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수 종의 생약제제가 MC3T3-E1 세포의 염기성 인산분해효소 합성에 미치는 영향
김대겸,김탁,피성희,김현아,최광수,유형근,신형식,Kim, Dae-Kyum,Kim, Tak,Pi, Sung-Hee,Kim, Hyun-A,Choi, Kwang-Soo,You, Hyung-Keun,Shin, Hyung-Shik 대한치주과학회 1999 Journal of Periodontal & Implant Science Vol.29 No.4
Several growth factors and polypeptidesare not commonly yet used for regenerators of bone tissue or alveolar bone because of the insufficiency of studies on their side effects, genetic engineering for mass production and stability for clinical application. Recently, many natural medicines, which have advantage of less side effects and possibility of long-term use, have been studied for their capacity and effects of anti-bacterial, anti-inflammatory and regenerative potential of periodontal tissues. Olibanum, Myrrha, Phlomis Radix, and Cimicifugae Rhizoma have been traditionally used as a drug for treatment of bone disease in oriental medicine. The objective of this study was to examine the ability of alkaline phosphatase(ALP) synthesis of rat calvarial osteoblast(MC3T3-E1) when several natural medicines were supplemented. MC3T3-E1 cells were cultured with ${\alpha}$-MEM(negative control), dexamethasone(positive control), and each natural medicines for 3 and 5 days. And then ALP synthesis was measured by spectrophotometer for enzyme activity and by naphthol AS-BI staining for morphometry. All of the natural medicines induced higher activity of ALP synthesis than the negative controls. Especially Olibanumind uced the higher activity than the positive controls (p<0.05). In the aspects of culturing time, except Cimicifugae Rhizoma, the natural medicines induced higher activity of ALP synthesis at 5 days than at 3 days (p<0.05). In morphometry, all of the natural medicines showed statistical significance compared to the negative control (p<0.05). Myrrha a n d Phlomis Radix showed larger positively stained area at 5days than at 3 days, whereas the others did not showed the difference between at 5 and at 3 days(p<0.05). These results indicate that several natural medicines have an inducing ability of ALP synthesis in MC3T3-E1 cells.
Three-dimensional vortex structure near a corner of a translating plate
김대겸,Kim, Daegyoum The Korean Society of Visualization 2015 한국가시화정보학회지 Vol.13 No.1
Three-dimensional vortex structures in the corner region of translating normal plates are visualized experimentally with defocusing digital particle image velocimetry. Vortex formation processes for three plates with corner angle $60^{\circ}$, $90^{\circ}$, and $120^{\circ}$ are compared in order to study the effect of corner shape on vortex formation. In all cases, the self-induction of the starting vortex and its interaction with the potential flow induced by the moving plate cause the vortex to change its form dynamically after the plate starts to translate. While the vortex near a corner follows the plate in the low corner angle of $60^{\circ}$, the vortex separates early from the plate and its forward motion becomes slow in the high corner angle of $120^{\circ}$. It is also found that the starting vortex can transport inward at the corner, which depends on the corner angle.