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대황감초음자(大黃甘草飮子)와 그 구성약물군(構成藥物群)이 Alloxan 유도 당뇨(糖尿) 백서(白鼠)의 혈청 조성 및 항산화 효과에 미치는 영향
고원도,곽동걸,신화석,최오철,박선동,Go Won-Do,Gwak Dong-Gul,Shin Hwa-Seog,Choi Oi-Chul,Park Sun-Dong 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
The purpose of this study was to reseach the effect of Daehwanggamchoeumja(大黃甘草飮子) and its component groups on diabetes, free radicals, and antioxidants system in Alloxan-induced diabetic rats. The experimental group was divided into three groups: Daehwanggamchoeumja(DG), and its components groups, Gamdutang (Gamcho&Daedu; DG-I) and Daehwanggamchotang(DG-2). The results were obtained as follows: 1. In the study of effect on diabetic metabolic dysfunction(Glucose, Triglyceride, Total Cholesterol, HDL Cholesterol, Total Protein, Albumin, Creatine, BUN), only DG has a significant effect. 2. In the study on free radical scavenging effect in vitro(the suppressing effect on peroxidation of linoleic acid on concentration, the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system, inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2Fe^{2-}$system, and the effect on Nitrate reductase activity), DG and DG-2 have more effect than DG-l relatively. 3. In the study on antioxidants system in vivo(The level of serum LPO, The level of hepatic LPO, Catalase, GSH, GST), only DG has a significant effect. These results suggest that Daehwanggamchoeumja(大黃甘草飮子) has an effect on diabetes, peroxidative damage by free radical, so it seems to be useful to prevent and treat diabetes. The mechanisms of these are supposed to be involved in antioxidant and three drugs' cooperative synergy effect.
高元島,朴賢俊,尹炳局,鄭成伊,朴宣東 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2
The purpose of this study is to observe the effects of Hwanglyuntang on serum reactions of CCI₄ treated rats. In this study the experimental rats were divided five groups(Normal, Control, Sample A, Sample B and Sample C). Under the same condition Normal group was fed basal diet and water, the Control group was injected with carbon tetrachloride(CCI₄, 0.5㎖/㎏) and fed a basal diet for 2 weeks, the Sample A group was injected with carbon tetrachloride(CCI₄, 0.5㎖/㎏) and fed the Hwanglyuntang extract(10㎖/㎏) for 2 weeks, the Sample B group was fed the Hwanglyuntang extract(10㎖/㎏) for 2 weeks and injected with carbon tetrachloride(CCI₄, 0.5㎖/㎏), the Sample C group was fed on the Hwanglyuntang extract(10㎖/㎏) for 2 weeks. The change in GOT, GPT, γ-GPT, ALP, LDH activity and Bilirubin level in blood serum were preasured. The obtained results are summarized as follows : It was found that GOT, GPT, γ-GPT, ALP LDH activity and Bilirubin levels in the blood serum of the sample groups, as compared with control group, sample group was significantly decreased.
고원진 ( Weon Jin Ko ),이병무 ( Byoung Moo Lee ),박원영 ( Won Young Park ),김진녕 ( Jin Nyoung Kim ),조준형 ( Jun Hyung Cho ),이태희 ( Tae Hee Lee ),홍수진 ( Su Jin Hong ),조주영 ( Joo Young Cho ) 대한소화기학회 2014 대한소화기학회지 Vol.64 No.6
A 49-year-old woman visited our hospital with dysphagia and chest pain. In another hospital, she was diagnosed as reflux esophagitis. Although she had taken proton pump inhibitor and prokinetics drugs for a long time, she was not relieved of any symptoms. On the basis of high resolution manometry and endoscopic ultrasonography findings, Jackhammer esophagus was diagnosed. In this patient, peroral endoscopic myotomy (POEM) was performed for long myotomy of thickened circular muscle. During the procedure, there were no significant complications and she was discharged uneventfully. Symptoms were completely improved during three months after POEM. Here, we report on a case of Jackhammer esophagus treated by POEM. (Korean J Gastroenterol 2014;64:370-374)