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원지(遠志)가 뇌혈류 저하에 의한 흰쥐 뇌조직의 산화적 손상과 해마신경세포 자연사에 미치는 영향
구용모 ( Yong-mo Koo ),곽희준 ( Hee-jun Kwak ),권만재 ( Man-jae Kwon ),송민철 ( Mincheol Song ),이지승 ( Ji-seung Lee ),신정원 ( Jung-won Shin ),손낙원 ( Nak-won Sohn ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.1
Objectives : Polygalae Radix (POL) has an ameliorating effect on learning and memory impairment caused by cerebral hypoperfusion. In regard to POL``s action mechanism, this study was carried out to investigate the effects of POL on oxidative damage and neuronal apoptosis induced by cerebral hypoperfusion in rats.Methods : The cerebral hypoperfusion was induced by permanent bilateral common carotid artery occlusion(pBCAO) in Sprague-Dawley rats. POL was administered orally once a day (130 mg/kg of water-extract) for 28days starting at 4 weeks after the pBCAO. Superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in the brain tissue were measured using ELISA method. Expressions of 4-hydroxynonenal (4HNE) and 8-hydroxy-2``- deoxyguanosine (8-OHdG) were observed using immunohistochemistry. In addition, neuronal apoptosis was evaluated with Cresyl violet staining, TUNEL labeling, and immunohistochemistry against Bax and caspase-3.Results : POL treatment significantly increased SOD activities and significantly reduced MDA levels in the cerebral cortex. The up-regulations of 4HNE and 8-OHdG expression caused by pBCAO in the CA1 of hippocampus were significantly attenuated by POL treatment. POL treatment also restored the reduction of CA1 thickness and CA1 neurons caused by pBCAO and significantly attenuated the apoptotic markers including TUNEL-positive cells, Bax, and caspase-3 expression in the CA1 of hippocampus. Conclusions : The results show that POL attenuated the oxidative damage in brain tissue and neuronal apoptosis in the hippocampus caused by the cerebral hypoperfusion. It suggests that POL can be a beneficial medicinal herb to treat the brain diseases related to cerebral hypoperfusion.
돌출길이 및 air gap size에 따른 가스분무 조업 시 가스거동 해석
권의혁 ( Eui Hyuk Kwon ),정훈제 ( Hun Je Jung ),장경수 ( Kyoung Soo Jang ),구용모 ( Yong Mo Koo ),한정환 ( Jeong Whan Han ) 대한금속재료학회(구 대한금속학회) 2014 대한금속·재료학회지 Vol.52 No.4
The optimization of the gas atomization for particle size control and optimal energy efficiency cannot be achieved simply, due to the lack of understanding of the basic atomization process. A numerical analysis is performed in order to optimize the manufacturing process and to understand the behavior of the gas at the end of the nozzle. In this study, the gas flow is analyzed numerically using a computational fluid dynamics software package (Fluent). It is found that a protrusion length of 3 mm is optimal for nozzles with a quick gas velocity and stable aspiration pressure. In addition, the impact on the air gap size is also investigated.