Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Surrogate Biomarker for Bevacizumab in Colorectal Cancer Liver Metastasis: A Single-Arm, Exploratory Trial

김여은,Bio Joo,박미숙,신상준,안중배,김명진 대한암학회 2016 Cancer Research and Treatment Vol.48 No.4

Purpose The purpose of this study is to investigate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and plasma cytokines and angiogenic factors (CAFs) as pharmacodynamic and prognostic biomarkers of bevacizumab monotherapy in colorectal cancer with liver metastasis (CRCLM). Materials and Methods From July 2011 to March 2012, 28 patients with histologically confirmed CRCLM received bevacizumab monotherapy followed by combined FOLFOX therapy. The mean age of the patients was 57 years (range, 30 to 77 years). DCE-MRI (Ktrans and IAUC60) was performed at baseline, first follow-up (3 days after bevacizumab monotherapy), and second follow-up (3 days after combined therapy). CAF levels (vascular endothelial growth factor [VEGF], placental growth factor [PlGF], and interleukin-8) were assessed on the same days. Progression- free survival (PFS) time distributions were summarized using the Kaplan-Meier method and compared using log-rank tests. Results The median PFS period was 11.2 months. Ktrans, IAUC60, VEGF, and PlGF values on the first follow-up day were significantly different compared with baseline values. No differences were observed on the second follow-up day. A > 40% decrease in Ktrans from baseline to first follow-up was associated with a longer PFS (hazard ratio, 0.349; 95% confidence interval, 0.133 to 0.912; p=0.032). Changes in CAFs did not show correlation with PFS time. Conclusion DCE-MRI parameters and CAFs are pharmacodynamic biomarkers of bevacizumab for CRCLM. In our study, change in Ktrans at 3 days after bevacizumab monotherapy was a favorable prognostic factor; however, the value of CAFs as a prognostic biomarker was not found.

Perfusion Parameters of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Patients with Rectal Cancer: Correlation with Microvascular Density and Vascular Endothelial Growth Factor Expression

김여은,임준석,최준정,김대홍,명성민,김명진,김기황 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.6

Objective: To determine whether quantitative perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlate with immunohistochemical markers of angiogenesis in rectal cancer. Materials and Methods: Preoperative DCE-MRI was performed in 63 patients with rectal adenocarcinoma. Transendothelial volume transfer (Ktrans) and fractional volume of the extravascular-extracellular space (Ve) were measured by Interactive Data Language software in rectal cancer. After surgery, microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression scores were determined using immunohistochemical staining of rectal cancer specimens. Perfusion parameters (Ktrans, Ve) of DCE-MRI in rectal cancer were found to be correlated with MVD and VEGF expression scores by Spearman’s rank coefficient analysis. T stage and N stage (negative or positive) were correlated with perfusion parameters and MVD. Results: Significant correlation was not found between any DCE-MRI perfusion parameters and MVD (rs = -0.056 and p = 0.662 for Ktrans; rs = -0.103 and p = 0.416 for Ve), or between any DCE-MRI perfusion parameters and the VEGF expression score (rs = -0.042, p = 0.741 for Ktrans; r = 0.086, p = 0.497 for Ve) in rectal cancer. TN stage showed no significant correlation with perfusion parameters or MVD (p > 0.05 for all). Conclusion: DCE-MRI perfusion parameters, Ktrans and Ve, correlated poorly with MVD and VEGF expression scores in rectal cancer, suggesting that these parameters do not simply denote static histological vascular properties.

Spontaneous Treatment of Renal Artery Pseudoaneurysm after Partial Nephrectomy: A Case Report

김여은,오영택,양승철,이도연 대한초음파의학회 2011 ULTRASONOGRAPHY Vol.30 No.4

A partial nephrectomy is being used increasingly for the removal of renal cell carcinomas. A renal artery pseudoaneurysm (RAP) is a rare, potentially life threatening complication after a partial nephrectomy. This paper presents a case of spontaneous thrombosis of RAP after a partial nephrectomy. The presented case is believed to be the largest in diameter (59 mm) among the reported cases of spontaneous treatment of RAP by complete thrombosis.

생활의 질적 향상을 위한 부엌의 작업대 및 수납장에 관한 연구

김여은,김은주,김재희,김현애,김희경,성은희,옥여명,이선희,전연희,조성진 연세대학교 생활과학대학 1985 婦學 Vol.18 No.-

The purpose of this study was to examine present conditions of kitchen work centers and cabinets and to determine responses of residents in relation to them. The sample comprised of 42 households in Seoul. A questionnaire was developed, which consisted of three parts; socio­demographic information of the households, present conditions of kitchen work centers and cabinets, and their responses in relation to them. Data was analyzed by hand, using frequency and percentage. Findings from this study were as follows: 1. L shape and one wall kitchen shape were dominated, 55.0% and 32.0% respectively. The kitchen work centers were arranged most frequently in sequence of refrigerator center, sink center, mixing center, cooking center, and serving center. 2. Widths/heights of kitchen work centers and cabinets were close to the recommended measurements, however the vertical distance between the top line of kitchen work centers and the bottom line of wall cabinets showed higher than the recommended measurement. 3. Residents were satisfied to some degree with the sequence of arrangement, heights, widths, design, and color of kitchen work centers and cabinets, however they need more storage space. 4. The functional aspect and design were the major factors influenced residents' decision making for the buying behavior of the kitchen work centers and cabinets.

무작위 배정된 운동 중재법이 노인의 균형에 미치는 영향에 대한 체계적 고찰

김여은 ( Kim Yeo-eun ),이윤정 ( Lee Yun-joung ),안선정 ( An Sun-joung ) 한국고령친화건강정책학회 2017 대한고령친화산업학회지 Vol.9 No.1

연구목적 본 연구에서는 체계적 고찰을 통하여 고령자의 균형 감각 무작위 배정된 운동 중재법 중 효과적인 방법을 확인하고자 한다. 연구 결과를 통해 고령자의 균형 감각의 치료적용에 대한 구체적이고 유용한 자료를 제공하고자 하며, 추후 고령자 균형을 위한 중재 적용 및 중재법 개발에 대한 기초자료를 제시하고자 한다. 연구방법 2000년 1월부터 2017년 4월까지 DBpia, KISS를 통해서 학위 논문 및 학회지에 게재된 논문을 검색하였고 주요 검색용어로는 고령자, 균형, 운동중재의 단어를 사용하였다. 연구결과 연구에 사용 된 연구는 총 11편이었다. 각 연구에서의 적은 n수로 내적 타당도는 2 평가를 받았다. 연구대상자는 총 11편의 논문 중 노인대상으로 한 연구가 5편과 여성 노인을 대상으로 한 연구가 5편이었으며, 나머지 1편은 장기노인요양 1등급 노인을 대상으로 적용되었다. 치료효과 측면에서는 운동프로그램이 10편에서 가설과 일치한 유의미한 효과를 얻은 것으로 확인되었다. 나머지 1편인 Son, & Park(2016)의 연구에서는 유의미한 효과는 얻지 못했으나, 동적·정적 평형능력의 향상이 있었다고 보고하였다. 고찰 본 연구에서는 운동 중재 프로그램이 균형 기능 뿐만 아니라, 우울증 감소, 근력 향상, 자세조절 능력 향상 등 다양한 효과가 있다는 결과를 보였다. 이러한 연구 결과를 바탕으로 추후의 연구에서는 운동 중재를 통한 세부적인 균형기능에 대한 효과성 검증 및 균형 수준별로 적용 가능한 운동중재 개발에 대한 보다 체계적인 연구가 진행되어야 할 것이다. Objective : The purpose of this study was to present the effect of randomized control exercise intervention for balance function on elderly. The results of this study will provide concrete and useful data on the application of the therapy of exercise, and will provide basic data on the development and intervention, analysis of the exercise intervention for further study. Method : This study was searched form papers published from Jan, 2000 to Apr, 2017 using DBpia, KISS based. key words using on the search were ‘Elderly’, ‘Balance’, ‘Exercise intervention’ and ‘Randomized control’. Results : Thirteen studies were included in this review. In all studies, internal validity of research evaluation was 2 in oder to small number of study groups. Among the 13 subjects, five were for elderly and five were for elderly women. the other research evaluation is long-term care patients(Grade 1). effects of exercise balance program had a meaningful effect consistent with the hypothesis in 10 subjects. The other study, Son, & Park (2016), reported that although there was no significant effect, there was an improvement in dynamic and static equilibrium capacity. Conclusion : In this study, it was shown that exercise intervention have various effects such as decreased depression,, improvement of muscle strength, posture control ability, flexibility, grip strength as well as balance function. Based on the results of this study, further study should be conducted to verify the effectiveness of detailed balance function through exercise intervention and to analyze more systematically applicable board game according to cognitive level.

Exploring Ways to Cope with Multivocality Encountered in Social Media

Marie Kim(김여은),Leena Yoon(윤이나),Hyungseo Nam(남형서),Juil Lee(이주일),Sang-Joon Kim(김상준) 한국인사조직학회 2019 한국인사ㆍ조직학회 발표논문집 Vol.2019 No.1

본 연구에서는 소셜미디어 플랫폼에서 다성성(multivocality)이 개입되는 현상을 포착하고, 실제 어떻게 소셜미디어의 유저들은 플랫폼상에서 다중인격성을 인지하고 이를 해결하려고 하는지 탐구하고자 한다. 특히 소셜미디어에서는 ‘포스팅’이라는 행위로 자신을 드러내는데, 본질적으로 소셜미디어에서는 이러한 포스팅을 바라보는 대상의 범위가 제한되어 있지 않아서 관계의 복잡성이 발생하게 되고, 자신의 의견을 제시하거나 주장을 함에 있어서 청중의 반응을 기대함에 있어서 모호성이 나타나게 된다. 소셜미디어 상에서 사람들은 이러한 관계의 복잡성을 해소하고 보다 강건한 방식으로 자신을 드러내는 방안을 모색하게 된다. 본 연구는 어빙 고프만의 자신 드러내기(self-presentation)에 대한 이론과 강건행위(robust action)의 개념을 통합하여 강간한 자신 드러내기 과정이 소셜미디어에서 어떻게 일어나고 있는지 고찰하고자 한다. 본 연구는 소셜미디어 플랫폼인 인스타그램을 사용하는 20-30 대 30 명을 심층인터뷰하고, 이들이 인지하고 있는 소셜미디어의 상황, 그리고 이 상황을 다루는 방식을 강건한 자신드러내기 과정으로 구체화하고자 한다. 연구의 결과는 인스타그램 유저들은 관계의 복잡성을 타개하기 위해서 스스로 다중인격성을 갖추고자 하였고, 이는 플랫폼 내에서 제공하고 있는 다양한 기능들을 활용함으로써 보다 강건하게 자신을 드러내고 있었다. 구체적으로 ‘강건한 자신드러내기’는 ‘편집(curation)’과 ‘분리(separation)’의 행동 패턴으로 나타나고 있었고, 특히 소셜미디어 플랫폼은 유저들이 자신드러내기를 보다 강건하게 할 수 있도록 다양한 기능들을 지속적으로 개발하고 있었다. This study pays attention to the situations where people in social media often encounter multivocality. Multivocality occurs when one interacts with diverse people with diverse interests and perspectives at a common space. In social media, by nature, user actions (e.g. postings, dialogs, pictures, other online materials) are widely shared with even the contacts who have incompatible views with the user’s. This requires users to deal with such multivocal situations. To act effectively in social media to credibly and reliably interact with their contacts, users craft their own ways in presenting their self in social media. To explore the behavioral responses to multivocality in social media, we incorporate the theory on self-presentation and robust action and argue that self-presentation in social media attempt to balance between robustness and flexibility. Robustness is achieved through disconnecting their contacts while flexibility enables users to incorporate all the perspectives from their contacts. To specify our argument, we conduct 30 in-depth interviews from those who have used a particular social medium (i.e. Instagram). With the interviews, we first specify the bases of multivocality into Audience, Interest, and Attention and given this, we classify two types of robust self-presentation in social media, i.e. Curation, and Separation. While users in social media respond to multivocality in various ways to make their self-presentation effective, the methods are based on the ongoing interactions with the social media themselves. Social media provide particular functions to the users to reconcile the multivocality issues. This suggests that the robust self-presentation is performatively devised through interacting with their social media as well as their contacts.

Robust Self-presentation: When and How Do People Present Themselves on Social Networking Sites (SNSs)?

Marie Kim(김여은),Leena Yoon(윤이나),Hyeongseo Nam(남형서),Juil Lee(이주일),Sang-Joon Kim(김상준) 한국경영학회 2019 한국경영학회 통합학술발표논문집 Vol.2019 No.8

User of social networking sites (SNSs) often encounter boundary complexity, as users interact with multitude of people of different social groups with diverse interests and perspectives in one common space. User actions (e.g. postings, dialogs, pictures, other online materials) on SNSs are, by nature, shared with a broad audience, even contacts who have incompatible views with the focal user. To act effectively, credibly, and reliably interact with their contacts, users craft their own ways in presenting themselves on SNSs. To explore the behavioral responses to boundary complexity on SNSs, we incorporate the theory on self-presentation and robust action and argue that individuals were able to better achieve a desired presentation of the self through structural reformation of the platform or rhetorical formulation through the platform. We conduct 30 in-depth interviews from those who have used a specific platform (i.e. Instagram). With the interviews, we first specify the bases of boundary complexities into Audience, Interest, and Attention and given this, we classify two processes of boundary management: authentic self-presentation and robust self-presentation. While users of SNSs respond to boundary complexities in various ways to make their self-presentation effective, the methods are based on the ongoing interactions with the platform. SNSs provide particular functions to the users to reconcile issues of boundary complexity. This suggests that the authentic self-presentation is performatively devised through interacting with their platform as well as their contacts.

Hepatic Lymphoma Representing Iso-Signal Intensity on Hepatobiliary Phase, in Gd-EOB-DTPA-Enhanced MRI: Case Report

안태란,김여은,박철희,정은아 대한자기공명의과학회 2015 Investigative Magnetic Resonance Imaging Vol.19 No.3

Image findings of hepatic lymphoma have been reported as variable, ranging from single or multiple small nodules to diffuse infiltrative patterns. On MRI, most hepatic lymphomas show T1 low signal intensity, T2 high signal intensity. Dynamic imaging reveals a hypointense appearance in the arterial phase, followed by delayed enhancement in the portal venous and transitional phase. In the hepatobiliary phase using a hepatocyte-specific contrast agent (which have recently aided in increasing the access to the focal liver lesions), hepatic lymphoma is known to exhibit low signal intensity. We report a case of hepatic lymphoma, which shows iso-signal intensity on hepatobiliary phase, using gadoxetic acid (Gd-EOB-DTPA).

작업치료사의 대인관계능력 및 감정노동과 직무스트레스와의 관련성

남소영,이성아,김여은,이강숙 대한작업치료학회 2020 대한작업치료학회지 Vol.28 No.2

Objective: The purpose of this study was to determine the association of interpersonal competence and emotionallabor with job stress in occupational therapists. Methods: The subjects of the study were 295 occupational therapists in Korea. All correspondence was conductedthrough SNS, and the analyzed questionnaires consisted of 9 items on general and job characteristics, 18 items oninterpersonal skills, 9 items on emotional labor, and 24 items on job stress. Results: The type of employment and payment were associated with job stress. Total interpersonal competence andtrust showed negative associations with job stress. Total emotional labor and frequency of emotional display andattentiveness to required displaying of rules showed a positive association with job stress. Conclusion: In this study, we found an association between interpersonal competence and emotional labor with jobstress of Korean occupational therapists. Therefore, it is necessary to enhance the interpersonal skills ofoccupational therapists such as their trust and to manage their emotional labor when performing their job. Inaddition, there is a need to conduct further studies related to job stress in terms of interpersonal competence andemotional labor for quality healthcare management. 목적 : 본 연구의 목적은 작업치료사들을 대상으로 대인관계능력 및 감정노동과 직무스트레스와의 관련성을 파악하는 것이다. 연구방법 : 전국의 임상에서 근무하는 295명의 작업치료사를 대상으로 SNS를 통하여 설문조사를 실시하였으며, 설문 문항은 총 60문항으로 일반적 특성 9문항, 대인관계능력 18문항, 감정노동 9문항, 직무스트레스 24문항으로 구성되었다. 결과 : 직무스트레스에 미치는 영향은 고용형태에서 정규직이 비정규직보다 직무스트레스가 높았으며 급여가 300만원 이상인 군에서 낮았다. 대인관계능력 전체영역과 그 하위변인인 신뢰감이 높아질수록 직무스트레스는 낮았고, 감정노동 전체영역과 하위 변인인 감정노동의 빈도 및 감정표현에 대한 주의에서는그 정도가 높아질수록 직무스트레스가 높았다. 결론 : 본 연구에서는 작업치료사들의 대인관계능력과 감정노동은 직무스트레스와 관련성이 있는 것으로나타났다. 따라서, 작업치료사들이 업무를 수행함에 있어 ‘신뢰감’등 대인관계능력의 증진과 감정 노동의관리가 필요하며, 앞으로 보건의료서비스의 질 관리를 위하여 직무스트레스와 관련된 다양한 연구가 더필요할 것이다.

Diffuse Large B-Cell Lymphoma in the Portal Vein

임현지,박미숙,김여은 대한영상의학회 2020 대한영상의학회지 Vol.81 No.3

Tumor thrombus in the portal vein without any liver parenchymal abnormality is extremely rare. In the liver, the primary tumor most frequently presenting with intravascular tumor thrombi is hepatocellular carcinoma and lymphoma is rarely considered. Even though thrombosis occurs quite often in lymphoma, cases of tumor thrombus are rare and cases of tumor thrombus in the portal vein are even rarer. Only four cases of lymphoma with portal vein tumor thrombosis have been reported to date and all cases were the result of direct extensions of a dominant nodal or extra-nodal mass. To our knowledge, there has been no report on diffuse large B-cell lymphoma (DLBCL) presenting only within the lumen of the portal vein and not intravascular B-cell lymphoma. We present the first case of DLBCL presenting only within the lumen of the portal vein in an immunocompetent patient.