조현병 환자들의 일상적 의사결정 과정에서 무쾌감증 및 자아존중감의 영향

김수정,김민경,홍연주,이선구,김재진,Kim, Soo-Jeong,Kim, Min-Kyeong,Hong, Yeon-Ju,Lee, Seon-Koo,Kim, Jae-Jin 대한생물정신의학회 2017 생물정신의학 Vol.24 No.3

Objectives Decision-making in patients with schizophrenia has been known to be inefficient in both cognitive and affective aspects. The purpose of this study was to investigate the influence of anhedonia and self-esteem on the decision-making process in schizophrenia. Methods Twenty patients with schizophrenia and 21 healthy controls performed the 'apparel purchase decision-making task', during which they were asked to respond to the preference, fitness, and price suitability, before making the final purchase decision. Generalized estimating equation and correlation analysis were conducted to explore for the difference of decision making patterns and influential factors between the two groups. Results The patients showed lower odds ratio (OR) of the fitness on the apparel purchase decision than the controls [OR 0.190 ; 95% confidence interval (CI) 0.047-0.762, p = 0.019). In the patient group, there was no correlation between the number of purchased trials and the severity of anhedonia, but the number of purchased trials was negatively correlated with the Rosenberg Self-Esteem Scale score at a trend level (R = -0.436, p = 0.055). Conclusions Patients with schizophrenia considered the fitness of clothes less than healthy controls on apparel purchasing decisions. Schizophrenia patients with lower self-esteem were intended to buy more clothes.

경기도 일개 지역사회 대표집단에서 고호모시스테인혈증의 유병률 및 관련요인에 대한 단면조사연구

김수정,임경숙,송미숙,강연지,이순영,Kim, Soo-Jeong,Lim, Kyung-Sook,Song, Mi-Sook,Kang, Yeon-Ji,Lee, Soon-Young 대한예방의학회 2009 예방의학회지 Vol.42 No.5

Background : Many previous studies have shown that elevated homocysteine in the serum is a well known risk factor for cardiovascular disease and this is associated with other risk factors for cardiovascular disease, but any Korean data on this is limited. Objectives : This study aimed to calculate the prevalence of hyperhomocysteinemia and to analyze the relation between elevated homocysteine and the lifestyle factors of Korean adults. Methods : We conducted a cross-sectional survey that included 650 men and 743 women (age range, 20 to 79 years) who were residents of Gwangju City in Gyeonggi-do. These subjects participated in the health interview and examination survey from November to December 2005. The total homocysteine, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride in the serum were measured. All the participants had their body composition measured such as height and weight, and we obtained health-related behavioral information through the self-entry questionnaire. Results : Very right-handed skewed distributions of homocysteine were shown in men and women. The prevalence of hyperhomocysteinemia was 22.6% in men and 13.7% in women in Gwangju city. On the multiple logistic regression analysis, hyperhomocysteinemia was associated with age (OR=1.02, 95% CI=1.01-1.04), male gender (OR=1.60, 95% CI=1.02-2.52), severe general physical activity (OR=0.32, 95% CI=0.15-0.69) and nutrient consumption (OR=0.49, 95% CI=0.31-0.76). Conclusions : There is a great prevalence of hyperhomocysteinemia in adults of Gwangju City, Korea and it was associated with both genetic factors and lifestyle risk factors. This study can suggest that comprehensive lifestyle modification is needed in order to diminish the prevalence of hyperhomocysteinemia and to prevent CVD.

COVID-19 유행 전후 소비트렌드에 따른 공간 사용 변화 특성

김수정(Kim, Soo-Jeong),박수빈(Park, Soobeen) 한국실내디자인학회 2021 한국실내디자인학회 학술대회논문집 Vol.23 No.3

Phenethyl Isothiocyanate가 Toll-Like Receptor Agonists에 의해 유도된 Nuclear Factor-κB 활성과 Cyclooxygenase-2, Inducible Nitric Oxide Synthase 발현에 미치는 효과

김수정 ( Soo Jung Kim ),박혜정 ( Hye Jeong Park ),신화정 ( Hwa Jeong Shin ),김지수 ( Ji Soo Kim ),안희진 ( Hee Jin Ahn ),민인순 ( In Soon Min ),윤형선 ( Hyung Sun Youn ) 한국응용생명화학회(구 한국농화학회) 2011 Journal of Applied Biological Chemistry (J. Appl. Vol.54 No.4

염증의 중요한 분자학적 기전에는 cyclooxygenase-2 (COX-2)에 의한 prostaglandins (PGs) 생성과 inducible nitric oxide synthase (iNOS)에 의한 nitric oxide (NO) 생성이 있다. 많은 종류의 박테리아나 바이러스가 전사요소인 nuclear factor-κB(NF-κB)를 활성화시켜 여러 타깃 유전자의 발현을 조절해 PGs나 NO와 같은 염증물질을 유도하게 된다. 우리는 이번 실험을 통하여 phenethyl isothiocyanate (PEITC)가 toll-like receptor (TLR) agonists에 의해 유도된 NF-κB활성과 COX-2, iNOS 발현에 어떠한 영향을 미치는지 알아 보았다. PEITC는 lipopolysaccharide (LPS)와 polyinosinic-polycytidylic acid (poly[I:C])에 의해 유도된 NF-κB활성을 억제시켰다. 또한 PEITC는 LPS와 Poly[I:C]에 의해 유도된 iNOS의 발현도 억제시켰다. 하지만 PEITC는 TLR agonists들인 LPS, Poly[I:C], 2kDa macrophage-activating lipopeptide (MALP-2), oligodeoxynucleotide 1668 (ODN1668)에 의한 COX-2 발현은 억제시키지 못하였다. 즉 PEITC가 TRIF-dependent 신호전달체계만을 조절하여 TRIF-dependent 신호전달체계에 의해 조절되는 iNOS는 억제하지만 MyD88-dependent 신호전달 체계에 의해 조절되는 COX-2는 억제하지 못한다는 것을 설명해준다. 이러한 결과는 iNOS와 COX-2가 서로 다른 메커니즘에 의해 조절된다는 것을 암시하며, PEITC가 여러 병원균들로부터 유도되는 염증반응이나 만성적인 질병들을 조절할 수 있음을 제시하는 중요한 결과이다. Toll-like receptors (TLRs) play an important role in induction of innate immune responses. The activation of TLRs triggers inflammatory responses that are essential for host defense against invading pathogens. Phenethyl isothiocyanate (PEITC) extracted from cruciferous vegetables has an effect on anti-inflammatory therapy. Dysregulated activation of nuclear factor-κB (NF-κB), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) has been shown to play important roles in the development of certain inflammatory disease. To evaluate the therapeutic potential of PEITC, NF-κB activation and COX-2 and iNOS expression induced by lipopolysaccharide (LPS, TLR4 agonist), polyinosinic-polycytidylic acid (Poly[I:C], TLR3 agonist), 2 kDa macrophageactivating lipopeptide (MALP-2, TLR2 and TLR6 agonist) or oligodeoxynucleotide 1668 (ODN1668, TLR9 agonist) were examined. PEITC inhibits the activation of NF-κB induced by LPS or Poly[I:C] but not by MALP-2 or ODN1668. PEITC also suppressed the iNOS expression induced by LPS or Poly[I:C]. However, PEITC did not suppress COX-2 expression induced by LPS, Poly[I:C], MALP-2, or ODN1668. These results suggest that PEITC has the specific mechanism for antiinflammatory responses.

PC방의 실내공기환경

김수정(Soo-Jeong Kim),전정윤(Chung-Yoon Chun) 한국생활환경학회 2004 한국생활환경학회지 Vol.11 No.1

The indoor air quality (IAQ) of the PC Room has grown more serious due to a sudden increase of internet use and popularization. The first aim of this study was to investigate the indoor air quality of the PC Room around the Shin-chon area in Seoul, by measuring the physical pollutant (carbon dioxide, carbon monoxide, airborne dust, formaldehyde, etc.). The second was to examine the correlation between the subjective air quality and the physical air quality. According to the result, the average of carbon dioxide slightly exceeded the standard (1000 ppm). Among 6 pc rooms, 4 ones almost approximated or exceeded it. The 3 places which showed the most uncomfortable air quality in the survey exceeded the formaldehyde standard. The average temperature was 25.35 degrees centigrade, and the relative humidity was below 30%. Airborne dust, temperature and formaldehyde showed close relation with subjective air quality that human feels. It seemed that airborne dust was recognized by turbidity and formaldehyde was felt through smelling. And the air in a low temperature was regarded as a fresher one than that in a relatively high temperature inspite of the same physical air pollution amount.

물리 지식 기반 딥러닝 기법을 이용한 대체 모델 개선

정영준,이상익,이종혁,이드아함드파지,서병훈,김동수,서예진,최원 한국농공학회 2022 한국농공학회 학술대회초록집 Vol.2022 No.-

Surrogate modeling of physical systems can offer an advantage in terms of computational cost compared to simulations; therefore, it can help some tasks that require a lot of repetitive simulations regarding similar physical systems (e.g. design optimization, uncertainty analysis, unknown parameter estimation) Data-driven surrogate models, however, require a massive amount of labeled data, which is often very hard to obtain by simulations or in-situ experiments. They also demonstrate relatively poor performance when interpreting unseen problems during training processes (i.e. out-of-distribution). In this study, we propose an improved hybrid surrogate model by integrating the physics-informed deep learning method with the general data-driven black-box model. The proposed hybrid model, pure data-driven model, and pure physics-informed model are compared when solving various problems. The prediction accuracies and applicability of the aforementioned models are compared with varying model parameter sizes and training dataset sizes while interpreting in-distribution and out-of-distribution tasks.

遺留分制度의 憲法的 根據와 法政策的 論議 - 獨逸 聯邦憲法裁判所 決定을 契機로 하여

김수정(Soo-jeong Kim) 한국가족법학회 2006 가족법연구 Vol.20 No.2

  In the decision of 2005. 4. 19, the German constitutional court(BVerfG) made his standpoint of forced share clear. Before this decision, the court leaved the problem uncertain, whether it is constitutionally required to create forced share provisions. In this case, the BVerfG decided that forced share is under the constitutional protection and absolute abolition of forced share would violate the German constitution.<BR>  One obvious argument for forced share is that a forced share for children could protect the decedent"s family more fully from a financial point of view. But because of social change which has happened after the enactment of German civil code, it is open to doubt whether the forced share in force is as before appropriate system. In my opinion the support function and consanguinity are still the strongest grounds for forced share. But more flexible way of balancing between the testamentary freedom and the forced heirship principle should be explored. Especially it should be taken into account that when the forced share is approved, even a successor can"t alter or deprive of it.<BR>  In common-law countries the family maintenance system provided the testator"s children and other dependents the opportunity to claim a part of the estate and this system is characterized by judicial discretion. In Germany this way of balancing is legislatively proposed, but the BVerfG refused this proposal clearly. But in my opinion legislature enjoy the wide discretion to enact concrete provisions, therefore even if the German forced share provisions adopted family maintenance system, this one would not violate necessarily the german constitution. And it should be considered that today the need to support testator"s children by forced share is greatly decreased.<BR>  And in this decision it was considered whether general clause should be enacted in forced share deprivation provisions. The BVerfG decided that a general clause, for example disruption clause or alienation clause is indefinite, therefore unconstitutional. But in modern society familial binding of estate is generally weakened, consequently forced share deprivation doesn"t have to be limited to extreme cases.

한국 가족의 변화 양상에 따른 가족복지정책의 평가와 발전방향

김수정(Soo-Jeong Kim) 영남신학대학교 2005 신학과 목회 Vol.24 No.-

The Purpose of this paper is to review the Korea family welfare policy and to present the direction of Family Welfare Policy through the change of Korea family. For this purpose, First, this paper examined the reason that Korea family is changed by and conception of the 'Family' and 'family welfare policy'. On the basis of this, examine the present and problems of Korea family welfare policy and try to find improvement direction of Family Welfare Policy. Recently, Korea family has experienced a sudden change. Low fertility rate and aged society cause to increase a burden of support to family and to make weak family function of care. And, Participation of women in public affair provokes need to socialization of care labor and cause couple conflict around role and power apportionment. In addiction to, increased individualism values requires relationship change within family and cause a divorce. After the intensive analysis of the problems of family welfare policy reviewing the definition and category of family welfare policy, this paper examined the reason that couldn't develop the Korea family welfare policy in practical direction of improvement. Until now, Korea family welfare policy has been enforced for specific family and individual and intervene after the fact. Finally, this paper suggests the direction of development plan of the family policy in Korea and discuss the task of the family policy. The direction of development plan of the family policy is as follows. 1) We have to form social solidarity for family welfare. 2) A universal family welfare policy rather than a select one is made. And the family policy is planed on the basis of family view and gender-recognition view. So each family member has to be able to reconcile work and family.

비만관련 사회경제적 비용의 성별 차이

김수정 ( Soo Jeong Kim ),조경원 ( Kyoung Won Cho ),오창석 ( Chang Seok Oh ),이선미 ( Sun Mi Lee ) 한국보건정보통계학회(구 한국보건통계학회) 2020 보건정보통계학회지 Vol.45 No.2

목적: 국민건강보험 빅데이터를 사용하여 비만의 질병발생 및 사망 위험을 평가하고, 비만의 사회경제적 비용을 산출하는 것을 목적으로 하였다. 방법: 2003-2004년에 일반건강검진을 받은 모든 수검자 중 체중 또는 키 측정값이 없는 사람, 중복수검자, 그리고 수검일 기준 과거 1년간 비만관련 질병 과거력이 있는 자를 제외하였고, 10,091,251명을 2015년 연도말까지 추적관찰한 코호트자료를 구축하였다. 이 코호트에 건강보험 자격자료, 건강검진자료, 의료이용자료, 통계청 사망원인자료를 연계하여 분석하였다. 연령과 건강 행태를 보정한 후 성별과 비만 정도에 따라 질병발생 및 사망에 대한 상대위험도를 산출하였다. 인구기여위험도는 국민건강영양조사 원시자료의 비만율과 건강 검진 코호트 분석을 통한 질병 발생 및 사망위험도를 이용하여 산출하였다. 비만의 사회경제적인 비용은 의료비, 간병비, 교통비를 포함하는 직접비와 조기사망에 따른 미래소득 손실액, 의료이용에 따른 생산성 손실액을 포함하는 간접비로 분류하여 산출하였다. 결과: 남성과 여성 모두 체질량지수가 증가함에 따라 당뇨병의 위험이 증가했다. 고도비만 남성의 당뇨병 위험은 정상 체중 남성의 4.83배 높았다. 비만 여성의 당뇨병 위험은 정상 체중 여성보다 4.01배 높았다. 비만의 사회 경제적 비용의 경우, 2015년의 남성과 여성의 비만 관련 직접비는 각각 50.8%와 85.9%로 직접비와 간접비에 성별 차이가 있었다. 결론: 비만은 질병발생과 사망의 중대한 위험 요인일 뿐 아니라 건강보험에서 경제적 손실 원인이기도 하다. 따라서, 향후 비만으로 판정된 수검자를 관리하기 위한 중재프로그램을 개발하는 것이 필요할 것으로 사료된다. Objectives: This study aimed to estimate the risk of disease- and death-causing obesity and to calculate direct and indirect costs using national health insurance big data. Methods: We constructed cohort data for 10,091,251 participants who underwent a national health screening between 2003 and 2004. Cox’s proportional hazard models were adopted to analyze the relative risk (RR) of related diseases and causes of death, adjusted for age, smoking, alcohol consumption, and exercise. Population attributable risk (PAR) of obesity was calculated considering prevalence of obesity and RR of incidence and death of obesity related diseases. Socioeconomic costs were estimated including direct and indirect costs. Results: The risk of diabetes increased with increasing body mass index (BMI). In severely obese males, the risk of diabetes was 4.83 times higher than in normal weight males. In severely obese females, the risk of diabetes was 4.01 times higher than in normal weight females. In case of the socioeconomic cost of obesity, the direct and indirect costs differed by sex: the direct cost of male and female obesity was 50.8% and 85.9% in 2015, respectively. Conclusions: This study identified that obesity is not only a significant risk factor of diseases and death but also the cause of economic loss for the health insurance sector. Therefore, it is considered that it is necessary to develop an intervention program to manage examinees who are determined to be obese.

비행청소년과 일반청소년의 사회적 지지와 자기격려 및 자기낙담의 관계

김수정(Soo-Jeong Kim),이종연(Jongyeun Lee) 충북대학교 교육개발연구소 2012 한국교육논총 Vol.33 No.1