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강민철,김형철,구제현,임원섭,함정현,정혜련,양영구 대한전자공학회 2014 Journal of semiconductor technology and science Vol.14 No.1
This paper presents a high-efficiency digital class-D audio amplifier using a composite interpolation filter for portable audio devices. The proposed audio amplifier is composed of an interpolation filter, a delta-sigma modulator, and a class-D output stage. To reduce power consumption, the designed interpolation filter has an optimized composite structure that uses a direct-form symmetric and Lagrange FIR filters. Compared to the filters with homogeneous structures, the hardware cost and complexity are reduced by about half by the optimization. The coefficients of the digital delta-sigma modulator are also optimized for low power consumption. The class-D output stage has gate driver circuits to reduce shoot-through current. The implemented class-D audio amplifier exhibited a high efficiency of 87.8 % with an output power of 57 mW at a load impedance of 16 Ω and a power supply voltage of 1.8 V. An outstanding signal-to-noise ratio of 90 dB and a total harmonic distortion plus noise of 0.03 % are achieved for a single-tone input signal with a frequency of 1 kHz.
2015∼2020년 동안 인천 지역 단일기관에서의 비결핵항산균 분포 및 항균제 내성률
김지우 ( Jiwoo Kim ),주효진 ( Hyo-jin Ju ),구제현 ( Jehyun Koo ),이혜영 ( Hyeyoung Lee ),박현환 ( Hyeonhwan Park ),송경철 ( Kyungcheol Song ),김자영 ( Jayoung Kim ) 대한임상검사과학회 2021 대한임상검사과학회지(KJCLS) Vol.53 No.3
본 연구는 인천지역에 위치한 단일기관의 비결핵항산균의 분포 및 항균제 내성률과 동반 세균 빈도를 조사한 것으로, 2015년부터 2020년까지 TB/NTM real-time PCR 검사가 의뢰된 8,258건의 환자 데이터를 후향적으로 검토하였다. 총 296건의 검체가 NTM 양성이었고, 발생률은 2015년 2.5% (30/1,209)에서 2020년 3.8% (66/1,740)로 증가하였다. NTM으로 확인된 296건 중, 54.7% (162/296)는 M. avium complex (MAC)에 속하는 균종으로 확인되었고, 그다음으로 M. abscessus complex (MABC) 20.9% (62/296), M. fortuitum 6.4%(19/296) 및 M. flavescens 3.4% (10/296) 순이었다. NTM 양성 검체 중, 약제내성검사가 의뢰된 검체는 76.7% (227/296)였다. 다제내성 NTM은 40.1% (91/227)였고, 광범위 내성 NTM은 59.9% (136/227)였다. NTM과 동시 감염은 43.4% (63/145)이었고 가장 흔한 균종은 Klebsiella pneumonia (23.8%, 15/63)였다. 본 연구는 인천지역의 NTM 분포 및 항균제 내성률과 동반 세균 빈도에 관한 최초 보고이다. NTM 감염의 비율은 점차적으로 증가하는 추세이며 효과적인 관리를 위해 적극적인 진료와 철저한 감염관리가 필요할 것이다. This study sought to investigate the distribution, antimicrobial resistance rate, and bacterial co-infection frequency of non-tuberculous mycobacteria (NTM) in a single center in Incheon, South Korea. A total of 8,258 specimens submitted for tuberculosis (TB)/NTM real-time PCR tests during the years 2015 to 2020 were retrospectively reviewed. In total, 296 specimens (3.6%) were NTM positive, and the positivity increased from 2.5% (30/1,209) in 2015 to 3.8% (66/1,740) in 2020. Of 296 NTM specimens, 54.7% (162/296) were identified as the Mycobacterium avium complex (MAC) followed by the Mycobacterium abscessus complex (MABC) 20.9% (62/296), M. fortuitum 6.4% (19/296) and M. flavescens 3.4% (10/296). Of the NTM-positive specimens, 76.7% (227/296) were tested for drug resistance. The results showed multidrug-resistant NTM in 40.1% (91/227) and extensively drug-resistant NTM in 59.9% (136/227) of these specimens. Of the 145 isolates taken for bacterial culture, bacteria/fungi co-infection with NTM accounted for 43.4% (63/145), in which the most common bacterial species was Klebsiella pneumonia (23.8%, 15/63). This study is the first report on the distribution and antimicrobial resistance of NTM in Incheon. As the proportion of NTM infections increases, active treatment and thorough infection control are required for effective management. Copyright Ⓒ 2021 The Korean Society for Clinical Laboratory Science. All rights reserved.