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Brain SPECT 영상의 Attenuation Correction 방법들에 대한 비교
조진우,김창호,나수경,이귀원,Jo, Jin U,Kim, Chang Ho,Na, Soo Kyung,Lee, Gui Won 대한핵의학기술학회 2012 핵의학 기술 Vol.16 No.2
이 연구의 목적은 Brain SPECT (Single Photon Emission Computed Tomography)의 Non-attenuation correction (AC-non) 영상에 대한 attenuation correction(AC) 방법 중 Chang's method와 CT based attenuation correction(AC-CT) 사이의 count를 비교하기 위함이다. phantom study는 증류수로 채워진 hoffman 3D phantom에 $^{99m}Tc$ 37Mbq을 투여하였고, patient study는 normal volunteer에 $^{99m}Tc$-HMPAO 750Mbq를 정맥주입하고 Siemens사의 Symbia T6로 Brain SPECT 영상을 획득하였고 뇌 정량 분석을 하였다. 각각의 방법들을 적용한 transverse image는 같은 위치에서 재구성 되었으며 각각 10, 20, 30번째 slice에서 6개의 region of interest(ROI)를 그려 AC-non 과 AC-CT 그리고 Chang's method의 count를 비교하였다. phantom study에서 AC-non, AC-CT, Chang's method의 각각 평균 count는 $4606.8{\pm}511.3$, $16794.6{\pm}2429.4$, $8752.6{\pm}896.5$이었으며 patient study에서 $5460.8{\pm}519.6$, $15320{\pm}1171.6$, $12795{\pm}1422.1$이었다. phantom study에서 AC-CT와 AC-non 사이의 비는 3.70이고 Chang's method와 AC-non 사이의 비는 1.92였으며 patient study에서는 각각 2.85, 2.38이었다. 우리는 이 연구를 통하여 AC-CT가 Chang's method보다 더 높은 AC을 해준다는 걸 알 수 있었다. 그리고 Chang's method는 patient study에서의 AC 값이 phantom study에서의 AC값보다 더 높다는 것을 알 수 있었다. brain SPECT/CT를 시행하는 경우 scatter correction을 같이 시행하고 bone에 의한 감쇠 정보를 반영할 수 있는 AC-CT가 chang's method보다 정확하다 할 수 있겠다. Purpose : The purpose of this study was to compare count between Chang's method and CT-based attenuation correction (AC-CT) among the attenuation correction (AC) methods for non-attenuation correction (AC-non) images of Brain SPECT (Single Photon Emission Computed Tomography). Materials and Methods : We injected $^{99m}Tc$ 37Mbq in a Hoffman 3D phantom filled with distilled water in the phantom study, and injected intravenously $^{99m}Tc$-HMPAO 740Mbq in a normal volunteer in the patient study, and then obtained Brain SPECT images with Symbia T6 of Siemens and conducted quantitative brain analysis. Transverse images to which each method was applied were rebuilt at the same position, and 6 regions of interest (ROI) were drawn on each of Slice No. 10, 20 and 30 and then the counts of AC-non, AC-CT and Chang's method were compared. Results : The mean counts of AC-non, AC-CT and Chang's method were $4606.8{\pm}511.3$, $16794.6{\pm}2429.4$, and $8752.6{\pm}896.5$, respectively, in the phantom study and $5460.8{\pm}519.6$, $15320{\pm}1171.6$ and $12795{\pm}1422.1$, respectively, in the patient study. In the phantom study, the ratio of AC-CT to AC-non was 3.70 and the ratio of Chang's method to AC-non was 1.92, and in the patient study, they were 2.85 and 2.38, respectively. Conclusion : From this study, we found that AC-CT makes higher AC than Chang's method. In addition, when Chang's method was used, AC in the patient study was higher than that in the phantom study. These results need to be considered also in other examinations.
김봉수,표성재,조용귀,신채호,조진우,김창호,Kim, Bong-Su,Pyo, Sung-Jai,Cho, Yong-Gyi,Shin, Chai-Ho,Cho, Jin-Woo,Kim, Chang-Ho 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.3
목적 : 환자의 피폭선량 감소를 위해 PET/CT검사 시Pitch를 조절하여 환자의 피폭선량을 줄일 수 있는 방법에 대해 고려해 보고 Pitch 조정이 CT 영상과 PET의 SUV값에 영향을 주어 변화가 있는지를 살펴 보고자 한다. 방법 : Siemens사의 Biograph Positron Emission Tomography (PET) Scanner (CT 형식 : TRCT-240-130 (WCT-240-130)을 사용하였다. 환자의 피폭선량 평가로는 CT 조사선량 측정기인 PTW-DIADOS 11003/1383를 사용하여 선량을 측정하였고 Pitch 조정이 CT 영상에 미치는 영향을 알아보기 위해 AAPM Standard Phantom을 이용하여 pitch 변화에 따른 CT 영상의 공간 분해능을 측정하여 비교하였다. 그리고, PET source consists of a solid radioactive cylinder phantom을 사용하여 Pitch 변화에 따른 Fusion 영상의 SUV값을 산출하여 PET/CT 영상에서 SUV값이 변하였는지 확인하였다. 결과 : 2slice CT scanner에서는 Pitch가 0.7~1.3까지는 방사선량이 크게 떨어지나 1.5~1.9까지는 방사선량의 감소가 작아졌으며 Pitch값이 커질수록 환자의 피폭선량이 작아지는 것을 알 수 있었다. 그리고 Pitch값의 증가에 따른 SUV값의 변화는 거의 없었으며. Pitch값이 PET SUV값에 영향을 주지 않는다는 것을 알 수 있었다. Pitch의 변화가 CT 영상에도 크게 영향을 주지 않는 것을 알 수 있었다. 결론 : 위의 결과로 PET/CT를 사용하는 병원은 영상의 왜곡이 없고 PET SUV값에 영향을 주지 않는 범위 내에서 각 병원에 맞는 Pitch값을 찾아서 환자의 피폭 경감을 위해 노력해야 할 것이다. 그리고 Multi-detector를 가진 CT scanner인 경우에 모두 해당 될 것이라 생각되며 향후 다른 장비에서도 이와 같은 실험이 필요하다 하겠다. Purpose: As the number of patients has increased since the installation of a PET/CT, we are now examining about 2500-3000 annually. We have realized that if we properly adjust a pitch under the same condition of a CT during a PET/CT exam, radiation quantity that reaches the patient can change. In order to reduce the exposure dose of a patient, the research examines a method of reducing the exposure dose of a patient by controlling the pitch during a PET/CT exam, viewing whether the adjustment of the pitch influences CT image and PET SUV. Methods: The equipment used is a Biograph Positron Emission Tomography (PET) Scanner (CT type: TRCT-240-130 (WCT-240-130)) of Siemens company. For the evaluation of exposure dose of a patient, we measured radiation quantities using a PTW-DIADOS 11003/1383, which is a CT radiation measurement instrument used by Siemens. We measured and analyzed the space resolutions of CT images caused by the change of pitches using an AAPM Standard Phantom in order to see how the adjustment of pitches influenced the CT images. In addition, in order to obtain SUVs caused by each change of pitches using a PET source made with a solid radioactive cylinder phantom, we confirmed whether the SUVs changed in the PET/CT images by calculating the SUVs of the fusion images caused by the change of pitches after obtaining CT and PET images and finishing the test. Results: 2slice CT scanner showed that radiation quantities largely dropped when pitches ranged from 0.7 to 1.3 and that the reduction of radiation quantities were smaller when pitches ranged from 1.5 to 1.9. That is, we found that the bigger pitch values are the smaller the radiation quantities of a patient are. Moreover, we realized that there is no change of SUVs caused by the increase of pitches and that pitch values do not influence PET SUVs and the quality of CT images. It is judged that using 1.5 as a pitch value contributes to the reduction of exposure dose of a patient as long as there is no problem in the quality of an image. Conclusions: When seeing the result of the research, hospital using a PET/CT should make an effort to reduce the exposure dose of a patient seeking pitch values appropriate for their hospital within the range in which there is no image distortion and PET SUVs are not influenced from pitches. We think that the research can apply to all multi-detectors having a CT scanner and that such a research will be needed for other equipments in the future.
초음파 상호상관 기법을 이용한 유체의 평균유속 측정 연구
김창호,이덕기,백종승,조문재,Kim, Chang-Ho,Lee, Dug-Ki,Paik, Jong-Seung,Jho, Moon-Jae 한국음향학회 1995 韓國音響學會誌 Vol.14 No.2
초음파 상호상관 기법을 파이프를 통해 흐르는 물의 유속측정에 적용하였다. 상호상관 기법을 활용하여 비삽입 방법으로 유체의 평균 유동속도를 측정할 수 있었으며, 이 기법을 이용한 비삽입, 비접촉식 측정방식은 기존의 기계식 유량계의 유동방해로 인한 공정에너지 손실을 크게 감소시키는 장점을 가지고 있다. 유동속도의 계산을 위해 실시간 FFT용 디지탈 신호처리기를 이용하였으며, 50mm에서 248mm의 유동관에서 유동 실험결과 0.25m/s에서 16m/s사이의 유속범위에서 평균유속의 측정 정확도는 약 $1\%$ 나타났다. 상호상관 기법의 유동측정 기술은 상수와 공업용수 등을 포함한 대부분의 액체유량 측정에 활용이 가능하다. An application of the cross correlation technique by adopting ultrasonic waves for water pipe flow measuring purpose is studied. It is a non-intrusive flow metering method by determining the time of the flight of the flow turbulent noise and its non-obstructing mechanism enables to reduce process energy loss due to the flowmeter obstruction. A digital signal processor for the purpose of the real time Fourier transform was employed for the fast time calculation of the flow velocity. The overall accuracy was found as about $1\%$ for flow velocities from 0.25 m/s up to 16 m/s and for the pipe inside diameters from 50mm to 248mm. The cross correlation technique can be used for the tap water utility including most common liquid flows.
하악 2급 이개부 병변 치료시 비흡수성 차폐막과 혈소판 농축 혈장의 임상적 효과에 대한 비교 연구
김창호,임성빈,정진형,홍기석,Kim, Chang-Ho,Lim, Sung-Bin,Chung, Chin-Hyung,Hong, Ki-Seok 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.3
This study was performed to compare the clinical effectiveness of two regenerative techniques for class II furcation involvements in human: a combination of bone grafts with PRP vs. GTR with bone grafts. The e-PTFE group was treated with non-absorbable membrane and bone grafts, the PRP group was treated with PRP and bone grafts Pocket depth, clinical attachment level, and gingival recession were measured at baseline and postoperative 6 months. Vertical and horizontal furcation depth were measured by re-entry surgeries at 6 months post-treatment Both groups were statistically analyzed by Wilcoxon signed Ranks Test & Mann-whitney Test using SPSS program (5% significance level). The results were as follows: 1. The change of pocket depth, clinical attachment level, vertical furcation depth and horizontal furcation depth in both groups was decreased significantly at 6 months than at baseline. (p<0.05) 2. The change of gingival recession in both groups was increased significantly at 6 months than at baseline. (p<0.05) 3. The change of alveolar crest absorption in both groups was increased at 6 months than at baseline but there were no statistically significant differences. 4. The change of pocket depth, clinical attachment level, vertical furcation depth and horizontal furcation depth in both groups was increased significantly at 6 months, but there were no statistically or clinically significant differences with both groups. 5. The change of gingival recession and alveolar crest absorption in both groups was increased at 6 months, but there were no statistically or clinically significant differences with both groups. In conclusion, the use of bone graft with PRP or GTR technique improved clinical index of the soft and hard tissue in mandibular class II furcation involvement but there were no statistically or clinically significant differences between bone graft with PRP and GTR technique.
서거정(徐居正) 초기시에 있어서의 공명(功名)의 문제와 시적 대응
金昌祜 ( Kim Chang-ho ) 동방한문학회 2020 東方漢文學 Vol.0 No.85
본고는 서거정 초기시에 있어서의 功名의 문제와 詩的 對應에 대해 고찰한 것이다. 그간 서거정 문학에 관해서는 성종 대의 역할이 주된 관심의 대상이 되면서, 이전 시기 문학 형성 과정의 특이성이 간과되었음을 볼 수 있다. 서거정은 출사 초반 급변의 정국에서 공명에 대한 열망을 가졌다. 그러나 한명회, 신숙주 등 절친한 이들이 공신의 반열에 오르고 핵심세력으로 부상하는 것을 지켜보아야만 했다. 그의 초기시는 이러한 상황을 배경으로 한다. 서거정의 초기시는 몇 가지 특징을 가진다. 同題 작품 내에서 주제의 충돌이 나타나는가 하면, 같은 시기 작품들 간에 상반된 주제 의식을 보이기도 한다. 정서의 면에서는, 공명에 대한 열정을 드러내기도 하지만 낙담 끝에 귀거래를 다짐하기도 한다. 이 같은 불안정성의 배후에는 공명의식이 핵심으로 자리하고 있다. 공명의식이 현실에서 수용되지 못하고 왜곡되는 지점에서 시인의 첨예한 시적 대응을 확인할 수 있다. 시적 대응은 주로 寓意의 방식이나 想像의 空間을 통해 이루어진다. 그는 진의를 왜곡하는 이들을 시의 편폭으로 끌어들인다. 그리고는 우회적으로 嘲弄하고 揶揄하는 방법을 택한다. 공명을 위한 상황의 개선이 어렵다고 느낄 때에는 상상의 공간을 활용한다. 이를 통해 상상 가능한 功業의 최대치를 표현함으로써 想像的 報償을 추구한다. 그러나 우의의 방식이나 상상적 보상은, 속성상 동전의 양면처럼 공명에 대한 懷疑와 연결되어 있다. 서거정 시의 온전한 이해를 위해서는 초기시에 나타나는 세계에 대한 자아의 치열한 대응에 유의할 필요가 있다. 한편 서거정의 초기시는 정치적 급변 상황에서의 인간 이해에 관한 풍부한 가능성 탐구의 실마리를 제공한다고 할 수 있다. This paper examines the issue of love of honor (功名) and poetic response in Seo Geo-jeong’s early poems. Seo Geo-jeong had a longing for love of honor in the sudden change of the political situation at the beginning of the career. However, he had to watch close friends like Han Myeong-hoe(韓明澮) and Shin Suk-ju(申叔舟) emerge as key forces. His early poems are surrounded by this situation. Seo Geo-jeong's early poems have several characteristics. In terms of subject matter, there may be conflicting subjects within the work of the same title, and the subject consciousness of the works of the same period would be sometimes contradicted. Behind the consciousness of early poems is the consciousness of love of honor. At the point where it is not accepted and distorted in reality, it can be confirmed that it shows a sharp poetic response. The poetic response is mainly achieved through an allegory method or a space of imagination. He draws those who distort true meanings into the space range of poetry. Then, he takes the method of indirectly mocking and booing (揶揄). When he feels that it is difficult to adjust the situation for love of honor, he uses the space of imagination. Through this, the imaginary reward is pursued by expressing the maximum value of the imaginable maneuvering (功業). However, the way of allegory and the imaginary reward, like the two sides of the same coin, are also linked to a deep skepticism about the fleetingness of love of honor. For a full understanding of Seo Geo-jeong’s poetry, it is necessary to pay attention to the fierce response of the ego to the world in early poems. On the other hand, Seo Geo-jeong's early poems can be said to provide a clue to the exploration of rich possibilities for human understanding in a situation of sudden political change.
김창호,유혜린,윤영수,김민영,Chang Ho Kim,Helen Lew,Young Soo Yun,Min Young Kim 대한안과학회 2006 대한안과학회지 Vol.47 No.4
Purpose: Nystagmus is a rare involuntary eye movement which has no known, specific, underlying diseases. Schizencephaly is also a rare disease. A child with generalized developmental delay came to the pediatric clinic. He showed schizencephaly on MRI, and was referred to department of rehabilitation. During rehabilitative evaluation, the patient was referred to the department of ophthalmology due to esotropia. We found that the patient had little esotropia, but did have nystagmus. Therefore, we report a case of congenital nystagmus associated with schizencephaly. Methods: A one-year-old boy showing schizencephaly on MRI and esotropia underwent examination. Results: The patient did not have a remarkable past or familial history, and didn`t show any other anomaly. There were no abnormal findings on slit lamp examination, and according to strabismus studies, he showed very little esotropia. He did show nystagmus. We couldn`t find any significant refractive error or ocular dysfunction on cycloplegic refraction and fundus examination, respectively. Visual evoked potential showed normal findings. On MRI, ordered by the pediatrician, open-lip type schizencephaly on the right frontal lobe and absence of septum pellucidum were seen. There was no endocrinologic abnormality. Conclusions: We report the case of a child with congenital nystagmus accompanied by schizencephaly, and present a literature review.
몇 발근환경인자가 주목삽수 (揷穗) 발근에 미치는 효과
김창호,남정칠 ( Chang Ho Kim,Jung Chil Nam ) 한국산림과학회 1985 한국산림과학회지 Vol.70 No.1
The purpose of this experiment lies in finding the most appropriate cutting condition of Taxus cuspidata Sieb. et Zucc. which has been considered valuable tree species in gardening. Statistical analysis was focused on the comparison of the average ratios of rooting beaween greenhouses and fields, based on the observation rooted autogenis. To conduct this survey, hardwood cutting of Taxus cuspidata Sieb. et Zucc. were performed at both places of experiment above on April 20, 1982 with rooting results calculated on October 31, 1982. After formation of cuttings, it was soaked in IBA 200 ppm for 12 hours and than put in a bed. A summary of the result is presented as follows; 1) Cutting at the greenhouse showed higher average rate of rooting than at fields. Same tendency was found regardless of the differences in treatment. 2) It was clear that IBA-treatment contributed remarkably to causing higher average rooting rate. As an evidence, when twenty centimeter cuttings were inserted sandy media, IBA-treated area resulted in eighty six percent of average rooting rate, as compared with only twenty three percent in nontreatment case. In case of field cutting, IBA-treatment brought about fifty three percent of rooting in comparison with eleven percent nontreatment. 3) When sandy soil, loam and brown soil were separately used as cutting media, the highest rooting rate was found in case of sandy soil, without any difference between the two experimental places above. 4) As a result of the analysis to seek the impact of the length of cuttings on rooting, the range of length form fifteen to twenty centimeter was apparently most appropriate. It was also found that the rate of rooting declined beyond twenty five centimeter. 5) Two kinds of rooting pattern were observed. One was the case that callus cell lump was created on the lower cut side of cuttings. Importantly, root radical were formed inside the lump to influence the germination of root system. The other relates to the case that adventitious root which look like lateral roots appeared at the stem region. In abstract, first, sandy soil was effectively recommended in case of hardwood cutting in April. Second, the most appropriate length of cuttings ranged between fifteen and twenty centimeters. Third, high density IBA treatment was clearly effective. Forth, for proper environmental management, both pre-disinfection of sail by sterilizer and maintenance of high relative humidity were essentially required.