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급성 천식발작 환자에서 치료 전후의 혈청 Eosinophil Cationic Protein 농도
김윤근(Yun Keun Kim),이상록(Sang Rok Lee),손지웅(Jee Wong Son),김우경(Woo Kyung Kim),박재경(Jae Kyung Park),지영구(Young Ku Jee),송숙희(Sook Hee Song),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.3
N/A Objectives: To prevent progression to fatal asthma it is essential to assess the severity of asthma and treat adequetely. But there was no objective index to evaluate the severity of airway inflammation in asthmatic patients, So we evaluated that serum ECP concentration is a objective parameter of airway inflammation in patients with acute severe asthmatic attack. Methods: We measured the parameters of asthamtic severtity(clinical parameter, FEV1, arterial blood gas, peripheral blood eosinophil counts, and serum ECP levels) before and after antiasthmatic treatment in 9patients with acute severe asthmatic attack, And we compared serum ECP concentrations of severe asthmatic patients with those of control patients with mild to moderate severity. Results: 1) The serum ECP levels in patients with acute asthmatic attacks compared to patients with mild to moderate, asthmatic severity were significantly increased. 2) The serum ECP levels and pheriperal blood eosinophil counts 2hours after antiasthmatic treatment were significantly lower than the value before treatment, but the total scores of clinical parameter, FEV1, and scores of arterial blood gases were not significantly different from the basal values, Conclusion: It is suggested that the serum ECP level is a objective parameter as a response to antiasthmatic treatment as well as a severity of airway inflammation in patients with acute asthmatic attack.
김윤근 ( Yun-keun Kim ),박복재 ( Bok-jae Park ) 한국통상정보학회 2017 통상정보연구 Vol.19 No.2
국제무역에서 전자상거래가 차지하는 비중은 급속도로 증가하고 있지만, 가장 기본적인 개념정의와 적용규범에 대한 합의도 이루어지지 않은 상태이다. WTO에서는 `디지털 콘텐츠`에 잠재적 무관세를 시행하는 한편 작업계획(Work program)을 통해 전자상거래에 대한 폭넓은 연구를 진행하고 있으며, 각국은 FTA 등의 협정을 통해 자국의 이익을 추구하고 있다. 본 연구는 한국이 체결·시행하고 있는 FTA 중에서 전자상거래에 관한 규정을 비교·분석하였다. 한국의 FTA전자상거래 규정은 무관세, 다른 장(chapter)의 규정과 충돌 시 다른 장의 규정 우선, 전자인증, 개인정보보호, 소비자보호 등에 대해서는 공통적이지만, 전자상거래의 대상을 각기 다르게 정의하고 있고, 전자상거래의 분류 및 적용규범에 대해서는 유보하고 있으며, 비차별대우에 대해 다르게 규정하는 등 일관성이 부족하고 체계적이지 못한 상황이다. 한국은 WTO 등의 연구에 참여하고, 미국, EU, 중국 등이 체결·시행하고 있는 FTA전자상거래 규정을 분석하여 적극적·탄력적으로 대처할 필요가 있다. Though electronic commerce has grown rapidly in international trade, there is no basic consensus for its concept and rule applied. So WTO has done practice of not imposing customs duties on digital contents and been researching overall on electronic commerce through Work Program while many countries of the world attempt to obtain their interests by stipulating chapter of electronic commerce in their FTAs. This paper has compared and analysed chapter of electronic commerce in all the FTAs which Korea has signed and enforced. Korea`s FTA stipulates commonly no customs duties, the other chapter`s priority when chapter of electronic commerce conflicts the other chapter, electronic authentication, protection of personal information and consumer protection. But it has weak consistency and framework as it has different provisions for the objects of electronic commerce respectively, reserves classification & applied rule for electronic commerce, stipulates differently on non discrimination treatment and so on. Korea should participate in the research of international organization including WTO and cope actively and elastically by analysing the provisions of electronic commerce of the other countries` FTA such as USA, EU, CHINA and so on.
기관지천식이 없는 일반인에서 메타콜린에 대한 기관지반응의 양상
김윤근,손지웅,이상록,김우경,조상헌,이명현,고영률,민경업,김유영 ( Yoon Keun Kim,Jee Wong Son,Sang Rok Lee,Woo Kyung Kim,Sang Heon Cho,Myung Hyeon Lee,Young Yull Koh,Kyung Up Min,You Young Kim ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Backgrognd: Bronchial hbyperresponsiveness (BHR) is a key feature of asthma, and may precede the development of asthma. Genetically determined and acquired factors may contribute to development of BHR. Objective .' To evaluate expression of bronchial responsiveness to methacholine according to age, sex, smoking habit, and atopy in general population without bronchial asthma, a cross sectional study was performed. Method: A total of 1,190 general population who composed of 408 subjects with age less than 19 years (young age group), 621 subjects with age from 20 to 40 years (middle age group), and 161 subjects with age more than 41 years (old age group) were enrolled. Evaluations were made by a questionnaire, serum IgE level and skin prick test to common inhalant allergens, and methacholine bronchial provocation test (MBPT). Bronchial responsiveness were evaluated by positive rate of MBPT (PC,p-methacholine 4 25mg/ml), and slope of dose- response curve (slope, %fall of FEV, / log[last concentration of methacholine, mg/ml]). Result: Positive rate of MBPT was 11.0%, and slope (mean+SE) was 10.6+0.2 %/mg/ml. Postive rate of MBPT was more prevalent in the young age group than in middle and old age groups (19.6% vs. 6.6% vs. 6.2%, p<0.05), and slope was higher in young age group than in other groups (14.4+0.4 vs. 8.6+0.3 vs. 8.9+0.5 %/mg/ml, p<0.05). No significant differences in positive rate of MBPT and slope were noted according to sex in young and old age groups. However, in the middle age group, slope was higher in females than in males (9.5+0.4 vs. 7.9+ 0.3 %/mg/ml, p<0.05). No significant differences of slope was observed according to smoking habit in males of middle age group, but in males of old age group, the slope was higher in subjects with smoking habit than those without it (9.6+0.8 vs. 6.5+0.9 %/mg/ml, p<0.05). Sig- nificant relationship was observed between geometric value of serum IgE level and slope(r=0. 152, p=0.009). The postive rate of MBPT and slope were significantly higher in subjects with positive skin rea,ctivity to common inhalant allergens than those without it (14.3% vs. 8.6%, p ( 0.05; 11.8+0.4 vs. 9.8+0.3 %/mg/ml, p<0.05). The difference of bronchial responsiveness according to skin reactivity was observed in young and middle age groups, but not in old age group. Conclusion : Bronchial responsiveness to methacholine is significantly higher in children than in adults, in middle-aged females than in middle-aged males. Atopy and smoking may have a dif ferent role to determine the bronchial responsiveness depending upon age and sex.