Loss of βPix Causes Defects in Early Embryonic Development, and Cell Spreading and PlateletDerived Growth Factor-Induced Chemotaxis in Mouse Embryonic Fibroblasts

강태인,이승준,권영희,박동은 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.8

βPix is a guanine nucleotide exchange factor for the Rho family small GTPases, Rac1 and Cdc42. It is known to regulate focal adhesion dynamics and cell migration. However, the in vivo role of βPix is currently not well understood. Here, we report the production and characterization of βPix-KO mice. Loss of βPix results in embryonic lethality accompanied by abnormal developmental features, such as incomplete neural tube closure, impaired axial rotation, and failure of allantoischorion fusion. We also generated βPix-KO mouse embryonic fibroblasts (MEFs) to examine βPix function in mouse fibroblasts. βPix-KO MEFs exhibit decreased Rac1 activity, and defects in cell spreading and platelet-derived growth factor (PDGF)-induced ruffle formation and chemotaxis. The average size of focal adhesions is increased in βPix-KO MEFs. Interestingly, βPix-KO MEFs showed increased motility in random migration and rapid wound healing with elevated levels of MLC2 phosphorylation. Taken together, our data demonstrate that βPix plays essential roles in early embryonic development, cell spreading, and cell migration in fibroblasts.

TV송출 기술

강태인 한국방송공학회 1996 방송과 미디어 Vol.1 No.1

기저세포모반증후군과 연관된 다발성 치성각화방종의 치료시 술전 조대술과 술후 교정적 맹출의 사용 치험 1례

강태인,박영주,남정훈,안장훈,강혜진,송준호,정재안,신진업,Gang, Tae-In,Park, Young-Ju,Nam, Jeong-Hun,Ahn, Jang-Hoon,Kang, Hae-Jin,Song, Jun-Ho,Chung, Jae-An,Shin, Jin-Eob 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.5

Basal cell nevus syndrome is a rare inherited disorder characterized by mulitple cutaneous basal cell carcinoma, pits of the palms and soles, cysts of the jaws, skeletal abnormalities and ectopic calcifications. Currently there are new lines of investigation based on biomolecular studies, which aim at identifying the molecules responsible for these cysts and thus early allowing an early diagnosis of these patients. We report a case of a 9-year-old boy with the various manifestation of basal cell nevus syndrome, which are multiple odontogenic keratocysts, pits of the soles, bifid ribs, ectopic calcification, macrocephaly, and hypertelorism, etc. Total five odontogenic keratocysts were found. For the reduction of the size of the odon-togenic keratocysts, following preoperative marsupialization, there were surgically enucleated. And the impacted upper right lateral incisor and canine are tracted orthodontically.

척추마취 하 제왕절개술 후 정맥 및 경막외 통증 자가 조절 장치의 제통 효과와 만족도 비교

강태인,이지향,반종석,민병우 대한마취과학회 2004 Korean Journal of Anesthesiology Vol.47 No.3

해외입양인 친생부모의 생애사 연구 : 자녀찾기 경험을 중심으로

강태인 한국가족학회 2014 가족과 문화 Vol.26 No.3

이 연구의 목적은 해외입양인 친생부모의 자녀찾기를 중심으로 한 생애경험을 이해하는데 있다. 이러한 목적을 달성하기 위해, 이 연구에서 자녀찾기를 경험한 두 명의 해외입양인 친생부모들을 대상으로 한 심층면접, 관찰, 기록물 등의 방법을 활용하여 자료를 수집하였으며, 생애사 접근을 통해 분석하였다. 분석결과는 참여자의 생애과정요약 및 생애이야기 서술, 주제 분석, 개입이슈 등으로 제시하였다. 분석결과 해외입양인 친생부모들의 생애경험에 나타난 주제는 ①"자녀상실: 부모 '얼굴'을 잃어버리고 이중 가면 쓰고 살아가기", ②"자녀 찾기: 부모의 잃어버린 '얼굴'찾기", ③"찾은 아빠(부모): '생부모'와 '친부모' 역할 사이에서 경계인으로 살아가기", ④"못 찾은 엄마(부모): 계속되는 후회와 기다림으로 살아가기" 등으로 나타났다. 이에 해외입양인 친생부모들의 자녀상실과 자녀재회과정에서 경험한 내용을 중심으로 입양절차, 아동유기, 사전·사후관리, 자녀찾기 등의 입양관련 개입이슈들을 검토하고 논의하였다. 논의결과를 바탕으로 해외입양인 친생부모들에 대한 사회적 개입과 지원에 필요한 정책적 제언과 실천적 개입방안을 제시하였다. This study's purpose is to understand the life experience of overseas adoptee-birth parents. For this purpose, the data were collected through in-depth interviews with two adoptee-birth parents who have the experience to search children and their documents and analyzed using life history approach. Results of analysis were composed of summarized life history, thick description of life history, theme analysis, and issues for intervention. The themes generated from analysis are ① 'losing children : living as parents without face and with wearing double mask of a sinner and a victim', ②'searching children: recovering a lost face of parents', ③ 'parents who met children: living as boundary people between role of real parents and birth parenting', ④ 'parents who did not meet children: living with lasting regret and waiting for children.' Researcher, also, examined intervention issues of adoption, adoption process, abandoning the children, pre-post adoption service, searching children. Based on the results of this study, the policies and practical guidelines for overseas adoptee-birth parents were suggested.

저작근극에서 발생한 전이된 갑상선 여포상암

강태인,허민석,안창현,최미,이삼선,최순철,박태원,Gang Tae-In,Heo Min-Suk,An Chang-Hyeon,Choi Mi,Lee Sam-Sun,Choi Soon-Chul,Park Tae-Won 대한영상치의학회 2002 Imaging Science in Dentistry Vol.32 No.3

Follicular carcinomas are the second most common form of thyroid cancer, accounting for 10 to 20% of all thyroid cancers. Follicular carcinomas have a propensity to metastasize via the bloodstream, spreading to bone, lungs, liver, and elsewhere. We described the case of a 48-year-old woman who presented with swelling of the left preauricular area, which was a consequence of a metastatic follicular carcinoma of the masticator space. Plain films showed illdefined erosive bony changes from the left condylar head to the mandibular notch. Contrast-enhanced CT images showed a well circumscribed round mass with well enhancement within left masticator space. On MR images, the mass was heterogenously hyperintense to the muscle on T2-weighted images and isointense or hyperintense to the muscle on Tl-weighted images, and showed good enhancement on contrast-enhanced Tl-weighted images. Upon microscopic examination, the metastatic mass was found to be composed of fairly uniform cells forming small follicles containing colloid, showing capsular and vascular invasion.

Numerical analysis for prediction of flow rate of the motor cooling fan

강태인,안철오,서인수,이상환 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.10

In this study, we analyzed the three dimensional unsteady flow around a motor cooling fan using the vortex panel method. For a popular type of motor cooling fan that has thin blades, we predicted the flow rate through numerical analysis without experimental data, such as the free stream velocity, which is a boundary condition of the flow field. We also calculated the flow rate for various cooling fan geometries and rotating speeds. For these fans, the numerical results showed flow rates within 3% of the experimental results.

The effect of radiographic imaging modalities and the observer's experience on postoperative maxillary cyst assessment

강태인,허경회,이원진,이삼선,허민석,최순철 대한영상치의학회 2014 Imaging Science in Dentistry Vol.44 No.4

Purpose: The purpose of this study was to compare the accuracy of postoperative maxillary cyst (POMC) diagnosis by panoramic radiographs versus computed tomography (CT) and by oral and maxillofacial radiologists versus non-specialists. Materials and Methods: Sixty-five maxillary sinuses with POMCs and 63 without any lesion were assessed using panoramic radiographs and CT images by five oral and maxillofacial radiologists and five non-specialists on a five-point scale. The areas under receiver operating characteristic (ROC) curves were analyzed to determine the differences in diagnostic accuracy between the two imaging modalities and between the two groups of observers. The intra-observer agreement was determined, too. Results: The diagnostic accuracy of CT images was higher than that of panoramic radiographs in both groups of observers (p<0.05). The diagnostic accuracy of oral and maxillofacial radiologists for each method was higher than that of non-specialists (p<0.05). Conclusion: The use of CT improves the diagnosis of POMC, and radiological training and experience leads to more accurate evaluation.

청각장애학교 교사가 인식하는 수어의 숙달도가 교수학습 방법과 근접발달대에 미치는 효과에 대한 구조 관계

강태인,최성규 한국청각언어장애교육학회 2023 한국청각·언어장애교육연구 Vol.14 No.3

이 연구는 청각장애학교 교사가 인식하는 수어의 숙달도, 교수학습 방법, 근접발달대의 구조 관계를 분석하기 위하여 조사연구로 수행되었다. 설문지는 수어 숙달도, 교수학습 방법, 근접발달대 각 10문항씩 총 30문항으로 구성되었고, 전국의 14개 청각장애학교에 재직 중인 초등학교 및 중등학교 교사를 연구대상으로 하였다. 연구결과는 다음과 같다. 첫째, 청각장애학교 교사가 인식하는 수어 숙달도는 청각장애학생의 교수학습 방법을 결정하는 주요 요인이다. 둘째, 청각장애학교 교사가 인식하는 수어의 숙달도는 청각장애학생의 근접발달대에 영향을 미치는 주요 요인이 아니다. 셋째, 청각장애학교 교사의 수어 숙달도가 교수학습 방법을 매개할 경우에 근접발달대가 고려된 수업이 가능한 구조이다. 넷째, 청각장애학교 교사의 수어 숙달도는 ‘숙달도’ 자체를 향상시키기 위한 노력에 따라서 교수학습 방법의 효율성이 달라질 수 있는 구조이다. 결론적으로 청각장애학교 교육의 효율성을 담보하기 위해서는 청각장애학교 교사의 수어 숙달도 및 교수학습 방법의 전문성 구축이 전제되어야 청각장애학생의 눈높이 교육이 실행될 수 있는 구조임을 이 연구에서 시사하고 있다. This study was conducted as a quantitative study to analyze the proficiency of sign language, teaching and learning methods, and structural relationships of the proximal development zone recognized by teachers in schools for the hearing impairment. The questionnaire consisted of a total of 30 questions, 10 each of sign language proficiency, teaching and learning methods, and proximal development. Exploratory and confirmatory factor analyzes were applied to find out the sign language proficiency level, teaching and learning method, and structural relationship of the proximal development zone of teachers at schools for the hearing impairment. SPSS 25.0 and AMOS 22.0 statistical programs were applied for all data processing. The results of the study were as follows. First, the sign language proficiency recognized by the deaf school teachers was a major factor in determining the teaching and learning methods for the education of hearing impaired students. Second, the level of proficiency in sign language perceived by teachers at schools for the hearing impairment was not a major factor influencing the proximal developmental zone of students with hearing impairments. Third, when the sign language proficiency of a teacher at a school for the hearing impairment mediates teaching and learning methods, it was possible to conduct classes considering the zone of proximal development. Fourth, the sign language proficiency of teachers at schools for the hearing impaired was a structure in which the efficiency of teaching and learning methods can vary according to the efforts to improve the ‘proficiency’ itself. In conclusion, in order to ensure the efficiency of education in schools for the hearing impairment, this study suggests that the teacher’s proficiency in sign language and the establishment of expertise in teaching and learning methods are the prerequisites for the structure in which the education of students with hearing impairments can be implemented at eye level.

양백(GB14) 전침자극이 뇌파 변화에 미치는 영향

강태리,Kang, Tae-Ri 경락경혈학회 2019 대한침구의학회지 Vol.36 No.4

Objectives : The purpose of this study was to examine the effects of electroacupuncture at GB14, on brain activity assessed on an electroencephalogram(EEG). Methods : (1) Thirty-four healthy participants were randomly divided into two groups, receiving either real acupuncture or non-penetrating sham acupuncture at GB14. (2) EEG measurements were conducted simultaneously before and after a 5-minute electroacupuncture stimulation, and the differences in the resulting EEG parameters were compared between the test and control groups. Results : (1) Absolute power increased significantly in the theta-wave channel of the occipital region and in the entire alpha-wave channel. (2) Relative power decreased significantly in the theta-wave channels of the frontal and occipital regions. (3) Coherence decreased significantly in the theta- and beta-wave channels of the parietal and occipital regions, and increased significantly in the alpha-wave channels of most areas. Conclusions : This study shows that electroacupuncture stimulation at GB14 activates the alpha frequency band in particular.