Mouse 갑상선에서 thyrotropin에 의한 thyroxine 유리에 미치는 methoxamine의 억제효과에 대한 protein kinase C의 관련

김세곤,김진상,Kim, Se-gon,Kim, Jin-sang 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.3

There is evidence that the sympathetic nervous system exerts a control on thyroid function via an adrenergic innervation of thyroid cells. Although it is clear that the inhibitory effects of catecholamines result from an activation of ${\alpha}_1$-adrenoceptors, the mechanisms involved in ${\alpha}_1$-stimulation are not fully understood. The effects of methoxamine and protein kinase C (PKC) activator on the release of thyroxine ($T_4$) from mouse thyroid were studied to clarify the role of PKC in the regulation of $T_4$ release in vitro. The glands were incubated in the medium, samples of the medium were assayed for $T_4$ by EIA kits. Methoxamine inhibited the TSH-stimulated $T_4$ release. This inhibition was reversed by prazosin, an ${\alpha}_1$-adrenergic antagonist. Futhermore, the inhibitory effect of methoxamine on the $T_4$ release stimulated by TSH was prevented by chloroethylclonidine, an ${\alpha}_{1b}$-adrenoceptor antagonist, but not by WB4101, an ${\alpha}_{1a}$-adrenoceptor antagonist. Also methoxamine inhibited the forskolin-, cAMP- or IBMX-stimulated $T_4$ release. These inhibition were reversed by PKC inhibitors, such as staurosporine and $H_7$. PMA, a PKC activator, completely inhibited the TSH-stimulated $T_4$ release, and its inhibition was reversed by staurosporine and $H_7$, but not by chelerythrine. R59022 (a diacylglycerol kinase inhibitor), like methoxamine, also inhibited the TSH-stimulated $T_4$ release, and its inhibition was also reversed by staurosporine. The present study suggests that methoxamine inhibition of $T_4$ release from mouse thyroid can be induced by activation of the ${\alpha}_{1b}$-adrenoceptors and that it is mediated through the ${\alpha}_1$-adrenoceptor-stimulated PKC formation.

원전지역 주민참여형 에너지교육 프로그램 효과성 분석

김세곤(Kim Se Gon),조준오(Jo Jun oh),김혜순(Kim Hye soon) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.21

본 연구의 목적은 원전지역 주민참여형 에너지교육 프로그램의 적용 효과성을 규명해보고자 하는 것이다. 프로그램 효과성 검증은 프로그램 참가자의 에너지 관련역량 증진 정도에 대한 평가, 프로그램 자체에 대한 CIPP 평가, 프로그램에 대한 만 족도 조사 등의 세 가지 접근으로 이루어졌다. 연구결과 첫째, 본 프로그램 참여자들의 에너지 관련역량은 경제적 비용 인식, 환경 보전 인식, 에너지 절약 의식, 에너지 절약 행동 등에서 통계적으로 유의미한 성장을 이루었다. 둘째, CIPP 평가에서는 산출평가가 가장 높이 나타났다. 셋째, 프로그램 총괄 평가는 프로그램 유용성 및 가치, 교육방법, 교육평가, 진행과정 중 ‘프로그램의 유용성 및 가치’가 가장 높게 나타났다. 결론적으로 본 연구결과는 원전지역 주민들을 참여시키는 에너지교육 프로램 개발의 필요성과 함께 프로그램 활성화를 위한 교육적, 정책적 방안 모색의 필요성을 시사한다. The program effectiveness test was divided into three parts: an evaluation of the program participant s energy - related capacity enhancement, a CIPP evaluation of the program itself, and a general evaluation of the program. Research Results Through this program, learners achieved statistically significant growth in economic cost recognition, environmental conservation awareness, energy conservation consciousness and energy saving behavior. In the CIPP evaluation, output estimates were higher than expected. The CIPP evaluation model is judged to be an evaluation model suitable for the energy community and energy democracy to pursue in this study because it voluntarily evaluates the decision making and academic achievement of the learner who participated in the education rather than the evaluation by the instructor. The overall program evaluation was divided into program usability and value, education method, evaluation of education, and progress. As a result of evaluation, utility and value of program was the highest. Through this study, it is expected that it will provide educational and policy implications on the formation of energy community for residents of nuclear power plant and the development of education program to raise energy related capacity of residents of nuclear power plant.

윈드서핑 참여자들의 참여 특성에 따른 운동욕구와 운동몰입의 관계 분석

김세곤(Kim, Se-Gon),박규남(Park, Kyu-Nam),김동건(Kim, Dong-Gun) 한국체육과학회 2014 한국체육과학회지 Vol.23 No.1

The purpose of this research is to carry out empirical analysis to assess whether there is a correlation between the variables such as wind surfing participants’ will to participate in sports activity and their immersion level depending on general attributes in order to assess impact. Survey was conducted targeting 160 people. Results of the stepwise regression analysis conducted following the correlation demonstrated that the cognitive immersion levels of {(β=-.262), (β=.544), (β=.574)} were manifested in case of the age; 30’s for the desire for health, 40’s for the desire for ostentation, and 50’s for the desire to socialize when examined by age. In case of those in their 40’s with desire for ostentation and those in their 50’s with the desire for fun, behavioral immersion{(β=.612) and (β=.405)} made an impact. As for the occupation, desire for purification in case of the salaried company workers were affected by cognitive immersion(β=-.352). As for the desire for ostentation, behavioral immersion{(β=.469) and (β=.282)} affected desire for socialization in case of the self-employed, and in case of the professionals/freelancers. As for the education level, desire for the body figure was affected by cognitive immersion(β=-.630) for those who attended high school or below. As for the desire for socialization, those who attended high school or below affected behavioral immersion (β=.371). As for the monthly income, those who make 2 Million or less, or 3.5 Million Won or less were affected by cognitive immersion{(β=-.553), (β=.414)}, respectively when it comes to those with desire for the body figure. As for the desire for socialization, those with 2.5 Million Won or less, or those with 3 Million Won or less, who seek fun affected behavioral immersion {(β=-.484) and (β=.404)}’ As for the experience, cognitive immersion(β=.534) was affected when the desire for socialization was six years, when the desires for ostentation were three and five years when it comes to the behavioral immersion{(β=.478) and (β=.616))’ As for the desire for the body figure, behavioral immersion(β=.474)) was affected at five years. As for the frequency, cognitive immersion(β=-.519) was affected when the desire for the body figure was 4~5 times. Meanwhile, desire for fun was once and did not exert significant effect on the behavioral immersion(β=-.349) by each general characteristics. Other sub elements of the desire for sports activity and sub elements of the immersion towards sports did not manifest significant effect.

6-Bromobenzo[4, 5]imidazo[1,2α]pyridin-8, 9-dione 유도체들의 Photosystem Ⅱ 저해활성에 관한 3D-QSAR 분석

김세곤(Se-Gon Kim),조윤기(Yun-Gi Cho),황태연(Tae-Yeon Hwang),성낙도(Nack-Do Sung) 한국농약과학회 2008 농약과학회지 Vol.12 No.1

대학평생교육원 스포츠프로그램 소비자의 만족과 구매 후 행동의 관계

김세곤 ( Se Gon Kim ),김재관 ( Jae Kwan Kim ) 한국스포츠리서치 2007 한국 스포츠 리서치 Vol.18 No.4

This paper has a purpose that obtains fundamental data for the management of College`s Continue educational center sports programs for more members` interests and satisfactions as the sports center which satisfies residents` needs and wants hereafter, through analyzing consumers` decisions by satisfactional degree of participants in programs related to sport opened by College`s Continue educational center. In this paper, the questionnaire inquiry was taken by 400 members who were taking sports programs opened by College`s Continue educational center in Cheon-an. Insufficient replies among collected data were ruled out and the others that could be analyzed were handled each through computer program "Window for SPSS V.10.0" by purpose of each analysis. Frequency analysis, t-test, One-way ANOVA, multiple regression analysis were used as statistical techniques. The error was α=.05 in every statistical data. Through this research, the conclusion was obtained like below. Fristly in satisfactional degree by participation types, this inquiry showed that participants who were taking squash/tennis course had the highest satisfaction on coach factor in course types. In participation continuing periods, participants who were taking for less than 1 hour at once showed the highest satisfaction on facility factor, program factor, management service factor. And in participation periods, participants who were taking for less than 1-2 years showed the highest satisfaction on program factor. Second it was indicated that coach factor, program factor and management service factor among satisfactional degree factors mainly affected participants` intentions of purchase again and recommendation.

대규모강의에서의 학습자참여 활성화방안에 관한 연구

김상무 ( Kim Sang-mu ),김수동 ( Kim Soo-dong ),김세곤 ( Kim Se-gon ),김영규 ( Kim Young-kyu ),주재훈 ( Ju Jae-hoon ) 동국대학교 교육연구소 2018 교육연구 Vol.3 No.1

대규모 인원이 수강하는 대학 강의에서 학생들의 참여를 유도하는 것은 교수자에게는 필요하면서도 중요한 과제이다. 수강생의 능동적인 학습참여 없이는 학습의 성과를 보장할 수 없기 때문이다. 이러한 문제의식에서 본 연구는 대규모 강의에서 학습자들의 수업참여를 활성화시킬 수 있는 교수방법을 연구하고자 했다. 연구자들이 생각하는 학생들의 참여를 활성화시킬 수 있는 교수방법을 1-2가지씩 조사하여, 실제 수업에서 활용하는 방법, 그리고 가능성과 한계를 함께 논의하기로 했다. 제안된 교수법은 문답법, 협동학습, 토론/토의법, 휴대폰 활용수업, 심포지움, 토크쇼, ICT활용 토론학습법이었다. 논의된 교수법들은 나름의 장단점을 가지고 있다. 강의의 목표와 특징에 따라 적절한 교수법을 활용하는 것이 중요하다. 몇 가지를 함께 수업에서 활용해보는 것도 학생들의 참여를 제고하는데 도움이 될 수 있을 것이다. It is necessary and important for professors to activate students' participation in a massive class at a university, because it can't insure the success of a university class without participation of students. In this critical mind, this study is to survey of teaching methods which activate students' participation. Every researcher of this study suggest one or two teaching methods to activate students' participation and discuss concrete application in a massive class and strength and weakness of each suggested method. They are question and answer, cooperative learning, discussion, class using cell phone, symposium, talk show, discussion using ICT. The suggested teaching methods have respectively their own strength and weakness. Therefore it is important to select appropriate methods according to the goal and characteristics of the class. It can be helpful to use some methods together to activate students' participation in a massive class.

보육교사의 직무만족이 아동학대 인식 및 방지노력에 미치는 영향

김혜정 ( Kim Hye Jeong ),김세곤 ( Kim Se Gon ) 동국대학교 교육연구소 2020 교육연구 Vol.4 No.2

본 연구는 보육교사의 직무만족이 아동학대 인식 및 방지노력에 어떠한 영향을 미치는지 알아보기 위해 수행되었다. 연구대상은 서울시에 위치한 어린이집에서 근무하는 보육교사 250명이다. 측정도구는 선행연구를 토대로 보육교사의 직무만족, 아동학대 인식 및 방지노력 척도를 수정 보완하여 사용하였다. 2019년 3월 한 달간 설문조사를 하여 최종 248부를 분석에 사용하였다. SPSS 20.0을 이용하여 신뢰도 검증, 빈도분석, t-test와 one-way ANOVA, 상관분석, 다중회귀분석을 실시하였으며, 연구결과는 다음과 같다. 첫째, 보육교사의 직무만족은 근무기관 유형에 따라 차이가 있었다. 아동학대 인식은 근무기관 유형, 직책에 따라 차이가 나타났으며, 아동학대 방지노력은 근무기관유형에 따라 차이가 있는 것으로 나타났다. 둘째, 보육교사의 직무만족, 아동학대 인식 및 방지노력 간에는 유의한 정적상관이 있는 것으로 나타났다. 셋째, 보육교사의 직무만족은 아동학대 인식 및 방지노력에 유의한 정적 영향을 미치는 것으로 나타났다. 본 연구의 결과를 토대로 보육교사의 직무만족을 높임으로 아동학대 인식 및 방지노력을 높여야 함을 논의하였다. This study was conducted to investigate the effect of child care teacher's job satisfaction on child abuse recognition and prevention. The subjects of study were 250 childcare teachers working in childcare centers in Seoul. As a measuring tool, based on previous studies, the childcare teachers job satisfaction and child abuse recognition and prevention were revised and supplemented. In March 2019, a questionnaire was conducted for a month and the final 248 copies were used for analysis. Reliability verification, frequency analysis, t-test and one-way ANOVA, correlation analysis, and multiple regression analysis were performed using SPSS 20.0. The research results are as follows. First, job satisfaction of child care teachers differed according to the type of working institution. The perception of child abuse differed according to the type of work organization and job title, and the efforts to child abuse prevention differed according to the type of work organization. Second, there were significant positive correlations between job satisfaction, child abuse recognition and prevention of childcare teachers. Third, job satisfaction of child care teachers has a significant positive effect on child abuse recognition and prevention. Based on the results of this study, we discussed that child abuse recognitoin and prevention should be improved by increasing job satisfaction of childcare teachers.

유아교육기관의 자유선택활동에 대한 운영 실태 및 교사인식

김경희 ( Kim Kyoung-hee ),김세곤 ( Kim Se-gon ) 동국대학교 교육연구소 2016 교육연구 Vol.1 No.1

본 연구에서는 유아교육기관의 자유선택활동에 대한 운영 실태 및 교사 인식을 알아보고자 하였다. 경상북도 K시 어린이집 41개소, 유치원 15개소의 만 3~5세 교사 190명이 연구대상이었다. 수집된 자료는 SPSS 18.0 프로그램을 통해 빈도분석, 기술통계분석, t-test, 일원변량분석이 이루어졌다. 첫째, 자유선택활동의 하루 운영 횟수는 1~2회, 하루 2시간이상이 가장 높았다. 교사들이 자유선택활동 계획 시 활용 자료는 `연령별 프로그램과 누리과정프로그램 등을 참고한다`가 많았고, 계획방법은`교육계획안에 의해 계획`하는 경우가 많았다. 자유선택활동 지원방법은`선택한 영역 앞에 상징물을 건다`가 많았다. 잘되는 영역은 `역할, 쌓기영역`이며, 가장 안되는 영역으로는 `수과학영역`이었다. 자유선택활동 계획의 어려움은 `활동을 계획하고 준비하는 시간이 부족하다`가 가장 많았고, 자유선택활동의 평가는 `대체로 잘 한다`, 평가방법은 `교사가 관찰한 바에 따라 일과 후 혼자 평가`가 많았다. 자유선택활동의 시간은 `충분하다`고 하였고 하루적정시간으로는 `2~3시간 미만`이 많았다. 둘째, 교사인식도 중 교육내용 및 방법에서는 `대체로 높다`이상이었다. 교육적의의 및 교육내용에서는 `자유선택활동시간은 유아들이 선택한 활동을 해봄으로써 스스로 만족감과 성취감을 느낄 수 있는 시간이다`라는 응답 빈도가 가장 높았다. This study aimed to understand the actual operation status and teacher`s awareness of elective activities in early childhood educational institutions. And it targeted 190 teachers in charge of 3-5 years old children in 41 daycare centers and 15 kindergartens in K city of Gyeongsangbuk-do. According to the result of the study, the figures mainly showed that the operating hour is 1-2 times and more than 2 hours a day. Programs of elective activities referred to children`s age and Nuri curriculum the most while showing lots of educational methods systematically reflected to the educational plan. Regarding the elective activity methods, the presentation of symbols such as name tags, pictures in front of the area selected by children was the top rate of the answers. The most activated part is the order of role, building up because kids just like it as playing game, on the other hand, the number and science part is the less activated due to the poor interplay between teachers and kids. The hardest point when teachers prepare the activities is the lack of time, and many of them evaluate the activities by themselves after class. According to them, the operation hour is enough and proper time is less than 2-3hours. Second, the awareness level of teachers for educational contents & methods was between `generally high` and `very high` and the differences in awareness depending on teachers` academic background were not significant. In regard of educational significance & educational contents, the response frequency of `The elective activity hour provides children with opportunities to feel satisfaction and accomplishment by practicing their own selected activities` was the highest.

유아 아버지와 어머니의 놀이참여와 양육참여가 자녀의 문제행동에 미치는 영향

김경희(Kim, Kyoung-Hee),김세곤(Kim, Se-Gon) 한국영유아보육학회 2021 한국영유아보육학 Vol.- No.127

본 연구는 유아 아버지와 어머니의 놀이참여와 양육참여가 자녀의 문제행동에 미치는 영향을 확인하여 문제행동을 중재할 수 있는 정보 제공의 목적으로 실행되었다. 이에 K시 소재에 거주하고 있는 유아 부모 240명과 그들의 자녀 240명을 대상으로 놀이참여, 양육참여, 유아 문제행동 검사를 실시하였다. 그 결과를 살펴보면 첫째, 어머니의 양육참여와 아버지의 놀이참여가 자녀의 문제행동을 감소시키는데 긍정적인 영향을 미쳤다. 둘째, 양육참여와 놀이참여의 하위변인이 유아 문제행동에 어떻게 영향을 미치는지 확인한 결과 어머니의 생활지원참여, 아버지의 게임참여, 어머니의 신체놀이참여, 상상놀이참여가 증가 할수록 유아의 문제행동이 감소하였다. 이와 같은 연구결과를 바탕으로 유아 어머니와 아버지의 놀이참여와 양육참여를 증진시킬 수 있는 방안을 모색하고 이를 길러주기 위한 다양한 정책과 프로그램 마련이 필요하다는 것을 시사한다. This study aims to determine how infant fathers and mothers" participation in play and parenting affects their children"s problem behavior. To achieve the purpose, a study was conducted on 240 parents and 240 infants residing in K city. Participation in play, participation in parenting, and the problem behavior of children were tested. For the analysis of the study, frequency, percentage, correlation analysis, and multiple regression analysis were performed. The research results are as follows. First, mother"s participation in parenting and father"s participation in play reduced the child"s problem behavior. Second, as mother"s participation in life support, father"s participation in games, mother"s participation in physical play, and imaginary play increased, infants" problem behavior decreased. Based on the results of this study, the data can be used to prepare specific methods for infant mothers and fathers to participate in parenting and play in the future.

원전지역주민 참여형 에너지 교육 프로그램 개발

김혜순(Kim, Hye soon),조준오(Jo, Jun oh),김세곤(Kim, Se Gon) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.23

본 연구에서는 에너지를 둘러싼 여러 문제 상황을 해결하기 위하여 원전지역주민들이 함께 참여하여 그들의 요구를 반영한 에너지 교육 프로그램을 개발하고자 하였다. 이를 위해 원전지역주민 1033명과 에너지 교육 전문가 20명을 대상으로 자료를 수집하여 분석하였다. 그 결과를 살펴보면, 최종 개발된 프로그램은 첫째, ‘원전 지역의 에너지와 관련한 다양한 문제 상황을 인식하고 해결하는데 적극적으로 참여할 수 있는 능력을 갖춘 인재 양성’이라는 목적 아래 세부 목표가 설정되었다. 둘째, 교육 과정의 체계는 에너지 지식, 에너지 문제해결기능, 에너지 문제해결에 대한 태도 등 3개 영역으로 구성되었다. 셋째, 교수학습방법은 크게 절차, 방법, 매체로 정리하였으며, 프로그램의 절차는 ‘도입 → 원전지역 에너지 문제 상황과 관련한 강의 → 원전 지역 에너지 문제 상황 탐색 → 문제의 해결방안 마련 → 실천 → 반성 및 정리’의 순서로 총 8차시에 걸쳐 이루어지도록 하였다. 구체적인 활동 방법은 창의적 문제해결 프로세스 중 액션러닝을 중심으로 한 실천, 참여, 사례, 놀이, 게임 등이 고루 사용되도록 하였다. 그리고 매체는 생활 속의 사례를 중심으로 시각물, 비디오물, 각종교,보재 등을 사용하였다. 넸째, 프로그램 평가는 학습자 평가로 자기평가, 과정중심 수시평가, 최종결과물 평가 중심으로 하였다. This study developed an energy education program that local residents participated together to solve various problems surrounding energy. For this purpose, 1033 residents and 20 energy educators were collected and analyzed. The results of this study are as follows. First, the final program aims to foster talented talent who can actively participate in recognizing and solving various problems related to energy in the nuclear region. Second, the curriculum consists of three areas: energy knowledge, energy problem solving ability, and energy problem solving attitude. Third, education and learning methods are divided into procedures, methods and media. The procedure of this program is related to the nuclear power problem of nuclear power plants → in order of lecture → exploration of energy problem of nuclear power plant → problem solving → practice → reflections and theorems. In particular, activities such as practice, participation, case, play, and games centered on behavioral learning were used in the creative problem-solving process. Fourth, the media used video, video, and various materials. Fifth, the program evaluation was evaluated by learner self - assessment, process - oriented assessment, and final evaluation.