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고준,이동빈,이동환,김남수 한국임상수의학회 2018 한국임상수의학회지 Vol.35 No.3
The aim of this study was to measure whole blood viscosity (WBV) and then to establish its referencevalues and identify correlation between WBV and hematology or serum chemistry in beagle. The experiment wasmade up of 82 healthy beagle dogs. Jugular vein blood samples (10 ml) were collected. WBV (cP) measured within4 hours after collection by U-shaped scanning capillary-tube viscometer (BVD-PRO1®) which is capable of measuringyield stress and viscosity of whole blood continuously over a wide range of shear rates from 1 s−1to 1000 s−1 is newtype of capillary tube viscometer and calculates viscosity using Casson fluid model. Measured values of WBV, Completeblood cell count, serum chemistry were analyzed by RM-ANOVA test. Mean diastolic and systolic WBV (cP) were29.032 ± 6.137 and 4.528 ± 0.865. Bodyweight (BW), Red blood cell count (RBC), Hemoglobin (HGB), Hematocrit(HCT), Alkaline phosphatase (ALP), Cholestetol (CHOL), Total protein (TP), Globulin, Chloride (Cl), Fibrinogen, werestatistically correlated with WBV over whole range of shear rates (p < 0.05). This study newly evaluated referencevalues of WBV by U-shaped viscometer in beagle. Correlation between WBV and BW, RBC, HGB, HCT, ALP, CHOL,TP, Globulin, Cl, Fibrinogen was presented.
고준,김지은,고은경,송성화,성지은,박찬규,이현아,김홍성,이재호,안범수,양승윤,임용,황대연 한국실험동물학회 2015 Laboratory Animal Research Vol.31 No.3
To evaluate the hepatotoxicity and nephrotoxicity of Galla Rhois (GR) toward the liver and kidney of ICR mice, alterations in related markers including body weight, organ weight, urine composition, liver pathology and kidney pathology were analyzed after oral administration of 250, 500 and 1,000 mg/kg body weight/day of gallotannin-enriched extract of GR (GEGR) for 14 days. GEGR contained 68.7±2.5% of gallotannin, 25.3±0.9% of gallic acid and 4.4±0.1% of methyl gallate. Also, the level of malondialdehyde (MDA), a marker of lipid peroxidation, was decreased with 19% in the serum of high dose GEGR (HGEGR)- treated mice. The body and organ weight, clinical phenotypes, urine parameters and mice mortality did not differ among GEGR-treated groups and the vehicle-treated group. Furthermore, no significant increase was observed in alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), blood urea nitrogen (BUN) and the serum creatinine (Cr) in the GEGR-treated group relative to the vehicle- treated group. Moreover, the specific pathological features induced by most toxic compounds such as CCl4 were not observed upon liver and kidney histological analysis. Overall, the results of the present study suggest that GEGR does not induce any specific toxicity in liver and kidney organs of ICR at doses of 1,000 mg/kg body weight/day, indicating that this is no observed adverse effect level (NOAEL).
지역사회 거주 뇌졸중환자의 수단적 일상생활동작과 자기 효능감이 보호자의 삶의 질에 미치는 영향
고준,이승희,이태관,정혜림,홍근호,홍기훈 대한지역사회작업치료학회 2015 대한지역사회작업치료학회지 Vol.5 No.1
목적 : 본 연구는 지역사회 거주중인 뇌졸중 환자를 대상으로 자기 효능감과 수단적일상생활동작의 정도로 자립 정도를 알아보고 이에 따른 보호자의 삶의 질을 파악해봄으로써 지역사회 거주 뇌졸중 환자와 보호 자간의 상관관계를 알아보고자 한다. 연구방법 : 2014년 5월 12일부터 2014년 5월 23일까지 총 2주간에 걸쳐 부산광역시에 위치한 3개 병원, 경 상남도 거제시 소재 2개 병원에 외래 치료중인 MMSE-K 24점 이상인 뇌졸중 환자 138명을 대상으로 설 문지(K-IADL, 자기효능감 측정도구, WHOQOL-BREF)를 이용해 자료를 수집하였으며 총 125부를 최종 적으로 분석 하였다. 결과 : 125명의 환자 중 남자는 70명, 여자는 55명이었으며 평균연령은 58.72세(16세∼82세)이었다, 대상자는 일반적 자기 효능감(p<0.01), 구체적 자기 효능감(p<0.01)과 보호자의 삶의 질 사이에서 유의한 상관관계 를 나타내었고 수단적 일상생활 동작과 보호자의 삶의 질 사이에는 유의한 상관관계가 나타나지 않았다. 결론 : 일반적 자기효능감과 구체적 자기효능감이 보호자의 삶의 질과 상관관계를 보였으며, 일반적 특성 중 경제상황 요인이 보호자의 삶의 질과 연관이 있는 것으로 나타났다. 결론적으로 뇌졸중 환자의 자기 효능감이 높을수록 보호자의 삶의 질도 높아지며 경제상황이 좋을수록 보호자의 삶의 질도 높게 나타났 다. 그러나 뇌졸중 환자의 수단적 일상생활동작 정도와 보호자의 삶의 질과의 상관관계는 나타나지 않았 다. 외래 치료중인 환자의 상황이 점점 만성화 되어 가고 있는 추세로 볼 때 현재 자신의 상태에 만족하 지 않고 좀 더 발전 할 수 있는 자기 효능감 회복에 대한 치료적 계획이 수립되어져야 할 것이다. Objective : This study is aimed to examine the degree of independence in stroke patients residing in a community based on their self-efficacy and Instrumental Activities of Daily Living and also correlation between community-residing stroke patients and their guardians by figuring out the life quality of their guardians. Methods : For total two weeks between May 12th and 23rd, 2014, this researcher collected data by using a survey (K-IADL, a scale to measure self-efficacy, WHOQOL-BREF) targeting 138 stroke patients who received over 24 points in MMSE-K among the outpatients of three hospitals located in Busan Metropolitan City and two hospitals located in Geoje-si, Gyeongsangnam-do, and total 125 sheets were finally used for analysis. Results : Among the 125 patients, 70 were males, and 55 were females, and their average age was 58.72 (16 to 82). The subjects’ general self-efficacy (p<0.01) and detailed self-efficacy (p<0.01) indicated significant correlation with their guardian’s life quality, and there was no significant correlation found between their Instrumental Activities of Daily Living and their guardian’s life quality. Conclusion : Their general self-efficacy and detailed self-efficacy indicated correlation with their guardian’s life quality, and among their general characteristics, the factor of their financial situation indicated correlation with their guardian’s life quality. In conclusion, when stroke patients’ self-efficacy is higher, their guardian’s life quality increases, too, and if their financial situation is more favorable, their guardian’s life quality gets higher. However, stroke patients’ Instrumental Activities of Daily Living did not indicate correlation with their guardian’s life quality. When looking at the chronic trend of outpatients, therapeutical plan must be established about the self-efficient recovery for the development of those who are not satisfied.
온라인 실행공동체(Communities-of-Practice) 활성화 요인과 스폰서의 영향
고준,엄기용,Koh, Joon,Om, Ki-Yong 한국경영정보학회 2006 Asia Pacific Journal of Information Systems Vol.16 No.2
Firms are increasingly adopting online communities-of-practice (CoPs) with strong managerial support in hopes of promoting knowledge sharing and creation within the organization. Excessive managerial concern and sponsoring, however, could harm the spontaneity of CoP participants, which is one of the pivotal characteristics of virtual communities, and in the end, have negative impact on their smooth operation. In this regard, this study examines the factors which affect the stimulation of CoPs and explores the difference in their operating mechanisms under two differing organizational structural settings by the existence of a sponsor. By analyzing 133 samples of CoPs in a globally leading company, this study found that the existence of a sponsor designated by the organization, has serious influence on the working of CoPs, That is, leaders' enthusiasm and the level of off-line activities are critical factors for the stimulation of CoPs which have no sponsor, while in case of CoPs that have their sponsors, neither leaders' enthusiasm nor the level of off-line activities are significantly related to the stimulation of CoPs. At the same time, the performance of CoPs which have their sponsors was found significantly higher than that of CoPs which have no sponsor. These results indicate that firms need to pay special attention to organizational sponsorship when introducing CoPs within their organizations.