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The Anti-hepatotoxic Effect of Ginseng in Rats: Meta-analysis
국세정,김건희,최기헌,한혜경 한국데이터정보과학회 2008 한국데이터정보과학회지 Vol.19 No.3
The purpose of this meta-analysis was to investigate the anti-hepatotoxic effect of ginseng in rats induced with CC14 or TCDD, the toxicities that cause liver damages. Primary studies were collected from the ScienceDirect database, the DBpia, and the KISS. The data on the effect factors in plasma and in enzyme are listed as many as possible: The effect factors were alanine transaminase (ALT), aspartate transaminase (AST), liver aminopyrine N-demethylase (AD), liver aniline hydroxylase (AH), liver 3,4-Methylenedioxyamphetamine (liver MDA), cytochrome P450 (P450), serum alkaline phosphatase (ALP), serum lactate dehydrogenase (LDH), cytochrome b5 (Cyto b5), glutathione reductase (GR), Liver glutathione S-transferase (GST), liver glutamyltransferase (GT), Liver(γ-GCS), serum liver 3,4-Methylenedioxyamphetamine (serum MDA), serum sorbitol dehydrogenase (SDH), serum total protein (TP), and serum γ-glutamyltransferase (γ-GT). In order to investigate the effect of ginseng, the standard mean difference (HG) between the group of rats induced with toxicity (RH) and the group of rats induced with ginseng (RHG) were combined, and the significance of HGs were tested. The combined HGs checked the biases caused by heterogeneity among studies and the publication biases. Then they were adjusted by using the random effect model and trim and fill method. Although the publication biases were assumed, among all plasma factors the HGs of ALT, AST, serum MDA, SDH, TP, and γ-GT were significant, and among all enzyme factors the HGs of liver MDA, Cyto b5, GR, GST, and GT were significant. The treatment with ginseng significantly affected the plasma and enzyme levels in rats induced with toxicity.
국세정,최기헌 덕성여자대학교 식물자원연구소 2009 식물자원연구소 논문집 Vol.8 No.
연속형 자료를 갖는 반응변수인 경우는 모수효과모형과 랜덤효과모형을 소개하고 예를 들어 설명한다.
The Anti-diabetic Effect of Ginseng in Experimental Diabetic Rats: Meta Analysis
국세정,한혜경,김건희,최기헌 한국자료분석학회 2008 Journal of the Korean Data Analysis Society Vol.10 No.3
The present study was carried out to summarize the effect of ginseng in the experimental diabetic rats by meta-analysis related studies. The association measure to test effect of ginseng was the standard mean difference(HG) between group of rats induced streptozotocin(STZ) and group of rats induced STZ treated with ginseng about the considered 10 effect factors. When the publication bias about combined HG of study was not considered, the level of food intake(FI), glucose, serum total glyceride(TG), glycogen and liver 3,4-methylenedioxyamphetamine(liver MDA) were significantly reduced(<0.05), and the level of glycogen was increased by treatment with ginseng(<0.01). After checking the indication of publication bias for the combined HG by using the funnel plot and Egger's linear regression test, the anti-diabetic effects of ginseng is clearly presented in glycogen (<0.05), but in FI, glucose, and TG were not significant(>0.05).
국세정,최기헌 덕성여자대학교 교육연구소 2008 植物資源硏究誌 Vol.7 No.-
동일한 목적을 가지고 독립적으로 시행된 많은 연구결과들이 쌓이고 있다. 독립적인 연구 결과들을 결합하여 합리적이고 체계적으로 처리 효과를 평가하는 통계 분석방법으로 메타분석이 많이 사용된다. 본 논문에서는 메타분석을 위한 특수목적의 소프트웨어 중의 하나로 엑셀과 호환이 자유로우며 비쥬얼 베이직을 기본언어로 한 MIX 프로그램을 소개하고,MIX 프로그램을 이용하여 대두 단백질의 LDL콜레스테롤 수치 감소 기능의 유무에 대한 분석을 실시하였다. 대두 단백질의 LDL콜레스테롤 수치 감소와 관련된 9개의 자료를 이용하였고,그래프 분석을 통하여 동질성을 만족하지 않은 두 개의 논문을 제거한 후 처리효과에 대한 추론을 실시하였다.