방수유출장치삽입술을 이용하여 여과포로 인한 감각이상을 치료한 1예

강규동,김연덕,AmanShahB,AbdulMajid,곽지현,JohnSalmon,임혜빈,Kui Dong Kang,MSc,Yeon Deok Kim,Aman Shah B,Abdul Majid,BSc,MB ChB,Jee Hyun Kwag,D,Phil&#,John Salmon&#,Hye Bin Yim 대한안과학회 2010 대한안과학회지 Vol.51 No.5

Purpose: To report a case of bleb dysesthesia successfully treated after Baerveldt tube implantation. Case summary: A 37-year-old woman presented with a history of persistent foreign body sensation and pain in the left eye. The patient was referred to our hospital and was diagnosed as having had plateau iris syndrome. Having shown no improvement with conservative management, she eventually received trabeculectomy in the left eye six months prior to her current presentation. Under the impression of bleb dysesthesia, she received artificial tears and a bandage contact lens. These, however, failed to alleviate her symptoms. She then had a compression suture of the bleb and bleb revision. These were performed sequentially but neither was effective. Finally, a Baerveldt tube implantation was performed successfully, and, three months later, bleb revision was performed using a donor sclera, which resulted in no further complaint of ocular discomfort. Conclusions: Bleb dysesthesia, although not a common postoperative complication, can occur after trabeculectomy and can be successfully treated with Baerveldt tube implantation. Patients should receive appropriate counseling and advice on bleb dysesthesia prior to undergoing trabeculectomy. J Korean Ophthalmol Soc 2010;51(5):790-793

광간섭단층촬영에 내장된 시신경섬유층두께 지표와 새로 계산된 지표의 녹내장 진단 정확도 비교

강규동,박찬기.Kui Dong Kang M.D.. Chan Kee Park M.D. 대한안과학회 2006 대한안과학회지 Vol.47 No.2

Purpose: To find the optimal parameter of retinal nerve fiber layer (RNFL) analysis using optical coherence tomography (OCT) and to compare the diagnostic precision between the new discriminant formula and the preprogrammed indicator (95%, 99% cut off value of normal RNFL thickness) in the diagnosis of glaucoma. Methods: The study comprised 499 eyes of 284 patients. Routine ophthalmic examinations, fundus examination, visual field test, OCT optic nerve head analysis and OCT RNFL analysis were performed. Results were analyzed and classified into normal, suspected glaucoma, and glaucoma groups. Results: There were 237 glaucomatous eyes and all parameters of the OCT RNFL analysis showed statistically significant differences between the glaucoma and non-glaucoma groups. The average RNFL thickness was most significantly correlated with the visual field indexes and was the most useful parameter in the detection of glaucoma. Using age, horizontal integrated rim area (HIRA) and average thickness, the accuracy, sensitivity and specificity of the new discriminant formula were 76.2%, 73.1% and 73.1% respectively. Conclusions: Average thickness was the most useful parameter in the detection of glaucoma. The next most useful parameter was inferior average thickness, and both were more precise than the preprogrammed indicator. The new discriminant formula is useful in the diagnosis and follow-up of the glaucoma patients.

마우스 안구건조증 모델에서 포도껍질 추출물인 안토시아닌 올리고머의 효과에 관한 연구

강규동,정재균,Ramsha Afzal,양현필,황형빈 한국식품영양과학회 2019 한국식품영양과학회지 Vol.48 No.4

This study was conducted to investigate the effects of anthocyanin oligomers on dry eye disease through animal experiments. To accomplish this, 80 eyes of 40 mice were used, and dry eyes were induced by administration of 0.02% benzalkonium chloride (BAC). Anthocyanin oligomers of two doses (10 mg/kg and 50 mg/kg) were administered once a day for 2 weeks, while the control group received 0.1% cyclosporine A (CA) eye drops twice a day. Under a slit lamp microscope, the degree of corneal erosion (NEI grading system), tear break up time (TBUT) and phenol red test were observed. Moreover, histopathologic analysis of the lacrimal gland and corneal tissue was also performed. In the anthocyanin oligomer group (50 mg/kg), NEI score was significantly lower than that of the BAC treated group, while the TBUT and the wet length of phenol red thread were significantly higher than in the BAC group (P<0.01). Analysis of corneal tissue by hematoxylin and eosin (H&E) staining showed that keratinization and thickening of the cornea epithelial layer was not more prominent than those of eyes treated with anthocyanin oligomer (50 mg/kg) and CA eye drops. Overall, our results demonstrated that this natural compound has potential positive effects on the clinical index of dry eyes in the murine dry eye model. 본 연구에서는 안토시아닌 올리고머(50 mg/kg)가 염화벤잘코늄으로 유발된 안구건조증에서 다양한 안구건조증 지표의 개선에 효과가 있음을 보여주었다. 본 연구에서 염화벤잘코늄을 안구에 점안하였을 때 안구표면에 다양한 반응이 나타났다. 염화벤잘코늄이 각막상피세포에 직접적인 손상을 주어서 각막상피세포의 편평상피화생(squamous metaplasia)이 나타났고 다양한 염증세포의 각막침윤이 관찰되었다. 이상의 결과로 보아 염화벤잘코늄을 이용한 안구건조증 유발 모델에서 안토시아닌 올리고머는 염화벤잘코늄의 점안 이후에 나타나는 다양한 염증성 사이토카인의 증가 및 이로 인한 세포 사멸을 억제함으로써 각막표면상피세포의 편평상피화생을 막아 안구건조증에 나타나는 다양한 변화를 개선시키는 것으로 추정해볼 수 있다. 이러한 안구건조증에서 안토시아닌 올리고머의 효과는 항염 작용과 더불어 안토시아닌이 본래 가지고 있는 강력한 항산화 작용에 의한 것으로 생각된다. 특히 본 연구에 사용된 안토시아닌은 단량체가 아닌 중합체로써 기존의 단량체보다 생리활성이 높을 것으로 생각되는데, 향후 추가적인 연구를 통하여 중합체의 우수한 생리활성이 추가로 규명된다면 다양한 안과영역에서 관심을 받을 것으로 생각된다. 안구건조증은 치료가 쉽지 않고 환자의 삶의 질까지 영향을 미치는 질환이다. 치료가 잘 되지 않는 이유 중에 하루에도 수차례씩 치료 약제를 점안하여야 하므로 환자의 순응도가 떨어지는 점이 있는데 경구 약제가 이러한 점을 보완해줄 수 있을 것이라 생각된다. 향후 좀 더 장기적인 연구, 염증 관련 단백질 분석 등과 점안제와 동시에 복용했을 경우의 효과 등에 대한 추가적인 연구가 필요할 것으로 생각된다.

소아에서 빛간섭단층촬영을 통하여 얻어진 지표를 이용한 녹내장의 판별

강규동,Aman Shah B. Abdul Majid,김연덕,곽지현,임혜빈 대한안과학회 2009 대한안과학회지 Vol.50 No.6

Purpose: To find the optimal parameter of retinal nerve fiber layer (RNFL) analysis in optical coherence tomography (OCT) for diagnosing glaucoma in children. Methods: The study was comprised of 127 eyes of 84 patients (aged 6 to 18 years) who visited our institute between March 2006 and February 2008. Subjects were classified into normal, glaucoma suspect and glaucoma groups, and each eye was scanned using Stratus 3.0 OCT. Routine ophthalmic examinations including fundus examination, visual field test and OCT RNFL analysis were performed. Results: There were 55 normal eyes, 27 glaucoma suspect eyes and 45 glaucomatous eyes. The average RNFL thickness was the most useful parameter to differentiate between the glaucoma and non-glaucoma groups. The next most useful parameter was inferior average thickness, followed by superior RNFL thickness. The sensitivity and specificity of the new discriminant of the formula used were 78%, and 68.6%, respectively. Conclusions: In OCT analysis, the average RNFL thickness is the most useful parameter in the diagnosis of glaucoma in children. The new discriminant of the formula is useful in the diagnosis of pediatric glaucoma patients. 목적: 소아에 있어서 빛간섭단층촬영을 통하여 얻어진 지표중에서 어떠한 지표가 녹내장 진단에 있어 유용한지 알아보고자 한다. 대상과 방법: 2006년 3월부터 2008년 2월까지 본원 안과에 내원한 6세에서 18세 사이의 소아 84명 127안을 대상으로 하였으며 모든 환자에게 안과학적 검사와 빛간섭단층촬영을 이용한 망막신경섬유층두께 분석을 시행하였다. 대상을 정상, 녹내장의증, 녹내장군으로 구분하여 결과를 후향적으로 조사하였다. 결과: 정상안은 55안, 녹내장의증안은 27안, 녹내장안은 45안으로 분류되었고 녹내장과 가장 높은 상관관계 및 민감도를 보이는 지표 는 평균 망막신경섬유층두께였고 하측, 상측 망막신경섬유층두께 순이었다. 상측, 하측, 평균 망막신경섬유층두께를 조합한 판별식의 판별력은 각각을 이용한 판별력보다 높았고 민감도는 78%, 특이도는 68.6%였다. 결론: 빛간섭단층촬영을 통하여 얻어진 지표 중에서 평균 망막신경섬유층두께, 하측 망막신경섬유층두께 순으로 녹내장 진단에 유용 하였고 높은 민감도와 특이도로 가지는 새로운 판별식을 이용하여 녹내장 진단하는 것이 유용하다.

일차 쇼그렌증후군 환자에서 안구표면염색점수와 침샘 신티그래피

박선경,강규동,김현승,황형빈 대한안과학회 2020 대한안과학회지 Vol.61 No.8

목적: 눈마름 임상증상을 보이는 일차 쇼그렌증후군(Sjögren’s Syndrome) 환자에서 안구표면염색점수와 정량화한 침샘 신티그래피지표 간의 상관관계 및 진단적 가치에 대해 분석하고자 한다. 대상과 방법: 2017년 7월부터 2019년 4월까지 류마티스내과에서 의뢰된 눈마름 임상증상을 보이는 쇼그렌 및 비쇼그렌증후군의 성인 51명의 의무기록을 후향적으로 검토하였으며, 일차 쇼그렌증후군과 비쇼그렌증후군 간에 안구표면염색점수와 침샘 신티그래피 각 지표의 차이가 있는지에 대한 비교에는 각각 Mann Whitney U-test 및 student t-test를 사용하였고, 안구표면염색점수와 침샘 신티그래피 지표 간의 상관분석은 Spearman correlation을 사용하였다. 결과: 안구표면염색점수(p=0.021), 귀밑샘의 excretion fraction (p=0.022), 턱밑샘의 excretion fraction (p=0.045)은 일차 쇼그렌증후군과 비쇼그렌증후군 두 군 간에 통계적으로 유의한 차이가 있었으며, 턱밑샘의 uptake ratio (rho=-0.369, p=0.008), 턱밑샘의 excretion fraction (rho=-0.359, p=0.010)은 안구표면염색점수와 통계적으로 유의한 음의 상관관계를 보였다. 결론: 안구표면염색점수는 일차 쇼그렌증후군에서 건성안의 정도를 평가하는 데에 있어서 표준진단법이며, 일차 쇼그렌증후군 환자가 초기에 눈마름 증상을 호소하지 않아도 침샘 신티그래피상에서 기능저하가 관찰될 때 반드시 안구표면병변의 유무를 확인해야 할 것이다. Purpose: To analyze the correlation between the ocular surface staining score and indices of salivary gland scintigraphy in patients with primary Sjögren's syndrome and dry eye symptoms, and to evaluate the diagnostic value of these indices. Methods: The patients were 51 adults with primary Sjögren's syndrome or non-Sjögren's syndrome plus dry eye symptoms, who were referred to our ophthalmology clinic for evaluation of the degree of dry eye at the Department of Rheumatology, from July 2017 to April 2019. The Mann-Whitney U test and student’s t-test were used for analyzing the ocular surface staining score and quantitative indices of salivary gland scintigraphy, respectively, in the primary Sjögren's syndrome and non-Sjögren's syndrome patients. Spearman correlation was used to analyze the correlations of ocular surface staining score with salivary scintigraphy indices. Results: The ocular surface staining score (p = 0.021), parotid gland excretion fraction (p = 0.022), and submandibular gland excretion fraction (p = 0.045) were significantly different between the primary Sjögren's syndrome and non-Sjögren's syndrome patients. The submandibular gland uptake ratio (r = -0.369, p = 0.008) and submandibular excretion fraction (r = -0.359, p = 0.010) were significantly negatively correlated with ocular surface staining scores. Conclusions: The ocular surface staining score was identified as the gold standard for evaluating the degree of dry eye in primary Sjögren's syndrome patients. If salivary gland dysfunction is identified by salivary gland scintigraphy, ocular surface staining should be performed to confirm the presence of ocular surface lesions, regardless of the presence of dry eye symptoms.

구간의 최고속도 설정 및 적용사례

김용석,강규동,Kim, Yong-Seok,Kang, Kyu-Dong 대한교통학회 2011 교통 기술과 정책 Vol.8 No.3

사고예측모형을 활용한 회전교차로 안전성 향상에 관한 연구 - 전라북도를 중심으로 -

김칠현,권용석,강규동 한국도로학회 2016 한국도로학회논문집 Vol.18 No.4

PURPOSES: There are many recently constructed roundabouts in Jeollabuk-do province. This study analyzed how roundabouts reduce the risk of accidents and improve safety in the province. METHODS: This study analyzed safety improvement at roundabouts by using an accident prediction model that uses an Empirical Bayes method based on negative binomial distribution. RESULTS : The results of our analysis model showed that the total number of accidents decreased from 130 to 51. Roundabouts also decreased casualties; the number of casualties decreased from 7 to 0 and the seriously wounded from 87 to 16. The effectiveness of accident reduction as analyzed by the accident prediction model with the Empirical Bayes method was 60%. CONCLUSIONS : The construction of roundabouts can bring about a reduction in the number of accidents and casualties, and make intersections safer.

Genetic risk score combining six genetic variants associated with the cellular NRF2 expression levels correlates with Type 2 diabetes in the human population

신재훈,이경미,신지민,강규동,노주원,조윤신 한국유전학회 2019 Genes & Genomics Vol.41 No.5

Background Type 2 diabetes (T2D) is known as an inflammatory disease. NRF2 (Nuclear Factor Erythroid 2 Like2) encodes a transcription factor that binds to antioxidant response elements (AREs) and regulates the expression of genes involved in many antioxidant responses. Objective This study aimed to gain insight into individual anti-inflammatory activity to prevent T2D development in humans. Methods We performed a genome-wide association study (GWAS) to identify genetic variants influencing NRF2 expression in LCLs (lymphoblastoid cell lines) generated from 74 different individuals. Association analyses between T2D or its related traits and genetic risk score (GRS) calculated by combining genetic variants detected from GWAS for cellular NRF2 expression were performed using data from 8715 subjects. The T2D prediction model using GRS was evaluated by measuring the area under the curve (AUC) of the receiver operating characteristics (ROC) curve. Results Our GWAS identified six genetic variants (SNP) showing suggestive evidence of associations with cellular NRF2 expression (P < 10− 6). Logistic regression analysis demonstrated that GRS was associated with an increased risk of T2D (P value = 0.003, OR = 1.13). In addition, linear regression analyses showed positive associations between GRS and fasting glucose (P value = 0.028, β = 0.62), 2-h glucose (P value = 0.0004, β = 1.13) and HbA1C (P value = 0.033, β = 0.03). In the T2D prediction model using GRS, the AUC of the ROC curve was 0.69. Conclusion This study highlights genetic variants associated with cellular NRF2 expression and suggests that the GRS of NRF2 expression-associated variants is likely to be a useful indicator of T2D development in the human population.

백내장 수술 안내 영상물 제작을 통한 고객 만족도 향상

문정일,박주완,최윤주,김연덕,강규동,송민혜,이경민,이상규,이미연,박지선,황현주 한국의료QA학회 2005 가을학술대회 Vol.2005 No.2

차량신호등 위치 조정을 통한 교차로 안전성 강화방안 연구

이점호(Jeom Ho Lee),강규동(Kang, Kyu-Dong),정진형 대한교통학회 2005 대한교통학회 학술대회지 Vol.49 No.-

정부에서는 교통사고 잦은 곳 개선사업을 1988년부터 꾸준히 추진해 오면서 매년 적게는 10%대 내외에서 크게는 28~40%대까지 교통사고 사망자를 줄여오는 커다란 성과를 거두어 왔으나 2000년 들어서는 교통사고 사망자 및 사고건수 감소 폭이 크게 줄어든 것이 사실이다. 따라서 본 연구는 신호 교차로의 기하구조 개선과 함께 신호교차로의 차량신호등위치조정에 따른 조정 전/후 교통사고 감소효과를 비교분석하고 향후 차량신호등위치조정과 더불어 실제 황색시간, All Red현시조정에 대해서도 검토하고자 한다.