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Pt-Sn/Alumina 촉매를 이용한 Methylcyclopentane의 Ring-enlargement 반응에서 Alumina 지지체의 영향에 관한 연구
권지선,박은서,전종기 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
Methylcyclopentane유도체로부터 고리확대반응을 통해서 부가가치가 큰 benzene을 제조할 수 있다. 본 연구에서는 다양한 종류의 alumina지지체와 여러 온도에서 소성한 η-alumina지지체에 백금과 주석을 incipient wetness 법으로 제조하였다. 촉매들의 물리적 및 화학적 특성을 N<sub>2</sub> adsorption, NH<sub>3</sub>-TPD, Pyridine-IR, TPR 및 XRD로 분석하였다. 연속식 고정층 촉매반응기에서 methylcyclopentane의 ring enlargement반응을 수행하여 alumina 지지체의 종류가 전환율, benzene 선택도 및 수율에 미치는 영향을 분석하였다.
권지선,윤도영,한현정,박종호 대한신경과학회 2013 대한신경과학회지 Vol.31 No.2
Cerebral achromatopsia, which refers to a loss of color vision, is a rare complication of posterior circulation stroke. We report two patients who presented with achromatopsia and dyschromatopsia (incomplete form of achromatopsia)respectively after acute posterior cerebral artery infarction. Lingual and fusiform gyri within the occipito-temporal area are known to be responsible for color perception.
비-안와-뇌 털곰팡이증에 의한 반복적인 뇌경색이 발생한 증례
권지선,김고운,송지선,김지영 대한의진균학회 2013 대한의진균학회지 Vol.18 No.1
Rhino-orbito-cerebral mucormycosis (ROCM) is caused by invasion of orbital and intracranial structures directly or through the blood vessels of fungi of the Order Mucorales. It is the most fulminant form of mucormycosis and can manifest brain abscess, cranial nerve palsies, thrombosis or aneurysm,as well as sinusitis, facial or nasal deformity. We report one ROCM case complicated by recurrent cerebral infarctions after involvement of cavernous sinus and meningeal inflammation, despite treatment with surgical debridement and high dose intravenous amphotericin B.
권지선,김상수,김지혜,남덕우 한국유전체학회 2012 Genomics & informatics Vol.10 No.2
Gene set analysis (GSA) is useful in interpreting a genome-wide association study (GWAS) result in terms of biological mechanism. We compared the performance of two different GSA implementations that accept GWAS p-values of single nucleotide polymorphisms (SNPs) or gene-by-gene summaries thereof, GSA-SNP and i-GSEA4GWAS, under the same settings of inputs and parameters. GSA runs were made with two sets of p-values from a Korean type 2 diabetes mellitus GWAS study:259,188 and 1,152,947 SNPs of the original and imputed genotype datasets, respectively. When Gene Ontology terms were used as gene sets, i-GSEA4GWAS produced 283 and 1,070 hits for the unimputed and imputed datasets, respectively. On the other hand, GSA-SNP reported 94 and 38 hits, respectively, for both datasets. Similar, but to a lesser degree, trends were observed with Kyoto Encyclopedia of Genes and Genomes (KEGG) gene sets as well. The huge number of hits by i-GSEA4GWAS for the imputed dataset was probably an artifact due to the scaling step in the algorithm. The decrease in hits by GSA-SNP for the imputed dataset may be due to the fact that it relies on Z-statistics, which is sensitive to variations in the background level of associations. Judicious evaluation of the GSA outcomes, perhaps based on multiple programs, is recommended.
Comparison of Erythrocyte Traits Among European, Japanese and Korean
권지선,김상수 한국유전체학회 2010 Genomics & informatics Vol.8 No.3
Erythrocyte traits are heritable and indirect indicators of blood diseases caused by erythrocyte, but their genetic factors are largely unknown. So we performed genome-wide association study in 8,842 Korean individuals to identify genetic factors influencing erythrocyte traits. We identified 40 associations for three erythrocyte traits at genome-wide significance levels (p<1×10−6). We compared these associated loci with those reported in genome-wide association studies of European and Japanese. Our findings include previously identified loci (HBS1L-MYB, TMPRSS6, USP49 and CCND3) in other studies and novel associations (MRDS1/OFCC1, CSDE1,NRAS and 8 other loci). For example, SNP rs4895440 of HBS1L-MYB intergenic region on chromosome 6q23.3 is one of the most associations influencing erythrocyte traits (p=8.33×10−27).
간호사의 환자안전문화인식과 조직의사소통이 환자안전관리활동에 미치는 영향
권지선,지은주 대한의료커뮤니케이션학회 2023 의료커뮤니케이션 Vol.18 No.1
Purpose : This study was conducted to investigate nurse’s perceptions of patient safety culture, organizational communication, and patient safety management activity levels and influential factors. Methods : A total of 183 nurses working at a general hospital located in “G.” was surveyed. The data were collected using a self-report questionnaire from July 12 to 25, 2018, and were analyzed usingSPSS/WIN 21.0. Results : The factors affecting the research subjects’ patient safety management activities were organizational communication (β=.41, ρ<.000) and their perceptions of patient safety culture (β=.18, ρ<.025), which revealed an explanatory power of 29.5%. Conclusion : The findings show the importance of organizational communication and perceptions of patient safety culture in patient safety management activities. Healthcare organizations should developprograms to address these influencing factors.