A Case of Pulmonary Fibrosis with Lung Lobe Torsion in a Pekinese Dog

고두민,Taejin Lee,Tae-Wang Kim,So Young Youm,신상경,안병우 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1

Pulmonary fibrosis (PF) is defined as a gradual, interstitial fibrous disease of the lung parenchyma. PF causes collapse of lung lobe which can lead to lung lobe torsion of another side. A 14-year-old male Pekinese dog was referred to Veterinery Medical Center, Chungbuk National University. The chief complaint was acute dyspnea. The dog had a history of chronic cough which lasted for 18 month and cough was deteriorated recently. Tachypnea was noted on physical examination. As a result of thoracic radiographs, ultrasonography and computed tomography, lung lobe torsion and collapse were diagnosed. A postmortem examination revealed lung lobe torsion of left cranial lobe and carnification of right cranial lobe. Histologically, severe and diffuse interstitial fibrosis with distortion of alveolar architecture and severe congestion and/or hemorrhage were noted in right cranial lobe and left cranial lobe, respectively. Although the cause of pulmonary fibrosis was undetermined, this case showed a typical lung lobe torsion caused by pulmonary fibrosis.

개 비장에서 발생한 myxoid liposarcoma 증례 보고

고두민,우상호,천두성,김준,오예인,김대용,Go, Du-Min,Woo, Sang-Ho,Cheon, Doosung,Kim, Jun,Oh, Ye-In,Kim, Dae-Yong 대한수의학회 2020 大韓獸醫學會誌 Vol.60 No.2

A 7-year-old Maltese was presented to a veterinary clinic for a history of anorexia, soft feces, and anemia. During abdominal sonography and computed tomography imaging, splenic mass was suspected. Laparotomy revealed the bloody ascites, and the enlarged spleen containing a large spherical mass. Microscopically, the splenic parenchyma was replaced by neoplastic cells with cytoplasmic vacuolation and abundant myxoid matrix. Cellular vacuolation and myxoid matrix were positive to Oil-Red-O and Alcian-blue stains. The neoplastic cells were positive to vimentin on immunohistochemistry. The case was diagnosed as myxoid liposarcoma. Based on a poor prognosis, the dog was euthanized three weeks after splenectomy.

페렛에서 발생한 coronavirus 감염 증례 보고

이수형,고두민,이정하,장운기,김대영,김대용,Lee, Su-Hyung,Go, Du-Min,Lee, Jeong-Ha,Jang, Woonki,Kim, Dae Young,Kim, Dae-Yong 대한수의학회 2016 大韓獸醫學會誌 Vol.56 No.4

A female domestic ferret (Mustela putorius furo) presented to a veterinary clinic with a clinical history of anorexia and poor body condition. Due to gradual deterioration of the body condition, explorative laparotomy was performed. Diffusely, the mesentery was severely thickened and adhered with prominent mesenteric lymph nodes. A portion of the mesentery and mesenteric lymph nodes were biopsied and fixed. Microscopic analysis revealed severe pyogranulomatous peritonitis and lymphadenitis, but staining revealed no bacterial organisms. However, immunohistochemistry for feline coronavirus exhibited strong immunoreactivity, primarily in the macrophages. Based on these results, the case was diagnosed as ferret coronavirus infection.

개의 담낭에서 발생한 carcinoid tumor 증례 보고

우상호,고두민,천두성,김재훈,최갑철,오예인,김대용,Woo, Sang-Ho,Go, Du-Min,Cheon, Doosung,Kim, Jae-Hoon,Choi, Gabchol,Oh, Ye-In,Kim, Dae-Yong 대한수의학회 2020 大韓獸醫學會誌 Vol.60 No.2

A 7-year-old female mixed-breed dog was presented to a veterinary clinic for pyometra. During abdominal ultrasonography, an abnormal finding was noted in the gallbladder. A cholecystectomy was performed. Grossly, the gallbladder wall was thickened with a polypoid nodular projection into the lumen. Microscopically, the polyp consisted of a solid sheet of round to polygonal-shaped cells that formed small packets with fibrovascular septa. The neoplastic cells contained abundant cytoplasmic eosinophilic granules. Immunohistochemically, the neoplastic cells were positive to chromogranin A and neuron-specific enolase, whereas they were negative to vimentin and cytokeratin. This case was diagnosed as a primary gallbladder carcinoid tumor.

Pathologic Features of a Systemic Dirofilariasis in a Dog

이태진,고두민,염소영,신상경,장동우,안병우 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.1

Canine heartworm disease typically is manifested by the presence of heartworms in the pulmonary artery and, to a lesser degree, the right ventricle. Systemic arterial dirofilariasis is an unusual manifestation of heartworm disease of dogs that results from aberrant migration of Dirofilaria immitis into the peripheral arterial circulation. A 3-year-old Jindo dog was referred to Veterinary Medical Center because of hindlimb lameness, paresthesia of hindlimbs and interdigital ischemic necrosis. Angiography and ultrasonography diagnosed as heartworm infestation. In necropsy, entangled heartworms were present throughout the body including lungs, kidney, small intestinal lumens and arteries in addition to the right ventricle and pulmonary artery. Histologically, lung showed adult heart worms in vessels, organized thrombotic vessels, and interstitial pneumonia featured by typeⅡ pneumocyte hyperplasia, thickened alveolar wall and compressed alveolar spaces. Chronic parenchymal lesions such as focal or diffuse necrosis, fibrosis and dystrophic calcification were remarkable in liver and kidney. The present case showed a typical canine systemic heartworm diasease caused by aberrant migration of Dirofilaria immitis.

Bilateral Triamcinolone Induced Subconjunctival Granuloma in the Treatment of Scleritis Accompanied by Scleral Ectasia in a Dog

강선미,고두민,김대용,서강문 한국임상수의학회 2018 한국임상수의학회지 Vol.35 No.4

A 6-year-old spayed female American Cocker Spaniel presented with episcleritis in the right and then theleft eye (OS) at eight month interval. Repeated intralesional triamcinolone acetonide was administered subconjunctivallyto both eyes (OU). During this period, scleral ectasia was revealed on ocular funduscopy OS and then confirmedon ultrasonography and computed tomography. A year later, conjunctival hyperemia occurred around remnanttriamcinolone particles and was treated by resection of these particles in the OU. A recurrence of episcleritis, whichdid not regress, required repeated triamcinolone subconjunctival injections four months later in the OU. Four monthsafter these injections OU, the dog was presented with bilateral conjunctival mass, which had developed over the previousmonth. The round-shaped masses with diameters of 1 cm were surgically resected from exposed scleral ectasia lesionof thin and bulging scleral surface in the OU. The cross-section of both masses showed a white-colored accumulationat the center and triamcinolone induced granulomas enclosing necrotic tissue were confirmed by impression cytologyand histopathological examination.

개에서 림프절 전이와 유미흉을 동반한 심낭막 중피종 증례 보고

이정하,이수형,고두민,김대용,Lee, Jeong-Ha,Lee, Su-Hyung,Go, Du-Min,Kim, Dae-Yong 대한수의학회 2016 大韓獸醫學會誌 Vol.56 No.4

Pericardial mesothelioma is a rare neoplasm in dogs. This report describes a case of pericardial mesothelioma in a 13-year-old Shih Tzu that presented with a clinical history of dyspnea. Hemorrhagic pericardial effusion and chylous pleural effusion with reactive mesothelial cells were identified by radiograph and cytology. Necropsy revealed multiple round nodules throughout the pericardium and regional lymph nodes in addition to chylothorax. Histopathology revealed invasive neoplasm on the pericardial surface with metastasis to the lymph nodes. The neoplastic cells were immunopositive to both cytokeratin and vimentin. Diagnosis of pericardial mesothelioma with regional lymph node metastasis was made.

개에서 발생된 안구 내 신경아교종

이수형,이민수,고두민,임재현,김대용,박영우 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.1

A 14-year-old, male Shih-tzu was presented with glaucoma in the left eye. Menace response was negative in the left eye. On ophthalmic examination, exotropia, buphthalmos, bulging of upper lateral globe and episcleral injection was detected in the left eye. Also, there was corneal edema, corneal pigmentation and hyphema in the left eye. The pupil was difficult to observe due to corneal lesions in the left eye. On ultrasonographic examination, an amorphous large mass protruding from the region of the optic disc into the vitreous was observed in the left eye. Enucleation was performed in the left eye. Histologically, the left intraocular mass was diagnosed as glioma. Immunohistochemically, the neoplastic cells were positive to glial fibrillary acidic protein.

페렛의 후복강에서 발생한 기형종

이보람,박준원,이수형,고두민,김대용 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.1

Retroperitoneal teratoma was described in a 20-month-old intact female ferret (Mustela putorius furo). Retroperitoneal mass about 8 × 5 cm in size was surgically removed and histopathologic examination was performed. Grossly, on cross section of the mass, the consistency was soft to firm and contained several cystic structures whichare filled with dried keratinous material. Histologically, the retroperitoneal mass consisted of embryologicallyheterogeneous tissues that include skin, bone and cartilage, adipose tissue, respiratory epithelium, and exocrine pancreatictissue. Based on the characteristic histologic features of the mass, a diagnosis of retroperitoneal teratoma was made. Adrenal gland or ovary was suspected as the origin of the tumor.

Dacryocystectomy for Chronic Dacryocystitis in a Beagle Dog

정영석,이송희,김수안,우상호,고두민,서강문,강선미 한국임상수의학회 2021 한국임상수의학회지 Vol.38 No.3

A 3-year-old spayed female beagle dog was presented with epiphora, severe hemorrhagic and purulent ocular discharge in the right eye (OD). A reflux of the discharge through the other canaliculi, associated with signs of chronic inflammation, was observed on cytology. Dacryocystorhinography revealed retention of contrast media ventral to the lower punctum, indicating complete obstruction and the potential presence of radiolucent foreign body. Ocular discharge subsided after the first treatment, including flushing of the nasolacrimal duct and application of topical antibiotics and corticosteroids, but clinical symptoms of the dacryocystitis waxed and waned thereafter. Surgical treatment was delayed for 8 months due to Dirofilaria immitis infection, and topical treatment and monthly flushing were maintained. On the day of operation, a foreign body was released through the fistula, while flushing for disinfection under general anesthesia, just before the surgery. Dacryocystectomy was performed to remove necrotic tissue and residual foreign body around the nasolacrimal cyst. Upon histopathologic findings, the removed foreign body was considered to be a plant, and the nasolacrimal cyst was comprised of chronic active ulcerative inflammation and necrotic tissues. At the 1-week recheck, improvement of epiphora and ocular discharge and healing of the surgical site was noted. In conclusion, nasolacrimal duct foreign body can be considered in recurrent dacryocystitis, despite nasolacrimal flushing and topical medication. In this study, dacryocystectomy was curative without recurrence of dacryocystitis or epiphora.