTC and HCC even if the FANC results of nodules were benign or indeterminate.
김원구(Won-Ku Kim),권순홍(Soon-Hong Kwon),정성원(Sung-Won Chung),권순구(Soon-Gu Kwon),박종민(Jong-Min Park),최원식(Won-Sik Choi) 한국트라이볼로지학회 2007 한국트라이볼로지학회지 (Tribol. Lubr.) Vol.23 No.6
The wear characteristics in supre-A dental material have been investigated. The wear tests were performed by using pin-on-disk wear tester at room temperature. Vickers hardness and fracture toughness measurement of dental materials were preformed. Microscopic observations on worn surfaces of specimens were conducted by SEM. The friction coefficient of supper-A material was investigated according to weight and slinging velocity. The hardness of supper-A material was a half of the enamel of natural teeth.
첫 세포검사에서 양성이며 추가 세포검사에서 악성의 증거는 없었으나 경과 관찰 중 현저한 크기 증가로 인하여 수술하게 된 갑상선결절의 수술 후 결과
김의영 ( Eui Young Kim ),김원구 ( Won Gu Kim ),김태용 ( Tae Yong Kim ),공경엽 ( Gyungyup Gong ),류진숙 ( Jin-sook Ryu ),윤종호 ( Jong Ho Yoon ),홍석준 ( Suck Joon Hong ),김원배 ( Won Bae Kim ),송영기 ( Young Kee Shong ) 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.2
Background and Objectives: Fine needle aspiration (FNA) cytology is the best test to diagnose malignancy in thyroid nodules. However, cytologic interpretation of FNA specimens is difficult in case that follicular neoplasm is suggested. The aim of this study was to evaluate the rate of malignancy in thyroid nodules which were cytologically diagnosed as benign at the first FNA cytology but the size of nodules increased during the observation period. Materials and Methods: Patients who underwent thyroid surgery in Asan Medical Center from 1996 to 2001 were enrolled. Patients who diagnosed as benign at the first FNA cytology and relatively rapid increase in the nodule size during the observation period were included in this retrospective study. Results: Total 283 patients were included in this study. Their mean age was 42 years and mean tumor size was 4.89 cm (range 2.0∼12.0 cm). In pathologic results, 223 (80.9%) patients had benign thyroid nodules with 191 nodular hyperplasia, 37 follicular adenomas and 1 hashimoto’s thyroiditis, respectively. Fifty four patients (19.1%) had malignancy with 35 follicular carcinomas, 17 papillary thyroid carcinomas and 2 poorly differentiated carcinomas, respectively. Conclusion: Surgical treatment could be recommended for patients with significant increase in size of thyroid nodule, even though the results of their initial FNA were benign.
Sunitinib이 갑상선 유두암 세포주의 성장 및 침습에 미치는 영향
한두희 ( Doo Hee Han ),최현정 ( Hyun-jeung Choi ),김원구 ( Won Gu Kim ),김의영 ( Eui Young Kim ),김태용 ( Tae Yong Kim ),김원배 ( Won Bae Kim ),송영기 ( Young Kee Shong ),윤종호 ( Jong Ho Yoon ) 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.2
Background and Objectives: Thyroid papillary cancer was known to have a good prognosis but it could have poor prognosis if there is local invasion or metastasis. Sunitinib, a multitargeted tyrosine-kinase inhibitor, has been reported to have an anticancer effect in experimental and clinical studies. In this study, we evaluated the effect of sunitinib on cell growth, migration, adherence in papillary thyroid cancer cell. Materials and Methods: We have evaluated the effect of sunitinib on TPC-1 (papillary thyroid cancer cell) and NPA (melanoma cell). Expression of target gene was evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) and immunoblot. Cell viability was measured by colorimetric assay and invasiveness of cancer cell was measured by migration assay and by anchorage independent growth assay. The change of protein level associated with cell proliferation and cell cycle were evaluated by immunoblot assay. Results: The expression of vascular endothelial growth factor receptor 2 (VEGFR2) and platelet derived growth factor receptor (PDGFR) were more prominent in NPA cell than TPC-1 cell. The proliferation of cancer cells were decreased by sunitinib in dose-dependent manner and NPA cell was more susceptible to sunitinib. The migration and anchoring dependent growth of cancer cells were more decreased in NPA cell by sunitinib. Cyclin inhibitor, p21<sup>Waf1/Cip1</sup> and p27<sup>Kip1</sup> were suppressed by sunitinib only in TPC-1 cell, but not in NPA cell. Conclusion: Sunitinib suppressed cancer cell proliferation and migration in NPA and TPC-1 cell. Sunitinib was less sensitive in papillary thyroid cancer cell than malignant melanoma cell. This difference could be related with suppression of p21<sup>Waf1/Cip1</sup> and p27<sup>Kip1</sup> by sunitinib in TPC-1 cell.
조정현(曺鼎鉉),김원구(Kim Won-Gu) 비교민속학회 2008 비교민속학 Vol.0 No.35
ByulShin-Gut is the special ritual of villages in local society. These rituals transmitted by three ways, that is, way of rural society, sea coast society and market place society. A network of local communities around this ritual involve several social aspect, economic aspect, historical aspect, cultural aspect, and art and so on. ByulShin-Gut as ritual and festival is performed by variety purposes and patterns. Hahoe ByulShin-Gut is the most representative traditional folk ritual in Korea. This ritual performed in the Poongsan area, Andong-city. ByulSin-Gut is the special ritual of village in local society as like Hahoe, Byungsan, Sudong and so on in Andong. But present day, this traditional rituals are not performed or performed in the artificial stage as a selected or inventive folk art. I note in this article that next, what is a peculiarity of ByulShin-Gut in Andong?, how this style ritual has been adapted in the local history? And I remarked a special aspects of ByulShin-Gut. The peculiarities of ByulShin-Gut in Andong are prescribed as next. A traditional ritual of communal society that has special aspects as distinct from general annual communal rituals, and has periodic pattern, that is, annual, three years, five years, and ten years, and festive ritual performed by the group of shaman and the maeul communities. Therefore a special elements of ByulShin-Gut is summarized up three points. the first is a special character of holding circle, the second is a special character of the main performing people and main performing items, and the third is a peculiarity of open structure in this kind ritual. Conclusionally, I think that a original peculiarity of Andong communal ritual is caused by the ritual pattern of ByulShin-Gut, and a history of Andong communal ritual is nothing but a adaptative process of ByulShin-Gut in the context of several and changing condition.