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골형성유도단백질의 첨가가 ${\Delta}^{12}-PGJ_2$가 유도하는 석회화에 미치는 영향
김원경,김경화,김종진,이영규,구영,Kim, Won-Kyung,Kim, Kyoung-Hwa,Kim, Jong-Jin,Lee, Young-Kyu,Ku, Young 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.2
Prostaglandin plays a significant role in the local control of bone metabolism associated with periodontal disease. ${\Delta}^{12}-PGJ_2$ is a natural $PGD_2$ metabolite that is formed in vivo in the presence of plasma. It is known for ${\Delta}^{12}-PGJ_2$ to stimulate calcification in osteoblastic cells. Bone morphogenetic protein(BMP) stimulated osteoblastic differentiation in various types of cells and greatly enhanced healing of bony defects. The purpose of this study was to evaluate the effect of rhEMP-2 on ${\Delta}^{12}-PGJ_2$ induced osteoblastic differentiation and mineralization in vitro. A human osteosarcoma cells line Saos-2 were cultured. In the test groups, 10-7M of ${\Delta}^{12}-PGJ_2$ or mixture of 10-8M of ${\Delta}^{12}-PGJ_2$ and 100ng/ml of rhBMP-2 or 100ng/ml of rhEMP-2 were added to culture media. After 1 day, 2 days and 4 days of culture period, the cell number was measured. Alkaline phosphatase activity was measure at 3 days. Reverse transcription polymerase chain reaction(RT-PCR) was performed to determine the expression of mRNA of bone matrix protein at 8 hours, 1 day and 7 days. The ability to produce mineralized nodules in rat osteoblasts(MC3T3-E1) was evaluated at 21 days. The results were as follows : 1. rhEMP-2 or mixture of rhBMP-2 and ${\Delta}^{12}-PGJ_2$ inhibited cell proliferation of human osteosarcoma cells. 2. rhEMP-2 or mixture of rhBMP-2 and ${\Delta}^{12}-PGJ_2$ stimulated alkaline phosphatase activity significantly higher than ${\Delta}^{12}-PGJ_2$ alone. 3. rhBMP-2 or mixture of rhEMP-2 and ${\Delta}^{12}-PGJ_2$ stimulated mineralization compared to ${\Delta}^{12}-PGJ_2$ alone. 4. mRNA of alkaline phosphatase, BMP-2, cbfa 1, Type I collagen were detected in the group treated with ${\Delta}^{12}-PGJ_2$/rhBMP-2, rhBMP-2 alone, ${\Delta}^{12}-PGJ_2$ alone. These results show that mixture of ${\Delta}^{12}-PGJ_2$ and rhBMP-2 causes more bone formation than ${\Delta}^{12}-PGJ_2$ alone while the bone formation effects of mixture of ${\Delta}^{12}-PGJ_2$ and rhBMP-2 are less than those of rhBMP-2 alone. Further researches would be necessary to clarify the interactions of these agents.
하수처리장 적용을 위한Semi-카플란 수차가 장착된 마이크로수력발전 시스템
채규정(Kyu Jung Chae),김동수(Dong Soo Kim),천경호(Kyung Ho Cheon),김원경(Won Kyoung Kim),김정연(Jung Yeon Kim),이철형(Chul Hyung Lee),박완순(Wan Soon Park) 大韓環境工學會 2013 대한환경공학회지 Vol.35 No.5
소수력발전은 하수처리장 에너지 자립을 위한 효과적인 대안이다. 본 연구는 유량변동이 크고 유효낙차가 낮은 중소형하수처리장(기흥레스피아) 적용을 위해 피치조절형 세미카플란(semi-kaplan) 마이크로수력발전의 적용 타당성을 평가하였다. 가변피치 semi-kaplan 수차는 유량조절을 위한 가이드베인은 생략하고 피치조절형 런너를 장착하여 기계적 결함은 줄이면서 유량변동이 큰 처리장에 특화된 기술이다. 마이크로수력발전 시스템은 설계조건(유량 0.35 m3/s, 유효낙차 4.7 m)에서 90.2%의 수차효율 달성이 가능하였고 발전용량은 13.4 kW로 산정되었다. 설비가동률 74%로 가동 시 연간 약 86.8 MWh 에너지 생산을 통해 2.1%의 에너지 자립이 가능하고 이는 연간 49톤의 CO₂ 감축효과와 맞먹는다. 경제성 평가결과 초기 건설공사비가 200,000,000원 이하인 경우에는 내부수익률은 6.1%, 순현가는 15,539,000원, 편익-비용률은 1.08, 투자회수년은 15.5년으로 경제성이 충분한 것으로 나타났다. Small scale hydropower is one of most attractive and cost-effective energy technologies for installation within sewage treatment plants. This study was conducted to evaluate the potential of a semi-kaplan micro-hydropower (MHP) system for application to sewage treatment plants with high flow fluctuations and a low head. The semi-kaplan MHP is equipped with an adjustable runner blade, and is without a guide vane, so as to reduce the incidence of mechanical problems. A MHP rating 13.4 kWp with a semi-kaplan turbine has been considered for Kiheung Respia sewage treatment plant, and this installation is estimated to generate 86.8 MWh of electricity annually, which is enough to supply electricity to over 25 households, and equivalent to an annual reduction of 49 ton CO₂. The semi-kaplan turbine showed a 90.2% energy conversion efficiency at the design flow rate of 0.35 m3/s and net head of 4.7 m, and was adaptable to a wide range of flow fluctuations. Through the MHP operation, approximately 2.1% of total electricity demand of Kiheung Respia sewage treatment plant will be achievable. Based on financial analysis, an exploiting MHP is considered economically acceptable with an internal rate of return of 6.1%, net present value of 15,539,000 Korean Won, benefit- cost ratio of 1.08, and payback year of 15.5, respectively, if initial investment cost is 200,000,000 Korean Won.
치주치료가 약물성 치은비대 환자의 치은두께에 미치는 효과에 관한 연구
김원경,백진,이영규,Kim, Won-Kyung,Baek, Jin,Lee, Young-Kyoo 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.4
The purpose of this study was to observe the effects of periodontal therapy, including nonsurgical periodontal therapy with azithromycin, surgical therapy, and maintenace therapy on the drug-induced gingival enlargement, by means of measuring gingival thickness. The test group of 18 patients with drug-induced gingival enlargement received scaling, root planing with azithromycin for 5 days, with or without surgical periodontal treatment. The control group of 18 patients who had not taken any medication, received scaling and root planing, with or without surgical periodontal treatment. Both groups received supportive periodontal therapy every 3 months for 2 years. The mean period of total treatment is 32 months in the test group and 31 months in the control group. The thickness of the buccal gingiva was measured using an ultrasonic device of $SDM^{(R)}$(Krupp Corp., Essen, Germany). The results revealed that the test $group(1.21{\pm}0.51mm)$ showed statistically thicker buccal gingiva than the control $group(1.01{\pm}0.3mm)$. In the test group, the buccal gingiva was thickest on 2nd molars and was thinnest on canines of both dental arches. In the control group, the buccal gingiva was thickest on central incisors in the maxilla and 2nd molars in the mandible, while the thinnest areas were on canines in the maxilla and 1st premolars in the mandible. It would be concluded that the periodontal treatment with azithromycin aids in decreasing the degree of the gingival enlargement but cannot prevent the recurrence completely.
알루미늄메쉬커튼과 2류체 포그시스템을 적용한 개방형축사의 에너지 절감시스템에 관한 연구
김원경,강민우,양지웅,이은숙,신홍건,박진규,최원식,Kim, Won-Kyung,Kang, Min-Woo,Yang, Ji-Woong,Lee, Eun-Suk,Shin, Hong-Gun,Park, Jin-Gyu,Choi, Won-Sik 한국산업융합학회 2020 한국산업융합학회 논문집 Vol.23 No.6
The control on temperature and humidity on the cow-house is essential to assure production efficiency and the control on disease of cows. Fog system and screen fence are typical methods to drop the temperature inside of cow-house during the summer season. This study focused on the change in temperature and humidity under the condition of application of those methods. The results indicate that the installation of atomizer and insulation curtain cause decrease in temperature and increase in humidity. However, Using both of methods at the same time doesn't make any additional meaningful effects on temperature and humidity.
김원경 ( Won Kyung Kim ) 대한설비관리학회 2003 대한설비관리학회지 Vol.8 No.1
In this Paper, the estimation method of painting process in the automobile plant using computer simulation techniques is studied to improve the bottle neck process, the weak point and the productivity. For model and analysis, Promodel is used which is a manufacturing orientid simulation software developed by Promodel corporation in the USA. Firstly, the result of the simulation shows that we can obtain capability improvement in the system performance using computer simulation. Secondly, the optimum system specification is decided by comparing reports generated by scenario in simulation program to find out the suitable conditions. Finally, the speed of conveyor and a pitch of painting body as the most critical parameters are chosen on the basis of exhaustive field evaluation to study their effects on the capacity of the process. The best alternative condition for the maximum capacity of the process is selected by computer simulation.
김원경(Won Kyung Kim),최재헌(Jae Heon Choi) 한국도시지리학회 2002 한국도시지리학회지 Vol.5 No.1
The purpose of this paper is to investigate the changing characteristics of the financial space in accordance with foreign financial capital investment into the Korean financial sector before and after 1997 economic crises in Korea. We focus two different type of banks such as foreigner owned domestic banks and foreign branching banks in terms of their location oriented strategies and spatial patterns of branch offices. There are quite different locational preferences between the foreigner owned domestic banks and foreign branching banks. The foreigner owned domestic banks prefer the advantageous location of high public accessibilities nearby bus stations and subway stations, while foreign branching banks prefer the car oriented location with large parking spaces and road facilities in reflecting their retail banking business strategies for niche markets.
경량전철차량 알루미늄 구조체 하중시험방법 연구 및 결과고찰
김원경(Kim Won-kyung),원시태(Won Si-Tae),전창성(Jeon Chang-Sung) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-
This study introduces the testing results of the AL car body which is applied to LRT. The LRT car body is made of aluminum structure materials like a sandwich panel. The static load test was performed to evaluate the structural characteristic and stability of the AL car body. Considering the vertical, compressive, twisting load and 3-point supporting, Bend natural frequency Measurement, Twist natural frequency Measurement type as a testing terms, the structural stability of a car body was evaluated.