http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
In silico Study on Binding Specificities of Cellular Retinol Binding Protein and Its Q108R Mutant
강현아,SRIRAMULU DINESH KUMAR,이선구 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.1
Cellular retinol binding proteins (CRBPs) are industrially important lipocalin proteins which can be potential targets for drug development, scaffold engineering, and biosensor development. The introduction of Q108R site-directed mutagenesis in this protein changes the ligand-binding specificities, but its structural effect is still unclear. In this study, the ligand-binding modes of CRBP and its Q108R mutant were studied by molecular docking approach. The specific interaction between the terminal functional groups of retinoids and 108th residue of the protein was determined to be conserved in the ligand-binding complexes, but the interaction patterns of non-binding complexes were identified to be significantly different from those of binding complexes. These results suggest that the specific interaction between 108 Q or R residue of CRBP(I) and terminal functional group of retinoid may be crucial in the formation of stable ligand conformation in the binding site.
Ru/RuO<sub>2</sub>전극에 성장한 PZT 박막의 특성에 관한 연구
강현일,최장현,박영,송준태,Kang, Hyun-Il,Choi, Jang-Hyun,Park, Young,Song, Joon-Tae 한국전기전자재료학회 2002 전기전자재료학회논문지 Vol.15 No.10
The structural and electrical properties of PZT (lead zirconate titante) thin films grown on Pt (platinum) and Ru/Ru $O_2$(ruthenium/ruthenium oxide) electrodes were investigated. Thin films of PZT were deposited on a variety of electrodes using the rf-magnetron sputtering process. PZT films exhibited polycrystalline structure with strong PZT (100) plane and weak (211) plane for an optimizied Pt electrode and (100), (101), (111), (200), (210), (211) planes for Ru/Ru $O_2$. Switching polarization versus fatigue characteristic of Pt/Ti electrodes showed 20% degradation up to 1 $\times$ 10$_{9}$ cycles. No significant fatigue was observed in the films on Ru/Ru $O_2$ electrodes up to Ix109 test cycles. The results show that the new Ru/Ru $O_2$ bottom electrodes are expected to reduce the degradation of ferroelectric fatigue.
전 국민 대상 DUR의 민감도 및 특이성 점검 : 약물상호작용을 중심으로
강현아,김해숙,오청환,신현택 한국보건사회약료경영학회 2011 한국보건사회약료경영학회지 Vol.3 No.1
Introduction To improve patient safety and appropriateness of drug usage in Korea, a DUR program has been operated by HIRA since 2008. However, the quality of the program has never been verified although it is the only DUR processing tool used nationwide. Purpose The aim of this study is to examine the sensitivity and specificity of the program focused on drug-drug interactions within and between prescriptions. Method A total of 655,928 prescriptions issued in a 650-bed hospital for 6 months were analyzed using HIRA-DUR program and a drug-interaction detection module developed by DIF-KOREATM (DI-module). In this study, the DI-module was adopted as a golden standard because it has been made up with a number of reliable references recommended by OBRA’0 and complemented with information on korean local drugs. Result The sensitivity and specificity of the HIRA program in detecting drug-interaction were 17.99% and 99.83%, respectively, when compared with the DI-module. Discussion Reasons for the differences could be speculated as follows; I) There were medicines not been checked by the HIRA program because they were not in national formulary or they were combination drugs. ii) The program did not include some pairs of active ingredients related to possible drug interaction because KFDA announced a list of them partially. iii) Certain dosage strength and forms of some KFDA-announced active ingredients were left out from the possible drug-interaction list of the HIRA program. Conclusion It is concluded that an effort to update the most recent information and to manage the possible drug-interaction list should be made on regular base by related organizations such as HIRA and KFDA to improve safety of patients in drug use.
지방정부의 가정외아동보호서비스 예산현황과 현장실무자의 예산운용 경험
강현아(Hyun Ah Kang),우석진(Seok Jin Woo),정익중(Ick Joong Chung),전종설(Jong Seri Chun) 한국아동복지학회 2012 한국아동복지학 Vol.- No.39
본 연구는 지방이양 이후 각 광역지방자치단체의 가정외보호서비스 예산규모 및 구조, 그리고 항목 등에서 어떤 공통점과 차이점을 보이는지 지자체 예산서를 통해 분석하였다. 또한 가정외보호서비스 실무자 대상으로 포커스그룹인터뷰를 실시하여 예산 확보 및 운영 현황에 대한 그들의 경험을탐색하고, 그 과정에서 그들이 느낀 문제점은 무엇인지 알아보았다. 분석결과, 예산 구조, 규모 및 항목에 있어 지자체별뿐만 아니라 보호서비스 유형별로도 큰 차이를 발견하였다. 이는 요보호아동이라는 시혜적 대상에 대한 국가적 차원의 보호가 적절히 이루어지지 않고 있으며, 형평성의 원칙에도 크게 어긋남을 의미한다. 이 결과를 바탕으로 본 연구는 적극적 리더십을 통해 중앙정부가 요보호아동을 위한 표준화된 서비스 수준과 표준보호비용을 마련할 것을 제안하였다. The purposes of the study were to analyze the sizes, items, and structures of out-of-home care budgets of 19 local governments in Korea. In addition, the study explored the experiences and opinions of child welfare workers securing and operating the budgets for children in care. We analyzed budget items of the local governments related to out-of-home care services and estimated the size of the budget for each local government. We also utilized focus group interviews with three groups of child welfare workers or foster parents. As we expected, the study results revealed wide differences in the items, sizes, and structure among the local governments and the types of the care services. Focus group participants also pointed out the problems of wide disparity among the local areas and the care types, Based on the results, we raised the issue of equity for children in care, equal treatment of equals, and suggests that Korean central government should provide standardized levels of services and expenditures for children in care.
강현아(Kang Hyun-Ah) 한국여성학회 2003 한국여성학 Vol.19 No.3
이 글은 5ㆍ18항쟁이라는 역사적 사건이 문화예술적으로 어떻게 재현(representation)되고 있는가, 그리고 젠더 이미지가 ‘5월 연극’ 텍스트에서 어떻게 재현되고 있는가를 연구하고자 하였다. 그래서 이 글은 여성주의적 시각에서 연극 텍스트들 가운데 여성/남성 등장인물과 이들의 텍스트 내의 위치에 대해, 그리고 여성/남성 등장인물의 젠더 이미지에 대해 분석하였다. 보다 구체적으로 이 글의 문제의식과 연구범위는 다음과 같다. 첫째, ‘5월 연극’ 텍스트에서 여성의 성(gender)적인 역할이 얼마나 억압된 상황에서 만들어지는가? 둘째, 여성의 이미지는 어떻게 재현되고 있는가? 셋째, 텍스트 내에서 왜 특정한 여성 이미지가 창출되었는가? 넷째, 그 이미지가 상징하거나 기호화하는 의미는 무엇인가? 결론적으로, ‘5월 연극’ 텍스트들은 여성의 삶과 경험을 왜곡하고 있다. 여성은 5ㆍ18항쟁의 주변적 존재이고 남성의 보조적 역할만 맡는 것으로 재현하고 있기 때문이다. 그리고 남성의 권위에 짓눌려 자기의사표현을 하지 못하고 남성의 결정에 따라가는 수동적 인물들로만 등장한다. 이렇게 여성을 주변적 존재로 재현하는 것은 5ㆍ18항쟁의 ‘진실’과도 분명 모순되는 것이다. 따라서 ‘5월 연극’ 텍스트에 등장하는 여성의 삶과 경험에 대한 새로운 인식이 필요하다. 즉, 연극 텍스트에 등장하는 여성인물들은 타자화되고 주변화된 존재가 아니라, 남성과 의식을 공유하는 주체적 존재로 재현되어야 할 필요가 있다. This study is designed to investigate how the historical event Gwangju Uprising represents in the cultural arts, and how the gender images represent in the theatre texts of Gwangju Uprising. Accordingly, this study analyzed the female and male characters and their positions and gender images in the text from the viewpoints of feminism. Further concretely, the critical mind and purview of this study are as follows. First, how much suppression was given in constructing the gender roles of the women in the texts of Gwangju Uprising theatre? Second, how the images of the women were shown? Third, why a specific woman image was created in the texts? Fourth, what the image stood for or its symbolization meant? In conclusion, the texts of Gwangju Uprising theatre distorted the lives and experiences of the women. The women are only revived as the minor roles of the Gwangju uprising and the assistant roles of the men. Moreover, the women are passive as just following the decision of the men without expressing their own thoughts due to the authority of the men. Like this, the representation of the women as the minor characters is obviously contradictory to the truth of the Gwangju Uprising. Therefore, it is necessary to newly recognize the lives and experiences of the women appearing in the texts of Gwangju Uprising theatre. That is, the woman characters in the theatre texts should be represented as the subjective existence sharing the awareness with the men, instead of being shown as the minor characters in the objective positions.
강현인,최태완,Gang, Hyeon-In,Choe, Tae-Wan 한국정보처리학회 2002 정보처리학회논문지B Vol.9 No.4
본 논문에서는 블록화된 영상의 관심영역 가중치 비교 알고리즘과 형상특징 가중치 비교 알고리즘을 결합하여 지폐를 실시간으로 분류하는 시스템을 하드웨어로 구현하였다. 구현된 시스템은 영상획득부, 전처리 및 영상처리부로 구성되어 있다. 영상획득부는 CIS(contact image sensor)에 의해 영상이 얻어지고, A/D 변환기와 PLD에서 전처리를 한다. 영상처리부는 전처리된 영상을 제안된 알고리즘에 의해 DSP에서 수행한다. 제안한 방법은 시뮬레이션을 통해 질의영상과 비교영상간의 식별율을 높일 수 있고 오염되거나 회전, 이동된 지폐에서도 향상된 성능을 가진다. 그리고 제안 방법은 영상의 블록화 효과에 따른 계산량의 감소와 병렬처리를 할 수 있는 시스템으로 구성할 수 있어서 검색율을 높이거나 검색시간을 줄일 수 있는 장점이 있다. In this paper, we implemented a real-time system improving the performance of the paper currency discrimination by integrating a weighted region of interest matching algorithm with a weighted shape feature matching algorithm of the blocked image. The system classifies the paper currency by comparing a query image with compared images based on the database that contain images of paper currency. Especially, the system has good efficiency at the contaminated, rotated, and translated paper currency. The system hardware consists of three parts as follows : the paper currency image acquired by CIS(contact image sensor) is applied to the pre-processing part with A/D converter and PLD. Finally the pre-processed image data are classified by the main image processing part with a high-speed DSP based on the proposed algorithm.