http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Preparation and evaluation of oral dissolving film containing local anesthetic agent, lidocaine
김보식,박규태,박민호,신영근,조정원 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.6
A lot of polymeric oral dosage forms have been invented for suitable drug delivery and compliance of patient. Oral dissolving film (ODF) offers a comfortable way to enable drug administration. The purpose of this study was to develop an ODF using lidocaine, with moderate mechanical strength and thickness, fast disintegration time and local anesthetic effect. Hydroxypropyl methyl cellulose, sodium alginate, glycerin, sodium lauryl sulfate, polyvinylpyrrolidone and citric acid were used to build the polymeric film base of the ODF. The optimal composition was determined by changing the ratio of individual excipients. The thickness was insignificantly varied in the range of 0.04 ± 0.01 to 0.06 ± 0.01 mm. On the other hand, the tensile strength was 1.23 ± 0.20 to 1.83 ± 0.30 N/cm2. Drug content in the films was evaluated and the values were 16 mg of lidocaine per each ODF (40 mg/strip). Lidocaine ODF formulation showed the release of 91.7% of lidocaine within 1 min and 96.3% of lidocaine in 5 min. These results suggested that lidocaine ODF was well prepared and showed the fast release of lidocaine.
고에너지 볼밀링된 Sm-Co 합금 분말의 미세조직 및 자성특성에 미치는 공정변수의 영향
김보식,장시영,Kim, Bo-Sik,Chang, Si-Young 한국분말야금학회 2010 한국분말재료학회지 (KPMI) Vol.17 No.2
Sm-16.7wt%Co alloy powders were prepared by high energy ball milling under the conditions of various milling time and the content of process control agent (PCA), and their microstructure and magnetic properties were investigated to establish optimum processing conditions. The initial powders employed showed irregular shape and had a size ranging from 5 to $110\;{\mu}m$. After milling for 5 h, the shape of powders changed to round shape and their mean powder size was approximately $5\;{\mu}m$, which consisted of the agglomerated nano-sized particles with 15 nm in diameter. The coercivity was reduced with increasing the milling time, whereas the saturation magnetization increased. As the content of PCA increased, the powder size minutely decreased to approximately $7\;{\mu}m$ at the PCA content of 10 wt%. The XRD patterns showed that the main diffraction peaks disappeared apparently after milling, indicating the formation of amorphous structure. The measured values of coercivity were almost unchanged with increasing the content of PCA.
고체지질입자 제조방법의 입자크기와 봉입율에 미치는 영향
김보식,김주헌,이경록,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2016 藥學論文集 Vol.31 No.-
The solid lipid particles (SLN) using a solid lipid similar to the biological lipids have a lot of attention in the pharmaceutical industry due to drug delivery, controlled release, improvement of bioavailability and decrease of adverse effects. SLN could be prepared by various methods such as high pressure homogenization, solvent emulsification evaporation, solvent emulsification diffusion, microchannel/microfluid, solvent injection, melting dispersion, double emulsion, microemulsion, ultrasonication and membrane contactor. In this review, effects of above preparation method of SLN on particle size, polydispersity and encapsulation efficiency were investigated.
페미니스트 형식주의: 근대 초기 영국 여성 예언문학의 미래
김보식 영미문학연구회 2023 안과 밖 Vol.- No.55
This paper outlines and assesses recent criticism calling for formalist approaches to early modern British women ’ s writing. In doing so, this paper proposes to read women ’ s prophecy through feminist formalism, a research methodology that combines historicist and formalist approaches centering on feminist insight, in order not only to improve a marked tendency to avoid studying women ’ s religious writings in a formalist vein, but also to help resolve the critical disjunction between the study of early modern British women ’ s literature and canonical literature in a creative way. This paper suggests that studying prophetic forms in a integrated literary history that encompasses mainstream and non-mainstream prophetic literature contributes to promote an academic dialogue between the study of noncanonical women writers and canonical male author scholarship. It can bring in new perspectives on the writings of canonical male authors in the context of the broader field of early modern culture beyond merely including women ’ s literature into the canon. It also hopes to provide a case study of investigating Milton and female prophets from an integrative perspective, which shows that analyzing women ’ s writings in relation to the broader literary canon enriches the study of early modern women writers and canonical literature.