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ICR 신생마우스에서 N-2-Fluorenylacetamide의 발암현상
김무철,강상균 중앙대학교 의과대학 의과학연구소 1981 中央醫大誌 Vol.6 No.4
This experiment was carried out to evaluate the tumor incidence in ICR newborn mice using N-2- fluorenylacetamide (FAA). FAA in 1% aquous gelatin was injected subcutaneously on the subscapular region of ICR newborn mice once daily during the first five days of life. Gross examination of viscerae was performed immediately after being sacrificed at 68th week of birth. Following results were obtained. 1. The weaning rates of 1% aquous gelatin control group and FAA-treated group were 97.5% and 83.6%, respectively. In refer to gelatin control group, weaning rate of FAA-treated group was decreased by 9%. 2. Survival rate at 68th week showed 55% in normal control group and 52% in gelatin-treated group, while in FAA-treated group showed 69%. 3. The statistical analysis of body weight of FAA-treated animal does not show significant deviation from the non-treated controls. However, FAA-treated male mice showed a slight increment in weight at 34th week of birth as a result of enhanced development of hepatoma and lung adenoma. 4. There were no significant difference of organ weight between control and FAA-treated groups except liver and lung, Increased weighs of liver and lung was seen in FAA-treated group due to development of hepatoma and adenoma. 5. Pulmonary adenoma and hepatoma were seen in FAA-treated mice at 68th week of birth. The incidence of pulmonary adenoma was 1% in normal and 11% in gelatin-treated groups, while FAA-treated group showed 18%. No hepatoma development was identified in normal, gelatin-treated group and in female mice 'th FAA-treated group. On the other hand, hepatoma developed in male FAA-treated mice with wi incidence of 64%.
Levamisole에 의한 Ehrlich 腹水癌 生存率 延長에 關하여
康相均,金武哲 중앙대학교 의과대학 의과학연구소 1979 中央醫大誌 Vol.4 No.1
Since B.C.G. was introduced into immune therapy of cancer several biologic as well as chemical immune therapy was established. The mechanisms of anticancerous effect by these agents were still unproved, however, many authors believe that immune system stimulation plays major role. Levamisole is one of antiparasitic drug which showed anticancerous effect in experimental animal by way of immune stimulation. Ehrlich ascites tumor was implanted into the mouse peritoneal cavity, then Levamisole effect was observed in this experiment. Levamisole was administered intraperitoneally and subcutaneouslly to the experimental animals. Single, three, four and seven times of doses were given to each animal group respectively. Survival day to experimental animal is compared with control group, and survival rate was observed. Obtained results were follows; 1. Mean survival days of control group was 10.8 days, while Levamisole administered prolongation. Increment of survival rate was range of 31.5-42.6% in the experimental groups. 2. The most prolonged survival days were seen in intraperitoneal single doses of Levamisole administered group. 3. The difference of dose or method of Levamisole administration showed no significant difference of survival day and rate of the experimental animal groups. The above results suggest anticancerous effect of Levamisole upon the Ehrlich ascites tumor cells by chemical stimulation.