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Somatostatin 수용체 스캔에 양성인 갑상선 여포선종이 동반된 말단비대증 1예
권석호,황영웅,박용범,윤용석,원영준,임승길,이현철,허갑범 대한내과학회 1997 대한내과학회지 Vol.53 No.3S
말단비대증으로 진단된 48세 여자에서 somatostatin 수용체 스캔에 양성인 갑상선종양을 발견하여, 병리소견상 갑상선 여포선종으로 밝혀진 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Recently, the new technique that allows the in vivo visualization in man of the somatostatin receptor positive tumor after iv adminstration of the 123I-coupled somatostatin analogue Tyr-octreotide (somatostatin receptor scan) was developed. We have experienced a forty eight-year-old female patient with acromegaly and multiple thyroid nodules. Somatostatin receptor scan was performed. Unexpectedly, both pituitary tumor and multiple thyroid nodules were presented with positive by somatostatin receptor scan and we thought that multiple thyroid nodules might be malignancy, probably medullary thyroid carcinoma. Therefore, bilateral subtotal thyroidectomy was performed and pathologic finding showed thyroid follicular adenoma.
심낭삼출과 갑상선 기능저하증을 동반한 터너 증후군 1예
허갑범,이현철,임승길,송영득,남재현,권석호,김진석,윤용석 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.4
Clinical manifestations of hypothyroidism are very various and these degree are related to the severity and duration of the disease. Pericardial effusions, one of the manifestations of hypothy- roidism, were relatively common in the past. However, recently they may not be so frequent representative of hypothyroid subjects. The higher frequency of Hashimotos thyroiditis in Turners syndrome, especially those with an X-isochromosome, compared with the general population is well known. The pathophysiological process of autoimmunity is thought to be linked with the presence of an abnormal X-chromosome. Recently we experienced a case of X-isochromosome Turners syndrome with hypothyroidism and pericardial effusion and report it with reviews of the literatures. (J Korean Soc Endocrinol 12:661-666, 1997)
한국인 폐경 후 여성에서 에스트로젠 수용체 유전자 다형성 및 뇨중 에스트로젠 대사물과 골밀도와의 상관성
이지현,허갑범,이현철,임승길,송영득,차봉수,원영준,권석호,정봉철 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.4
Background: Estrogen status is important for maintaining the homeostasis of bone. Estrogen has direct effects on bone cells, through binding to the high-affinity estrogen receptor. Several recent studies suggest that there might be genetically determined variations in biosynthesis and function of estrogen receptor in postmenopausal osteoporosis. Also the main cause of postmenopausal osteoporosis is decreased level of serum estrogen, whereas there had been some suggestion that the remaining estrogen have some effect on bone metabolism after menopause. We investigated the relationship between estrogen receptor gene PvulI polymorphism and bone mineral density(BMD), and the relationship between 18 urinary metabolites of estrogen and BMD in Korean postmeno- pausal osteoporosis. Methods: We examined the PvuII polymorphism of the estrogen receptor gene in 5' upstream region and the first intron by restrietion frapnent length polymorphism analysis in 62 postmeno- pausal wornen, BMD was measured by DEXA. The urinary estrogen metabolites were determined by GC/MS(Gas Chromatography-Mass Spectrometry) at Korean Institute of Science and Techno- logy Doping Control Center. Results: BMD of the spine and the femoral neck correlated with body weight, height, body mass index as we expected. There was no polymorphism of PvuII restriction site on 5 upstream region of estrogen receptor gene. Whereas the prevalen~ee of the PP, Pp, pp genotype in the first intron of estrogen receptor was 12.9%, 45.2%, 41.9%, respectively. But, there was no correlation between PvuII genotype and the spinel and femoral neck BMD. 2(OH)E2 among 18 urinary metabolites of estrogen, showed a negative correlation with the spinal and femoral neck BMD(r =-0.2551, p$lt;0.05, and r =-0.3341, p$lt;0.01, respectively), and the ratio of 16a(OH)E2/2(OH)E1$gt; revealed a positive correlation with the spinal BMD(r =0.3057, p$lt;0.05). In stepwise multiple regression analysis, body weight, 2(OH)E2, 16a(OH)E1, 2(Meo)E1 were independent predictors of the spinal bone density, and body weight and 2(OH)E2 were independent predictors of the femoral neck bone density. Conclusion: These results suggested that restrietion fragment length polymorphism analysis of the estrogen receptor gene with PvuII restriction enzyme was not helpful for early detection of patients at risk of developing osteoporosis. However, the ratio of 16-hydroxylation to 2-hydroxylation of estrogen metabolism was reduced in postmenopausal women and high catecholestrogen formation might be a greater risk factor for osteoporosis (J Kor Soc Endocrinol 11:468~478, 1996).