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김갑병 대구효성가톨릭 대학교 1997 연구논문집 Vol.54 No.2
Purpose:These studies were designed to determine the effect of inhibition of calcium translocation through L-type channels and inhibition of the release of intracellular bound calcium from the sarcoplasmic reticulum(SR) on the ability of the bladder to generate pressure and empty. Methods:Using our isolated rabbit whole bladder preparation, we investigated the effect of selectively inhibiting either the translocation of extracellular calcium using Diltiazem[D](10μM) or intracellular calcium induced calcum release using a combination of Thapsigargin(40μM)+Ryanodine(80μM)[T & R] on the responses to either maximal field stimulation(32Hz, 80V, lms) or maximal bethanechol stimulation(250μM). Two experiments were performed:in the first, the bladder contracted isometrically with 15ml, saline and in the second, the bladder contracted and emptied the 15ml. saline into a bottle hanging from a force transducer, allowing simultaneous measurement of pressure and volume emptied. Flow rate, rate of pressure generation, and work performed were calculated from pressure and volume emptied. Results:Diltiazem produced significant inhibitions of the maximal isometric response to FS. The time to maximal rpessure generation was significantly reduced, whereas the mean rate of pressure generation was increased. R & T inhibited maximum pressure generation to the same degree as Diltiazem. However, there was no effect on the time to maximal pressure generation but the mean rate of pressure generation was significantly reduced. D reduced the percentage volume emptied in response to FS to a significantly greater extent than the response to bethanechol whereas R & T reduced the response to FS and the bethanechol equally. Both drug treatments resulted in significant reduction in the total amount of work performed by the bladder in response to both FS and bethanechol. Conclusions:Bladder function is dependent upon both translocation of extracellular calcium through L-type calcium channels and the stimulated release of calcium from SR(both IP3-sensitive and insensitive sites). Inhibition of either site results in signigicant reductions of the ability of the bladder to generate and sustain pressure, generate power, and perform work. These results are consistent with the hypothesis that several forms of expeimental bladder dysfunction may be directly related to significant alterations in calcium homeostasis that results in the observed dysfunction in the ability of the bladder to generate pressure and empty.
김갑병,류현열 고신대학교 의학부 1986 高神大學校 醫學部 論文集 Vol.2 No.1
Renal angiomyolipoma is a sort of benign tumor of the kidney, which is composed of the mixture of blood vessels, fat tissue and smooth muscle. It commonly occurs in association with tuberou sclerosis, which is characterized by epilepsy, mental retardation, adenoma sebaceum, and other lesions such as retinal phakomas and harmatomas of the kidney, brain, and other viscera. Herein we present a case of the renal angiomyolipoma with tuberous sclerosis in a 52-year old female.
혈관 장애성 발기부전증의 진단에 있어서 동위원소 발기음경혈류도 검사
김갑병,김세철 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.1
Hemodynamic study of the penile erection was done was done using ^99mTc-pertechnetate and papaverine HCl in 66 patients of the erectile dysfunction and 15 cases of the normal volunteers. The causes of the impotence were arteriogenic in 17 cases, venogenic in 4, diabetogenic in 10, neurogenic in 4, hyperprolactinemic in 1, and psychogenic in 30, ranging from 19 to 70 years of age. The normal control group ranged from 21 to 38 years of age. The Election Penogram Indexes were calculated on the time-activity curve of the radioisotope erection penogram, and was compared with the findings of Snap-Gauge band tests, Penile Brachial Index(P.B.I.). The results were as follows: 1. The arterial index(Index A)and venous index(Index A) related to the etiology of the impotence: A) Index A was 1.26±0.57 in normal control group, 0.44±0.17 in arteriogenic, 0.68±0.21 in venogenic, 0.58±0.27 in diabetogenic, 0.62±0.48 in neurogenic, 1.29 in hyperprolactinemic and 0.99±0.37 in psychogenic impotence. Index A was significantly correiated with the penile arterial inflow in accordance with the etiologic diseases of the impotence. B) Index V was 0.09±0.04 in normal control group, 0.11 ±0.08 in arteriogenic, 0.39±0.11 in venogenic, 0.16±0.07 in diabetogenic, 0.19±0.08 in neurogenic, 0.19 in hyperprolactinemic and 0.08±0.07 in psychogenic impotence. Index V was representative of the penile venous oytflow or leak during erection. 2. Correlation of Index A with Snap-Gauge band tests and P.B.I.: A) Correlated in 85.7% with Snap-Gauge band tests. B) Correlated with mean P.B.I. of each etioligic diseases of the impotence. Index A, however, had more diagnostic value than P.B.I. 3. Correlation of Index V with Snap-Gauge band tests and P.B.I.: A) Correlated in 100% with Snap-Gauge band tests. B) Not correlated with P.B.I. In conclusion, the radidisotope erection penogram was a very useful method in diagnosis of the organic impotence, particularly to differentia arteriogenic and venogenic in vasculogenic impotence. Furthermore it could be easily performed, and was noninvasive.
김갑병,류현열 고신대학교(의대) 고신대학교 의과대학 학술지 1986 고신대학교 의과대학 학술지 Vol.2 No.1
Renal angiomyolipoma is a sort of benign tumor of the kidney, which is composed of the mixturer of blood vessels, fat tissue and smooth muscle. It commonly occurs in association with tuberous sclerosis, which is characterized by epilepsy, mental retardation, adenoma sebaccum, and other lesions such as retinal phakomas and harmatomas of the kidney, brain, and other viscera. Herein we present a case of the renal angiomyolipoma with tuberous sclerosis in a 52-year old female.