말 데이터베이스 구축

김대수,조운종,허재원,최은상,조병욱,김희수,Kim Dae-Soo,Jo Un-Jong,Huh Jae-Won,Choe Eun-Sang,Cho Byung-Wook,Kim Heui-Soo 한국생명과학회 2006 생명과학회지 Vol.16 No.3

공개된 데이터베이스들에서 말에 대한 생물학적인 데이터와 지놈 데이터를 분석하여 말 데이터베이스를 구축하였다. 말 데이터베이스는 말의 생물학적인 데이터와 지놈 데이터를 생물정보학적인 분석방법으로 분석하고 이들 데이터를 통합하여 제공하는데 목적을 두고 있다. 본 데이터베이스는 말의 생물학적 데이터와 지놈 분석 데이터 그리고 생물정보학적인 분석프로그램을 제공하는 인터페이스로 구성하였다. 또한 사용자의 편의를 돕기 위해서 쉽게 이용할 수 있도록 웹 메뉴를 구성 하였으며 말에 대한 다양한 정보를 제공할 수 있게 하였다. 말 데이터베이스를 이용할 수 있는 웹 주소는 http://www.primate.or.kr/horse이다. We have built a database server called HorseDB which contains the genome annotation information and biological information for horse from public database entries. The aims of HorseDB are the integration of biological information and horse genome data on genome scale using bioinformatic methods. To facilitate the extraction of useful information among collected horse genome and biological data, we developed a user-friendly interface system, HorseDB; an Integrated Horse Resource and web Service. The database is categorized by the general horse information data, a sequence annotation data, and a world-wide web analysis program interface. The database also provides an easy access for user to find out the useful information within horse genomes and support analyzed information, such as sequence alignment and gene annotation results. HorseDB can be accessed at http://www.primate.or.kr./horse.

치매환자에서 transposable elements에 의한 유전자 발현조절의 생물정보 분석

김대수,허재원,하홍석,김태홍,조운종,김희수,Kim, Dae-Soo,Huh, Jae-Won,Ha, Hong-Seok,Kim, Tae-Hong,Jo, Un-Jong,Kim, Heui-Soo 한국생명과학회 2006 생명과학회지 Vol.16 No.7

노년에 나타나는 정신병적 증상의 가장 흔한 원인 질환으로 만성적이고 서서히 악화되는 진행성이면, 기억력, 사고력, 학습능력 및 판단력 등의 손상을 포함한 인지기능의 장애이다. 고령화 사회가 도래하면서 노인성 치매환자가 매년 급격히 늘고 있으며 매년 수만 명이 노인성치매에 걸려 본인뿐 아니라 가족까지도 많은 고통에 시달리고 있다. 특히 노인성 치매의 경우는 환자 본인의 문제가 아니라 젊은 노동력을 환자의 보호자로 필요함으로 국가적 노동력의 손실로 이어지고 있다. 현재 연구에서 우리는 노인성 치매와 transposable elements와의 상호관계를 밝히기 위하여 공개된 유전자 데이터베이스에서 EST (expressed sequence tags)를 이용하여 생물정보학적 인 분석방법과 프로그램을 이용하여 치매의 원인으로 추정되는 후보유전자들을 찾아내었다. 이러한 분석을 통하여 치매환자에서 transposable elements의 발현으로 인해 유전자의 발현에 변화를 가지는 98개의 후보 유전자를 찾아내었다. 노인성질환인 치매와 transposable elements의 분석방법을 이용하면 치매의 원인을 규명하는데 많은 도움이 될 것이다. Dementia is a progressive disease of increasing the dysfunction of intellectual and physical ability. In the aging society, many families are suffering from the caring the patients who are diagnosed with dementia. However, dementia is a complex disease affected by the genetic and environmental agents. In the present study, we investigated the transposable elements in relation to dementia. From the analysis of dementia EST (expressed sequence tag) sequences, we found dementia candidate genes, and analyzed expression profiles and repeat elements using bioinformatics tools. This analysis showed that 98 genes were affected in their mRNA sequences by transposable elements expression. Their expressions were affected by the integration of different transposable elements (SINE, LINE, LTR, DNA) during the primate evolution. We believe that our work will be of significant interest to genome scientists, and may help them gain insight into implication of transposable elements expression in dementia.

탄성 고투자율 자성체의 공극진동에 따른 전자기 특성에 관한 모델

김대수,김왕곤,홍진웅 ( Dae Soo Kim,Wang Gon Kim,Jin Woong Hong ) 한국전기전자재료학회 1996 전기전자재료학회논문지 Vol.9 No.9

인동등(忍冬藤)이 인간 유래 악성 흑색종 세포의 유전자 발현에 미치는 영향

김대수,최정화,김종한,박수연,강성인,Kim, Dae-Su,Choi, Jeong-Hwa,Kim, Jong-Han,Park, Soo-Yeon,kang, Seong-In 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.1

Objective : This study was designed to investigate anti-cancer and whitening activities (LC). So it was investigated the effects of LC on proliferation rates of melanoma genetic profile by LC. Methods : The genetic profile for the effect of LC on human derived melanoma cell, SK-MEL-2, was measured using microarray technique, and the functional analysis on these genes were conducted. Total 441 genes were up-regulated and 830 genes down-regulated in cells treated with LC. Genes induced or suppressed by LC were all mainly concerned with basic signalling pathways, which are involved in cell growth, differentiation and migration. Especially, many genes, which are related in apoptosis and cell cycle arrest were up-regulated by treatment with LC, and genes related in cell cycle were down-regulated. Result : The network of total protein interactions were identified by using cytoscape program, and some key molecules, such as BCL2L1, SIN3A, SMAD2 and c-myc that can be used for elucidation of therapeutical mechanism of medicine in the future. Conclusion : These results suggest possibility of LC as addition drug and whitening cosmetics. In addition, it was also suggested that related mechanisms are involved in BCL2L1, SIN3A, SMAD2 and c-myc related signalling pathways.

화기조경탕(化氣調經湯)의 여러 가지 분획에 따른 S-180 암(癌) 세포주(細胞株) 억제(抑制) 효과(效果)

김대수,최정화,김종한,박수연,Kim, Dae-Su,Choi, Jeong-Hwa,Kim, Jong-Han,Park, Soo-Yeon 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1

Objecgtive : The aim of present study was to investigate inhibition effect of Whakijogyung-Tang(WJT) on the tumor cell lines. This study estimated the cytotoxicity of WJT about viability of S-180 and NlH3T3. Methods : The cytotoxicity of WJT about viability of cells were tested using a colorimetric tetrazoliun assay(MTT assay) Results and Conclusion : 1. Water extract of WJT had $IC_{50}$ of 863 ${\mu}g/ml$ in S-180 cell lines, but cytotoxicity of NIH3T3 was not significant difference compare with S-180. 2. n-Hexane fraction of WJT had similar cytotoxicity between S-180 and NIH3T3, but that could not have $IC_{50}$ in S-180 cell lines. 3. Ethyl acetate fraction of WJT had low degree cytotoxicity both S-180 and NIH3T3 cell lines. 4. Significantly, Butanol fraction of WJT had differenct citotoxicity between S-180 and NIH3T3. 5. $H_2O_2$ fraction of WJT had no cytotoxicity both S-180 and NIH3T3.

都市環境色彩改善方案에 관한 硏究 -아파트 表面色을 對象으로-

김대수,조정송,Kim, Dae-Soo,Cho, Jung-Song 한국조경학회 1990 韓國造景學會誌 Vol.18 No.3

The purpose of this study was to suggest an improvement proposal for colors in urban environment with special regard to the surface color and their situations of apartment buildings in Seoul. For this goal, 167 cases of different color types of apartment buildings were surveyed. And, the survey was performed in the view of color by areas, by localtion, by builder, by paint year, by built year, by appearance of building, and by surface texture to prove the influencing factors on the surface colors. These collected data analyzed and compared with the existing studies to find out the changing trend of colors. The results are as follows : 1) The use of neutral gray($26.4{\%}$) and warm color(YR, Y, GY; 56.4%) were dominant and the usage trend of higher 'value'(87.4%) and lower 'saturation'(73.0%) was obvious. Especially, the use of PB and P was noticeable. 2) In comparing the existing studies, the changing trend in the surface color pattern was found. That is, neutral gray was used dominantly in 1970's, warm color(YR, Y)in the middle of 1980's. In the end of 1980's, warm color were also used dominantly same as before and GY, PB, P were used noticeably with some rising tendency of higher 'value' and lower 'saturation' was obvious. 3) The results of analysis by localtion shows that the different color groups might exist in Seoul city. Neutral gray and YR were dominant in zone I. Warm colors(YR, Y, GY)were prevailed in zone II, III, IV. In zone V, many colors were evenly used. In zone VI, middle values at warm color were dominant. Progressively, these color groups with further study could be considered in the color management in urban environment possibly. 4) Surface color of apartment buildings were different from their builders. 5) Concerned with the painted year, the use of higher 'value' and lower 'saturation' was increased gradually with the change of times. 6) the analysis by the built year revealed that the 'value' of surface colors on the old buildings was lower than that of the new ones. 7) The 'value' of colors on the surface with texture was higher than that of the surface without texture. 8) In the combination of two colors, the use of 'value' with difference at the same 'hue' was found harmonions in many cases, but the 'saturation' in usage was included in the ambiguity (Moon & Spencer's term). The ambiguity in color harmony should be improved in the near future.

SCM Strategy and Best Practices Implementation in SMEs

김대수,Kim Dae-Soo The Korean Operations Research and Management Scie 2006 經營 科學 Vol.23 No.1

Over the last decade, the field of supply chain management (SCM) and e-business has received an enormous amount of attention from practitioners and academicians. However, little has been known about how and to what extent small- to medium-sized enterprises (SMEs) are implementing SCM initiatives and e-business practices. This paper proposes a comprehensive research model and presents the survey results of these practices of SMEs located in Wisconsin and illinois, U.S., In terms of competitive strategy and priority, value chain activity priority, supply chain and e-business integration focus, SCM best practices implementation focus and challenges, and business performance. The analysis reveals several valuable insights into how SMEs should run their businesses in today's volatile, rapidly changing customer economy.

각막지형도(topography) 각막곡률로부터 토릭 각막형상의 수식화

김대수,Kim, Dae Soo 한국안광학회 2011 한국안광학회지 Vol.16 No.4

목적: 수평축과 수직축 비가 다른 토릭각막의 형상을 수학적인 함수로 표현하여 각막곡률 분포의 분석과 콘택트 렌즈 착용에 필요한 눈물두께 계산에 적용한다. 방법: 각막을 타원함수로 가정하고 함수로부터 유도된 곡률반경식과 각막 토포그라피 측정 곡률반경을 일치시켜 타원함수의 변수를 결정하였다. 계산은 작성한 엑셀프로그램을 사용하였다. 결과: 중심이 각막 정점에 위치하지 않는 리본(나비)형 토포그라피 이미지를 가지는 직난시 각막의 수평, 수직 각 축에 대해 각막의 형상을 수치적으로 알 수 있는 타원함수를 구하였다. 결론: 각막에 대해 고도의 수차 등이 요구되지 않는 응용, 예를 들면 콘택트렌즈 피팅, 난시교정 등에 각막 형상을 단순한 타원함수로 표현하는 것이 편리할 것으로 판단된다. Purpose: To represent the shape of toric corea in the elliptical function for the determination of curvature distribution and lacrimal thickness between cornea and contact lens when the lens is fitted. Methods: Topography measurements of corneal curvature and curvature equation derived from the assumed elliptical function were evaluated using the Excel program which included the necessary equation derived. Results: Mathematical expressions for the cornea whose ribbon shaped-topography image, in which the center does not coincide with the corneal apex, can be determined. Conclusions: For the application where the higher accuracy on the cornea is not required, such as higher order aberration, the cornea cal be expressed in the simple elliptical function.

백서다형핵백혈구의 화학주성에 미치는 치태의 영향에 관한 연구

김대수,황광세,Kim, Dae-Soo,Hwang, Kwang-Se 대한치주과학회 1985 Journal of Periodontal & Implant Science Vol.15 No.1

이중 주파수 액정을 적용한 액정 셔터의 고속 응답 특성

김대수,한승환,배건,전철규,Kim, Dae Soo,Han, Seung Hwan,Bae, Geon,Jhun, Chul Gyu 한국전기전자재료학회 2014 전기전자재료학회논문지 Vol.27 No.5

In this paper, by using a dual frequency liquid crystal material, we propose a liquid crystal device with a fast response characteristics. The dual frequency liquid crystal material has a positive dielectric anisotropy value at a low frequency. With a high frequency, the dielectric anisotropy becomes negative. Therefore, the relaxation process is governed by not only the elastic deformation, but also the dielectric interaction. The measured decay time and rise time were 0.88 ms and 0.33 ms, respectively.