몽고리안 저빌에서 뇌허혈시 GR89696이 parvalbumin 발현 신경세포에 미치는 영향

권영배,양일석,이장헌,Kwon, Young-bae,Yang, Il-suk,Lee, Jang-hern 대한수의학회 1999 大韓獸醫學會誌 Vol.39 No.1

Ischemic damage in the selectively vulnerable populations of neurons is thought to be caused by an abnormal accumulation of intracellular calcium. It has been reported that the neurons, expressing specific calcium binding proteins, might effectively control intracellular calcium concentrations because of a high capacity to buffer intracellular calcium in the brain ischemic condition. It is uncertain that parvalbumin, one of the calcium binding proteins, can protect the neurons from the cerebral ischemic damage. Recently, treatment of kappa opioid agonists increased survival rate, improved neurological function, and decreased tissue damage under the cerebral ischemic condition. Many evidences indicate that these therapeutic effects might result from regulation of calcium concentration. This study was designed to analyze the changes of number in parvalbumin-positive neurons after cerebral ischemic damage according to timepoints after cerebral ischemic induction. In addition, we evaluated the effect of GR89696 (kappa opioid agonist) or naltrexone(non selective opioid antagonist) on the changes of number in parvalbumin expressing neurons under ischemic condition. Cerebral ischemia was induced by occluding the common carotid artery of experimental animals. The hippocampal areas were morphometrically analyzed at different time point after ischemic induction(1, 3, 5 days) by using immuno-histochemical technique and imaging analysis system. The number of parvalbumin-positive neurons in hippocampus was significantly reduced at 1 day after ischemia(p<0.05). Furthermore, the number of parvalbumin-immunoreactive neurons was dramatically reduced at 3 and 5 days after cerebral ischemic induction(p<0.05) as compared to 1 day group after ischemia, as well as sham control group. Significant reduction of parvalbumin positive neurons in CA1 region of hippocampus was observed at 1 day after cerebral ischemic induction. However, significant loss of MAP2 immunoreactivity was observed at 3 day after cerebral ischemia. The loss of parvalbumin-positive neurons and MAP2 immunoreactivity in CA1 region was prevented by pre-administration of GR89696 compared to that of saline-treated ischemic group. Furthermore, protective effect of GR89696 partially reversed by pre-treatment of naltrexone. These data indicate that parvalbumin-positive neurons more sensitively responded to cerebral ischemic damage than MAP2 protein. Moreover, this loss of parvalbumin-positive neurons was effectively prevented by the pretreatment of kappa opioid agonist. It was also suggested that the changes of number in parvalbumin-positive neurons could be used as the specific marker to analyze the degree of ischemic neuronal damage.

"본초정화(本草精華)" "인부(人部)"에 대한 고찰

권영배,엄동명,김홍균,Kwon, Young-Bae,Eom, Dong-Myung,Kim, Hong-Kyoon 한국한의학연구원 2005 한국한의학연구원논문집 Vol.11 No.2

Study on ${\ulcorner}$Bonchojeonghwa${\lrcorner}$, which is one of the most specialized medical books in Boncho(Herbal Medicines), has been done by comparing it with some other medical books published in the Chosun dynasty. Though there was not meaningful result on e names of Korean medicine by this study and more study should follow in the future, from medicines recorded in ${\ulcorner}$Inbu (a chapter of medical ingredients from human body)${\lrcorner}$, we can reach on some results as follows by comparing in names of Korean medicines, their medical components, relevant explanations and etc. 1. Though it is difficult to know the author and the published year due to absence of the preface and epilogue, the publication is presumed to date from mid-l7th century, from the facts that Muheeong's ${\ulcorner}$Shinnongbonchokyongso${\lrcorner}$ is in the ${\ulcorner}$Bonchojeonghwa${\lrcorner}$'s reference list, and that there is not Hangul expression in the names of medicines nor the Ching dynasty’s books as a reference. 2. As a result of studying on the names of medicines recorded in ${\ulcorner}$Inbu${\lrcorner}$ of the Chosun dynasty's famous medical books, before ${\ulcorner}$ Bonchojeonghwa${\lrcorner}$, 19 medicines in ${\ulcorner}$Hyangyakjipsungbang${\lrcorner}$, 25 in ${\ulcorner}$Donguibogam${\lrcorner}$, and after ${\ulcorner}$Bonchojeonghwa${\lrcorner}$, 6 in ${\ulcorner}$Uimumbogam${\lrcorner}$, 4 in ${\ulcorner}$Kwangjebikup${\lrcorner}$, 11 in ${\ulcorner}$Bangyakhappyon${\lrcorner}$. And there are 37 medicines which are unique, ${\ulcorner}$Bonchojeonghwa${\lrcorner}$ has 31, the biggest records among them. 3. As a result of studying on the names of medicines recorded in 「Inbu」 of the ${\ulcorner}$Bonchojeonghwa${\lrcorner}$ and ${\ulcorner}$ Donguibogam${\lrcorner}$, 22 medicines were recorded in the both books, 9 were only recorded in ${\ulcorner}$Bonchojeonghwa${\lrcorner}$ and 3 were only recorded in ${\ulcorner}$Donguibogam${\lrcorner}$. 3 out of the total 37 medicines recorded in ${\ulcorner}$Inbu${\lrcorner}$ are only recorded in ${\ulcorner}$Hangyakjipsungbang${\lrcorner}$, and more study on this is needed. 4. From the contents recorded in ${\ulcorner}$Bonchojeonghwa${\lrcorner}$ and ${\ulcorner}$Donguibogam${\lrcorner}$, Benchojeonghwa is more in detail than Donguibogam. Thus, it was specialized in Boncho (Herbal Medicines) enough to be compared with general medical books, and played a good role in leading medical science's specialization. 5. Late Chosun dynasty's medical study on Boncho (Herbal Medicines) just like ${\ulcorner}$Bonchojeonghwa${\lrcorner}$ didn't lead to an active development of knowledge communication due to Confucian ethics. This limitation created the trend relying on general medical books or Yaksungga (songs of memorizing Boncho information) for Boncho information, but Boncho information of late Chosun dynasty became more in detail. That is, while Bokhapbang, combination of various medicines, were developed in China, Danmibang, single medicine but different intensity, were developed in Chosun. And thus, even though the kinds of medicines became smaller, but its contents became rather rich. 5. The medicines recorded in ${\ulcorner}$Bonchojeonghwa${\lrcorner}$ and ${\ulcorner}$Donguibogam${\lrcorner}$ are, from the view point of today, unclean or rather uncomfortable to use. Out those medicines, Bunchung, Hwasijangsanginkol, Hongyon, Gonidoogun, Inkondang had been

1898년 제주 농민항쟁의 검토

권영배 ( Young Bae Kwon ) 역사교육학회 1990 역사교육논집 Vol.15 No.1

『 의병문서 』 를 통해 본 구한말 전기의병항쟁

권영배(Kwon Young Bae) 대구사학회 1995 대구사학 Vol.49 No.1

N/A

『 의병문서 』 를 통해 본 구한말 전기의병항쟁

권영배(Kwon Young Bae) 대구사학회 1996 대구사학 Vol.51 No.1

N/A

초등학생의 학업동기 향상을 위한 통합적 학업상담 프로그램의 효과

권영배(Kwon Young Bae) 학습자중심교과교육학회 2012 학습자중심교과교육연구 Vol.12 No.2

본 연구의 목적은 초등학생의 학업동기 향상을 위해 통합적 학업상담 프로그램을 구안하고 실시하여 이 프로그램이 초등학생들의 학업동기에 어떠한 효과가 있는지 를 검증하는데 있다. 본 연구에서 개발한 프로그램이 효과가 있는지를 검증하기 위해 경기도의 한 초 등학교 6학년 1개반, 26명을 대상으로 프로그램을 실시하였다. 검사도구로는 학업동 기 검사를 사용하였고, 자료처리는 반복측정 변량분석(repeated measurement)으로 통계적 분석을 하였다. 연구결과, 통합적 학업상담 프로그램에 참여한 학생들이 비 교집단에 비해 학업동기 점수가 유의하게 향상된 것으로 나타났다. 또한, 학생 소감 문, 학부모의 학생행동에 대한 변화 평가를 분석한 결과, 본 연구의 학업상담 프로그 램이 학생들의 학업동기를 향상시키는 데 도움이 되었음을 알 수 있었다. The purposes of this research were to develop a integrated academic counseling program for academic motivation of elementary school students and to examine the effectiveness of the program on academic motivation and academic skills of the students. This program was conducted with twenty-six sixth grade students of a class of one elementary school, Gyeonggi province. To examine the effectiveness of the program, the measures for academic motivation were administered to the students of the experimental group and control group rights before the experiment for the pre-test, right after the experiment for the post-test, and the delay-test. The data collected were analyzed according to the Repeated Measurement Statistical Models using 12.0 SPSS/WIN program. The results of the analysis indicate that the integrated academic counseling program made significant positive effects on the academic motivation of the elementary school students. Also, the analysis of the students written evaluation report and the parents evaluation for their student behavioral changes manifest that the academic motivation of the students has improved throughout the program.

한말 조선에 대한 중립화 논의와 그 성격

권영배 ( Young Bae Kwon ) 역사교육학회 1992 역사교육논집 Vol.17 No.1

[Activities of University Student] 한국과학기술원(KAIST) 기계공학과 자작 자동차 팀 REX

권영배(Young Bae Kwon) 한국자동차공학회 2001 오토저널 Vol.23 No.4

한말 의장(義將) 원용팔(元容八)의 현실인식과 거병논리

권영배 ( Kwon Young-bae ) 세명대학교 지역문화연구소 2005 지역문화연구 Vol.4 No.-

This study intends to analyze perceptions of the realities and logic for raising the euibyeong, or the righteous army, of Won Yong-pal, who led his eubyeong at Wonju, Gangwon Province, in the late Joseon period. Major observations can be summed up as follows. Won Yong-pal proudly recognized the Joseon kingdom as the only civilized state of “So Junghwa,” or the Little China, after the fall of Ming China in 1644. He deplored that his country was in grave danger because of treacherous acts of villainous subjects and Japanese inroads. His raising of the euibyeong army was based on the logic that he should take revenge on the Japanese who killed the queen and despised the king, that he should preserve Koreas proper traditions and expel the foreign barbarians who defamed Koreas indigenous customs, and that he should rescue his country from corrupt officials who disordered government and put the people in distress. His logic increasingly moved from that of dichotomy of civilization vs. barbarism to that of salvation of his country. When he raised the euibyeong, he maintained that if Joseon fell, it could exert an evil influence upon the whole world, including the Qing Empire in China, and thus every country on globe, under the banner of "manguk gongbop, or the common cause of the world, should help Joseon maintain its sovereignty. It is worthy of attention that he tried to overcome hwai-ron, or the dichotomous concept of the Middle Kingdom vs. barbarians, that regarded the Western nations as beasts. Although Wons views of the realities and logic for raising the euibyeong were expressed in his manifestos, they might be considered perceptions of Neo-Confucian scholars at that time who proposed cheoksa, or rejecting heterodoxy. These scholars,including Won Yong-pal himself, were members of the Hwaseo School. Won Yong-pals raising of the euibyeong at Wonju is of importance in the followingrespects. First, he led the van in the so-called “middle period” euibyeong movement of the late Joseon dynasty. Second, his euibyeong movement means the resurrection of Yu In-seoks euibyeong movement at Jecheon, North Chungcheong Province. Third, his euibyeong movement demonstrates a close relationship between the early movement and the middle movement.

학업상담 프로그램의 효과에 관한 메타분석

권영배(Kwon Young Bae),신문승(Shin Moon seung) 학습자중심교과교육학회 2012 학습자중심교과교육연구 Vol.12 No.3

본 연구는 학생들의 학업상담 프로그램들이 학업성취와 학업관련 변인에 미치는 효과를 메타분석을 통하여 알아보고자 하였다. 이를 위해 문헌고찰을 통하여 분석 대 상과 분석 방법을 정하고, 1988년부터 2012년 2월까지 발표된 석․박사 학위논문 중 학생들의 학업요인을 직접 다룬 학업상담 연구 104편을 선정하여 194개의 효과크기 를 산출․분석하였다. 연구결과, 학업상담 프로그램이 학업성취도에 미치는 전체 평 균 효과크기는 0.78로 나타났다. 학업상담 프로그램 유형별로는 학업기술 프로그램 (1.01)이 가장 큰 효과 크기를 보였다. 중재변인별로 살펴본 결과, 학교급의 경우 고 등학교(0.93), 학업수준은 부진학생(0.86), 집단구성은 소집단(0.83), 회기수는 20회 이 상(0.92), 회기 기간은 10-19주 사이(0.87), 회기 단위시간은 50분미만(0.78)에서 높은 효과크기를 보였다. 종속변인별로는 학업스트레스 감소(-1.8)에서 가장 큰 효과크기 를 보였다. 본 연구의 결과는 향후 학교현장에서 새로운 학업상담 프로그램을 개발하 는 데 방향을 제시할 것이다. The purpose of this study was to examine the effects of an academic counseling program on academic achievement and learning related variables. One hundred and four studies among dissertations published from 1988 to February 2012 were chosen for meta-analysis. Each dealt with factors that effect the students\ academic achievement and one hundred ninety four effect sizes were calculated. The result of the study indicated that the overall average effect size of the program on academic achievement was 0.78. The effect size of academic skills among the program types was the largest. The effect size of the counseling program on learning-related intervening variable was also calculated. The effect sizes were much larger with high school level (0.93), underachieved groups (0.86), small size groups (0.83), the groups which have over twenty sessions (0.92), the groups whose session was between 10-19 weeks (0.87) and less than fifty minutes (0.78). Among dependent variables, reduction of stress by academic performance showed the largest effect size. The results of the study will provide useful insight for further studies to develop a new academic counseling program.