치매환자에서 transposable elements에 의한 유전자 발현조절의 생물정보 분석

김대수,허재원,하홍석,김태홍,조운종,김희수,Kim, Dae-Soo,Huh, Jae-Won,Ha, Hong-Seok,Kim, Tae-Hong,Jo, Un-Jong,Kim, Heui-Soo 한국생명과학회 2006 생명과학회지 Vol.16 No.7

노년에 나타나는 정신병적 증상의 가장 흔한 원인 질환으로 만성적이고 서서히 악화되는 진행성이면, 기억력, 사고력, 학습능력 및 판단력 등의 손상을 포함한 인지기능의 장애이다. 고령화 사회가 도래하면서 노인성 치매환자가 매년 급격히 늘고 있으며 매년 수만 명이 노인성치매에 걸려 본인뿐 아니라 가족까지도 많은 고통에 시달리고 있다. 특히 노인성 치매의 경우는 환자 본인의 문제가 아니라 젊은 노동력을 환자의 보호자로 필요함으로 국가적 노동력의 손실로 이어지고 있다. 현재 연구에서 우리는 노인성 치매와 transposable elements와의 상호관계를 밝히기 위하여 공개된 유전자 데이터베이스에서 EST (expressed sequence tags)를 이용하여 생물정보학적 인 분석방법과 프로그램을 이용하여 치매의 원인으로 추정되는 후보유전자들을 찾아내었다. 이러한 분석을 통하여 치매환자에서 transposable elements의 발현으로 인해 유전자의 발현에 변화를 가지는 98개의 후보 유전자를 찾아내었다. 노인성질환인 치매와 transposable elements의 분석방법을 이용하면 치매의 원인을 규명하는데 많은 도움이 될 것이다. Dementia is a progressive disease of increasing the dysfunction of intellectual and physical ability. In the aging society, many families are suffering from the caring the patients who are diagnosed with dementia. However, dementia is a complex disease affected by the genetic and environmental agents. In the present study, we investigated the transposable elements in relation to dementia. From the analysis of dementia EST (expressed sequence tag) sequences, we found dementia candidate genes, and analyzed expression profiles and repeat elements using bioinformatics tools. This analysis showed that 98 genes were affected in their mRNA sequences by transposable elements expression. Their expressions were affected by the integration of different transposable elements (SINE, LINE, LTR, DNA) during the primate evolution. We believe that our work will be of significant interest to genome scientists, and may help them gain insight into implication of transposable elements expression in dementia.

초음파 분무법으로 제조한 $(Y,Gd)BO_3:Eu^{3+}$ 형광체의 발광특성에 관한 연구

김대수,이임렬,Kim, Dae-Su,Lee, Rhim-Youl 한국재료학회 2000 한국재료학회지 Vol.10 No.3

초음파 분무법으로 $(Y,Gd)BO_3:Eu$의 PDP 적색 형광체를 제조하여 147nm VUV 여기에 따른 발광 특성을 분석하였다. 초음파 분무에 사용된 전구체 용액은 Y, Gd, Eu의 아세트산염과 $H_3BO_3$를 증류수에 용해하여 1.7MHz의 초음파 분무기로 고온의 반응관내로 분무하였다. 분무된 액적은 반응관내에서 통과시 불충분한 반응으로 C-C와 C-H를 함유한 비정질 상이었으나, $1100^{\circ}C$에서 추가 열처리 한 시편은 고상반응법으로 제조한 형광체와 동일한 결정구조와 성분을 보였다. 고상반응법으로 제조한 형광체의 분말 크기는 $3{\mu\textrm{m}}$으로 조대하고 불균일한 분포를 보인 반면, $500^{\circ}C$에서 분무한 후 $900^{\circ}C$에서 열처리하여 제조한 $(Y_{0.7}Gd_{0.3})_{0.95}BO_3:Eu_{0.05}\;^{3+}$ 형광체의 모양은 비교적 구형이었으며 평균 입자크기는 $0.7{\mu\textrm{m}}$로 미세하고 균일한 분포를 하고 있었다. 147nm VUV 여기시 초음파 분무로 제조한 $(Y_{0.7}Gd_{0.3})_{0.95}BO_3:Eu_{0.05}\;^{3+}$ 형광체의 적색 발광강도는 고상반응법으로 제조한 시편이나 상용품인 $(Y,Gd)BO_3:Eu$ 형광체에 비해 그 휘도가 증가되었다. The $(Y,Gd)BO_3:Eu$ red phosphors for PDP application were synthesized by ultrasonic spray method and then their photoluminance properties were investigated under 147nm VUV irradiation. The precursor solution of acetates of Y, GD and Eu and boric acid diluted in water was sprayed using 1.7 MHz ultra-sonic sprayer into the reaction tube held at high temperature. The as-sprayed particles were amorphous phase having C-C and C-H bonds due to the insufficient thermal reaction during the pass along the tube. But the sprayed samples followed by heat treatment at $1100^{\circ}C$ had the same crystal structure and chemical composition as those samples followed by solid state reaction. It was found that the $(Y_{0.7}Gd_{0.3})_{0.95} BO_3:Eu_{0.05}^{3+}$ phosphor particles synthesized by spray at $500^{\circ}C$ and then heat treated at $900^{\circ}C$ had a spherical-like shape and fine particle size at $0.7{\mu\textrm{m}}$ having a narrow size distribution, while the phosphor particles made by solid state reaction was $3{\mu\textrm{m}}$ coarse and non-uniform size distribution. The emitting intensity under 147nm VUV excitation for $(Y_{0.7}Gd_{0.3})_{0.95}BO_3:Eu_{0.05}^{3+}$ phosphor prepared by spray method was found to be higher than those phosphor made by solid state reaction and the commercial $(Y,Gd)BO_3:Eu$ product.

A Study on the Phosphorescent Characteristics of Blue $\textrm{Ca}\textrm({Al}_{0.97}\textrm{B}_{0.03})_2\textrm{O}_4$: $\textrm{Eu}^{+2},\;\textrm{Nd}^{+3}$ Phosphor

김대수,이임렬,Kim, Dae-Su,Lee, Im-Ryeol Materials Research Society of Korea 1999 한국재료학회지 Vol.9 No.1

The change of phosphorescent property with chemical modification and co-doping of Nd as an auxiliary activator in CaAl$_2$$O_4$: Eu\ulcorner, Nd\ulcorner phosphor, employing Nd\ulcornerion(0.6%) and an co-activator maintained its afterglow for 4.5 hours. And also the initial persistent brightness and phosphorescent property were further improved both by substituting Al by B atoms and incorporation of Nd\ulcorner ion. It was found that the persistent time was 30 hours for&Ca(Al_{0.97}\;B_{0.03}) $_2$$O_4$:EU\ulcorner(0.3%), Nd\ulcorner(0.6%) phosphor.

세침흡인 세포검사로 진단한 폐의 포상 연부육종 - 1예 보고 -

김대수,오영륜,고영혜,Kim, Dae-Su,Oh, Young-Lyun,Ko, Young-Hyeh 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2

Alveolar soft part sarcoma(ASPS) is a rare malignant neoplasm with a distinct clinicopathologic entity of which fine needle aspiration(FNA) cytologic findings have been described in only a few reports. Although patients usually present with an isolated soft-tissue mass in the extremity, metastasis can occur in about 13 % of total cases and the most frequent metastatic site is the lung. We have recently experienced a FNA cytologic case of ASPS in the lung. A 23-year-old female patient was admitted to this hospital due to 2-month-history of cough She had been good in health before the visit. Chest computed tomography revealed multiple, variable sized, bilateral pulmonary nodules. Physical examination and other staging work up revealed no other lesions except for pulmonary nodules. A percutaneous transthoracic FNA was performed from the pulmonary nodules. The smear was cellular and most cells were arranged singly. In addition, a few clusters lined by thin-walled vasculature with a pseudoalveolar pattern were present. Some of the tumor cells were large and polygonal lo oval with abundant granular or vacuolated cytoplasm. Most cells were naked nuclei showing finely granular chromatin pattern with prominent central nucleoli.

A New Distributed Parallel Algorithm for Pattern Classification using Neural Network Model

김대수,백순철,Kim, Dae-Su,Baeg, Soon-Cheol 한국전자통신연구원 1991 전자통신 Vol.13 No.2

In this paper, a new distributed parallel algorithm for pattern classification based upon Self-Organizing Neural Network(SONN)[10-12] is developed. This system works without any information about the number of clusters or cluster centers. The SONN model showed good performance for finding classification information, cluster centers, the number of salient clusters and membership information. It took a considerable amount of time in the sequential version if the input data set size is very large. Therefore, design of parallel algorithm is desirous. A new distributed parallel algorithm is developed and experimental results are presented.

탄성 고투자율 자성체의 공극진동에 따른 전자기 특성에 관한 모델

김대수,김왕곤,홍진웅 ( Dae Soo Kim,Wang Gon Kim,Jin Woong Hong ) 한국전기전자재료학회 1996 전기전자재료학회논문지 Vol.9 No.9

이중 주파수 액정을 적용한 액정 셔터의 고속 응답 특성

김대수,한승환,배건,전철규,Kim, Dae Soo,Han, Seung Hwan,Bae, Geon,Jhun, Chul Gyu 한국전기전자재료학회 2014 전기전자재료학회논문지 Vol.27 No.5

In this paper, by using a dual frequency liquid crystal material, we propose a liquid crystal device with a fast response characteristics. The dual frequency liquid crystal material has a positive dielectric anisotropy value at a low frequency. With a high frequency, the dielectric anisotropy becomes negative. Therefore, the relaxation process is governed by not only the elastic deformation, but also the dielectric interaction. The measured decay time and rise time were 0.88 ms and 0.33 ms, respectively.

都市環境色彩改善方案에 관한 硏究 -아파트 表面色을 對象으로-

김대수,조정송,Kim, Dae-Soo,Cho, Jung-Song 한국조경학회 1990 韓國造景學會誌 Vol.18 No.3

The purpose of this study was to suggest an improvement proposal for colors in urban environment with special regard to the surface color and their situations of apartment buildings in Seoul. For this goal, 167 cases of different color types of apartment buildings were surveyed. And, the survey was performed in the view of color by areas, by localtion, by builder, by paint year, by built year, by appearance of building, and by surface texture to prove the influencing factors on the surface colors. These collected data analyzed and compared with the existing studies to find out the changing trend of colors. The results are as follows : 1) The use of neutral gray($26.4{\%}$) and warm color(YR, Y, GY; 56.4%) were dominant and the usage trend of higher 'value'(87.4%) and lower 'saturation'(73.0%) was obvious. Especially, the use of PB and P was noticeable. 2) In comparing the existing studies, the changing trend in the surface color pattern was found. That is, neutral gray was used dominantly in 1970's, warm color(YR, Y)in the middle of 1980's. In the end of 1980's, warm color were also used dominantly same as before and GY, PB, P were used noticeably with some rising tendency of higher 'value' and lower 'saturation' was obvious. 3) The results of analysis by localtion shows that the different color groups might exist in Seoul city. Neutral gray and YR were dominant in zone I. Warm colors(YR, Y, GY)were prevailed in zone II, III, IV. In zone V, many colors were evenly used. In zone VI, middle values at warm color were dominant. Progressively, these color groups with further study could be considered in the color management in urban environment possibly. 4) Surface color of apartment buildings were different from their builders. 5) Concerned with the painted year, the use of higher 'value' and lower 'saturation' was increased gradually with the change of times. 6) the analysis by the built year revealed that the 'value' of surface colors on the old buildings was lower than that of the new ones. 7) The 'value' of colors on the surface with texture was higher than that of the surface without texture. 8) In the combination of two colors, the use of 'value' with difference at the same 'hue' was found harmonions in many cases, but the 'saturation' in usage was included in the ambiguity (Moon & Spencer's term). The ambiguity in color harmony should be improved in the near future.

화기조경탕(化氣調經湯)의 여러 가지 분획에 따른 S-180 암(癌) 세포주(細胞株) 억제(抑制) 효과(效果)

김대수,최정화,김종한,박수연,Kim, Dae-Su,Choi, Jeong-Hwa,Kim, Jong-Han,Park, Soo-Yeon 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1

Objecgtive : The aim of present study was to investigate inhibition effect of Whakijogyung-Tang(WJT) on the tumor cell lines. This study estimated the cytotoxicity of WJT about viability of S-180 and NlH3T3. Methods : The cytotoxicity of WJT about viability of cells were tested using a colorimetric tetrazoliun assay(MTT assay) Results and Conclusion : 1. Water extract of WJT had $IC_{50}$ of 863 ${\mu}g/ml$ in S-180 cell lines, but cytotoxicity of NIH3T3 was not significant difference compare with S-180. 2. n-Hexane fraction of WJT had similar cytotoxicity between S-180 and NIH3T3, but that could not have $IC_{50}$ in S-180 cell lines. 3. Ethyl acetate fraction of WJT had low degree cytotoxicity both S-180 and NIH3T3 cell lines. 4. Significantly, Butanol fraction of WJT had differenct citotoxicity between S-180 and NIH3T3. 5. $H_2O_2$ fraction of WJT had no cytotoxicity both S-180 and NIH3T3.

SCM Strategy and Best Practices Implementation in SMEs

김대수,Kim Dae-Soo The Korean Operations Research and Management Scie 2006 經營 科學 Vol.23 No.1

Over the last decade, the field of supply chain management (SCM) and e-business has received an enormous amount of attention from practitioners and academicians. However, little has been known about how and to what extent small- to medium-sized enterprises (SMEs) are implementing SCM initiatives and e-business practices. This paper proposes a comprehensive research model and presents the survey results of these practices of SMEs located in Wisconsin and illinois, U.S., In terms of competitive strategy and priority, value chain activity priority, supply chain and e-business integration focus, SCM best practices implementation focus and challenges, and business performance. The analysis reveals several valuable insights into how SMEs should run their businesses in today's volatile, rapidly changing customer economy.