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- 저자 : 김범주 ( Boem Ju Kim ) (검색결과 1 건)
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김범주 ( Boem Ju Kim ),김행미 ( Heng Mi Kim ),안두홍 ( Doo Hong Ahn ),이원정 ( Won Jung Lee ) 대한주산의학회 1990 大韓周産醫學會雜誌 Vol.1 No.1
Atrial natriuretic peptide(ANP) is a circulating hormone in the human fetus. Human fetus is able to increase ANP release in response to volume expansion and in direct proportion to heart rate. In this study, we attemped to determine the normal range of ANP in umbilical blood and to evaluate the clinical conditions in which the ANP levels may increase. ANP in the umbilical arterial and venous blood obtained at delivery were measured in 21 normal newborns. The ANP concentration in the umbilical arterial blood(mean ±SD, 19.77 ± 14.85 pg/dl) was significantly correlated with that in the umbilical venous blood(17.55 ± 13.70 pg/dl)(r=0.816). The plasma ANP concentration was not correlated with plasma creatine kinase(total, or MB fraction), maternal weight gain during pregnancy or change of hematocrit after birth. There was no difference of ANP concentration according to delivery method or presence of fetal distress. The ANP concentrations in the umbilical arterial, venous and maternal venous blood from mother suffering from pregnancy-induced hypertension were 34.5±15.0 pg/dl, 38.2±16.4 pg / dl and 71.3±37.1 pg/dl respectively. Each of them were significantly hihger than that from normal mother(15.0±11.6 pg/dl, 12.16±7.1 pg/dl and 30.8±18.7 pg/dl)(P<0.05). Our results suggest that cord blood ANP level is influenced by the maternal ANP level by placental transfer.
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