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강영,박하나로,정우진,안순현 대한이비인후과학회 2019 대한이비인후과학회지 두경부외과학 Vol.62 No.1
Background and Objectives Oropharyngeal cancer is one of those cancers with increasingincidence, and the therapeutic choices remain controversial. This study aims to evaluate the influenceof changes in the primary treatment on the prognosis of oropharyngeal cancer patients. Subjects and Method A total of 135 patients treated for oropharyngeal cancer in a singleinstitution from 2004 to 2017 were analyzed in this study. Disease-free survival rate and the 3-,5-year survival rates were calculated according to various radical primary treatments, whichincluded concurrent chemo-radiation or radiation therapy, and surgery. Other outcomes includingfunctional outcomes and treatment duration were also reported. Results The proportion of patients who were no-evidence-of-disease state at the last followup was 97.8% for the group who underwent surgery as radical primary treatment, followed byconcurrent chemo-radiation or radiation therapy (84.1%). The five-year survival rate was 0.7963[95% confidence interval (CI): 0.6746-0.8765] for the concurrent chemo-radiation or radiationtherapy group and 0.9488 (95% CI: 0.8093-0.9870) for the surgery group. When surgerywas chosen as radical primary treatment for appropriately selected patients, approximately30% of the patients could avoid radiation therapy. Gastrostomy or admission for supportive careas functional outcome showed no significant difference between treatment groups. Conclusion Our results show various treatment outcomes depending on the radical primarytreatment. These results can be used in clinical decisions and patient counselling.
Actinomycin D에 依한 核小體 形成部位의 活性 抑制에 關한 硏究
姜榮,金丁中,韓斗錫,鄭然泰 圓光大學校 醫科學硏究所 1987 圓光醫科學 Vol.3 No.2
Stainability of nucleolar organizer region with silver solution in human metaphase chromosome was investigated to detect the polymorphism among different individuals and the intensity of silver staining of nucleolar organizer region in interphase cells was investigated to analyze the preferential inhibition of the synthesis of rRNA by actinomycin D in cultures of human peripheral lymphocytes. The results obtained were as followings ; 1. The average number of silver positive nucleolar organizer region in human acrocentric chromosome was varying 6.5-9.2. 2. The amount of silver positive material in the interphase cells decreased with according as dose and treated time of actinomycin D. Results described indicate each individual showed remarkable variation in number of silver positive nucleolar organizer region and actinomycin D inhibited silver positive nucleolar organizer region activity.
6 가 크롬이 백서의 배양섬유모세포에 미치는 세포독성에 관한 연구
강영,반승일,김양일,김형주,정연태 원광대학교 환경과학연구소 1992 環境科學硏究誌 Vol.1 No.1
To investigate the cytotoxicity of Cr^6+, the colorimetric assays of neutral red (NR) and tetrazolium MTT, the measurements of the protein content and the rate of DNA synthesis, and sister chromatid exchange(SCE) analysis were performed in fibroblasts cultured in the medium containing various concentrations of Cr^6+. Electron microscopy of Cr^6+ treated rat fibroblasts was also carried out. The results were as follows ; 1. NR uptake was decreased dose-dependently and NR_90 and NR_50 values of Cr^6+ were 0.2 μM and 1.7μM respectively. 2. Cr^6+ induced the dose-dependent decrease of the activity of mitochondrial succinic dehydrogenase and MTT_90 and MTT_5o valyes were 0.5μM and 5.5 μM respectively. 3, Protein content in rat fibroblasts treated with Cr^6+ decreased dose-dependently. 4. Cr^6+ inhibited DNA synthesis dose-dependently and the rate of DNA synthesis at concentration of Cr^6+ 1.0μM(1.7μM, NR_50) was 33% of the control. 5. Frequency of sister chromatid exchange(SCE) increased dose-dependently and the frequency of sister chromatid exchange at concentration of Cr^6+ 1.0μM was noted to be 8.8 per cell. 6. Light microscopy revealed dose dependent reduction of cell number and decrease in cell size after Cr^6+ treatment. Electron microscopy of cultured fibroblasts treated with Cr^6+ showed dilatation of cisternae of granular endoplasmic reticulum drastic decrease of polyribosomes and increase in number of lysosomes. Above results indicated that Cr^6+ induced severe toxic effect on cultured cell, and suggested that DNA damage by Cr^6+ can be resulted inhibition of cell growth and decrease in cell viability.