RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      • 좁혀본 항목

      • 좁혀본 항목 보기순서

        • 원문유무
        • 음성지원유무
        • 원문제공처
        • 등재정보
        • 학술지명
        • 주제분류
        • 발행연도
        • 작성언어
        • 저자

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI등재

        조선 후기 사족 가계(家系)의 계승방식에 관한 연구 - 부안 청호고씨 사례를 중심으로 -

        고민정 ( Ko Minjung ) 한국고문서학회 2019 古文書硏究 Vol.55 No.-

        본고에서는 부안 청호고씨의 사례를 통해서 17세기부터 19세기에 이르는 사족 가계의 계승방식에 대해 고찰하였다. 청호고씨는 전라도 옥구를 중심으로 세거하던 제주고씨 일파가 부안현 하서면 청호리 일대로 이거하면서 형성되었다. 이들은 대대로 무과에 급제하여 무반벌족으로서의 입지를 굳혔으며, 특히 고희가 호성공신으로 녹훈되면서 여러 특전을 부여받게 되었다. 청호고씨는 적장자로 이어지는 가계계승을 지향하였으나 그것이 실현되기 어려울 때에는 입후, 이종, 입양의 방식으로 가계를 지속시켰다. 17세기 친생자가 없어서 후사가 단절될 상황에 놓이게 되자 피계승자와 가장 가까운 혈연 관계에 있던 이를 입후하였다. 18세기 적장손이 폐적되고 계후자를 세우기 어려운 상황에 놓이게 되자 기존의 계승 관계를 새롭게 정립하는 이종을 행하여 피계승자와 가장 가까운 혈연 관계에 있는 이를 새로운 계승자를 세웠다. 19세기 기존의 적장자가 사망한 후 계승 구도를 둘러싸고 서파와 적파가 대립하는 양상이 나타나게 되자 관의 도움을 받은 적파에 의해서 새로운 계후자의 입양이 이루어지게 되었다. 다만 이 경우는 서파와의 대립 과정에서 양육의 의미가 포함되었기 때문에 입양이라 칭했으나 사실상 입후와 동일한 행위로 볼 수 있다. 이렇게 볼 때 입후, 이종, 입양은 구체적인 방식이 다르기는 하지만 결과적으로는 항렬에 맞는 순차적인계승 관계의 형성을 지향하고 있음을 확인할 수 있다. 그리고 청호고씨가 이러한 방식을 선택한 것은 적장계열과 가장 가까운 친족 관계에 있는 자손을 후사로 세우기 위함이었던 것으로 보인다. 즉 이들의 계승은 항렬을 토대로 친족간의 질서를 준수하였으며, 계승자를 선택할 때에는 적파의 테두리 안에서 혈연적 친소관계를 중시하였음을 알 수 있다. This study is to observe the phenomenon of long-lasting gentry pedigree after the consciousness of succession was reinforced in the Joseon society and to review its characteristics. Therefore, the aspect of Buan Cheongho Ko family's succession for three centuries from the 17th to 19th century is traced. Cheongho Ko family started to be formed as Ko Se-ho who resided in Okgu moved to Haseo-myeon, Buan-hyeon with his wife's family in the 16th century. Because Ko Se-ho, who established a family hometown, and his descendents passed the military service examination and entered government service, and especially Ko-hee was entitled a contributor by being in attendance on King Seonjo during Japanese Invasion of Korea in 1592, the family came to consolidate its footing as the distinguished military nobility family. The succession structure of Cheongho Ko family from the 19th Ko Se-ho to the 29th Ko Jin-ho shows mostly primogeniture succession. However, in case there was no primogeniture, the succession was done by adoption and next eligible child. This perspective indicates that the succession by adoption and next eligible child pursued the sequential succession relation according to the degree of kindred although the specific methods of practicing family succession were different. In addition, Cheongho Ko family used these methods in order to carry on family line with children who were closest to primogeniture.

      • SCOPUSKCI등재

        최신 연구 소개 : Toll-like Receptor 5 결핍 생쥐에서 대사증후군과 장내 미생물의 변화

        고재성 ( Jae Sung Ko ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.3

        요약: 비만, 고혈당증, 고지질혈증, 인슐린저항, 지방간이 동반되는 대사증후군이 빠르게 증가하고 있다. 영양과다와 신체활동의 감소는 비만을 일으키고 만성 염증을 활성화시켜 인슐린에 대한 반응을 둔화시키고 일부에서 2형 당뇨병을 유발한다. Toll-like receptor 5 (TLR5)는 장점막에서 미생물의 flagellin을 인지하는 막단백(transmembrane protein)으로 선천면역(innate immunity)의 구성인자이다. 이번 연구에서 TLR5 결핍(T5KO)생쥐는 야생(wild-type)생쥐에 비해서 신체질량(body mass)이 20% 이상 많고 지방질량과 복부지방이 증가하였다. 이러한 지방질량의 증가는 혈청 중성지방과 콜레스테롤, 혈압의 증가와 상관관계가 있었다. 염증성 사이토카인인 interferon-γ와 interleukin-1β의 증가도 동반되었다. T5KO생쥐는 야생생쥐에 비해서 금식 후 혈당이 높고, 포도당 유발에 대한 인슐린 반응이 증가하고, 외부 인슐린 투여에 반응이 감소하는 인슐린저항이 관찰되었다. 고지방식이를 주면 T5KO생쥐에서 당뇨병이 발생하고 간의 지방증이 관찰되어 대사증후군이 악화되었다. T5KO생쥐는 야생생쥐에 비해서 10% 이상 음식섭취가 많았다. 음식섭취를 제한하면 신체질량, 지방질량, 혈당, 지질, 인슐린의 증가를 막을 수 있지만, 외부 인슐린 투여에 대한 반응 감소는 지속되어 인슐린저항이 음식섭취의 증가로 인한 것은 아님을 시사하였다. Lipopolysaccharide (LPS) receptor인 TLR4가 음식으로 유발되는 대사증후군에 관여한다는 보고가 있어서 T5KO생쥐에서 TLR2 혹은 TLR4를 제거하였으나 대사증후군은 지속되었다. 반면에 TLR3를 제외한 모든 TLR 신호에 관여하는 MyD88을 제거하면 대사증후군이 발생하지 않았다. 이 결과는 TLR5 결핍시에 TLR2나 TLR4를 제외한 다른 TLR의 활성 혹은 MyD88 의존 면역매개물이 대사증후군과 관련된 염증을 유발한다는 것을 시사한다. T5KO생쥐에게 항생제를 투여하면 장내 미생물의 수가 90% 감소하고 대사 증후군이 개선되었다. T5KO생쥐와 야생생쥐의 장내 미생물은 종(speceis)의 구성에 차이를 보였다. T5KO생쥐의 장내 미생물을 야생형 무균생쥐에게 이식하면 과식, 비만, 고혈당, 인슐린저항, 염증성 사이토카인의 증가가 발생하였다. 이러한 결과는 T5KO생쥐에서 장내 미생물의 변화가 대사 증후군의 발생에 중요한 역할을 하는 것을 시사한다.

      • KCI등재후보

        Description of Lycoris chinensis Traub var. sinuolata K. Tae et S. Ko ex K. Tae et S. Ko (Amaryllidaceae)

        태경환,고성철 한국식물분류학회 2003 식물 분류학회지 Vol.33 No.4

        본 연구는 신종 발표시 기록하지 않았던 진노랑상사화 Lycoris chinensis Traub var. sinuolata K. Tae et S. Ko에 대하여 라틴어 기재를 추가하였고, 또한 근연관계에 있는 L chinensis Traub와 L. aurea Herb를 포함한 새로운 분류군에 대한 검색표를 제시하였다. For Lycoirs chinensis Traub var. sinuolata K. Tae et S. Ko ex K. Tae et S. Ko, Korean endemic plant, latin description is add to the previous study, and a key including L. chinensis Traub and L. aurea Herb. which are closely related to the above variety, is newly provided.

      • 現代國語의 語末語尾에 대한 構造的 硏究 : 非終結語尾의 것을 중심으로

        高永根 서울大學校 語學硏究所 1975 應用 言語學 Vol.7 No.1

        1. The are many sentence-final endings in modern Korean. They are divided into conclusive endings and non-conclusive endings depending on whether they conclude a sentence or not. It may be said that the important point of non-conclusive endings is the lack of sentence types and speech levels. The purpose of this paper is to analyze non-conclusive endings, and investigate their syntagmatic relationship to adjacent forms. From the functional viewpoint, non-conclusive endings can be classified into conjunctive(連結語尾) and derivatives(轉成語尾). The former shows primary function; the latter shows non-primary function. Furthermore, conjunctives can be subdivided into coordinatives and subordinatives according to their function. Coordinatives and subordinatives can be subdivided into word-conjunctives and sentence-conjunctives, respectively. 2. It may be said that non-conclusive endings which were listed in the traditional grammars and dictionaries can not be analyzed further. However, among them there are complex forms which consist of mood and aspect morphemes, and final endings.(e.g. u˘myo˘nso˘: myo˘+nso˘; chamaja: cha+maja) The problems I faced in analyzing non-conclusive endings were as follows: (1) I did not identify the items beginning with ko˘(ko˘nu˘l, ko˘ni, ko˘ndae, ko˘du˘n, etc.) as complex forms. When we take the above mentioned items as complex forms, the remaining elements nu˘l, ni, ndae, tu˘n etc. can not be combined with other norphemes; moreover they cannot be attached directly to the verbal stems. At the same time, we cannot give any meaning to the morpheme ko˘ which probably cannot be further analyzed. (2) I identified the items o˘followed by so˘and taga as morphemes. In dictionaries so˘and taga are listed as emphatic particles. Since the addition of taga, so˘to o˘is not obligatory, o˘so˘, o˘taga can be regarded as unanalyzable morphemes. (3) The complex forms which consist of ki and case marker e or lo, o˘and delimiter to can be also regarded as unanalyzable morphemes. The deletion of the case markers and a delimiter makes sentences ungrammatical. If the deletion of delimiters does not exert an influence on the grammaticalness, the delimiters can be separated from preceding elements, e.g. nu˘ndedo, u˘myo˘nso˘do o˘yaman etc. 3. Non-conclusive endings do not combine with all the adjacent forms. First, tense morphemes precede non-conclusive endings. However, there is many restrictions in actual combinations. We can classify non-conclusive endings into three groups according to the combination with tense morphemes: some cannot be combined with any tense element; some cannot be combined with o˘ss; Some can be combined with o˘ss and kess. There are differences between coordinatives and subordinatives in conbination with tense morphemes. For example, u˘myo˘nso˘as a coordinative can not be combined with o˘ss. However, u˘myo˘nso˘as a subordinative can be combined with o˘ss. Secondly, case markers and delimiters follow non-conclusive endings. There are also many restrictions in this case.

      • 심미 수복 치료의 관점에서 바라본 Ko's Coloring을 이용한 Monolithic zirconia crown의 가능성

        고경훈,Ko,,Kyung-Hun 대한심미치과학회 2016 Journal of the Korean Academy of Esthetic Dentistr Vol.25 No.2

        CAD/CAM의 발전으로 기존의 많은 보철물이 지르코니아로 대체되고 있다. 하지만 많은 치과기공사가 지르코니아 색조재현에 많은 어려움을 겪고 있다. 시행착오를 겪으며 이에대한 해결을 위해 많이 노력하였고 이에 이 논문에서는 Ko's coloring 기법에 대해 설명하고자 한다. According of the development and spread of CAD/CAM, a number of prostheses we have done had been replaced. Dental technicians have a difficulty reproducing natural color when producing these zirconia crowns. Difficulty reproducing natural color when producing these zirconia crowns. In my case, in the beginning of experimenting with zirconia, I had a hard time dealing with zirconia and I have tried solve these problems. Therefore, I would like to share Ko's coloring technique made of my effort with you.

      • KCI등재

        고방(古方)으로 치료한 두드러기 환자 39례의 임상보고(臨床報告)

        탁명림,김미보,변석미,고우신,윤화정,Tark,,Myoung-Rim,Kim,,Mi-Bo,Byun,,Seok-Mi,Ko,,Woo-Shin,Yoon,,Hwa-Jung 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.3

        Objectives : This study was designed to investigate the chronical features of urticaria and the effects of urticaria treatment with Ko-Bang(古方). Methods : We treated 39 patients for urticaria with Ko-Bang(古方), who visited to care urticaria at the Dept. of Dermatology Oriental medical hospital Dong-eui university from Jan, 2008 to Sep, 2009. This study was assessed using the chart analysis and the follow-up survey by telephone. Results & Conclusions : 1. 39 outpatients were surveyed, who were 20 males and 19 females. And patients who were ages 21-30 were the largest group, 11(28.21%). Among the 39 patients, acute urticaria patients were 8(20.5%), chronic urticaria patients were 31(79.5%), and contraction of a disease period between 6 weeks with 3 months was 17.9%. 2. The causes of urticaria were measured unknown 37.5%, foods 37.5%, drugs 25% in acute and unknown 35.5%, a change of temperature 29%, foods 16% in chronic. And suspected provocation factors were measured unknown and foods each 12 cases. The most of accompanied symptoms was itching sign(34 cases), the second most was self-conscious fever(10 cases). 3. Out of treat prescription(Ko-Bang,古方), Injinho-Tang(茵蔯蒿湯) was used most in 5 cases, Daehwanghwangryunsasim-Tang(大黃黃連瀉心湯), Hwangryun-Tang(黃連湯), Daesiho-Tang(大柴胡湯) were used in each 4 cases, Galgeun-Tang(葛根湯), Chijadaehwangsi-Tang(梔子大黃?湯), Sosiho-Tang(小柴胡湯) were used in each 3 cases, Gaemagakban-Tang(桂麻各半湯), Chijasi-Tang(梔子?湯),Oryeongsan(五笭散) were used in each 2 cases. 4. When the processes of treatment were classified by one poison(一毒), there were the 19 cases (48.7%) which was caused by Bun(煩), the 12 cases(30.8%) by Water(水) and the 4 cases(10.3%) by Gyur(結).

      • KCI등재

        Balb/c 마우스에서 초과 추출물의 3주간 반복 경구투여 독성평가

        박주형 ( Ju Hyeong Park ), 조영락 ( Young Rak Cho ), 고혜진 ( Hye Jin Ko ), 정원식 ( Wonsik Jeong ), 안은경 ( Eun Kyung Ahn ), 오준호 ( Junho Oh ), 오좌섭 ( Joa Sub Oh ) 한국응용생명화학회(구 한국농화학회) 2015 Journal of Applied Biological Chemistry (J. Appl. Vol.58 No.2

        본 연구는 다양한 효능을 지닌 초과(Amomum tsao-ko Crevostet Lemaire)의 안전한 이용을 위한 독성평가로 식품의약품안전처 고시 제2014-6호 ‘의약품등의 독성시험기준'에 맞는 독성시 험법에 따라 Balb/c mouse를 이용하여 3주간 반복경구투여를 통해 초과의 안전성을 확인하고자 하였다. 3주간 반복 경구투여 후 체중, 장기중량 측정, 혈액분석 및 혈액생화학 검사를 실시하여 안전성을 확인 한 결과, 초과에 의한 특별한 증상이나 체중, 장기중량의 변화는 관찰되지 않았으며, 복대동맥으로부터 채혈한 혈액을 통한 혈구분석결과에서도 대조군과 초과 추출물 투여군 간의 통계적인 유의성을 관찰 할 수 없었다. 또한 혈청을 이용하여 간기능(GOT, GPT, LDH, ALB, TP-S, T-BIL, DBIL), 신장기능(BUN, CRE), 지질영양 관련(TG), 전해질 관련 (I.P) 지표들의 생화학분석을 수행한 결과, 대조군과 유사하게 모두 정상 범위 내의 결과를 나타내었다. 이러한 결과를 통하여 초과 추출물의 최대무독성용량은 최고 투여량인 2000 mg/kg 이상으로 판단되며, 본 연구결과는 초과의 기능성 식품, 화장품, 의약품 등 다양한 소재로서의 활용에 안전성 관련 기초자료로 이용될 수 있을 것으로 사료된다. Abstract In the present study, we investigated the oral toxicity of Amomum tsao-ko Crevost et Lemaire, (Zingiberaceae) extract in Balb/c mice (BALB, n=60) for 3 weeks. Balb/c mice (10 mice/ group, 6 group, 20±2 g, 6 weeks) were orally administered for 21 days, with dosage of 250, 500, 1000, 2000 mg/kg/day. Ethanolextract of A. tsao-ko did not affect any significant change of mortality, clinical signs, organs and body weights. Also, there were not significantly difference from the naive group (control) in hematological and serum biochemical examination. Consequently, these findings indicate that 3-week treatment with the ethanol extract of A. tsao-ko was not any toxic effects in Balb/c mice and the no-observed adverse effect level (NOAEL) for oral toxicity was determined to be 2000 mg/kg/day under our experimental conditions.

      • KCI등재

        Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity

        김도현,박홍재,박현수,이재웅,CheMyong,Ko,계명찬,최제민 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

        Estrogen receptor alpha (ERα) is a sex hormone nuclear receptor that regulates various physiological events, including the immune response. Although there have been some recent studies on ERα regarding subsets of T cells, such as Th1, Th2, Th17, and Treg cells, its role in follicular helper T (TFH) cells has not yet been elucidated. To determine whether ERα controls TFH response and antibody production, we generated T cell-specific ERα knockout (KO) mice by utilizing the CD4-Cre/ERα flox system (CD4-ERα KO) and then analyzed their phenotype. At approximately 1 year of age, CD4- ERα KO mice spontaneously showed mild autoimmunity with increased autoantibody production and CD4+CD44+CXCR5+Bcl-6+ TFH cells in the mesenteric lymph nodes and spleen. We next immunized 6–8-week-old CD4-ERα KO mice with sheep red blood cells (SRBCs), which resulted in an increased proportion of TFH cells and germinal center (GC) responses. In addition, 17β-estradiol (E2) treatment decreased TFH responses in wild-type mice and suppressed the mRNA expression of Bcl-6 and IL-21. Finally, we confirmed that the production of high-affinity antigen-specific antibodies and isotype class switching induced by NP-conjugated ovalbumin immunization were elevated in CD4-ERα KO mice under sufficient estrogen conditions. These results collectively demonstrate that the female sex hormone receptor ERα inhibits the TFH cell response and GC reaction to control autoantibody production, which was related to estrogen signaling and autoimmunity.

      • Developmental Characteristics of SCNT Pig Embryos Knocked-out of Alpha-1,3-Galactosyltransferase Gene

        Shim,,Joo-Hyun,Park,,Mi-Rung,Yang,,Byoung-Chul,Ko,,Yeoung-Gyu,Oh,,Keon-Bong,Lee,,Jeong-Woong,Woo,,Jae-Seok,Park,,Eung-Woo,Park,,Soo-Bong,Hwang,,Seong-Soo The Korean Society of Animal Reproduction 2009 Reproductive & developmental biology Vol.33 No.3

        This study was performed to comprehend the developmental characteristics of cloned embryos knocked out (KO) of $\alpha$-1,3-galactosyltransferase (GalT) gene. Immature oocytes were collected and cultured for 40 hrs (1-step) or 20hrs (with hormone) + 20hrs (without hormone) (2-step). The embryos transferred with miniature pig ear fibroblast cell were used as control. The reconstructed embryos were cultured in PZM-3 with 5% $CO_2$ in air at $38.5^{\circ}C$ for 6 days. To determine the quality of the blstocysts, TUNEL and quantitative realtime RT-PCR were performed. The embryos were transferred to a surrogate (Landrace) at an earlier stage of the estrus cycle. The maturation rate was significantly higher in 2-step method than that of 1-step (p<0.05). The blastocyst development of GalT KO embryos was significantly lower than that of normal cloned embryos (p<0.05). The total and apoptotic cell number of GalT KO blastocysts was not different statistically from control. The relative abundance of Bax-$\alpha$/Bcl-xl ratio was significantly higher in both cloned blastocysts than that of in vivo blastocysts (p<0.05). Taken together, it can be postulated that the lower developmental potential and higher expression of apoptosis related genes in GalT KO SCNT embryos might be a cause of a low efficiency of GalT KO cloned miniature pig production.

      • KCI등재

        Assessment of Adipocyte Differentiation and Maturation-related Gene Expression in the Epididymal Fat of Estrogen Receptor α Knockout (ERαKO) Mouse during Postnatal Development Period

        전용필,CheMyong,Ko,이기호 한국발생생물학회 2020 발생과 생식 Vol.24 No.4

        The absence of functional estrogen receptor α (Esr1) results in an overgrowth of the epididymal fat, as observed in estrogen receptor α knockout (ERαKO) mouse. The present research was aimed to evaluate expression of various molecules associated with adipocyte differentiation and maturation in the epididymal fat of ERαKO mouse at several postnatal ages by using quantitative real-time polymerase chain reaction. The highest transcript levels of all molecules were detected at 12 months of postnatal age, except leptin which the mRNA level was increased at 5 months of age and was unchanged until 12 months of age. The expression levels of CCAAT enhancer binding protein (Cebp) alpha, androgen receptor, and lipoprotein lipase were decreased at 5 months of age but increased at about 8 months of age. The mRNA levels of Cebp gamma and sterol regulatory element binding transcription factor 1 remained steady until 8 months of age. Continuous increases of transcript levels during postnatal period were found in Cebp beta, estrogen receptor (ER) beta, fatty acid binding protein 4, and delta like non-canonical Notch ligand 1. The increases of peroxisome proliferator-activated receptor gamma and adiponectin mRNA levels were detected as early as 8 months of age. The levels of fatty acid synthase and resistin transcript at 5 and 8 months of age were lower than that at 2 months of age. These findings show the aberrant expression patterns of genes related to adipocyte differentiation and maturation in the postnatal epididymal fat pad by the disruption of ER alpha function.

      맨 위로 스크롤 이동