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Sung-Hwan Kim(김성환), In-Chul Lee(이인철), Sung-Su Kang(강성수), Changjong Moon(문창종), Sung-Ho Kim(김성호), Dong-Ho Shin(신동호), Hyoung-Chin Kim(김형진), Jin-Cheol Yoo(유진철), Jong-Choon Kim(김종춘) 한국생명과학회 2011 생명과학회지 Vol.21 No.6
본 연구는 대나무 숯과 대나무 잎의 급여가 육계의 성장과 사료효율 및 육질에 미치는 영향을 조사하기 위해 30일간 각각 0.5%의 농도로 급여하였다. 시험결과, 대숯과 대잎 시험군에서 시험기간 중 사망률은 대조군에 비해 낮아진 반면, 출하 시 체중과 증체량은 대조군에 비해 유의성 있게 증가하였다. 또한 대조군에 비해 대숯과 대잎 시험군의 사료효율도 개선되었으며, 계육의 전단력은 대조군에 비해 유의성 있게 감소하였다. 대숯을 급여한 닭에서의 지방함량은 통계학적 차이는 없었으나 감소경향을 나타낸 반면, 대숯과 대잎을 급여한 닭에서의 불포화 지방산 비율은 증가경향을 나타내었다. 계육의 관능검사 결과, 대숯과 대잎 시험군의 선호도는 대조군에 비해 높게 나타났다. 혈액 및 혈청생화학 검사항목에서는 대조군과 시험군간에 유의성 있는 차이가 인정되지 않았다. 본 시험결과는 대나무 숯과 대나무 잎의 사료첨가 급여가 육계의 성장과 사료효율 및 육질을 개선시키는 것으로 나타났다. 본 연구결과는 사료첨가제로서 대나무 숯과 대나무 잎의 유용성과 개발가능성을 시사해 주고 있다. The present study was conducted to investigate the effects of dietary supplementation with bamboo charcoal (BC) and bamboo leaf (BL) on growth performance, feed intake, feed conversion efficiency, and meat quality in broiler chickens. Broiler chickens were fed for 30 days with a diet containing 0.5% bamboo charcoal or bamboo leaf. The results showed that the mortality rate during the study period was slightly lower in the BC and BL groups than the control group, while terminal weight and weight gain were significantly higher in the BC and BL groups than the control group. Dietary supplementation with BC or BL also improved feed conversion rate compared to chickens in the control group. Shear force was significantly lower in the BC and BL groups than that of the control group. The fat content of chickens fed with BC tended to decrease, while the ratio of unsaturated fat acid of chickens fed with BC or BL tended to increase, although without a statistically significant difference. Sensory evaluation revealed that overall acceptability was slightly higher in the BC and BL groups than the control group. There was no statistically significant change in the hematology and serum biochemistry parameters, compared with the control group in any group tested. The results of this experiment indicated that dietary supplementation with BC and BL may improve growth performance, feed conversion efficiency, and meat quality in broiler chickens.
김성호(Sung-Ho Kim), 김세라(Se-Ra Kim), 이해준(Hae-June Lee), 김종춘(Jong-Choon Kim), 장종식(Jong-Sik Jang), 강창모(Chang-Mo Kang), 류시윤(Si-Yun Ryu), 조성기(Sung-Kee Jo) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.1
We induced the activation of melanocytes in the epidermis of C57BL/6 mice by ultraviolet B (UVB) irradiation and observed the effect of green tea extract (GTE) on the formation, and decrease of UVB-induced epidermal melanocytes. C57BL/6 mice were irradiated by UVB 80 mJ/㎠ (0.5 mW/sec) daily for 7 days, and GTE was intraperitoneally or topically applied before or after irradiation. To estimate change of epidermal melanocytes, light microscopic observation with dihydroxyphenylalanine (DOPA) stain was performed. Split epidermal sheets prepared from the ear of untreated mice exhibited 11-13 melanocytes/㎟, and one week after UV irradiation, the applied areas were increased number of strong DOPA-positive melanocytes with stout dendrites. But intraperitoneal or topical treatment with GTE before each irradiation interrupted UVB-induced pigmentation and resulted in a marked reduction in the number of epidermal melanocytes as compared to the number found in UVB-irradiated and untreated skin. The number and size of DOPA-positive epidermal melanocytes of intraperitoneally or topically applicated GTE group were also significantly decreased as compared to that of only UV irradiated group at 3rd and 6th weeks after irradiation. The present study concludes GTP has a potential of inhibitor on UVB-induced pigmentation and depigmenting agent.
김성호(Sung-Ho Kim), 김세라(Se-Ra Kim), 이해준(Hae-June Lee), 강창모(Chang-Mo Kang), 김종춘(Jong-Choon Kim), 김일화(Ill-Hwa Kim), 장종식(Jong-Sik Jang), 류시윤(Si-Yun Ryu), 조성기(Sung-Kee Jo) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2
Cytogenetic and hematological analysis was performed in peripheral blood of pig in the high background radiation area (HBRA) (Goesan-gun) and control area. The frequency of micronuclei (MN) in peripheral blood lymphocytes from pig was used as a biomarker of radiobiological effects resulting from exposure to environmental radiation. An estimated dose of radiation was calculated by a best fitting linear-quadratic model based on the radiation-induced MN formation from the swine lymphocytes exposed in vitro to radiation over the range from 0 Gy to 4 Gy. When analysed by Iinear-quadratic model the line of best fit was y=0.0102D²+0.0250D+0.011[y=number of MN/cytokinesis-blocked (CB) cells and D=irradiation dose in Gy]. MN rates per 1,000 CB lymphocytes of pig from HBRA and control area were 9.20±3.88 and 11.00±2.98, respectively. There were no significant differences in MN frequencies and hematological values in pig between HBRA and control area.
In this study we assessed the influences of ultraviolet (UV) light B radiation on epidermal ATPase-positive dendritic cell (DC) and the effect of green tea treatment in ICR mouse. The extent of changes following 200 mJ/㎠ (0.5 mW/sec) was studied at 0, 6, 12, 18, 24, 30 or 36 hours after exposure. SBCs were decreased by 6 hours after irradiation. There was tendency to decrease from 6 hours to 24 hours and had little further change from then to 36 hours after irradiation. The mice that received 0, 50, 100, 200, 300 or 400 mJ/㎠ of UVB were examined 24 hours after irradiation. The DCs were decreased as the radiation dose increases from 100 to 400 mJ/㎠. The frequency of UVB (200 mJ/㎠)-induced DC decrease was reduced by treatment of green tea (i.p. and topical application, p<0.01).
Purpose: If the survival of patients suffering from severe blunt trauma is to be improved, appropriate interventions should be taken immediately. The purpose of this study is to evaluate the clinical utility of end-tidal carbon dioxide (ETCO2) as a surrogate marker for predicting both the need for intervention and the prognosis. Methods: This is a prospective observational study. Nasal cannula was applied to measure ETCO2, and the following parameters, which are known to be related to the prognosis for a patient, were recorded: injury severity score (ISS), revised trauma score (RTS), arterial blood gas (ABG), lactate, and hemoglobin (Hb). To evaluate the outcome, we investigated the details of emergent interventions and expired patients. Results: A total of 93 patients were enrolled in this study. Emergent intervention was significantly associated with systolic blood pressure (sBP, p-value=0.001), ETCO2 (p-value<0.001), serum lactate level (p-value<0.001), pH (pvalue< 0.003), HCO3 (p-value=0.004), base excess (p-value<0.002), ISS (p-value<0.001) and RTS (p-value=0.005). In the multivariate logistic regression, only ETCO2 (odds ratio (OR): 0.897, 95% confidence interval (CI): 0.792-0.975, pvalue= 0.048) and ISS (OR: 1.132, 95% CI: 1.053-1.233, p-value=0.002) were associated with emergent intervention whereas ETCO2 (p-value=0.973) and ISS (p-value=0.511) were not statistically significant in predicting the survival of patients in the univariate analysis. An optimal ETCO cut-off of 29 mmHg on the ROC curve was determined, with the area under the ROC curve (AUC) being 0.824 (0.732-0.917)]. Conclusion: This study has revealed that ETCO2, which can be rapid and easily measured through a nasal cannula, and the ISS may be prognostic indicators of emergent interventions in Emergency Departments. [ J Trauma Inj 2014; 27: 133-8 ]
본 연구팀에서는 방사선으로부터 위장관과 면역조혈계를 방호하기 위하여 당귀, 천궁, 백작약으로 새로운 생약복합물 HIM-I을 개발하였고, HIM-I을 에탄올 침전하여 에탄올 분획(HIM-I-E)과 조다당 분획(HIM-I-P)을 얻은 후, HIM-I에 조다당 분획을 첨가하여 HemoHIM을 제조하여 실험하였으며, 과산화수소를 이용하여 산화적 스트레스를 유발한 후 HemoHIM의 apoptosis 억제 효과를 측정하였다. 과산화수소를 세포주에 처리한 결과 세포독성 증가, 세포막 파괴, subG1기 세포 증가, DNA 절단 현상 등이 관찰되었다. 이때 HIM-I, HIM-I-P, HemoHIM을 첨가하여 전처리 배양한 다음에 과산화수소로 apoptosis를 유도하였다. 그 결과 과산화수소에 의한 세포독성, 세포막 파괴, subG1기 세포, DNA 절단현상 등이 현저하게 감소하는 것으로 나타났다. 전반적으로 HemoHIM의 방호 효과는 HIM-I-P와 비슷하였으며 HIM-I보다 높은 것으로 나타났다. 이상의 결과로 HemoHIM은 면역기능 방호?회복 물질로서 뿐만 아니라 산화적 스트레스에 대한 항산화제로서 유용하게 활용될 수 있을 것으로 생각된다. In our previous study, a novel herb mixture (HIM-I) of Angelica gigas radix, Cnidium officinale rhizoma, and Paeonia japonica radix was developed to protect the intestinal and immune systems and promote its recovery against radiation damage. A new herbal composition (HemoHIM) with the high immune modulating activity was developed from HIM-I. HIM-I was fractionated into ethanol fraction (HIM-I-E) and polysaccharide fraction (HIM-I-P). And HemoHIM was prepared by adding HIM-I-P to HIM-I. HemoHIM showed more effective than HIM-I in immune modulation as well as radioprotection. The present study is designed to investigate the protective effects of HIM-I, HIM-I-P, and HemoHIM on hydrogen peroxide (H₂O₂)-induced apoptosis of human promyelocytic leukemia (HL-60) cells. It was shown that H₂O₂ treatment reduced the viability of cells, and increased appearance of DNA ladders, hypodiploid (subG1) cells, and phosphatidylserine translocation level. Pretreatment of HemoHIM significantly reduced the cytotoxic effect induced by H₂O₂, associated with reducing the translocation of phosphatidylserine, hypodiploid cells and DNA ladders. HemoHIM appeared to be more protective than HIM-I against H₂O₂-induced apoptosis whereas, it exhibited similar activity to HIM-I-P. These results indicated that HemoHIM might be an useful agent for protection against oxidative stress (H₂O₂)-induced apoptosis as well as immune modulation, especially since it is a relatively nontoxic natural product.
생체내에 존재하는 효소 등의 단백질은 그 골격을 이루는 아미노산 이외에 다양한 형태로 금속 원소들과 킬레이션을 이루고, 고유한 생리활성을 나타낸다. 단백질과 금속과의 킬레이션을 체계적으로 연구하기 위하여 가수분해 하여 얻은 펩타이드와 Zn(Ⅱ) 이온을 반응시키고, MALDI-TOF 질량분석기로 킬레이트 반응전 후의 펩타이드의 분자량을 측정하여 킬레이트 반응 생성물을 확인하는 분석법을 개발하고자 한다. In living system, various types of metal chelated protein show their intrinsic biological activities. In order to investigate the chelation reaction between protein and metal, zinc chelated peptide was systhesized by the peptide, hydrolyzed protein, with zinc. And simple analytical method fot the chelation reaction was developed using MALDI-TOF mass spectrometry.
최근 LG화학은 ‘하이페리어(HYPERIER)'라 불리우는 고차단성의 고급 엔지니어링 플라스틱 신소재를 개발하였다. 이 소재는 LDPE(Low-Density Poly Ethylene)로 구성된 나노복합소재로 만들어졌으며, 여러 층으로 구성된다. 생산라인에서 산출된 최종 생산품의 품질을 보증하기 위해서는 하이페리어 내부에 존재하는 층들의 존재 유/무를 식별하기 위한 시험장비가 요구된다. 본 논문에서는 하이페리어 내부에 존재하는 층들의 유무를 조사하기 위해 사용될 수 있는 초음파 테스트 장치를 소개하고, 사람이 직접 계측된 신호를 검사하여 품질을 분류하는 기존의 시스템의 성능향상을 위해 FFT와 PCA, BP 신경망을 통하여 품질을 분류(양품/불량품)하는 기법을 제안하며, 시뮬레이션을 통하여 제안된 기법의 유용성을 확인해 보고자 한다. Recently, LG chemical corporation developed new material called HYPERIER, which has an excellent barrier characteristic. It has many layers which are made of nano-composite within LDPE(Low-Density Poly Ethylene). In order to guarantee the quality of the final product from the production Line, a certain test equipment is required to investigate the existence of layers inside the HYPERIER. In this work, ultrasonic sensor based test equipment for investigating the existence of inner layers is proposed. However, it is a tedious job for human operators to check the existence by just looking at the resounding waveform from ultrasonic sensor. Therefore, to enhance the performance of the ultrasonic test equipment, Fast Fourier Transform(FFT) and Principle Components Analysis(PCA) and Back-Propagation Neural Network(BPNN) are utilized which is used for classification of Quality. To verify the feasibility of the proposed scheme, some experiments are executed.