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Ehrlich 복수암의 피하이식에 대한 능동면역 생쥐의 비장 및 장간막 임파절의 반응
고흥수,박희설,홍재흥 최신의학사 1972 最新醫學 Vol.15 No.9
It is a well known fact that immunotherapy of tumor consists of active immunization, passive immunization, adoptive immunization and treatment with immunogeneic nucleic acids. It has now been firmly established that active immunization of a susceptible animal with live tumor cells given in subliminal dose, with properly killed tumor cells, or with the oncogenic virus establishes immunity and solid resistance to challenge with either the oncogenic virus or with tumor cells. Kown and Kim (1972) observed a high level of immunity was produced in mice against subcutaneously implanted Ehrlich carcinoma by mounting of diffusion chamber containing live tumor cells and suggested the immunity produced by live tumor cell was cell--mediated. It is also a well known fact that in the cell-mediated immune reaction a small thymus-dependent lymphocyte transforms into a large pyroninophilic cell at the thymus-dependent area-paracortical area of the lymph node and periarterial sheath of the spleen, in response to antigen, which will elicit either a delayed hypersensitivity reaction or an allograft rejection response (Parrott et al. , 1966). In this paper we made an attempt to observe the response of thymus-dependent area both of t .e spleen and the lymph node of the survived mice following active immunization with live Ehrlich ascites tumor cell in intraperitoneally mounted diffusion chamber against subcutaneously challenged tumor. The results were as follows: Proliferation of large lymphoid cells in periarterial sheath of the spleen and paracortical area of ! i the mesenteric lymph node and tile development of paraccri.cal area of the nicserteric lymph node was prominent in the survived mice 40 days after subaxiilar challenge. of E arlich ascites tumor, which is inoculated 4 or 5 weeks after mounting or 2 weeks after removal of mounted diffusion chamber for 1 or 2 week duration.
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박찬규(CK Park),양인환(IW Yang),고흥수(HS Koh),홍성선(SS Hong) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.6
Ovarian tumors are one of the many neoplasms seen in the practice of gynecology. Becaus of the various types no basic etiology has been established. Numerous classifications have been devised based on etiology, histology and embryology, but no one has been universally accepted by gynecologists or pathologists. Only a few statistical surveys on ovarian tumors have been reported in Korea and even the small numbers of reports show great variation in their results. The author undertook this study because of the importance of a clinico-pathologic survey of ovarian tumors as observed in Korea. A Clinico-pathological as well as statistical survey was made on a series of 230 ovarian tumors admitted, operated upon and confirmed with post-operative histopathologlcal study as the Department of Obstetrics & Gynecology and Department of Surgery, Severance Hospital, Yonsei University during a period of 5 years and 7 months from January, 1961 to July, 1966. The results obtained are as follows: 1. The incidence of benign tumors was 87.4% of all ovarian tumors while that of malignant ones 12.6%. 2. Age distribution of benign tumors was between 26-46(average 36 years), while that of malignant ones 31-59(average 45 years). 3. Menstruation was regular in 57.8%, irregular in 11.7% and the rest were amenorrheic. Patients with benign tumors had regular cycle in 59.7%, irregular in 11.7%. 4. Among the subjective symptoms complained of by the patient, 51.3% noticed a lower abdominal mass, 47.4% complained of lower abdominal pain and 15.6% had backache. 5. As to objective signs among the ovarian tumors, ascites were observed in 27 cases(11.7%), cachexia in 6 cases(2.6%). In malignant tumors ascites and cachexia Were noted in 65.5%, 20.7% respectively while in benign ones none had cachexia and only 3.9% had ascites. 6. The size of benign and malignant ovarian tumors were average 11cm, 10.5cm respectively while that of non-neoplastic cyst among the benign tumors was average 9.9 cm. 7. Of all the ovarian tumors 45.9% were noted in the right ovary, 33.8% in the left. Benign tumors were observed 51.3% in right ovary, 37.8% in left while among the malignant tumors 24.1% were right, 17.2% in left. We can see the greater occurrence of tumors in right ovary in both the benign and malignat catagory. 8. The order of incidence of the benign tumors was dermoid cyst 30.4%, pseudomucinous cystadenoma 15.4%, simple cyst 14.4% and serous cystadenoma 11.4% while the incidence of the malignant ones was serous papillary cystadenocarcinoma 34.5% krukenberg tumor 24.1% and pseudomucinous cystadenocarcinoma 20.7%. 9. Among the neoplastic ovarian cysts dermoid cysts were bilateral in 14.8%, serous cystadenoma in 8.7% and pseudomucinous cystadenoma in 6.4%. 10. The incidence of malignancy in the serous neoplasms, pseudomucinous ones and dermoid cysts was 43.5%, 19.4% and 1.6% respectively while the malignancy of all the ovarian tumors was 12.6%.
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