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소아과 영역 감염증에 대한 SAGACIN의 임상적 연구
마재숙,최영륜,황태주,손철 대한화학요법학회 1985 대한화학요법학회지 Vol.3 No.1
SAGACIN is a new aminoglycoside antibiotic with a broad spectrum of antimicrobial activity smilar to that of gentamicin. The clinical studies on SAGACIN were performed in the pediatric field and following results were obtained. 1) SAGACIN was administered intramuscularly to 30 pediatric patients who had bacterial infections: 12 cases with urinary tract infections and 18 cases with pneumonias. The therapeutic results in 12 cases with urinary tract infections were excellent in 6 cases) good in 3, fair in I and poor in 2, and the clinical effectiveness rate (defined as the sum of excellent and good response) was 75.0%. In the 18 cases with pneumonias, the clinical response was excellent in 4 cases, good in 9, fair in 1 and poor in 4, and the clinical effectiveness rate(defined as the sum of excellent and good response) was 72.2%. The overall clinical effectiveness rate (defined as the sum of excellent and good response) in the total 30 patients was 73.3%. In the bacteriological results, the eradicative effects on causative organisms in urinary tract infections and pneumonias were seen in 66.67% a:nd 55.55% respectively, and the overall eradicative effect on causative organisms in the total 30 patients was 60.0%. 2) No side effects were observed and there were no abnormalities in the laboratory findings of complete blood count, liver function tests, urinalysis, BUN and creatinine level.
6개월 여아에서 일측성으로 발생한 급성 파종성 뇌척수염 1례
박기원, 김근모, 안여현, 우영종, 마재숙, 류인훈(Ki Won Park, Keun Mo Kim, Y대 Hyeon Ahn, Young Jong Woo, Jae Sook Ma, In Hoon Ryu) 대한소아신경학회 1996 대한소아신경학회지 Vol.3 No.2
A six months old female infant was admitted with an abrupt onset of high fever and prolonged left hemiconvulsion followed by left hemiparesis. She hand a history of an acute upper respiratory tract infection with improvement two weeks before the admission. On admssion, EEG showed lazy phenomenon in the right side and diffuse slowing on the right hemisphere. MRI revealed multiple patchy lesions of high signal intensity in the right basal ganglia and periventricular areas on the T2WI. There was no abnormal finding on the magnetic resonance angiography. She had recovered with conservative treatmen and the unilateral brain lesions were progressively disappeared on the follow-up MRI studies. These unilateral demyelination lesions might be considered as one of the causes of acute infantile hemiplegia or hemiconvulsion-hemiplegia syndrome(HHS) in infancy, and the ADEM should be included as a cause of HHS.
만성 B형 간염 바이러스 감염 환자에서 혈청 Cytokine에 관한 연구
김병주,마재숙,황태주,Kim, Byung-Ju,Ma, Jae-Sook,Hwang, Tai-Ju 대한소아소화기영양학회 1998 Pediatric gastroenterology, hepatology & nutrition Vol.1 No.1
목 적: 혈청 B형 간염 바이러스 표면 항원(HBsAg)이 양성인 만성 보유자 35명에서 혈청 Th1계 싸이토카인(IL-2, TNF-${\alpha}$ 및 IFN-${\gamma}$)과 Th2계 싸이토카인(IL-4와 IL-10)을 측정하여 만성 B형 간염 바이러스 감염 환자의 병태에 따른 싸이토카인의 변화를 구명하고자 하였다. 방 법: 대조군은 항 HBs 항체 양성인 정상 소아 7명이었고 환자군 35례중 HBeAg 양성군은 20례, 항 HBe 항체 양성군은 15례이었으며 간 조직검사를 시행한 19례중 만성 지속성 간염은 10례, 만성활동성 간염은 9례이었다. 말초 정맥혈로부터 혈청을 분리하여 aminotransferase, B형 간염 바이러스 표지자 검사 및 ELISA로 싸이토카인(IL-2, TNF-${\alpha}$, IFN-${\gamma}$, IL-4 및 IL-10)을 측정하였다. 결 과: 1) HBe 항원 양성인 환자에서 항 HBe 항체 양성인 환자에 비해 그리고 만성 활동성 간염 환자에서 지속성 간염 환자에 비해 의의 있게 혈청 AST와 ALT치가 높았다. 2) HBe 항원 양성인 환자에서 항 HBe 항체 양성인 환자에 비해 IL-10이 의의 있게 높았다. 3) 만성 활동성 간염 환자에서 지속성 환자에 비해 통계학적인 의의는 없었으나 측정한 모든 싸이토카인이 높은 경향을 보였다. 4) 혈청 아미노전이 효소치가 100 U/L 이상인 환자에서 IL-2, TNF-${\alpha}$, IFN-${\gamma}$ 및 IL-10이 높은 경향을 보였고 혈청 아미노전이 효소치가 정상인 환자에서 효소치가 높은 환자에 비해 IL-4가 높은 경향을 보였다. 결 론: Th2계 싸이토카인인 IL-10의 증가는 간염의 활성도보다는 HBe 항원의 지속성과 관련이 있고 Th1계의 싸이토카인인 IL-2, TNF-${\alpha}$ 및 IFN-${\gamma}$는 간염의 활성도 증가와 관련이 있음을 시사하였다. Purpose: The aim of this study was to clarify the serum cytokine pattern in patients with chronic HBV infection in terms of their clinical state. Methods: Intravenous blood samples were taken from 35 patients who were seropositive for HBsAg for at least 6 months and 7 healthy controls. Samples were initially tested for serum aminotransferases and serologic markers for hepatitis B virus by EIA. Serum levels of interleukin(IL)-2, tumor necrosis factor-alpha (TNF-${\alpha}$), interferon-gamma (IFN-${\gamma}$), IL-4, and IL-10 were measured by ELISA. Results: Among 35 patients, seropositive for HBeAg was 20 and for anti-HBe was 15. The histologic diagnosis of 19 patients underwent liver biopsy were chronic persistent hepatitis (CPH) in 10 and chronic active hepatitis (CAH) in 9. Serum IL-10 level in patients seropositive for HBeAg was significantly higher than that in patients seropositive for anti-HBe (p<0.05). All measured cytokine levels in patients with CAH were higher than those of patients with CPH. High values of all measured cytokines except IL-4 were seen in patients with AST and ALT > 100 U/L. High level of IL-4 was seen in patients with normal aminotransferase levels. Conclusion: These results were thought to indicate that anti-inflammatory Th2-like cytokine (IL-10) production in chronic HBV infection is related to circulating HBeAg rather than activity of hepatitis and that Th1 cytokines seem to be associated with the increasing activity of hepatitis.