오공약침의 아만성독성 시험 및 생산량 증가방안에 관한 연구

김성철,Kim, Sung-Chul 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.4

Purpose The purpose of this study was to investigate sub-chronic toxicity of scolopendrid pharmacopuncture in mouse and method of increasing output of scolopendrid pharmacopuncture. Methods In order to prove the clinical safety of scolopendrid pharmacopuncture during 90 days, We have observed the physical reaction(side effect) and clinical pathology test after scolopendrid pharmacopuncture treatment and investigated method of increasing Output of scolopendrid pharmacopuncture for 90%, 80%, 70% ethanol. Results In subchronic toxicity test, there was no significant sign in clinical sign, opthalmological values, body weights, hematological values and urinalysis values. And we could see that food consumptions and water consumptions increased significantly, albumin, triglycerides, GPT in blood chemical values and Liver, Testis(right) in organ weights changed significantly in some groups, compared with those in the S1 group. But these changes were observed within the scope of physiology. So there was no sign of toxication in subchronic toxicity test, and we can tell that NOAEL(No Observed Adverse Effect Level) is above 0.286mg/kg/day. And 70% ethanol solution of scolopendrid was yielded the most amount of substance. Conclusions This study demonstrates that scolopendrid pharmacopuncture is to treatment of safety for a long time and we can obtain much amount from 70% ethanol solution of scolopendrid.

수직 직근의 단계적 부분 건절제술을 통한 상사시 치료

김성철,임혜빈,AlbertWBiglan,Sung-Chul Kim,Hye-Bin Yim,Albert W Biglan 대한안과학회 2005 대한안과학회지 Vol.46 No.4

Purpose: To evaluate the effectiveness of graded (adjustable intraoperatively) partial vertical rectus muscle tenotomy at the insertion in correcting small degrees of hypertropia. Methods: All patients with best corrected visual acuity of better than 6/30 in both eyes who had undergone only partial tenotomy of vertical rectus muscle(s) over a 30-month period were included. Improvement was evaluated 6 weeks postoperatively as the change in alignment in prism diopters (PD) in primary gaze and in the field of action of the affected rectus muscle(s). Binocular function was evaluated by Titmus stereoacuity and the Worth 4-light tests. Results: All 24 patients who met the inclusion criteria had diplopia preoperatively, and this had resolved in 17 (71%) postoperatively (P<0.005). Prisms were used by 6 preoperatively vs. 2 postoperatively (P<0.05). The average vertical deviation in primary gaze decreased from 8 PD to 2 PD (P<0.005). In the field of action of the treated rectus muscle, hypertropia decreased from an average of 8 PD to 3 PD (P<0.005). For the available pre- and post-operative assessments, stereoacuity improved after 10 of the 18 (56%) procedures and Worth 4-light testing showed improvement or maintenance of fusion after 13 of 19 procedures (68%). Conclusions: Graded vertical rectus partial tenotomy can effectively reduce small degrees of hypertropia and associated diplopia, improve binocular function, and reduce or eliminate the need for prism correction.

X선영상증배관의 상대변환계수 측정에 관한 검토

김성철,신성일,이선숙,허준,김성수,Kim, Sung-Chul,Shin, Sung-Ill,Lee, Sun-Sook,Huh, Joon,Kim, Sung-Soo 대한방사선기술학회 1997 방사선기술과학 Vol.20 No.2

For the Evaluation of X-ray image intensifier, we measured radiation dose at input of I. I., brightness and fluorescence at output of I. I. by using X-ray exposure meter, optometer and fluorescence meter for the relative conversion factor. Especially, by using fluorescence meter, we could easily get relative conversion factor without having regulated machine by JIS. Since using, the quality of image intensifier is going down. Consequently, it needs continuous quality maintenance.

경기론(經氣論)에 근거(根據)한 사상체질(四象體質) 형성(形成)에 관한 문헌적(文獻的) 고찰(考察)

김성철,Kim, Sung-Chul 사상체질의학회 2003 사상체질의학회지 Vol.15 No.2

Objective: The purpose of this study is to discourse upon that the construction of Sasang Constitutional Medicine has a significant property of Oriental Medicine by explaining the disparity of the viscera and bowels of four constitutions through the special quality of ying-qi and wei-qi circulating in human body on the basis of the channel-qi theory of ${\ulcorner}Huangdi$ $Neijing{\lrcorner}$ Conclusion: 1. Primordial-qi is the congenital essence inherited from the parents and pectoral-qi, ying-qi and wei-qi is the acquired essence derived from the food and air that human eat and breathe. 2. Ying-qi and wei-qi circulates in the meridian system by the strength and pushing of pectoral-qi under the influence of primordial-qi 3. Ying-qi, by the pushing function of pectoral-qi, determines large lung-small liver and small lung-large liver according to the innate quantity of qi and blood. 4. Wei-qi, by the pushing function of pectoral-qi, determines large spleen-small kidney and small spleen-large kidney according to the innate quantity of qi and blood. 5. The heart in the theory of the meridian system's fetus-nourishing and Sasang Constitutional Medicine is involved in the formation of viscera and bowels as governing human body and seven emotions. 6. It is considered that Taiyang person and Taiyin person have the constitution influenced by ying-qi. 7. It is considered that Shaoyang person and Shaoyin person have the constitution influenced by wei-qi. The inquiry into several literatures on the basis of the channel-qi theory of ${\ulcorner}Huangdi$ $Neijing{\lrcorner}$ leads us to the idea that the construction of Sasang Constitotional Medicine is another well-implied representation of the property of the meridian doctrine in the existing Oriental Medicine. And it is considered that the more continual studies of literatures and Sasang Constitutional Medicine Acupuncture are necessary henceforth.

GIS를 이용한 개발지역 주변 하늘다람쥐 잠재서식지 평가

김성철,전영신,임춘우,정철운,Sung Chul Kim,Young Shin Jeon,Chun Woo Lim,Chul Un Chung 한국환경과학회 2023 한국환경과학회지 Vol.32 No.5

In this study, 12 environmental factors were used to evaluate the potential habitat of Pteromys volans living around some development areas. The analyzed value ranged from 0 to 20.1, and the area with a score of 10 or less was analyzed to have a low possibility of inhabiting Pteromys volans. To verify the analyzed results, a field survey was conducted on areas with 10 or more scores, and traces of habitat of Pteromys volans were confirmed in areas with 16 or more scores. All the areas with an evaluation score of 16 or higher showed high crown density and age class. However, despite the high crown density and age class, the evaluation score in some areas was low owing to the influence of other environmental factors. Therefore, in evaluating Pteromys volans habitats, it is necessary to apply various and complex criteria suitable for field conditions rather than applying uniform and fragmentary environmental factors only.

근위축성 측삭경화증에 대한 한방 치료의 임상선행연구

김성철,나원민,임나라,이도상,장은하,송봉근,Kim, Sung-Chul,Na, Won-Min,Lim, Na-Ra,Lee, Do-Sang,Jang, Eun-Ha,Song, Bong-Keun 대한약침학회 2009 Journal of pharmacopuncture Vol.12 No.1

Objectives : This study was to investigate the effect of Oriental medical treatment on ALS. Methods : We investigated 12 ALS patients which were admitted to Gwang-Ju O.M. hospital from Oct. 14, 2008 to Nov. 14, 2008. All patients were treated by SAAM-acupuncture, herb medication, Bee venom Pharmacopuncture therapy, Needle-embedding therapy, etc. We evaluated patients using the Amyotrophic lateral sclerosis Functional Rating Scale-Revised(ALSFRS-R), Medical Research Council (MRC) Scale. Results : After 30 days, mean ALSFRS-R score of patients was improved from $28.42{\pm}7.83$ to $29.08{\pm}7.99$, and mean MRC Scale of patients was improved from $24.79{\pm}8.37$ to $25.34{\pm}8.45$. But in both cases, the variation was not statistically significant. After 30 days, mean ALSFRS-R score and mean MRC Scale of patients was more improved in subjects with bulbar-onset, onset age: 51-60yrs., disease duration: 24-48mo. And the results showed partially significant difference. Conclusions : We think that the results of this case be a pilot study that proves the effect of Oriental Medical treatment on ALS.

침도 침술시 부작용과 예방법에 관한 연구

김성철,Kim, Sung-Chul 대한침구의학회 2008 대한침구의학회지 Vol.25 No.4

Objectives : Analyze according to types of event causing the adverse outcome due to acupotomy, and discuss problems and safety reqirements to using this therapy in Korea. Methods : Based upon the indication, contraindication, treatment procedures, clinical obsevations, acupotomy-related adverse outcome case reports, the factors of damaging event were classified. Results : The main factors of adverse outcome by acupotomy were anatomical ignorance, contamination of device or hospital staff, failure to notice preexisting disease(cardiovascular disease, hypertension, renal failure, hemophilia, chronic Liver Disease, etc.), unskilled treatment procedures(massive bleeding) and techniques(nerve injury, hepatic and splenic injury, Pneumothorax). Conclusions : It is mandatory to prepare adequate sterilie aseptic technique. The clinician should ensure understand genernal health state of patient and anatomical direction.

PMIPv6에서 사전 인증 기법과 경로 최적화를 이용한 효율적인 핸드오버 기법에 관한 연구

김성철,문일영,조성준,Kim, Seong-Chul,Moon, Il-Young,Cho, Sung-Joon 한국정보통신학회 2010 한국정보통신학회논문지 Vol.14 No.5

PMIPv6 is a network-based mobility support scheme, proposed and standardized by NetLMM WG of IETF. It is proposed to solve problems of conventional mobility schemes, and to improve inefficiency of those. The standard document describes network components and detailed procedures to provide mobility to MN. But it describes only a handover procedure between MAGs, not between LMAs. In order to support seamless connectivity of MN efficiently, a handover procedure between LMAs is necessary. The proposed scheme in this paper utilizes a route optimization procedure to prevent inefficiency of inter-LMA tunneling scheme. At the same time, the proposed scheme utilizes a pre-authentication scheme to reduce handover latency. According to the result of performance evaluations, the proposed scheme greatly reduces handover latency, compared to conventional mobility support schemes. PMIPv6는 IETF의 NetLMM WG에서 표준화를 진행하는 네트워크 기반 이동성 지원 기법으로서, 기존의 단말 기반 이동성 지원 기법의 문제점과 비효율성을 개선하기 위해 제안되었다. IETF에서 공개한 표준 문서는 MN에게 이동성을 제공하기 위한 네트워크 구성 요소와 그 구체적인 동작 및 핸드오버 절차에 대해 서술하고 있다. 그러나 MAG간 핸드오버에 대해서만 정의되어 있고 LMA간 핸드오버에 대해서는 정의되어 있지 않다. 따라서 MN에게 보다 효율적으로 끊김 없는 인터넷 접속을 제공하기 위해서는 LMA간 핸드오버 기법이 함께 사용되어야 한다. 본 논문에서 제안하는 기법은 기존에 제안된 LMA간 핸드오버 기법의 단점인 LMA간 터널을 사용하지 않고, 경로 최적화 절차를 거쳐 효율적인 전송 경로를 사용한다. 또한 핸드오버 지연을 줄이기 위해 사전 인증 기법을 도입하였다. 성능 분석 결과에 따르면 제안하는 기법이 기존의 이동성 지원 기법에 비해 핸드오버 지연을 크게 감소시키는 것을 확인할 수 있었다.

오공약침(蜈蚣藥鍼)에 대한 연구현황분석(硏究現況分析)과 치료법(治療法)에 관한 연구(硏究)

김성철,Kim, Sung-Chul 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.2

Objectives : We review a result of studies until the present and suggest the method of medical treatment for the clinical treatment of Scolopendrid Herbalacupuncture. Methods : We analysis the paper of the bibliographic studies, the experiment studies and the clinical studies from 2001 developed Scolopendrid Herbalacupuncture and grope for the course of studies. Results : 1. Scolopendrid Herbalacupuncture is proved the clinical safety by the aninmal and human tests. 2. The pharmacological action of Scolopendra subspinipes mutilans L. Koch is anti-convulsive action, analgesic action, lowering blood pressure, anti-inflammatory action, anti-tumor action and microbe inhibition 3. Scolopendrid Herbalacupuncture has been a fine effect to the entrapment neuropathy and inflammatory. 4. Scolopendrid Herbalacupuncture was thought effective on a acute phase and to the excessive symptoms. The Sub-chronic toxicity experiment observing the response after hypodermic medication over 90 days, The Genetic-mutagenic toxity experiment and the clinical effect studies are necessary.

초오 약침 개발을 위한 백서 독성 연구 및 생리활성에 대한 연구

김성철,안성훈,김성하,이상관,송봉근,Kim, Sung-Chul,Ahn, Seong-Hun,Kim, Sung-Ha,Lee, Sang-Kwan,Song, Bong-Keun 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.1

Objective : We investigate toxicity of Aconiti ciliare tuber and antioxidant activity of Aconiti ciliare tuber Pharmacopuncture to develop safe Aconiti ciliare tuber Pharmacopuncture and find out the effect. Methods : In order to investigate toxicity of Aconiti ciliare tuberm, we administered Aconiti ciliare tuberm orally to rats and examined the survival rate, comparing with the survival rate of rats administered by Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae. We examined the in vitro biological activity of Aconiti ciliare tuber Pharmacopuncture, including the total polyphenol content, and ABTS radical scavenging. Results and Conclusions : The $LD_{50}$ of Radix aconitum simmered with Semen Glycine and Radix Glycyrrhizae was 9.0g/kg, on the other hand, the $LD_{50}$ of Aconiti ciliare tuberm was more than 15g/kg. The total polyphenol contents of Aconiti ciliare tuberm Pharmacopuncture was 2.31mg/L. The 2,2'-azinobis-3-ehtlbezothiazoline-6-sulfonic acid radical decolorization (ABTS) was 10.26%. We conclude that Aconiti ciliare tuberm is not highly toxic, Aconiti ciliare tuber Pharmacopuncture has a little antioxidant effect.