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김연주,김연주,김용배,이익재,권진이,김규보,차지혜,김명수,조인영,김정훈,박재현,김진희,김주리,신경환,김수산 대한암학회 2022 Cancer Research and Treatment Vol.54 No.2
Purpose This study aimed to investigate the impact of postoperative radiotherapy (PORT) in de novo metastatic breast cancer (dnMBC) patients undergoing planned primary tumor resection (PTR) and to identify the subgroup of patients who would most benefit from PORT. Materials and Methods This study enrolled 426 patients with dnMBC administered PTR alone or with PORT. The primary and secondary outcomes were overall and progression-free survival (OS and PFS), respectively. Results The median follow-up time was 53.7 months (range, 3.1 to 194.4). The 5-year OS and PFS rates were 73.2% and 32.0%, respectively. For OS, clinical T3/4 category, triple-negative breast cancer (TNBC), postoperative chemotherapy alone were significantly poor prognostic factors, and administration of PORT failed to show its significance. Regarding PFS, PORT was a favorable prognostic factor (hazard ratio, 0.64; 95% confidence interval, 0.50 to 0.82; p < 0.001), in addition to T1/2 category, ≤ 5 metastases, and non-TNBC. According to the multivariate analyses of OS in the PORT group, we divided the patients into three groups (group 1, T1/2 and non-TNBC [n=193]; group 2, T3/4 and non-TNBC [n=171]; and group 3, TNBC [n=49]), and evaluated the effect of PORT. Although PORT had no significance for OS in all subgroups, it was a significant factor for good prognosis regarding PFS in groups 1 and 2, not in group 3. Conclusion PORT was associated with a significantly better PFS in patients with dnMBC who underwent PTR. Patients with clinical T1/2 category and non-TNBC benefited most from PORT, while those with TNBC showed little benefit. Purpose This study aimed to investigate the impact of postoperative radiotherapy (PORT) in de novo metastatic breast cancer (dnMBC) patients undergoing planned primary tumor resection (PTR) and to identify the subgroup of patients who would most benefit from PORT.Materials and Methods This study enrolled 426 patients with dnMBC administered PTR alone or with PORT. The primary and secondary outcomes were overall and progression-free survival (OS and PFS), respectively.Results The median follow-up time was 53.7 months (range, 3.1 to 194.4). The 5-year OS and PFS rates were 73.2% and 32.0%, respectively. For OS, clinical T3/4 category, triple-negative breast cancer (TNBC), postoperative chemotherapy alone were significantly poor prognostic factors, and administration of PORT failed to show its significance. Regarding PFS, PORT was a favorable prognostic factor (hazard ratio, 0.64; 95% confidence interval, 0.50 to 0.82; p < 0.001), in addition to T1/2 category, ≤ 5 metastases, and non-TNBC. According to the multivariate analyses of OS in the PORT group, we divided the patients into three groups (group 1, T1/2 and non-TNBC [n=193]; group 2, T3/4 and non-TNBC [n=171]; and group 3, TNBC [n=49]), and evaluated the effect of PORT. Although PORT had no significance for OS in all subgroups, it was a significant factor for good prognosis regarding PFS in groups 1 and 2, not in group 3.Conclusion PORT was associated with a significantly better PFS in patients with dnMBC who underwent PTR. Patients with clinical T1/2 category and non-TNBC benefited most from PORT, while those with TNBC showed little benefit.
온라인 사용 후기의 유형에 따른 효과 연구 : 자기해석의 조절적 역할
김연주,이희준 한국광고학회 2020 광고학연구 Vol.31 No.7
본 연구는 온라인 구전 정보의 특성 변수인 사용 후기의 방향성(긍정/부정)과 후기 유형(사실 적/평가적)의 상호작용 관계와 이러한 상호작용에 영향을 미치는 자기해석(self-construal) 성향에 관해 알아보고자 하였다. 연구 결과, 부정적 온라인 사용 후기가 긍정적 온라인 사용 후 기보다 소비자들의 구매 결정에 영향을 미치는 정보 유용성 인식이 높았다. 또한, 긍정적 온라인 후기와 부정적 온라인 후기가 정보 유용성 인식에 미치는 효과 차이는 평가적 정보보다 사실적 정보의 경우 더 큰 것으로 나타났다. 자기해석 성향에 따른 사용 후기의 효과 차이를 알아본 결 과 유의한 상호작용 효과가 나타났는데, 독립적 자기 해석자의 정보 유용성 인식에 부정적 온라 인 후기의 경우 사실적 정보와 평가적 정보 간에 유의미한 효과의 차이를 보였다. 반면, 상호의 존적 자기 해석자의 경우 후기 유형 간의 유의미한 차이가 없는 것으로 밝혀졌다. 본 연구는 온 라인 사용 후기의 유형이 소비자들의 의사결정에 미치는 효과의 차이를 실증하였으며, 자기해석 성향의 개념이 온라인 커뮤니케이션 전략 수립에 미치는 시사점을 제시하였다. This study is to investigate the differences in consumers' perception of informational usefulness to make a purchase intention according to the types of online product reviews (negative vs. positive / factual vs. evaluative), and the current study also explores the moderating roles of self-construal in the mechanism. The findings show that consumers' perception of informational usefulness is the highest when the type of online product reviews is negative, and the difference between the positive online reviews and the negative online reviews on the perception of information usefulness is greater in the case of factual information than in evaluative information. As a result of examining differences in the effects of user reviews according to the self-construal theory, a significant interaction effect was found. In the case of negative online reviews in recognition of information usefulness of independent self-construal, there was a significant difference between factual information and evaluative information. On the other hand, in the case of interdependent participants, there was no significant difference between the types of reviews. This study demonstrates the difference in the effect of the types of online product reviews on consumers' decision-making, and this study suggests the implications of the concept of self-construal in establishing an online communication strategy.
韓國産 Physcia科 地衣植物의 分系分析에 對한 硏究
김연주,이득영,박승태 全北大學校 科學敎育硏究所 1988 과학과 과학교육 논문지 Vol.13 No.-
In order to elucidate the phylogenetic relationship of 8 genera on Korea Physciaceae (lichen), cladistic analysis by Karris'method carned conducte d on the basis of 14 characters. Also a new method designed by authors wasmore informative than Wagner tree. In the analysis the genus, Anaptychia, which is regarded as more primitive in upper cortex, spore, hypothecium, medulla color and chemical substances, was taken as a hypothetical ancestor for computing branching sequence. The phylogenetic sequence of each taxa was estimated as Anaptychia, Heterodermia, Physconia, Physciopsis, Phaeophyscia, Physcia, Dirinaria, and Pyxine. The cladogram revealed that ancestor group was Anaptychia and Heterodermia and advanced group was Dirinaria and Pyxine. Cladogram constructed by a new method revealed close relationship among the genus 1) Anaptychia, Heterodermia, 2) Physconia, Physciopsis, Praeophyscia, Physcia and 3) Dirinaria, Pyxine. And they were well accord with cluster analysis and present classification system. In conclusion, the obtained cladogram by a new method was considered to have more rather information on phylogenetic and phenetic relationships than the previously reported Wagner trees.