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흰쥐의 위십이지장에서 방사선 조사에 의하여 유발된 Apoptosis와 세포증식능의 변화
민병운 ( Byung Woon Min ),황구연 ( Koo Yeon Hwang ) 대한임상검사과학회 2003 대한임상검사과학회지(KJCLS) Vol.35 No.2
Radiation-induced apoptosis has been extensively studied in the small intestine where has higher cell proliferation and lower frequency of cancer. There has been no report about radiation-induced apoptosis in the stomach despite high incidence of cancer. The aim of the present study was to evaluate the alterations of radiation-induced apoptosis and cell proliferation in rat stomach. Sprague-Dawley rats were exposed to a single dose of 2 Gy gammy rays and sacrificed at 1, 2, 4, 8, 12, 24 and 48 hours after irradiation. Apoptotic cells and bodies were observed by light and electron microscopy and in situ end labeling (ISEL). Immunohistochemical staining for proliferating cell nuclear antigen (PCNA) was performed simultaneously to evaluate the cell proliferation. Apoptotic index (AI) was defined as the mean number of ISEL-positive cells per fifty longitudinally sectioned gastric glands or duodenal crypt-villi. PCNA index (PI) was also measured by same method of AI. The distribution of ISEL- or PCNA-positive cells was expressed in tripartition on the stomach and quintile on the duodenum from the base of the mucosa. Morphological features of apoptosis were observed with light and electron microscope. The control levels of AI for the stomach and duodenum were 0.12 and 0.26, respectively. After irradiation, an increase of AI from the control levels was observed; AI for the stomach and duodenum reached a peak at 2 hour (0.26) and 4 hour time points (2.05) respectively. Thereafter, AI of both values were declined and returned to the control levels at up to 48 hours time point. The peak position of radiation-induced apoptosis was middle third in the proximal stomach, lower third in the distal stomach, and crypt (1/5-2/5) in the duodenum, respectively. The control levels of PI for the stomach and duodenum were 3.71 and 16.87, respectively. After irradiation, the time course of PI in the gastroduodenum were correlated well with AI. The distribution of PCNA- positive cells was coincident with ISEL-positive position.
양근호,민병운,Yang, Keun-Ho,Min, Byung-Woon 한국전자통신학회 2013 한국전자통신학회 논문지 Vol.8 No.6
In this paper, the research is to develop a system that can detect the breakage of the rubber belt conveyor system in the transport of the raw materials required for the operation of logistics. We are to develop a system that can detect the breakage of the belt due to the electronic system of belt breakage occurs by placing the material on the inside of the belt, electric induction to minimize the damage of the belt. The belt repair costs, or reorder the steps of the logistics transit time can be reduced. Induced in the coil, and belt embedded in the transmitted signal as a way to detect the breakage of the belt was to detect the damage of the belt by detecting the electrical phenomena induced in the coil at the receiving end. 본 논문에서는 물류 시스템에서 원료의 운송 작업에 필요한 컨베이어 고무벨트의 파손을 감지할 수 있는 시스템 개발에 대한 연구이다. 벨트의 내부에 전기 유도가 가능한 재료를 삽입하여 벨트의 파손이 발생했을 경우 전자 시스템에 의한 벨트의 파손을 감지할 수 있는 시스템을 개발하여 벨트의 파손을 최소화하도록 하였다. 따라서 벨트의 수리비용이나 운송 중인 물류의 재정리 단계의 시간을 줄일 수 있다. 벨트의 파손을 감지하기 위한 방법으로 송신 신호를 벨트 내에 삽입된 코일에 유도하고, 수신 측에서 코일에서 유도되는 전기 현상을 감지하여 벨트의 파손을 감지하도록 하였다.
양근호,민병운,Yang, Keun-Ho,Min, Byung-Woon 한국전자통신학회 2013 한국전자통신학회 논문지 Vol.8 No.9
본 논문에서는 알칼리성 또는 산성을 띠는 특정 용액 내에서 전기분해 원리를 이용하여 금속 표면을 산화시켜 절연피막을 형성하는 장치를 개발한다. 기존에는 주로 양극에만 펄스 형태로 전압을 인가하는 단극성(unipolar) 방식이지만 본 논문에서는 H-브리지를 이용하여 양극에 양(+)전압과 음(-)전압을 번갈아 가면서 전압을 공급하는 양극성(bipolar) 장치를 제작하였으며, 금속 시편의 특성에 맞는 다양한 전기적인 조건을 가지고 산화피막을 형성할 수 있는 장치를 개발하였다. 공급전류 가변은 PWM 변조를 이용하였으며, (+)와 (-)의 극성변화는 H-브리지를 이용하여 양극성 펄스전압을 공급할 수 있도록 하였다. 그 결과로써 단극성보다 균일한 기공을 갖는 피막이 형성되었다. In this paper, alkaline or acidic solution, in particular the principle of electrolysis to oxidize the metal surface to form a device isolation film is developed. In the past, mainly in the form of pulse voltage is applied to the anode only a unipolar method, but in this paper by using the H-bridge to the amount of the positive (+) voltage and the negative supply voltage, alternating voltage polarity devices were fabricated according to the characteristics of metal specimens with different electrical conditions to form an oxide film on the device was developed. Supply current variable was used for the PWM modulation, (+) and (-) polarity change of the H-bridge bipolar pulse voltage to supply the was that. As a result, a more uniform pores with unipolar film was formed.
C57BL/6 마우스에서 고지방 식이와 CCl4로 유발한 간섬유증에 미치는 커큐민의 보호효과
제갈승주 ( Seung Joo Jekal ),민병운 ( Byung Woon Min ),박호 ( Ho Park ) 대한임상검사과학회 2015 대한임상검사과학회지(KJCLS) Vol.47 No.4
Curcumin, a major polyphenolic compound of turmeric, is well known to prevent non-alcoholic steatohepatitis (NASH) related to obesity. The aim of the study was to investigate the effect of curcumin on hepatic fibrosis induced by carbon tetrachloride (CCl4) in obese mice. CCl4 was administrated in mice fed a normal diet (ND) or a high fat diet (HFD) for 7 weeks together with or without curcumin. It was conducted to examine for metabolic profiles, adipocyte size, and liver fibrosis by serum biochemistry, histology and immunohistochemistry. Also, Apoptosis of hepatic cells was determined by the TUNEL method. Treatment with curcumin significantly lowered the body weight, fasting glucose, serum AST and ALT, and decreased the adipocyte size, the number of macrophage and mast cells in adipose tissue, and collagen deposition in liver tissue in the HFD+CCl4 group compared with the findings of the HFD+CCl4 group. In contrast, treatment with curcumin on the ND+CCl4 group did not show a significant difference except the body weight and mast cell number when compared with the ND+CCl4 group. Furthermore, curcumin significantly reduced the number of parenchymal apoptotic cells, whereas it increased the number of non-parenchymal apoptotic cells, especially resembling an activated hepatic stellate cell in the liver. Taken together, this data suggests that curcumin might be an effective antifibrotic drug for the prevention of liver disease progression in obese mice. Thus, the development of curcumin as a therapy for obesity and liver fibrosis is supported.
마우스의 복벽에서 결합조직에 대한 금속 이식체의 생체적합성 비교
김국렬(Kuk Ryul Kim),이민호(Min Ho Lee),김병일(Byung Il Kim),민병운(Byung Woon Min),김명훈(Myung Hoon Kim),최은상(Eun Sang Choe),조현욱(Hyun Wook Cho) 한국독성학회 2004 Toxicological Research Vol.20 No.1
The purpose of this study is to compare the biocompatibility of commercial purity Ti, Ti-6Al-4V and Ti-6Al-7Nb alloy specimens with and without surface treatment in mouse abdominal connective tissue in vivo. Each metal was implanted into specific abdominal subdermal tissue site of female mouse. After 4 weeks, the implants were removed and abdominal tissues were fixed, dehydrated and embedded in glycol methacrylate resin. And the tissues were histologically prepared for microscopical evaluation. It was characterized by the presence of connective tissue with fibrous capsule surrounding the implant. The fibrous tissue surrounding the implant was studied to determine the biocompatibility of implanted metals. The average thickness of the fibrous capsule formed around the implant was much thinner for the hydrogen peroxide added hydrochloric acid solution-treated specimen than for the others. The results of this evaluation indicate that modification of the surface properties<br/> of titanium and titanium alloy implants changes the biological properties in the abdominal connective tissue. In conclusion, these observations suggest that the proper surface treatment performed<br/> in the study is effective for the improvement of biocompatibility.