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김순이,김신미 성인간호학회 2003 성인간호학회지 Vol.15 No.3
Purpose: This study was performed to identify and understand the nature of attitude patterns regarding dying process exhibited in the elderly persons who lived in the community setting. Method: Q methodology was applied. Ten elderly were selected from the senior centers and requested to answer open ended questions by using written questionnaires. Additionally, 12 other elderly from different senior centers were interviewed in depth, and their statements were recorded via voice pen by researchers to derive Q-population. From the 120 Q-population, 33 Q-sample were selected, 22 P-sample were rated by 1 to 9 oint scale respectively for Q-sorting. For Q-type analysis, pc QUNAL was used. Result: Three types of attitude patterns were identified, which were valuing dignity, seeking provision of nature, and avoiding of dying process. Conclusion: The significance of this study is as follows : Discovery of 3 attitude patterns of elderly toward dying. better understanding about elderly's perspectives for favorable dying, and informations for possible development of nursing strategies for elderly who is facing death.
김순이 성인간호학회 2000 성인간호학회지 Vol.12 No.4
This Qualitative nursing research used a helmeneutic phenomenological approach to discover meaning in an self-transcendence experience. The ultimate aim of the inquiry was to discover the essence of self-transcendence experience and to promote understanding. The study used van Manen's Methodology of phenmonological research. Multiple strategies for data collecting were utilized : in depth face-to-face interview and analysis of elders' literature. The following themes of experience emerged : Accepting becoming older as a natural phenomenon, transferring to one's own sons and daughters' oriented life. Maintaining harmonious relationship with neighbors and peer, observing real situations with silence, forming internal integrity with perseverance, compromising own's real situation, actualizing one's death, giving up roots of life, depending on God and conforming to human limitation. From this study essential themes for understanding self-transcendence experience and needs for continuing inquiry were identified.
Structure-Activity Relationship Studies of Novel Oxygen-incorporated SAHA Analogues
김순이,김학성,Ying Lan Jin 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.1
Novel oxygen-incorporated SAHA (oxa-SAHA) analogues, in which oxygen was inserted in the alkyl linker connecting the hydroxamic acid moiety and amide group, were synthesized and their inhibitory activities on histone deacetylase were evaluated. The most active oxa-SAHA analogue potently inhibited histone deacetylase, almost as potently as SAHA. Various structural modifications in the amide, but not the hydroxamic acid, significantly affected the inhibitory activities of the derivatives. Based on the inhibitory data, the N-phenyl moiety of the amide turned to be a better modification site for enhancing the inhibitory activity.