Transiently Intraoperative Occlusion of uterine arteries with endoscopic vascular clip preceding laparoscopic myomectomy

권용순,노현진,이수정,안준우,이상훈 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

To determine whether performing transiently intraoperative occlusion of uterine arteries (TOUA) immediately before laparoscopic myomectomy can reduce intraoperative complications. In a retrospective case-control study, laparoscopic myomectomy with and without TOUA was examined. Data were analyzed from 89 laparoscopic myomectomies performed by a single surgeon (Y.S Kwon) at Ulsan University Hospital between March, 2011 and March, 2012. Surgical outcomes included preoperative myoma size, number of myoma, operative time, and operative blood loss. Data were analyzed via 2-tailed Student t test. forty nine women underwent laparoscopic myomectomy with TOUA with endoscopic vascular clip. Forty control patients underwent laparoscopic myomectomy alone. The TOUA group had no case of nerve or vascular injury during the operation time. The mean time of both occlusions of uterine arteries is 15 minutes. The TOUA group had a lesser mean blood loss during the operation rather than the other group with laparoscopic myomectomy alone (67.5 versus 116.8 mL, p=0.001). There were no significant differences in size and number of uterine myomas and intra-operative complications. There was no case of conversion of laparoscopy to laparotomy in the both groups. TOUA performed immediately before laparoscopic myomectomy facilitated minimally invasive surgery with lesser blood loss, with no differences in other intraoperative complications.

『98 지역주민 건강증진을 위한 영양캠페인』을 마치고

권용순 대한영양사회 1998 國民營養 Vol.199 No.-

우리 교회 명교사를 소개합니다 : 의성제일교회 아동부 송진양선생님

권용순 장로회신학대학교 기독교교육연구원 2013 교육교회 Vol.427 No.-

Pure Basaloid Squamous Cell Carcinoma of the Uterine Cervix: A Case Report

권용순,김용만,최가원,김영탁,남주현 대한의학회 2009 Journal of Korean medical science Vol.24 No.3

Basaloid squamous cell carcinoma of the uterine cervix is an extremely rare malignancy of the female genital tract with a poorer clinical outcome than squamous cell carcinoma of the uterine cervix. We report a case of pure basaloid squamous cell carcinoma of the uterine cervix. A 70-yr-old woman with vaginal bleeding was referred to our institute. A basaloid squamous cell carcinoma of the uterine cervix, of International Federation of Gynecology and Obstetrics (FIGO) stage Ib1, was diagnosed by a loop electrosurgical excision procedure cone biopsy. A radical hysterectomy was performed, along with bilateral salpingo-oophorectomy, pelvic lymph node dissection, and para-aortic lymph node sampling. Pathologic findings were consistent with a basaloid squamous cell carcinoma confined to the cervix without an extracervical tumor. No further treatment was administered and there was no clinical evidence of recurrence during the 12 months of follow-up. Follow-up for the patient is ongoing. Although basaloid squamous cell carcinoma of the uterine cervix is thought to behave aggressively, accumulation of data on these rare tumors is necessary to determine whether their behavior differs significantly from that of conventional cervical squamous cell carcinoma of similar clinical stage. These data would be useful for defining the best diagnosis and treatment for these rare tumors.

Ovarian Cancer during Pregnancy: Clinical and Pregnancy Outcome

권용순,목정은,임경택,이인호,김태진,이기헌,심재욱 대한의학회 2010 Journal of Korean medical science Vol.25 No.2

The aim of this study is to evaluate the clinical feature and pregnancy outcome in patients with ovarian cancer diagnosed during pregnancy. We retrospectively analyzed the medical records of 27 patients diagnosed with ovarian cancer during pregnancy at Cheil General Hospital & Women’s Healthcare Center from January 1996to December 2006. Mean age of the patients was 29.1 yr (range 23-40), and a mean follow-up period was 57 months (range 7-112 months). Of 27 patients, 15 (55.5%)had borderline malignancies, 7 (25.9%) had epithelial malignancies and 5 (18.6%)had germ cell tumors. A total of 26 patients received a conservative surgery preserving pregnancy. The mean time for surgical intervention during pregnancy was 20 weeks of gestational age. Of the 27 patients, 26 had full term delivery of a healthy baby without any congenital malformation. Only one patient with epithelial ovarian cancer had a relapse at 19 months after the first conservative operation with adjuvant chemotherapy. There were few data for managing patients with ovarian cancer diagnosed during pregnancy. This study results could help establish a guideline for management of ovarian malignancy complicating pregnancy.

Hexamethylmelamine as Consolidation Treatment for Patients with Advanced Epithelial Ovarian Cancer in Complete Response after First-Line Chemotherapy

권용순,남주현,김대연,서대식,김영탁,김종혁,김용만 대한의학회 2009 Journal of Korean medical science Vol.24 No.4

The aim of this study was to assess the efficacy of consolidation therapy with hexamethylmelamine (HMM) in patients with advanced epithelial ovarian cancer (EOC). Patients treated at our hospital between January 1997 and November 2006 and in documented clinical complete response from advanced ovarian cancer following front-line platinum-based therapy were retrospectively analyzed. The patients treated with HMM were compared to the patients of matched counterpart without consolidation therapy. Of 102 patients enrolled, 49 were treated with HMM and 53 received no consolidation treatment. For patients with HMM and observed patients, the mean age were 54.6 and 55.6 yr; the distribution of stage was similar (P=0.977); the optimal surgery was performed in 36 (73.5%) and 44 (83%) (P=0.336); the recurrence rate were 27 (55.1%) and 33 (62.3%) (P=0.463); and the median progression-free survival were 38 months and 21 months for patients with HMM and observed patients (P=0.235). No treatment-related adverse events were reported during the followup period. Although this study failed to show the significant survival benefit of consolidation therapy with HMM in patients with advanced EOC, we consider that our study can contribute data to investigate the effectiveness of consolidation therapy in epithelial ovarian cancer.

자궁 경부암의 임상 조직학적 요인들과 T 조절 림프구 분포와의 상관 분석

권용순 ( Yong Soon Kwon ),김용만 ( Yong Man Kim ),이하영 ( Ha Young Lee ),이신화 ( Shin Wha Lee ),이정남 ( Jung Nam Lee ),김종혁 ( Jong Hyeok Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.12

목적: 자궁 경부암과 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3과의 상관 분석을 통해 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3의 임상적 의의를 찾고자 한다. 방법: 17명의 자궁 경부암 환자의 말초 혈액을 항 CD4, CD25 mAb 그리고 항 Foxp3 mAb와 결합하는 림프구 세포를 획득하여, flow cytometry을 이용한 Foxp3를 정량화 한다. 이후 자궁 경부암의 임상적, 인구 통계학적 특성과의 상관 분석을 실시한다. 분석된 특성들은 연령, 신장, 체중, 비만도, 최대 종양 직경, 자궁 방 침범 유무, 임파절 침범 유무, 그리고 림프관 종양 침범 유무 등으로 이루어진다. 결과: 여러 자궁경부암의 임상적, 인구 통계학적 특성들 중 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3는 최대 종양 직경과 통계적 유의한 상관성을 갖는다 (p value = 0.012, Spearman`s rho 상관 계수 = 0.593). 결론: 진행된 자궁 경부암의 초기 종양의 크기와 말초 혈액의 T 조절 림프구 특이 Forkhead Box Transcription Factor FoxP3사이에는 통계적 유의한 상관관계를 나타내며, 이는 종양 크기와 항 종양 면역 체계와의 유의한 상관성을 지님을 시사한다. Objective: The aim of this study is to determine which clinicopathological factors have the significance in proportion of regulatory T lymphocytes in patients with cervical cancers. Methods: Blood samples were collected preoperatively from 17 patients with uterine cervical cancers (stage: IB, IIA) diagnosed at Asan medical center from May 2006 to October 2006. Patients were limited to who never been treated after diagnosis. We analyzed phenotypes of lymphocytes through flow cytometry by using anti CD3 antibodies, anti CD4 antibodies, anti CD25 antibodies and anti Transcription Factor Foekhead Box P3 (FoxP3) antibodies. Following analysis by flow cytometry, it was determined the relation between the proportion of regulatory T lymphocytes and clinicopathological factors of patients, including age, height, weight, BMI, maximum tumor diameter, lymphovascular tumor emboli, parametrial invasion, and lymph node metastasis. Results: Among many clinicopathological factors in patients with cervical cancer, only maximum tumor diameter was significantly correlated with the proportion of CD4+CD25+highFoxP3+ regulatory T lymphocytes (p=0.012, Spearman`s rho Correlation Coefficient=0.593). Conclusion: This is the first report to document the relation between uterine cervical cancer and the proportion of regulatory T lymphocytes in peripheral blood. In terms of positive correlation between the primary tumor size and the proportion of regulatory T lymphocytes in peripheral blood, we suggest that the spread mechanism of uterine cervical caner, especially direct invasion, will be related with the anti-tumor immune tolerance state. Further studies are necessary to explain the specific spread mechanisms and systemic antitumor immunity in cervical cancer.

Hexarnethylmelamine as consolidation treatment for patients with advanced epithelial ovarian cancerin complete response after first -Line chemotherapy

권용순 ( Yong Soon Kwon ),( Joo Hyun Nam ),( Dae Yeon Kim ),( Dae Shik Suh ),( Jong Heok Kim ),( Yong Man Kim ),( Young Tak Kim ) 대한산부인과학회 2007 대한산부인과학회 학술대회 Vol.93 No.-

자궁 내 제대 혈관 수혈을 통한 태아 적아구증의 산전 치료 1 예

권용순(Yong Soon Kwon),원혜성(Hye Sung Won),김소라(So Ra Kim),정지윤(Ji Youn Chung),이필량(Pil Ryang Lee),이인식(In Sik Lee),김암(Ahm Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12

N/A Fetal erythroblastosis caused by maternal Rhesus alloimmunization brings a significant clinical problem, eventually leading to fetal hydrops and intrauterine fetal death. Repeated blood transfusions into the umbilical vein are the treatment of choice for fetal erythroblastosis with severe hydrops. The purpose of this report is to introduce our experience with a case of fetal erythroblastosis, recovered after intraumbilical venous transfusions. The fetus has been received the intraumbilical venous transfusions for four times from 29 weeks of gestation. Fetal hydrops and cardiomegaly, as well as polyhydramnios were improved markedly after transfusions. A healthy baby was delivered at 34 weeks of gestation. Intraumbilical venous transfusion may be a safe and effective treatment on the case with severe aggressive anemic and hydropic isoimmune fetus.

노인소비자의 건강기능식품 구매결정요인과 구매 만족도

권용순(Yong Soon Kweon),민지연(Jiyeon Min),유현정(Hyun Jung Yoo) 충북대학교 생활과학연구소 2010 생활과학연구논총 Vol.14 No.2

This study examined what were the factors influencing on the buying decision making and satisfaction of health food among the elderly. The questionnaire survey method was utilized and 200 elderly who were living at Daejeon and Cheongju were selected. And, frequency, percentage, average, standard deviation, factor analysis and regression analysis were used by SPSS 12.0. The findings were as following: Firstly, most of the elderly consumers experienced taking of health food and they mostly bought it at special shop at the range of price of 50,000 to 100,000 won. And, they took health food to keep good health and believed they were very effective. Secondly, the elderly consumers affirmatively thought at common level that health food would help improve physical conditions, and they rather negatively thought that the food would prevent aging. Thirdly, the elderly consumers were relatively satisfied with convenience of taking of health food, and they were satisfied with price, dose and service after buying, etc at medium level or lower. And, buying of the elderly's buying of health food was affected by psychological factor more than by social characteristics. In particular, the elderly who affirmatively thought of health food were likely to be satisfied with the food.