악성 흉수, 결핵성 흉수 및 부폐렴 삼출액과 농흉에서 Interferon-gamma, Interleukin-2 Receptor, Interleukin-6, Interleukin-10 농도의 비교

김명훈,김승준,박용근,김석찬,이숙영,김영균,김관형,문화식,송정섭,박성학,Kim, Myung-Hoon,Kim, Seung-Joon,Park, Yong-Keun,Kim, Seok-Chan,Lee, Sook-Young,Kim, Young-Kyoon,Kim, Kwan-Hyoung,Moon, Hwa-Sik,Song, Jeong-Sup,Park, Sung-Hak 대한결핵및호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.49 No.5

연구배경 : Cytokine은 주요한 염증 매개 물질로서 질환에 따라 다른 양상을 보일 수 있어, 흉수를 일으키는 다양한 원인 질환의 감별에 이용되어 왔다. 이 중에서 악성 흉수, 결핵성 흉수, 부폐렴 삼출액 및 농흉에서 INF-${\gamma}$, IL-2R, IL-6, IL-1를 동사에 측정하여 비교한 연구는 많지 않아 본 연구를 시행하게 되었다. 방법 : 흉수를 주소로 내원한 환자 중에서 흉수 천자로 삼출액이 확인된 환자들을 대상으로 흉수를 채취하여, ELISA kit를 이용하여 INF-${\gamma}$, IL-2R, IL-6, IL-10 농도를 측정하였다. 결과 : 악성 흉수, 결핵성 흉수, 부폐렴 삼출액 및 농흉에서 흉수 내의 cytokine의 순서대로, INF-${\gamma}$는 $16.7{\pm}50$, $295.5{\pm}585.5$, $10.0{\pm}0$ pg/ml, IL-2R은 $3247.4{\pm}1713.3$, $7423.5{\pm}3752.8$, $3790.2{\pm}3201.1$ pg/ml, IL-6는 $600{\pm}12.8$, $556.4{\pm}161.7$, $514.4{\pm}224.8$ pg/ml, IL-10은 $28.2{\pm}55.5$, $11.3{\pm}11.7$, $98.4{\pm}141.7$ pg/ml로 각각 측정되어, 결핵성 흉수가 다른 원인의 흉수에 비해 IL-2R 농도가 의 있게 높았으며, IFN-${\gamma}$ 농도도 높은 경향을 나타내었으며, 부폐렴 삼출액에서는 IL-10농도가 다른 원인의 흉수에 비해 의미있게 높았다. 결론 : 결론적으로 흉수 내의 IL-2R농도 측정은 결핵성 흉수와 다른 원인의 흉수를 감별하는데 어느 정도 도움이 될 것으로 사료되며, IL-10 측정은 부폐렴 삼출액과 다른 원인의 흉수를 감별하는데 어느 정도 도움을 줄 것으로 생각된다. Background : Cytokines are chemical mediators that control and modulate many inflammatory processes. They work in different fashions in a variety of diseases. Discriminating between malignant effusion, tuberculous effusion, and parapneumonic effusion are crucial from the clinical view-point in Korea. In the current study, interferon-gamma (IFN-${\gamma}$), soluble interleukin-2 receptor (IL-2R), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured for this purpose. Methods : Pleural fluids from patients with malignant disease, tuberculosis, parapneumonic effusion and lung empysema were collected and gauged using commercial ELISA kits. Results : 34 patients were enrolled in this study. Among these 15 cases were malignant effusions, 12 were tuberculosis pleurisy and 7 were parapneumonic effusion and lung empyema. The levels of cytokines measured in this study were as follows, in order of frequency, malignant effusion, tuberculous effusion, parapneumonic effusion and lung empyema. The levels of INF-${\gamma}$ were higher in tuberculous effusion than in malignant or parapneumonic effusion ($295.5{\pm}585.5$ vs. $16.7{\pm}50$ vs. $10.0{\pm}0$ pg/ml, p>0.05). The levels of IL-2R were higher in tuberculous effusion than in malignant or parapneumoruc effusion ($7423.5{\pm}3752.8$ vs. $3247.4{\pm}1713.3$ vs. $3790.2{\pm}3201.1$ pg/ml, p<0.05). No significant differences were found in the levels of IL-6 between the groups ($600{\pm}12.8$ pg/ml in malignant effusion, $556.4{\pm}161.7$ pg/ml in tuberculous effusion, $514.4{\pm}224.8$ pg/ml in parapneumoruc effusion). IL-10 levels were higher in parapneumoruc effusion than in malignant or tuberculous effusions ($98.4{\pm}141.7$ vs. $28.2{\pm}55.5$ vs. $11.3{\pm}11.7$ pg/ml, p<0.05). Conclusion : These results suggest that the measurement of IL-2R levels in pleural fluids may be a useful means of differentiating between tuberculous effusion and pleural effusions of other origins, and that the measurement of IL-10 levels in pleural fluids may be useful to differentiate between parapneumonic effusion and pleural effusions of other origins.

정상근과 근막 유발점이 활성화된 근육의 초음파 영상의 비교

김명훈,김수현,김현진,Kim, Myung-Hoon,Kim, Su-Hyon,Kim, Hyun-Jin 대한물리치료학회 2013 대한물리치료학회지 Vol.25 No.2

Purpose: The objective of this study was to offer primary clinical data examining whether change of imaging structure and quantitative evaluation of muscle activity on myofascial trigger points can lead to implementation of an analytical technique for evaluation of myofascial pain diagnoses. In addition, we examined the effect of a variety of mediation techniques, in order to examine neuromuscular physiological characteristics of myofascial trigger points muscle by comparing differences in pressure pain threshold and ultrasound imaging. Methods: Participants in the study included 30 adults in their twenties. The subjects were divided into the normal and myofascial trigger points groups. Clinical outcomes were evaluated by pressure pain threshold for pain and ultrasound imaging was performed for evaluation of the structural characteristics of muscle. Independent t-test was used for statistical analysis. Results: The two groups showed statistical significance in the change in pressure pain threshold (p<0.05). Findings of ultrasound imaging analysis showed no significant differences, increased muscle thickness was observed (p>0.05). Findings of ultrasound imaging analysis showed significant differences, increased muscle echodensity was observed (p<0.05). Findings on ultrasound imaging analysis showed significant differences, increased muscle white area index was observed (p<0.05). Conclusion: From these results, active myofascial trigger points muscle showed quality deterioration on ultrasound imaging. Thorough evaluation of imaging structure and physiological characteristics can be useful quantitative analytical techniques for diagnosis of myofascial pain syndrome and a primary factor reflected in physical therapy intervention.

키네시오 테이핑과 발목관절 근력 운동이 균형지수에 미치는 변화

김명훈,이정훈,김찬규,Kim, Myung-Hoon,Lee, Jeong-Hun,Kim, Chan-Kyu 대한물리치료학회 2009 대한물리치료학회지 Vol.21 No.3

Purpose: This study examined that effect of a change in balance index on ankle Kinesio taping, muscle strength exercises and taping after muscle strength exercises in 30 healthy adult subjects. Methods: The Sway Index of the left, right, front and back on stable, toes up and linear were compared using a Balance System, a balance experimental instrument. Results: The pre and post experimental balance index regarding stable, toes up, and linear were taken for the Kinesio taping group, lower extremities muscle strengthening group, and muscle strengthening with the Kinesio taping group. Statistically significant decreases were observed in all variables except for the left and right pre and post experiment results under stable conditions. Conclusion: The balance index of exercise with taping was lower than that of exercise only. There is a need for objective research on the long-term applications and post-exercise. The body balance appears to be influenced by ankle stabilization using taping.

허리 및 하지 근력운동 후 스트레칭이 20대 남성 허리 유연성에 미치는 효과

김명훈,김현진,Kim, Myung-hoon,Kim, Hyun-jin 대한물리치료과학회 2019 대한물리치료과학회지 Vol.26 No.1

Background: The purpose of this study was to the effects of stretching on lumbar flexibility after lumbar and lower muscle strengthening exercise. Design: Randomized Controlled Trial. Methods: 24 subjects without back pain in their twenties were divided into 12 experimental groups and 12 control groups. The experimental group performed a stretching program after muscle strength exercise. In the control group, only muscle strength exercise was performed, and total exercise was performed 24 times a week for 8 weeks to compare and analyze before and after experiment. Results: The results of this study are as follows: 1) There was no statistically significant difference in both before and after weight of experimental group and control group. 2) There was no statistically significant difference in both before and after skeletal muscle levels of experimental group and control group. 3) There was no statistically significant difference in both before and after fat mass of experimental group and control group. 4) There was a statistically significant difference in both before and after trunk forward flexion of experimental group and control group. Conclusion: This research showed a positive affect on increasing flexibility, which is expected to have a great effect on improvement of flexibility in the future.

항에스트로겐이 성체 수컷 마우스 수출소관의 형태적 변화에 미치는 효과

김명훈,Kim, Myung-Hoon 대한물리치료과학회 2003 대한물리치료과학회지 Vol.10 No.1

본 연구는 수컷 생식기관내 에스트로겐 작용을 구명하기 위한 과정의 일환으로 항에스트로겐 물질인 ICI 182,780을 투여하고, 이로 인한 수출소관의 형태적 변화를 관찰하였다. 대조군과 처리군 간에 수출소관의 관강 직경은 처리후 8일째에 팽창하기 시작하여 59일째까지 지속되었고, 처리군 마우스의 수출소관내의 상피세포 높이는 대조군과 비교해 볼 때, 처리 후 경과기간 내내 감소되었다. 사이세포 높이가 최대로 감소된 곳은 처리된 마우스 수출소관의 근위부로 38% 감소하였으며, 수출소관 상피세포내의 핵상 세포질의 높이는 처리군 마우스의 근위부, 원추부, 원위부에서 각각 46%, 39%, 33% 감소된 것으로 나타났다. 항에스트로겐, ICI 182,780을 수컷 마우스에 투여한 본 실험에서, ${\alpha}ERKO$ 유전자 변형 동물에서 관찰되었던 것과 유사한 생식기관의 형태적 변화가 나타났다. 즉 항에스트로겐이 에스트로겐 수용체와 결합하여 에스트로겐의 기능을 차단하고 이로 인해 수출관의 관강 분비물 재흡수가 억제되어 분비물이 축적됨으로써 다양한 형태적 변환가 초래된 것으로 사료된다. 따라서 수컷 생식기관내의 중요한 에스트로겐 기능중의 하나는 수출소관 부위의 분비물 재흡수 작용이라고 할 수 있다. This study was designed to investigate the function of estrogen in related with the effects of the antiestrogen on morphologic changes of efferent ductules of the adult male mouse. Estrogen is synthesized in the male reproductive system and is found in high concentrations in rete and seminal fluids. Adult male mice, 30 days old, were injected subcutaneously with ICI(5mg/mouse) once per week for 8 weeks. Tissues were fixed by vascular perfusion on days 8, 10, 12, 14, 16, 25 and 59 post-treatment. The lumen of efferent ductules began to dilate from the day 8 and continued to the day 59 post-treatment. Epithelial cell height in the efferent ductules of the treated mice decreased all the time periods, compared to the control. Cell height in proximal region of the efferent ductules in the treated groups decreased most by 38%. Supranuclear cytoplasmic height in epithelial cell of the ducts also showed the decrease of 46%, 39% and 33% in proximal, conus and common regions in the treated groups, respectively. ICI 182,780 treatment in the male mouse reproduced a similar morphological abnormalities that were observed in the efferent ductules of the ${\alpha}ERKO$ mouse.

고강동 콘크리트의 현황과 그 미래

김명훈,Kim, Myeong-Hun 한국건설안전협회 2005 建設 安全技術 Vol.31 No.-

물리치료사의 직무만족과 이직의도에 관한 연구

김명훈,Kim, Myung-Hoon 대한물리치료과학회 2001 대한물리치료과학회지 Vol.8 No.1

This study was attempted to examine the relationship between job satisfaction and turnover intention of physical therapist in order to suggest some method to enhance their job performance and the degrees of job satisfaction. High turnover intention of physical therapist is one of the serious problems at the present time which providing low quality physical therapy. The data were collected from July 1, to August 31, 2000 and analyzed by ANOVA, Pearson Correlation Coefficients. The summarized result are as follows: 1. The job satisfaction score of physical therapists showed the highest of the pride of patient treatment and total mean score was 2.96. 2. Those who were in the range of 26 to 30 years of age showed the strongest desire to leave the hospital 3. There were 68.8% in male. 47.6% in female who hoped to turnover intention. 4. There were significant difference between those who want to leave and those who want remain in relation patient number, work hospital work years. 5. There were no significant difference between those who want to turnover intention and those who want remain in relation patient number and work years. 6. The major reason for job satisfaction were work time and work areas.

영국의 의료체계

김명훈,Kim, Myeong-Hun 대한병원협회 1993 대한병원협회지 Vol.22 No.1.2

레코드 컨티뉴엄 이론의 기원에 관한 연구 라이프사이클 모델과의 비교를 중심으로

김명훈,Kim, Myoung-hun 한국기록학회 2021 기록학연구 Vol.- No.68

본 연구에서는 레코드 컨티뉴엄 이론의 기원을 20세기 중반 이후 호주의 기록관리 상황 및 라이프사이클 모델과 결부하여 분석하였다. 레코드 컨티뉴엄 이론에 대한 심도 있는 이해를 위해서는 형성 배경 및 과정에 대한 고찰이 필요하며, 아울러 라이프사이클 모델에 대한 반향으로 구축된 이론체계란 점에서 라이프사이클 모델 자체에 대한 분석 역시 전제되어야 하기 때문이다. 이를 위해 우선 레코드 컨티뉴엄 이론형성의 역사적 배경 분석을 목표로, 1950년대 호주의 독립된 공공기록관리 체제의 모색 과정 속에서 미국의 라이프사이클 모델을 집중적으로 조명하게 된 배경 및 과정을 고찰하였다. 이어 라이프사이클 모델의 형성 배경과 함께 의미 및 한계를 고찰하였다. 라이프사이클 모델의 주요 내용 및 의의, 한계를 고찰하기 위해서는 어떠한 상황 속에서 형성되었는지에 대한 분석이 필요하며, 아울러 레코드 컨티뉴엄 이론이 라이프사이클 모델에 대한 비판을 통해 형성되었다면, 라이프사이클 모델이 지닌 의의 및 한계에 대한 고찰이 필요하기 때문이다. 이러한 분석을 토대로 마지막으로 호주의 새로운 기록생산 환경 속에 라이프사이클 모델의 적용에 따른 문제점과 더불어, 이를 기반으로 새롭게 태동된 레코드 컨티뉴엄 이론의 기원이 된 요소들을 고찰하였다. In this study, the origin of the record continuum theory was analyzed in conjunction with the record management situation in Australia after the mid-20th century and record lifecycle model. For an in-depth understanding of the record continuum theory, it is necessary to consider the background and process of its formation, and to analyze the lifecycle model itself in terms of a theoretical system built with reflections on the lifecycle model. To this end, first of all, with the aim of analyzing the historical background of the formation of the record continuum theory, the background and process that led to intensive illumination of the US lifecycle model in the process of seeking an independent public records management system in Australia in the 1950s were reviewed. Then, the meaning and limitations of the lifecycle model were considered along with the background of the formation. In order to examine the main contents, significance, and limitations of the lifecycle model, it is necessary to analyze the circumstances under which it was formed. Based on this analysis, finally, the problems associated with the application of the lifecycle model in Australia's new record creation environment, as well as the factors that were the origin of the newly born record continuum theory were examined.

정상안압녹내장, 고안압녹내장 및 정상 대조군 사이의 식생활 습관 비교

김명훈,박성철,이선희,기창원,Myung Hun Kim,Sung Chul Park,Seonheui Lee,Changwon Kee 대한안과학회 2011 대한안과학회지 Vol.52 No.2

Purpose: To compare the dietary patterns between normal or high tension glaucoma patients and a normal control population. Methods: A survey using the self-assessment food-frequency questionnaire was given to normal tension glaucoma (NTG) or high tension glaucoma (HTG) patients who visited a glaucoma clinic between June 2008 and September 2008. Healthy Korean subjects who had received routine health examinations at Samsung Medical Center between October 2007 and September 2008 were evaluated with the same questionnaire. Statistical analysis of variable factors including fatty fish, seaweeds, soy products and greasy meats, was performed to compare between groups. Results: Sixty-two of NTG patients, 25 of HTG patients and 29,376 normal subjects were included in the present study. The mean age of each group was 51.3 ± 13.4, 51.8 ± 17.4 and 50.5 ± 10.4 years, respectively. No significant difference in dietary pattern was found between the subjects with glaucoma and the normal controls (p > 0.2 in all factors). The dietary pattern of NTG and HTG patients showed no statistically significant difference in all factors (p > 0.2). Conclusions: There was no significant difference in a dietary pattern between glaucoma patients and normal subjects. In terms of glaucoma, no possible beneficial or harmful food was found. J Korean Ophthalmol Soc 2011;52(2):216-221