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강현배,서진근 대한수학회 2001 대한수학회논문집 Vol.16 No.3
칼데론 문제와 유한번 측정 역전도체 문제에 대한 중요한 결과들을 설명하고, 그 응용으로서 전기임피던스 영상기법에 대하여 설명한다.
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Cerebrolysin Attenuates Astrocyte Activation Following Repetitive Mild Traumatic Brain Injury
Hyun Bae Kang(강현배),GiHun Kim(김기훈),HyunJoong Kim(김현중),Sa Rang Han(한사랑),Dong Jin Chae(채동진),Hee-Jung Song(송희정),Dong Woon Kim(김동운) 한국생명과학회 2013 생명과학회지 Vol.23 No.9
만성외상성뇌병증(Chronic traumatic encephalopathy, CTE)은 운동선수와 매우 밀접하게 관련되어 있으며 장기간에 걸쳐 반복적인 외상성뇌손상(traumatic brain injury, TBI)로 인한 퇴행성뇌질환이다. 신경영양인자(neurotrophic factor)는 여러 종류가 알려져 있으며 이들은 뇌와 척수의 물리적 손상시에 신경보호효과가 있다. 따라서, 신경영양인자의 혼합물인 cebrolysin을 이용하여 CTE질환에 가장 적합하다고 여겨지는 repetitive mild TBI (rmTBI) 모델에서 cerebrolysin의 신경보호효과를 알아보고자 하였다. 실험군은 5군(groups 1 and 2: rmTBI for 4 weeks following cerebrolysin injection for 4 weeks; groups 3 and 4: rmTBI for 8 weeks with or without cerebrolysin injection for 4 weeks; group 5: control)으로 나누어 진행하였다. CTE의 가장 대표적 표시인자인 tau 단백질의 인산화를 조직학적으로 조사한 결과, 대뇌겉질과 해마내 CA3 영역에서 phospho-tau단백질의 발현이 증가되었으며 cerebrolysin (10 μl of 1 mg/ml)를 미정맥으로 투여시 p-tau발현이 감소되었다. CTE의 병인으로 알려진 별아교세포와 미세아교세포의 활성을 각각의 표시인인 GFAP, iba-1을 이용하여 면역조직화학염색을 시행 하였다. 별아교세포의 활성은 rmTBI에 의하여 증가하였으며 cerebrolysin에 의해 회복되었으나 미세아교세포의 활성은 관찰되지 않았다. 또한 rmTBI모델에서 체내 탐식세포(macrophage)의 뇌내유입유무를 관찰하고자 CD45 염색을 시행하였으나 유의한 차이를 관찰하지 못하였다. 이상의 결과를 종합하면, cerebrolysin이 rmTBI에 의한 tau단백질의 인산화 및 별아교세포의 활성을 조절하는 것으로 사료된다. 따라서 cerebrolysin이 CTE 환자에 대한 치료 약물의 후보가 될 수 있음을 시사한다. Chronic traumatic encephalopathy (CTE), which is common in athletes, is a progressive neurodegenerative disease and a long-term consequence of repetitive closed head injuries. CTE is regarded as a chronic brain syndrome due to the effects of repetitive traumatic brain injury (TBI). Because neurotrophic factors are neuroprotective in models of brain and spinal cord injuries, we examined the effects of cerebrolysin, a mixture of various neurotrophic factors, on brain pathology in a mouse model of repetitive mild TBI (rmTBI), which is a good model of CTE. Five groups were created and treated as follows: groups 1 and 2: rmTBI for 4 weeks following cerebrolysin injection for 4 weeks; groups 3 and 4: rmTBI for 8 weeks with or without cerebrolysin injection for 4 weeks; group 5: control. We found that p-tau expression was increased in the pyramidal layer of the cortex and hippocampus, particularly the CA3 region, but not in the CA1 region and the dentate gyrus (DG). Intra-tail vein administration of cerebrolysin (10 ml of 1 mg/ml) after/during rmTBI treatment reduced p-tau expression in both the cortex and hippocampus. Histological analysis revealed mild astrocyte activation (increased expression of glial fibrillary acidic protein (GFAP)) but not microglia activation (ionized calcium binding adaptor molecule 1 (iba-1) expression) and peripheral macrophage infiltration (CD45). Additionally, administration of cerebrolysin after rmTBI resulted in reduced astrocyte activation. These observations in rmTBI demonstrated that cerebrolysin treatment reduces phosphorylation of tau and astrocyte activation, attenuates brain pathology, and mitigates function deficits in TBI. Taken together, our observations suggest that cerebrolysin has potential therapeutic value in CTE.
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SHOTA FUKUSHIMA,YONG-GWAN JI,강현배,YOSHIHISA MIYANISHI 한국산업응용수학회 2023 Journal of the Korean Society for Industrial and A Vol.27 No.2
This is a review paper on recent development on the spectral theory of the Neumann-Poincare operator. The topics to be covered are convergence rate of eigenvalues of the Neumann-Poincare operator and surface localization of the single layer potentials of its eigenfunctions. Study on these topics is motivated by their relations with the cloaking by anomalous localized resonance. We review on this topic as well.
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내분비장애물질에 노출된 넙치의 호흡대사와 혈액화학적 변화
김홍윤(H.Y. Kim),조현서(H.S. Cho),강현배(H.B. Kang) 한국해양환경·에너지학회 2004 한국해양환경공학회 학술대회논문집 Vol.2004 No.-
cute and chronic toxicity studies, using four compounds tributyltin (TBT), benzo(a)pyrene aP), nonylphenol (NP) and bisphenol A (BPA), were performed on olive flounder, Paralichthys vaceus. The 96 hr-LC50 for TBT, BaP, NP and BPA at 21.1±0.3℃ were 16, 25, 140 and 1100ppb, respectively. The chronic tests were flow-through method in the concentration of 5% (low conc.) and 10% (high conc.) to 96 hr-LC50, and run for 62 days. In the case of the flounder which exposed to each compound, growth rates of body weight were significantly decreased and serum glucose levels were elevated as compared to control value. Oxygen consumption rate was remarkably increased by exposing fish to sub-lethal concentration of each compound.
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