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비대칭적 상호의존론에 입각한 타지키스탄의 식량안보 분석
강하람,최우익 서울대학교 러시아연구소 2023 러시아연구 Vol.33 No.2
This study conducted an analysis of Tajikistan's food security issues from an external perspective. Although Tajikistan internally promoted policies to strengthen food security after the independence from the former Soviet Union, but it experiences food instability depending on its relations with Russia and Kazakhstan. As a result, Tajikistan's food security was analyzed based on the theory of asymmetric interdependence. The analysis found that Tajikistan had a high asymmetric interdependence on Russia and Kazakhstan. Tajikistan was in a food crisis when relations with major trading partners changed, including Kazakhstan's wheat export restrictions, Russia's cancellation of oil duty-free agreements, and Western economic sanctions in 2014 and 2022. Serious asymmetrical relationships in food security have a significant impact on survival security. Therefore, Tajikistan should reduce its asymmetric dependence on major trading partners to strengthen food security, diversify relations with other countries, and increase its competitiveness so that it can become internally self-reliant.
강하람,임수빈,김초롱,모정순,박수정,정한솔 한의병리학회 2023 동의생리병리학회지 Vol.37 No.4
Renal fibrosis (RF) is a prominent pathological feature of chronic kidney disease (CKD), characterized by excessive accumulation of extracellular matrix components, resulting in progressive renal function loss. The fibroblast-to-myofibroblast transition (FMT) plays a pivotal role in renal fibrosis pathogenesis, driving aberrant deposition of extracellular matrix proteins and disruption of tissue architecture. Targeting FMT has emerged as a promising strategy to combat renal fibrosis and preserve kidney function. Silymarin, a flavonoid extract derived from Silybum marianum seeds, has gained attention for its therapeutic potential, particularly in liver diseases, due to its potent antioxidant and anti-inflammatory properties. However, the precise mechanisms underlying its effects on FMT remain unclear. This study aimed to investigate the therapeutic potential of silymarin in inhibiting FMT in NRK-49F renal interstitial fibroblasts. Transforming growth factor-beta 1(TGF-β1) plays a crucial role in promoting FMT through the activation of intracellular signaling pathways and induction of key fibrotic markers, including alpha-smooth muscle actin (α-SMA) and vimentin. Silymarin demonstrated significant downregulation of FMT markers, including α-SMA and vimentin, in TGF-β1-stimulated NRK-49F cells. Our findings highlight silymarin as a promising therapeutic candidate for mitigating renal fibrosis and managing CKD.
강하람,박유정,안성모,이유빈,이하림,천경식 한국환경생물학회 2022 환경생물 : 환경생물학회지 Vol.40 No.1
This study aimed to investigate the flora of Jinjosan Mt. (Uljin-gun, Gyeongsangbuk-do). The vascular plants were surveyed 9 times between March 2019 and April 2020. The results of this survey revealed a total of 414 taxa comprising of 87 families, 274 genera, 365 species, 12 subspecies, 32 varieties, and 5 forms. Among them, 9 taxa were Korean endemic plants and 5 taxa were rare plants of Korea. In addition, the specific plants by floristic region were 66 taxa including 1 taxon of grade IV, 18 taxa of grade III, 24 taxa of grade II, and 23 taxa of grade I. Additionally, eight taxa were classified as plants adaptable to climate change. Thirty-one taxa were of alien plants and three taxa were of ecosystem disturbance species, which were also investigated. The percentage of naturalized plants species and the urbanization index were estimated to be 7.5% and 5.0%, respectively. Our results provide basic data on vascular plants flora, and will guide the conservation processes of plant resources such as plant diversity and distributional changes in Jinjosan Mt. 본 연구는 경북 울진군에 위치한 진조산 지역에 분포하는 관속식물을 조사하여 기초자료를 제공하고자 하였다. 조사는 2019년 3월부터 2020년 4월까지 총 9회에 걸쳐 수행하였으며, 그 결과 진조산에 분포하는 것으로 확인된 관속식물은 87과 274속 365종 12아종 32변종 5품종으로 총 414분류군이었다. 조사된 414분류군 중 한국특산식물은 9분류군이었으며, 희귀식물은 5분류군이었다. 또한 식물 구계학적 특정식물은 총 66분류군으로, 등급별로는 IV 등급 1분류군, III 등급 18분류군, II 등급 24분류군 그리고 I등급 23분류군이었다. 또한 기후변화 적응 대상식물은 8분류군이었으며, 외래식물은 31분류군, 생태계교란 야생식물은 3분류군으로 조사되었고, 귀화율과 도시화지수는 각각 7.5%, 5.0%로 나타났다. 본 연구는 관속식물의 분포에 관한 기초자료로서 진조산의 식물다양성 및 분포변화 등의 자원 보존을 위한 중요한 정보로 활용될 것으로 판단된다.