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Ethanol 및 Acetaldehyde가 家兎의 腎機能에 미치는 影響
郭錫球,朴海根 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1
The present study was performed to evaluate the change in the renal functions produced by the continuous infusion of either ethanol or acetaldehyde in rabbits. A total of 19 rabbits were divided into two groups; ethanol infusion group(6 rabbits for 3.5g% and 6 rabbits for 7g%) and acetaldehyde infusion group(7 rabbits for 0. 4%). Either ethanol or acetaldehyde was added for 80 min in the rate of 1. 05 or 2.10g/hr in the ethanol group and 120mg/hr in the acetaldehyde group after the control period in which the basal solution of 0. 45NaC1/L with 30g glucose was infused for 20 min. The urine and blood samples were collected in the control period, and also in the experimental group every 20 min for 80 min after either ethanol or acetaldehyde was added. The samples were also collected twice at an interval of 20 min after the addition of ethanol or acetaldehyde was discontinued. The following measurements were made in the control and experimental groups;urine flows, plasma clearance of inulin, PAH and electrolytes, rates of reabsorption and urinary excretion of electrolytes and osmolar substances. The blood ethanol concentration was measured by the potassium dichromate method, plasma inulin and PAH by the method of Schreiner and Smith, respectively. Osmolality of urine and plasma was measured by osmometer(Advanced, 3WII), and Na^+ and K^+ concentration were measured by flame photometry (Beckman, KLiNa flame). The results obtained are summarized as follows: 1. Urine flow rate was reduced after infusion of 3. 5 and 7g% ethanol, but significant osmotic diuresis was induced by 0.4% acetaldehyde infusion. 2. Renal plasma flow and glomerular filtration rate showed a tendency to decrease with ethanol infusion, but not with acetaldehyde infusion. 3. Osmolar substance and K^+ clearance were reduced by ethanol but increased significantly by acetaldehyde. 4. Percent reabsorption of K^+ filtered was significantly decreased by acetaldehyde infusion. 5. Urinary excretion of osmolar substances and Na+ were reduced by ethanol but increased significantly by acetaldehyde infusion. The above results suggest that the diuretic action of ethanol is modified partly by acetaldehyde induced osmotic diuresis.