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피록시캄의 피부투과 및 소염효력에 대한 알코올성 하이드로겔 시스템의 영향
기민효(Min Hyo Ki),신희종(Hee Jong Shin),이강우(Kang Woo Lee),김재욱(Jae Wook Kim),김정우(Jung Woo Kim),홍청일(Chung Il Hong) 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.3
These studies were designed to determine the effect of hydroalcoholic gel system (lower alkanol concentration : 40-60%) compared to general hydrogel system (lower alkanol concentration : 10-35%) on transdermal delivery of piroxicam and its anti-inflammatory activity. Piroxicam was incorporated into a hydroalcoholic gel and a hydrogel containing polymers, solvents, and cosolvents. The pH of gel was about 6.3-7.3 and the solvent mixtures were composed of water and various concentrations of ethanol (35, 40, 50, and 60%). For the in vitro study, the skin permeation of piroxicam from the gel formulations was investigated using Franz modified diffusion cells fitted with hairless mouse skin. For the in vivo study, the anti-inflammatory activity of hydroalcoholic gel was compared to other commercial products (piroxicam hydrogel and ketoprofen hydrogel) in rat and human. The anti-inflammatory activity was determined using carrageenan-induced foot edema model in rat. For the clinical study, it was evaluated from determining efficacy and acceptability with 98 patients suffering from musculoskeletal pain. A novel piroxicam hydroalcoholic gel was successfully formulated in the range of 40-50% of ethanol as solvent, more than 10% of propylene glycol, 5% of Transcutol^ⓡ and 1% of benzyl alcohol. The skin permeation of piroxicam using hydroalcoholic gel system was greater than that of general hydrogel system (flux : 139.1-148.2 ㎍/㎠/hr vs. 43.0-84.5 ㎍/㎠/hr) in vitro. In carrageenan-induced edema model, the anti-inflammatory activity of hydroalcoholic gel was better than that of piroxicam hydrogel for edema inhibition (75.1% vs. 62.9%, p<0.01). In clinical study, each visual analogue of pain scale (improvement point: 15.57 point vs. 3.61 point, p<0.05) and global acceptability assessment (satisfied patients: 76.2% vs. 47.7%, p<0.05) of new hydroalcoholic gel was significantly increased compared to ketoprofen hydrogel. The inclusion of piroxicam to the hydroalcoholic gel system was found to improve significantly the skin permeation in vitro and the anti-inflammatory activity in vivo.
이해방 ( Hai Bang Lee ),정제교 ( Je Kyo Jeong ),손세일 ( Se Il Sohn ),변영로 ( Young Ro Byun ),기민효 ( Min Hyo Ki ),서중기 ( Jung Ki Seo ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Drug delivery system(DDS) has been extensively applied the various areas as (1) novel methods for drug administration through several route, (2) development of novel polymeric carrier, and (3) tissue engineering and regenerative medicine. The aim of this review is to report the recent progress of "Development of controlled drug delivery system" supported by Korean Intellectual and Economy(KOIE) for 2004~2009. This project is composed by 5 subproject as (1) development of novel osmotic pump, (2) development of liposome delivery system, (3) development of DDS by bile acid transporter, (4) protein drug delivery system using thermo-sensitive hydrogel, and (5) development of novel transdermal drug delivery system. DDS system might be the core and platform technology for the application of diagnosis, bioinstrument, tissue engineering, regenerative medicine and pharmaceutical industries.