혈액투석 환자의 고칼륨혈증 치료에 대한 칼륨의 세포 내 이동방법에 의한 단일 및 병합 치료요법

김병훈(Byoung Hun Kim),양석철(Suck Chul Yang),김호중(Ho Jung Kim) 대한내과학회 1998 대한내과학회지 Vol.54 No.2

N/A Objectives : We evaluate the efficacy of transcellualr K-lowering effect at 1 hour following mono-therapy compared to that of dual-therapy, and aimed to find the sage and rapid method for acute therapy of hyperkalemia before dialysis in 10 F5RD patients with maintenance hemodialysis. Method: For ten patients of end stage renal failure with body weight between 55 and 65 Kg and a predialysis plasma potassium greater than 5.5 mEq/I., we studied in three separated phases separated from one another by at least 1 week. After 1 hour following mono-therapy (2mEq/Kg of NaHCO3 in interavenous infusion, 10 units of regular insulin with 50ml of 50% glucose in i.v. push, or 15mg of salbutamol in nebulizer) or dual therapy(NaHCO3 + Insulin with glucose, NaHCO3 + salbutamol, or salbutamol + insulin with glucose) for hyperkalemia, we compared the efficacy and safety of each transcellular K shifting methods. Results Bicarbonate infusion induced a signigicant raise in plasma bicarbonate and pH from baseline values in both mono-therapy and dual-therapy without any significant difference each other. Among mono-therapeutic regimens, bicarbonate alone failed to lower plasme K from baseline levels (-0.11±0.15 mEcq/L, P=NS) whereas two other regimens effectively lowered plasma K (-0.62±0.06 mEq/L in insulin with glucose, -0.57±0.04 mEq/L in salbutamol, P vs. basal <0.05 in both). The K-lowering effects in the three combined regimeds of dual therapy were more prominent as compared to that of three regimens of monotherapy (-0.96±0.08 mEq/L in NaHCO3 + salbutamol, -1.20±0.6 mEq/l. in NaHCO3 + insulin with glucose, and -1.20±0.10 mEq/L in salbutamol + insulin with glucose, respectively)(P<0.05). Two patients in mono- y with salbutamol alone were resistant to the hypokalemic effect, however in dual therapy with simultaneous administration of salbutamol and bicarbonate resolved it. Also, hypoglycemia (<60mg/dL of fasting glucose) was noted in 4 patients in mon-therapy of insuli with glucose alone, 2 in dual-therapy of insulin with glucose + NaHCC3, but none in insulin with glucose + salbutamol. Conclusion: Dudal-therapeutic regimens lowered plasma potassium more effectively than mono-therapeutic regimens, and among them, the combination of insulin with glucose plus salbutamol could be recommended as an efficacious and safe modality in the acute therapy of hyperkalimia in ESBD patients.

이상성(Biphasic) 폐 모세포종

김병훈 ( Byoung Hun Kim ),전석훈 ( Seok Hoon Jeon ),이경상 ( Kyung Sang Lee ),양석철 ( Suck Chul Yang ),윤호주 ( Ho Joo Yoon ),신동호 ( Dong Ho Shin ),김인순 ( In Soon Kim ),박성수 ( Sung Soo Park ),이정희 ( Jung Hee Lee ),박찬금 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.5

내용기반 영상 검색을 위한 ART2 를 이용한 양자화 방법에 관한 연구

김병훈 ( Byoung-hun Kim ),구경모 ( Kyung-mo Koo ),박용민 ( Yong-min Park ),차의영 ( Eui-young Cha ) 한국정보처리학회 2004 한국정보처리학회 학술대회논문집 Vol.11 No.2

본 논문에서는 칼라 정보 기반 영상 검색에서 양자화 과정을 거치면서 나타나는 문제점의 해결방안으로 ART2 신경회로망을 이용한 양자화 방법을 제시한다. 영상을 양자화하면 비슷한 칼라를 가진 픽셀이 다른 칼라로 나누어지는 경우가 발생하여 영상 검색 성능을 떨어뜨린다. 따라서 본 논문에서는 양자화를 하기 전에 ART2 신경회로망을 이용하여 영상에 존재하는 여러 칼라들을 클러스터링하여 같은 클러스터 속한 비슷한 칼라의 픽셀들은 같은 칼라로 양자화되도록 하였다. 실험에서 영상 검색에 제안한 방법을 적용하였을 때, 검색의 성능 향상에 도움이 된다는 것을 확인할 수 있었다.

옵션시장에서 변동성 추정모형의 성과분석

김병훈(Byoung Hun Kim),여성칠(Sung Chil Yeo) 건국대학교 경제경영연구소 2009 商經硏究 Vol.34 No.2

본 논문에서는 KOSPI200 지수와 한국거래소에서 제공하는 옵션의 내재변동성자료를 이용하여 변동성의 예측력 비교에 대한 분석을 실시하였다. 이를 위하여 KOSPI200 지수의 과거자료를 이용하여 시계열자료의 이분산성을 논의하고 그에 의하여 설명될 수 있는 일반화된 자기회귀 조건부 이분산 모형을 적용한 후 변동성의 예측 시계열자료를 구하였다. 또한 실현변동성과 역사적변동성을 산출하여 옵션시장 자체에서 확인할 수 있는 이론적 변동성인 내재변동성과 일반화된 자기회귀 조건부 이분산 모형에 따른 변동성의 예측치가 얼마나 정확하게 변동성을 예측하는 가를 분석하였다. 예측기간에 대해 일반화된 자기회귀 조건부 이분산 모형을 통한 변동성 예측자료가 내재변동성과 역사적변동성에 비해 보다 더 나은 예측 결과를 보여주고 있다. In this paper, a comparative study for forecasting performance of the volatility estimation models has been conducted based on the data of KOSPI200 Index and implied volatility provided by Korea-Exchange. The generalized autocorrelation with conditional heteroskedasticity(GARCH) models are applied to obtain the information of the volatilities from KOSPI200 Index. Based on the information of the estimation results of GARCH models and implied volatility model, the realized volatility and historical volatility are evaluated to compare the forecasting performance between the GARCH models and the implied volatility model. The GARCH models are shown to have a better forecasting performance than the implied volatility model during the prediction period.

카타디옵트릭 카메라를 이용한 직각교차실린더맵에 관한 연구

구경모 ( Kyung-mo Koo ),김병훈 ( Byoung-hun Kim ),김하영 ( Ha-young Kim ),차의영 ( Eui-young Cha ) 한국정보처리학회 2004 한국정보처리학회 학술대회논문집 Vol.11 No.1

본 논문에서는 일반적인 실린더 맵에서 구현하지 못하는 시점이동의 한계를 보완하고 현실감 있는 실시간 영상기반 환경 탐색을 위해 완전시야를 갖는 직각 교차 실린더 맵을 제안한다. 제안한 알고리즘에서는 한 대의 카메라와 하나의 볼록거울의 조합으로 이루어진 카타디옵트릭 카메라를 이용하여 수평, 수직 두 개의 전(全)방향 이미지를 얻고, 이미지를 실린더에 매핑한 뒤 두 실린더를 합하는 방법을 이용하였다. 실험에서는 제안한 방법이 기존의 방법에 비해 시선이동 뿐만 아니라 환경 탐색에 자유로워짐을 확인한다.

만성 혈액투석 환자에서의 대사성 산혈증과 음이온차의 양상

손정일(Chong Il Sohn),김병훈(Byoung Hun Kim),신진호(Jin Ho Shin),양석철(Suck Chul Yang),박용수(Yong Soo Park),한동수(Dong Soo Han),안명주(Myung Ju Ahn),손주현(Ju Hyun Sohn),이인홍(In Hong Lee),김순길(Soon Kil Kim),이정희(Jung Hee Lee 대한내과학회 1996 대한내과학회지 Vol.51 No.2

N/A Objectives: The aim of the present study is to evaluate the prevalence of the various patterns of metabolic acidosis and anion gap among chronic hemodyalysis patients. Methods: Analysis of predialysis arterial blood gases and anion gap patterns was performed in 67 stable chronic outpatient hemodialysis patients(>1 year) with acetate buffer. Blood samples were drawn from the arterial line of the atreriovenous fistula for determination of blood electrolytes, chemistries, and analysis of blood gases at the beginning of hemodyalysis. Results: The degree of metabolic acidosis was mild to moderate with mean pH 7.33±0.039. 82% of a total 67 patients had pH between 7.30 and 7.39 with 18% of them between 7.20 and 7.29. Simple as mixed metabolic acidosis was shown in 49 of 67 patients(73%) and 18 of 67 patients(27%), respectively. In comparison of both groups, the group with mixed metabolic acidosis had significantly lower pH(7.29±0.04 vs 7.34±0.03, p<0.001) with higher pCO₂(38.5±3.4, p<0.005) and anion gap(19.6±4.1 vs 17.6±2.9, p<0.05). The classical high anion gap of end stage renal disease (range, 16 to 29 mEq/L) was also noted in 20 of 67 patients(30%). The linear regression analysis between anion gaps and total serum carbon dioxide contents (TCO₂) didn't show any significant correlation in all patients as well as the two subdivided groups with high and normal anion gap. Furthermore, only 13 of 67 patients(20%) were included between 80 and 120% in the ratio of delta anion gap(ΔAG) over delta TCO₂(dTCO₂). Therefore, the majority of hemodialysis patients (80%) showed the discrepancy between the degrees of d AG and ΔTCO₂. The analysis of unmeasured cations(K, Ca) and anions(albumin, phosphate) in the calculation of anion gap(Na ?Cl ?HCO₃) between two groups of high and normal anion gap of all patients as well as 49 patients of simple metabolic acidosis didn't reveal any discernible contributions to the changes of anion gap. Conclusion- This study therefore showed that the mixed acid-base balance and normal anion gap metabolic acidosis is not an exception in chronic stable hemodialysis patients. Also, the impact of hemodialysis in end stage renal disease patients seemed to lead the changes in values of unidentified anions besides fixed mineral acids and/or in those of unrecognized ionic equivalents of plasma constituents.

3D 해양 캐릭터의 모바일 서비스를 위한 시스템 설계

강경헌(Gang Gyeong-Heon),김병훈(Kim Byoung-Hun),윤재홍(Youn Jae-Hong),김은석(Kim Eun-Seok),허기택(Hur Gi-Taek) 한국콘텐츠학회 2006 한국콘텐츠학회 종합학술대회 논문집 Vol.4 No.2

모바일 콘텐츠 제작 및 서비스 기술의 발달과 3D 게임전용 폰의 등장은 3D 모바일 콘텐츠 서비스에 대한 관심을 고조시키고 있다. 그러나 유선환경에 비해 낮은 대역폭과 연결 시간에 따른 데이터 요금의 부담을 갖는 모바일 환경에서, 대용량 콘텐츠인 모바일 3D 콘텐츠의 효율적인 서비스 기술에 대한 연구는 미비한 상태이다. 본 논문에서는 대용량의 3D 해양 캐릭터들을 효과적으로 검색하고 모바일 기기로 다운로드하기 위한 효과적인 캐슁 정책을 이용하여, DB로 구축되어 유선 인터넷으로 서비스되는 사이버 아쿠아리움의 해양객체 정보를 모바일 환경에서 제공할 수 있는 3D 해양 캐릭터의 모바일 서비스 모델을 제안하고자 한다. The interest in the service of 3D mobile contents becomes larger due to the technological advance of production and services of mobile contents and the appearance of the exclusive mobile phone for 3D game. Therefore, the researches about the efficient mobile services of large 3D contents are wanted in the circumstances of the narrow bandwidth and the burden of the connection charge of wireless mobile communications. In this paper, we suggest a strategy of caching for looking up and downloading the 3D marine characters efficiently and a system model for mobile service of 3D marine characters. The suggested system is designed for serving efficiently the high-quality 3D characters through the wireless mobile communications using the database on the 3D marine objects of cyber aquarium constructed for the services through the wired internet.

간세포암종 환자에서 간동맥색전술후 혈청 Angiogenin , bFGF 및 EGF의 상승

이숭환(Soong Hwan Lee),조용현(Yong Hyeon Jo),김병훈(Byoung Hun Kim),김홍주(Hong Ju Kim),이창화(Chang Hwa Lee),이재영(Jae Young Lee),남승우(Seung Woo Nam),백인규(In Kyu Paik),박찬현(Chan Hyun Park),이동후(Dong Hoo Lee) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.3

N/A Background/Aims: Angiogenesis, the induction of the formation of blood vessels, is critical to the development, progression, and metastasis of animal and human tumors. Tumor cells may produce factors which either induce or inhibit angiogenesis and that the onset of angiogenic activity is determined by the balance of these factors may be generalizable to other tumors. Hepatocellular carcinoma is hypervascular tumor and transcatheter arterial embolization(TAE) is widely used to treat patients with unresectable hepatocellular carcinoma. To evaluate changes of angiogenic factors after TAE for hepatocellular carcinoma, we investigated serum angiogenin, bFGF and EGF at the pre-TAE and the post-TAE among the seven patients with hepatocelluar carcinoma. Methods: Angiogenin, bFGF and EGF concentrations in sera were measured at pre-TAE and 3 days after TAE by employing ELISA. The statistical analysis was evaluated by Student's t-test. Results: 1) Angiogenin concentration at pre-TAE and post-TAE was 197.57+28.82ng/ml(mean+standard error) and 225.89>32.06ng/ml, respectively(p=0.022). 2) bFGF concentration at pre-TAE and post-TAE was 6.71+1.83 pg/ml and 21.68+5.58 pg/ml, respectively(p=0.036). 3) EGF concentra- tion at pre-TAE and post-TAE was 195.09+40.29 pg/rnl and 258.11+36.12 pg/ml, respectively (p=0.014). No correlation, however, was present among angiogenin, bFGF, and EGF at both of pre-TAE and post-TAE state. Conclusions: These results indicate that certain angiogenic factors, such as angiogenin, bFGF, EGF, were increased significantly at post-TAE in comparison to pre- TAE, which may reduce the therapeutic effect of TAE for hepatocellular carcinoma. We suggested that the tissue injury/destruction associated with ischemia by hepatic artery embolization are generally considered to represent a fundamental stimulus for angiogenesis in post-TAE. Therefore, suppression of angiogenesis at post-TAE may be important in improving survival for the patients with hepatocellular carcinoma since tumor growth and metastasis are angiogenesis-dependent. (Korean J Gastroenterol 1996; 28:391 - 401)

만성간질환에서의 혈청 procollagen 1/3 propeptides 농도비 측정의 의의

유용걸(Yong Keol Yoo),이숭환(Soong Hwan Lee),김병훈(Byoung Hun Kim),조영중(Young Jung Cho),백인규(In Kyu Paik),유병무(Byeong Moo Yoo),이오영(Oh Young Lee),한동수(Dong Soo Han),손주현(Joo Hyun Sohn),최호순(Ho Soon Choi),이동후(Dong Ho 대한소화기학회 1996 대한소화기학회지 Vol.28 No.6

N/A Background/Aims: Most of Ihe chronic liver diseases of variable etiologies are accompanied by a pathobiochemical reaction So-called fibrosis. Liver fibrosis was recently recognized as all the complexity of dynamic changes of the hepatic extracellular matrix(ECM). And ECM consists of four major components: collagen, glycoprotein such as fibronectin and laminin, proteoglycan, and elastin. Among these, collagen I and III are the representatives of disproportion of synthesis and degradation in conjunction with fibrogenesis. To elucidate the clinical significance of procollagen propeptide I(PICP) and III(PIIINP) measurements among the sera out of patients with chronic liver diseases, radioimmunoassay 4vas employed in this investigation. Methods: Sera tested were obtained from pathologically-proven 54 patients; 4 cases of fatty liver, 11 cases of chronic persistent hepatitis, 13 cases df chronic active hepatitis, 15 cases of liver cirrhosis and 11 cases of hepatocellular carcinoma. All:the patients except 4 cases of fatty liver were shown positivity of HBsAg. PICP and PIIINP radioimmunoassay kits(Farmos Diagnostica, Oulunsalo, Finland)were purchased for this study. ResOlts: PICP concentration (mean+standard error) was highest in liver cirrhosis (280.06>39,83 pg/L). PICP in liver cirrhosis was significantly elevated in cornparison to that (109.30+14.58) in fatty:liver(p=0.045), that (122.22>10.26) in chronic persistent hepatitis (p=0.003), and that (158.59>21.58) in chronic active hepatitis(p=0.016), PICP in hepatocellular carcinoma was decreased to 1'94.05+ 29.89. Similarly, PIIINP concentration revealed highest level in liver cirrhosis(17.29+3.58 pg/L). This value was significantly higher than that of chronic persistent hepatitis(5.12+0.59)(p=0.008). Contrarily to these results, concentration ratio of PICP/PIIINP was high in fatty liver (29.27>6.29) and chronic persistent hepatitis (25.04+2.00), These value were statistically higher than that of chronic active hepatitis (17.632.67) (p=0.043). PICP/PIIINP ratio in liver cirrhosis (21.58+3.29) showed no statistical difference. Conclusions: On the basis of these data, it is suggested that the elevation of PICP and PIIINP in the sera of the patients with chronic liver diseases means emerging the liver cirrhosis. And the ratio of these markers can be helpful in differential diagnosis of chronic liver diseases. (Korean J Gastroenterol 1996; 28:815-823)

궤양성 대장염과 동반된 상장간막정맥 및 간문맥 혈전증 1예

김병훈,한동수,조윤주,송승찬,전용철,손주현,안명주,박경남 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3