X-방사선 ( ^60^Co ) 에 조사된 새앙쥐의 상해에 대한 「 아답태겐 」ⓡ 의 효과에 관한 연구 ( A Study on the Effect of ADAPTAGEN , Korean Ginseng Components , for the Injured Mouse by X - ray ( 60Co ) Irradiation )

공태훈,유성렬,윤주억,유영상,노정미,김선희,김희정,박수정,이동화 고려인삼학회 1991 Journal of Ginseng Research Vol.15 No.3

人蔘이 血液像과 細胞徵粒子에 미치는 影響에 관한 硏究

孔泰勳 東國大學校 1967 論文集 Vol.3-4 No.-

The results of the effect of Ginseng on blood and chondriome in Rat are as follows; 1. The contents of serum-cholesterol increased 13∼14% in 34 days with 2㏄ of Ginseng juice fed to each rat per day. But this increase has not exceeded that in the case of the 24 days experiment conducted simultanously. 2. It is clear that the Ginseng group has increased the body weight ratio in the Prostate and Sub-kidney more significantly than the control group. 3. The rats diet on the Ginseng administered for 34 days has not affected the total number of the erythrocyte and leucocyte. 4. Feeding the Ginseng juice has resulted in increasing the number of basophilic leucocyte found in the blood of rats. The neutrophilic leucocyte has tended to shown on increase when the experiment was based on the F_0.1 probability. 5. Feeding the Ginseng juice has increased the number of chondriome in tissue cell of the prostate and liver. When the Experiment is based on the F_0.1 probability, the number of chondriome in the tissue cell of testis and sub-kidney has tended to show on increase. It seems to have an inclination that the number of the distribution of chondriome approximately increased as the samely rate in proportion to the increase of weight of hormone organs in rats.

人蔘담배의 效能에 관한 硏究(제2보) : Haemoglobin, Cholesterol, Total protein A/G ratio의 變異에 관하여

孔泰勳 東國大學校 1971 論文集 Vol.8-9 No.-

흰쥐에 對하여 다음과 같은 담배연기의 沈漬液을 1日 0.5cc씩 腹腔注射하였던 바 血色素, Cholesterol, Total-protein, A/G ratio에 대하여 몇가지 영향을 주는 결과를 얻었기에 이에 報告한다. a. T液; 3.2gm%의 「백조담배」를 연기로 하여 蒸溜水에 용해시킨 것. b. GⅠ液; 10%의 人蔘을 담배에 混合하여 연기로 하고 이를 위와 같이 한 것. c. GⅡ液; 20%의 人蔘을 混合하여 위와 같이 한 것. 1) 담배는 血色素量, Serum-Cholesterol, serum total-protein, A/G ratio를 모두 低下시킨다. 2) 10%의 人蔘을 混合한 담배는 血色素, Serum-Cholesferol를 약간 增加시키지만, Serum total-protein과 A/G ratio는 低下시킨다. 3) 20%의 人蔘을 混合한 담배연기는 위의 모든 面에서 惡化되였다. 그런까닭에 人蔘을 10%以下로 담배에 混合한다는 것은 Serum total-protein과 A/G ratio를 除外하고는 모두 良好하였으나 混合化의 決定은 앞으로의 문제로 된다. On injecting tabacco-smoke and ginseng-tabacco solution (0.5cc per days) to the abdominalis of a rat. We found the following effects on haemoglobin, serum-cholesterol, serum-total-protein and Albumin/Globulin ratio. a. Tabacco solution; Distilled water containing 0.5cc of solution of 0.16gm of "Backcho" cigarettes. b. 10% and 20% ginseng-tabacco solution; Distilled water containging a solution of the smoke of cigarettes mixed in with 10% ginseng content respectively. 1) Smoke produced by common cigarettes like "Backcho" reduces the content of haemoglobin, Serum-ceholesterol, serum-total-protein and the albumin/globulin ratio. 2) The smooke of 10% ginseng-tabacco slightly increases the haemoglobin and serum-cholesterol, but it decreases the serum-total-protein and the A/G ratio. 3) The smoke of 20% ginseng-tabacco decreases all of the components listed above. Based on these finding, we conclude that ginseng-tabacco mixture with lower than 10% ginseng content increases all components except serum-total-protein and the A/G ratio. However, further search is needed to determine the ratio of mixture for ginseng and tabacco.

Germanium으로 施肥된 人蔘의 動物效果에 관한 硏究

孔泰勳 東國大學校 1973 論文集 Vol.12 No.-

人蔘이 햄스터의 血色素와 A/G率에 미치는 영향에 관하여

孔泰勳 동국대학교 농림과학연구소 1969 農林科學 論文集 Vol.3 No.-

Giving unprocessed ginseng to the hamster(Mesocricetus auratus) a gram per day for 25 days, I obtained the following results : 1. A significant increase in hemoglobin has been registered as a result of the supply of ginseng. 2. A significant increase in the serum-total protein has also been recorded after 15th day of the supply of ginseng. 3. Outwardly, it shows A/G rotio gradully increasing from the 10th day following the supply of ginseng. But the significant increase in shown ofter 25th day of ginseng supply. This means that the component of allumin has increased more than that of globutin. In short, the Hb and total protein and albumin in serum increase as a results of 25 days of giving ginseng to the hamsters.

高麗人蔘엑스主劑의 抗癌劑가 쥐의 肉腫癌(Sarcoma 180)에 대한 效果에 관하여

孔泰勳,李愚允 동국대학교 1979 論文集 Vol.18 No.-

The medicine which consists mainly of alkaloid of ginseng extract mixed with some herb anti-carcinogenes has a measure of cure effect on Saroma 180 of mice. The medicine, named GS 103, was processed to acquire alkaloid by hydrolysis with hydrochloric acid after extracting organic solute from ginseng with petroleum ether and distilled it with 35% ethanol, and then added such anti-cancer herb medicines as Astragalus membranaceus A., Coalogyne bulbodicoids F., Licorice, and 2 others. The nonadded medicine was named as「GSS-1」and obove medicine added was named as GSS. The GSS was treated orally on mice(B.W. 15-20 gm) (♂) inoculated after 24 hours with 0.2ml of ascites tumor cell of Sarcoma 180. The feeds were general solid type with fish meal and special type without fish meal. The result form five repetitive experiments is as followings. (1). Organic germanium prolonged the life span of Sarcoma 180 mouse for nearly 30%, but not cured the disease. (2). Meat and powdered milk mixed in the feeds for mouse infected with Sarcoma 180 were brought about detrimental effects. (3). Neucleus and cell membrane of the Sarcoma 180 cell of the mouse treated with GSS were dimly visible when stained with Harris Haematoxylin. This is considered to be due to the disolution of the cells by the medicine. When stained with Trypan blue, only dead Sarcoma 180 cells of the mouse treated with GSS were stained. (4). All of the mice infected with Sarcoma 180 died within 15-20 days. But the average 37% of all mice infected with Sarcoma 180 and treated on feed with GSS survived. And treated plots on feed (with GSS) prolonged the life span by 45% to 85%. While in the infected plots with Sarcoma 180 by enforced providing GSS in the mouth, we observed 90% survival rate. (5). Ascites were much larger and made many fatty masses in the Sarcoma 180 mouse abdomen just before the death. It seems to be a physiological characteristic of Sarcoma 180 mouse. (6). W.B.C. Rapidly decreased from 100% to 27%, Platelet decreased from 100% to 95% just before the death, but it iwas not seemed to be large varities. Especially, rapid increase of basophile, and monocyte, decrease of lymphocyte made believe that Sarcoma 180 mice were in the poisening status, and clear increase of myelocyte, juvenilocyte and stab strongly supported this theory. (7). Increase of serum total protein, rapid decrease of albumin and slowly increase of γ-globulin as a nonselective protein losing pattern were believed the cause of thoraic ascites and abdominal ascites development. This belief was due to various kinds of feed as meat and skim powdered milk. (8). Total protein of abdominal ascites slightly increased, but albumin slowly increased against the case of serum. This phenomenon seemed to believe that losing blood components from the each organ were nonselectively stored in the abdomen. (9). Cholesterol increased at once following the progress of cancer cell, and decreased just before the death. This phenomenon was especially characteristics of live cell carcinoma. But it was worthy of notice that the blood components conents of cured Sarcoma 180 mouse were likely back to those values of normal mouse. (10). Serum and abdominal ascites total lipoproteins increased following the progress of cancer cell, but lipoprotein rapidly decreased. It seemed to believe that this phenomenon was related to the decrease of serum albumin and r-globulin, and the lowering of fatty acid oxidation(NAD system) in the poisening status dued to strange materials(Meister, et al, 1950). But abdominal ascites lipoprotein was excluded in this phenomenon.

쥐에 있어서 Mitochondria의 分布性과 그 變異에 關한 硏究

孔泰勳 東國大學校 1964 論文集 Vol.1 No.-

The synthetic results in this experiment are follows; 1. The distribution mumbers of mitochondria in the tissue cells by different organisms are various from each other by the physiological function in same individual. In the tisiue cells that the metabolism and excretion are active respectively in general, the distribution numbers are numerous, while this is organized in order of brain, liver, sub-kidney, muscle and gonads. 2. Seeing from the statistics, the male seems to have more distribution number of mitocondria than female, howerver such a status can not be exceeding the scope of standard deviasion. Therefore I think there should be reguested more wider range of research for above. 3. The distribution ratio is being reduced by giving no food to mice, and this status proceeds in pursue of next four steps such as consumption stage, wasting stage, endanger stage and fatal stage. 4. The reduction ratio in fatal stage are figured as follows; brains 64.19%, livers 62.08%, gonads 61.86% and muscles 48.27%. The more organisms having active metabolism the more reduction ratio and distribution numbers increased. 5. The reduction effect of mitochondria is made by its solution. 6. The morphological varieties is being proceeded gradually by the extension of starvation hours.

人蔘의 連作과 이의 力價에 관한 硏究

孔泰勳,趙敏基,李愚允 東國大學校 1977 論文集 Vol.16 No.-

This research is to study the possibility of repeated cultivation of Ginseng. Two year ginseng roots were transplanted on April 7, 1975 in 39.6M^2 field, devided into 12 lots (treatments), where 6 year roots had been harvested on September 1974. The lots are some fertilized with germanium, some with trace minerals and a control with only manure. Four year ginseng roots by 1977 in repeated cultivation were studied for their suvivals and their effects on animal physiological titers. The following results were obtained. 1. 40% of the four year roots were survived in the lot No.5 which were fertilized with 5gm of GeCl_4 per 3.3m^2, while none were survived in the control and only 0-7% were Survived in the other lots. Germenium is beleived to have critical effect on the repeated cultivation of ginseng. 2. The germanium fertilized lots had more leaves and later defoliation then the trace minerals fertilized treatments. 3. Soil chloropicrin used as soil disinfestant did not have any effect. 4. The distribution of nematodes were least in the germenium fertilized (lot No.4, No.5 and No.10) and zeolite fertilized lots. 5. The distribution the microorganisms were also least in the germanium lots. 6. The extracts of these ginseng, grown in a repeated cultivation condition, were given to the chicken and rats in every ten days. The physiological titers were compared the results are as follows. a) When 0.1mg of Depovirin (testosterone) was given every day to male chicken, the size and weight of the crown (cockscomb) were significantly increased, while the ginseng extract did not have any effects. The results were same for the testis weight. b) In the castrated rats only the ones treated with Depovirin were effective on the seminal vesicle, prostate gland and epididymis as in the male chicken. c) whn the ginseng extracts were given to the rats, the ginseng growth under the repeated cultivation condition increased the weight of the seminal vesicle, prostate gland and epididymis, while the ginseng growth under the normal condition increased the weight of the adrenal body. 7. The content of the hemoglobin was significantly increased when the animels were given extracts of the ginseng grown under the repeated cultivation.

담배연기로서의 人蔘의 作用에 관하여 : 血淸總蛋白과 血淸脂肪에 대한 檢討 On the Serum-cholesterol and Serum-total Protein

孔泰勳 동국대학교 농림과학연구소 1971 農林科學 論文集 Vol.4 No.-

On injecting the 0.5cc solution of tabacco-smoke and ginseng-tabacco-smoke to the abdominalis of a rat, we found the following effects on serum-cholesterol and serum-total-protein. 1) The smoke produced by common cigarettes like "Backjo" reduces the content of serum-cholesterol and serum-total-protein. 2) The smoke of 1% ginseng-tabacco slightly increases the serum-cholesterol but it decreases the serum-total-protein. 3) On the serum-cholesterol, the smoke of 20% ginseng-tabacco lead to more evil effect than 10% ginseng-tabacco. Based on these finding, when we mix the tabacco with ginseng, We assumed that ginseng-tabacco mixture with lower then 10% ginseng content, or it make use of the alcohol extractive instead the ginseng its self, or it shall be reformed to decrease way of content of Nicotine and tar in cigarette.

돌발성 난청의 예후에 영항을 미치는 인자

공태훈 대한의사협회 2023 대한의사협회지 Vol.66 No.10

Background: Sudden sensorineural hearing loss (SSNHL) refers to rapid and often unexplained decline in auditory acuity. Reported recovery rates for SSNHL vary across studies; however, these are usually within the range of 40% to 60%. Although numerous studies have investigated factors that affect auditory restoration, prediction of patients’ hearing recovery remains challenging. Current Concepts: Natural recovery rates for SSNHL range between 32.0% and 65.0%, and treatments commonly include systemic steroid therapy and intratympanic dexamethasone injections. Adjunctive treatments, such as antiviral agents, vasodilators, anticoagulants, hyperbaric oxygen therapy, and stellate ganglion block therapy are also utilized. Recovery typically occurs within 2 weeks, and approximately 66.0% of patients have complete or partial hearing restoration. Recovery predominantly occurs early; approximately 78.2% to 90.0% patients recover within 1 month and >98.0% within 3 months. Age is an important factor associated with recovery; patients aged ≥40 years show low recovery rates. Coexisting dizziness is generally associated with unfavorable outcomes. Hearing loss severity and types (based on the frequency-specific pattern of hearing impairment) are associated with poor prognosis. Additionally, systemic conditions like hypertension and diabetes are implicated as etiopathogenetic contributors. In addition to a variety of audiological assessments to evaluate cochlear function, environmental factors, including particulate matter and air pollution affect outcomes. Discussion and Conclusion: During SSNHL treatment, evaluation of factors known to affect recovery is important to determine patients’ hearing restoration potential. Proactive patient counseling is necessary to guide treatment decision-making, particularly for initiation of auditory rehabilitation following incomplete or lack of recovery. Significant variables that affect hearing recovery are useful prognostic indicators. These studies are expected to provide better understanding of the pathophysiology of SSNHL and offer an evidence-based foundation for therapeutic interventions.