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한국전통무용이 중년여성의 정신건강과 생활만족도에 미치는 영향
공미숙,정광조 한국예술심리치료학회 2008 예술심리치료연구 Vol.4 No.2
This study's aim is twofold: first, it analyzes how positively the therapy adopting Korean traditional dance influences on a group of middle-aged women's mental health and life satisfaction. Second, it tries to present some fundamental materials for the educational programs that can be developed from this kind of therapy. The results are summarized as followed. First, the average figure was relatively decreased from (M=126.20) of pre-test to the average figure (M=97.37) of post-test (p<.01). Second, it analyzed the influence of participation into dance therapy in life satisfaction of middle-aged women and got the result that there was a meaningful difference (p<.01) in statistics; the average figure was changed from (M=90.77) of pre-test to (M=100.47) of post-test.
나영정,조수현,공미숙,이재규,정미애,김경헌 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.2
Thoracic aortic aneurysm is associated with increased morbidity and mortality in pregnancy. Various pregnancy-related physiologic changes appear to make pregnancy a high risk situation for rupture of an arterial aneurysm. The hemodynamic and endocrine changes of pregnancy appear to be the cause of arterial alterations which may lead to new aneurysm formation and/or weakening of preexisting aneurysms. Successful term pregnancy and cesarean delivery of a patient with aortic aneurysm is presented.
박준용,박경근,김선미,공미숙,함준수 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.1
We investigated the relationship of gallstones in the diabetic patients and analyzed their clinical course and related factors. A collective review of 11,302 diabetic patients from January 1979 to December 1993 were carried out at Hanyang university hospital. Of the 323 cases with gallstones, 180 cases were evaluated for age, body mass index, duration of disease, HbAlc, fasting blood sugar, AST/ALT, cholesterol level and TG level. The result was as follows : 1) The prevalence of gallstones in the diabetics studied was 2.86%. 2) The compostition of the gallstones were not related to age, and pigmented stones were the most commonly seen. 3) The incidence of cholecystectomy was 0.27% in men, and 0.47% in women. The prevalence of gallstones in diabetic patients was higher than in the normal population, which could be explained by the decreased motility of the gallbladder or obesity. However, this study could not find a significant difference in age, body mass index, cholesterol level, and TG level when comparing patients with or with out gallstones.
자궁경부무력증에서 Beriplast (TM) 를 이용한 Modified McDonald cerclage 15 예의 경험
황정혜,문형,박문일,이문휘,공미숙,정성로 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.8
Objectives : As a main treatment modality of Incompetent Internal Os of Cervix(IIOC), Transvaginal cerclage(TVC) has been performed. But Transabdominal cervico-isthmic cerclage(TCIC) has been selected in cases of at least one history of failed TVC and severe damaged uterine cervix, very short or congenital anomalous cervix, or removed state of uterine cervix due to another disease. However, this TCIC has not been popularized, due to dangerous operation procedure, and two laparotomies. There are also difficult operative situation performing TVC & TCIC, such as bulging amniotic membrane and in patients who have medical contraindication of laparotomies. In this reason, we designed Modified Mcdonald cerclage using Beriplast (TM) as an alternative of TCIC. Methods : We involved 15 patients who visited recurrent abortion clinic of Hanyang University Hospital, diagnosed as IIOC, who were appropriate for the above mentioned TCIC indications or had bulging amniotic membrane through cervical canal. Briefly explaining the procedure, at proximal portion of internal os of cervix, first cerclage was performed and about 1-2cm distal from first cerclage, second cerclage was done. For doing this, it is important that first cerclage band is as proximal as possible. And then, 1-3cc of Beriplast(TM) was injected in cervical canal between two McDonald cerclages. Results : The mean gestational age at operation was 16.9±4.3weeks. The live births were 13 cases among 15 cases(success rate was 86.7%). In 13 cases of success, the mean interval time between operation and delivery was 21.0±4.1weeks, and mean body weight of neonates was 3094±535gm. The failed 2 cases were as followings; one case failed after 2 weeks postoperatively and the other case was twin pregnancy. Conclusions : The burden of patients as well as of operator is considered as obstacles in performing TCIC in IIOC patients. In this circumstances, we designed the Modified McDonal cerclage. This method would be useful in cases of above mentioned operation indications. We named this procedure as $quot; Candy operation$quot;.
부인암 세포주에서 항암제 투여에 따른 신생혈관 형성 관련 유전자 전령 리보핵산 및 단백질 표현 양상에 관한 연구
김영재 ( Young Jae Kim ),공미숙 ( Mi Sook Kong ),이영미 ( Young Me Lee ),장성렬 ( Sung Yeoul Chang ),김승룡 ( Seung Ryong Kim ),김경태 ( Kyung Tai Kim ),황윤영 ( Youn Yeung Hwang ),조삼현 ( Sam Hyun Cho ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.3
연구목적: 본 연구자는 확립된 세포주에서 세포독성제 및 면역 조정제에 의한 항신혈관 형성효과를 확인하고자 하였다. 유방암 세포주 MCF-7, 자궁 경부 편평 상피암 세포주 SiHa, 난소암 세포주 A2780, 그리고 cisplatin 내성 난소암 세포주 A2780-CDDP에서 cisplatin, paclitaxe l(taxol), 및 thalidomide로 처리한 후에 vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), 그리고 thrombospondin-1,2 (TSP-1,2)의 전령 리보 핵산 및 단백질의 표현 양상의 변화를 규명하고자하였다. 연구대상 및 방법: 유방암 세포주 MCF-7, 자궁 경부 편평 상피암 세포주 SiHa, 난소암 세포주 A2780, 그리고 cisplatin 내성 난소암 세포주 A2780-CDDP에서 cisplatin, paclitaxel (taxol), 및 thalidomide로 각각 처리한 후에 vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), 그리고 thrombospondin-1,2 (TSP-1,2)의 전령 리보 핵산 및 단백질의 표현 양상의 변화를 규명하고자 RT-PCR, 단백 추출 및 Western blot assay를 사용하였다. 결과: 난소암 세포주 A2780과 동일 세포주에서 분리한 cisplatin 내성 주 A2780-CDDP, 유방암 세포주 MCF-7 및 자궁경부 편평 상피암 세포주인 SiHa에서 VEGF gene은 212 bp, bFGF는 238 bp, 그리고 TSP-1은 492 bp로 합성되었으나 TSP-2 는 합성되지 않았으며 VEGF 및 bFGF 단백질은 각각 21 KDa와 17 KDa로 합성되었으나 TSP-1 단백질은 합성되지 않았다. 각 세포주의 VEGF gene의 발현 정도는 cisplatin, taxol 및 thalidomide에 별 큰 영향을 받지 않았다. bFGF gene의 발현 정도는 taxol처리 후 유방암 세포주에서 만 감소하였으며 TSP-1 gene의 발현도는 taxol 처리 후 유방암 세포주에서 자궁경부암 세포주 보다 큰 폭의 감소가 있었고 난소암 세포주에서 thalidomide처리 후 뚜렷한 감소를 보였다. Cisplatin, taxol, 그리고 thalidomide에 VEGF 및 bFGF 단백질 발현도는 아무런 영향을 받지 않았다. 결론: 난소암 세포주 A2780, cisplatin 내성 난소암 세포주 A2780-CDDP, 유방암 세포주 MCF-7, 그리고 자궁경부 편평 상피암 세포주 SiHa에서 VEGF, bFGF 그리고 TSP-1 gene들 및 단백질의 발현 양상은 cisplatin 처리에 의해 변화되지는 않는 것으로 확인되어 난소암, 유방암 그리고 자궁경부암에서 cisplatin의 신혈관 형성 억제 효과 판정에는 VEGF, bFGF 및 TSP-1 등의 직접적인 단백 발현 양상만을 표적으로 삼기 보다는 기저층 파괴를 담당하는 신호 전달체등의 발현 변화를 동시에 분석하여야 할 것으로 사료되며, 통계적으로 유의하지는 않았지만 taxol 처리에 따른 신혈관 형성 단백 유전자들의 발현 양상에 있어 bFGF가 유방암 세포주에서 약간 감소되었고, TSP-1은 유방암 세포주에서 자궁경부암 세포주보다 약간 더 많은 감소를 보여 bFGF와 TSP-1은 유방암 및 자궁경부암에서 taxol의 신혈관 형성 저해 연구의 평가 기준으로 재연구될 필요가 있을 것으로 생각된다. 역시 통계적으로 유의한 정도는 아니었으나 Thalidomide 처리에 따른 전기 단백질들의 표현 양상에는 난소암 세포주 A2780에서 TSP-1 단백 발현의 감소가 다른 세포주보다 많은 것으로 나타나, 실험 방법에 따라 같은 세포 독성제라도 신혈관 형성 저해 효과 판정이 다르다는 것을 확인시켜 줌과 동시에 향후 thalidomide를 난소암의 보조적 치료제로 이용하는 연구의 필요성을 제시하였다. Objective: Angiogenesis is central role to both the proliferation and metastasis of malignant tumor. The intense interest in angiogenesis has also lead to a re-examination of the activity of established cytotoxic agents which are known to be an antiangiogenic effect anecdotally. In this study, anti-angiogenic effect of cisplatin, paclitaxel and thalidomide was evaluated in human ovarian cancer cell lines and cervical cancer cell line. Methods: Human ovarian cancer cell line A2780, cisplatin resistant human ovarian cancer cell line A2780-CDDP, human breast cancer cell line MCF-7, and squamous cell uterine cervical carcinoma cell line SiHa were used to evaluate the level of mRNA and protein expression of VEGF, bFGF and TSP-1, 2 before and after the treatment with cisplatin, paclitaxel, and thalidomide using RT-PCR, protein extraction, and Western blot. The results were analyzed with Wilcoxon signed rank test in the SAS ver 8.1. Results: Targeted mRNAs were synthesized as 212 bp VEGF, 238 bp bFGF, and 492 bp band sized except mRNA of TSP-2 via RT-PCR. The protein of VEGF and bFGF were appeared as 21KDa and 17 KDa size, however, the protein of TSP-1 was not appeared through western blot. No effect of cisplatin on protein expression was measured in these cell lines, but paclitaxel influenced the expression of bFGF in MCF-7 cell line and the expression of TSP-1 in MCF-7 and SiHa cell lines. TSP-1 expression was influenced by thalidomide in A2780 cell line. The protein expression of VEGF and bFGF were not influenced following treatment with cisplatin, paclitaxel, and thalidomide. Conclusion: These results were suggested that bFGF and TSP-1 will be used as a target gene for the assay of antiangiogenic effect of paclitaxel in breast and uterine cervical cancer tissue and TSP-1 will be used as that of thalidomide in ovarian cancer. Furthermore, thalidomide will be tried as an adjunctive agent for the improvement of the survival in the case of the patient with ovarian cancer.