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김광중,김원석 대한피부과학회 1981 大韓皮膚科學會誌 Vol.19 No.1
Many investigators have attempted to elucidate the basic pathogenic mechanisms of atopic dermatitis through clinical and laboratory investigations and haute no longer attached to the etiological significance to IgE which is known to iae a mediator of the so-called atopic diseases. In recent years, many authors have reported some abnormalities not only in tln,. humora.l but also in cellular immune status of patients with atopic dermatitis. although such findings are more or less controversial. The present study was undertaken to evaluate the cell-mediated immune status of patients with atopic. dermatitis using several in vitro and in vivo immune parameters. Forty patients between the ages of 2 and 13 years were observed at the Department of Dermatology of Seoul National University Hospital from March 1980 through September 1980. The diagnosis of atopic dermatitis was based on the well-delineated clinical arid historical features and all patients were not given systemic corticosteroid therapy for 2 months before study. Agematched 15 children comprised the control group. Peripheral blood T lymphocytes, (early and late) were enumerated by the E-rosette technique in 40 atopic subjects and 15 control subjects. Delayed cutaneous hypersensitvity to intradermal trichophytin, candidin and PPD were measured in 30 patients and 15 controls. Active sensitization with DNCB was performed on 30 patients and 15 controls. The results were summarized as follows. 1. The mean percentage of T lymphocytes (late) in 40 patients with atopic dermatis and 15 control subjects was 56.2% and 64.3% respectively. The mean percentage of T lymphocytes (early) in 40 patients and 15 controls was 40.6% and 51.4% respectively. There was a significant decrease of both early and late T lymphocytes in patients with atopic dermatitis (p$lt;0.05). 2. The percentage of subjects showing positive delayed cutanfous hypersensitivity reaction to intradermal trichophytin, candidin and PPD was 6.7%, 6.7% and 60% respectively in 30 atopic patients and was 73% 60% and 93% respective in 15 controls. There was a marked depression in delay ed cutaneous hypersensitivity in patients with atopic dermatitis (p$lt;0.01). 3. The percentage of subjects showing positive sensitization with DNCB was 50% in 30 atopic patients and 93% in controls. A marked decrease in DNCB sensitizability was evident in patients with atopic dermatitis. (p$lt;0.01.) From the results, we confirmed that the patients with atopic dermatitis have strong evidence of defective cell-mediated immunity.
陸上 · 水泳 · 氷上選手의 性格 特性에 關한 硏究 : 韓國優秀選手를 中心으로 Centering on Korean Excellent Athletes
金光中 瑞逸專門大學 1985 論文集 Vol.5 No.-
This study is designd to examine the personality characteristics of ice skating athletes swimmers, and for this purpose I tried to investigate 187 athletes (made : 97, female : 90). The results of the imvestigation are as follows: 1. Personality charcteistics of male athletes. (1) lceskating athletes showed the highest percentage(70%) in sociability and lowest percentage (44%) in stability. (2) Swimmers showed the highest percentage (74%) in sociability and lowest percentage (45%) inmanliness. (3) Ice skaters showed the highest percentage (69%) in impulsiveness and the lowest percentage (25%) in maliness. (4) The common personality characteristics of the athletles of three types is that they were very strong in activeness and inclination to rule others. 2. personality characteristics of male athletes. (1) Ice skating athletes showed the highest percentage (71%) in manliness and the lowest percentage (37%) in discretion. (2) Swimmers showed the highest percentage (79%) in impulsiveness and the lowest percentage (42%) in stabilrty and objectivess. (3) Ice skaters showed the highest percentage (83%) in objectiveness and the lowest percentage (51%) in discretion. (4) the common personality charateristics of the athletes of three types is that they were very stong in activeness and very weak in self-control power and that they lacked in thonghtfulness, logical sense, and aesthetic sense. (5) Athletes showed the inclination that they were strong in activeness, dominating power, impolsiveness, manliness and sociadility and very weak in stability, objectiveness, and discretion.
인체 흑색종 세포주 A - 137 에 대한 감마 인터페론의 세포 살해능 , 증식 억제능 , HLA항원 표현에 관한 연구
김광중,박성회,이유신 ( Kwang Joong Kim,Seong Hoe Park,Yoo Shin Lee ) 대한피부과학회 1990 大韓皮膚科學會誌 Vol.28 No.2
Interferon preparations, in addition to their antiviral properties, may inhibit cell growth and multiplication, enhance the expression of cell surface antigens and influence some functions of T-1ymphocytes, macrophages and natural killer cells. The study was performed in order to investigate the cytolytic effect, antiproli ferative effect and HLA antigen expression effect of the gamma-interferon(IFN- r ) on human melanoma cell line A-375. the cytolytic activities were checked by 'Cr release assay, the antiproliferative activities were analyzed by the 'H-thymidine uptake test and HLA antigen expressions were observed by the indirect imrnuno fluor esent method. The results were as follows : 1. The cytolytic effect of the peripheral rnononuclea.r cells treated with INF- on A 375 human melanoma cell line was increased to 31.4%, 36.5%, 33.9%, 53.9 %, 13.9% respectively in the experiment 1, 2, 3, 4, 5 as compared to control group (-11.4%, 3.6%, 18.5%, 35.5%, 6.7% respectively). 2. 1ri the dose response check of the peripheral mononuclear cells treated with INF r to A 375, the cytolytic effect was definitely observed at 200U/ml concentration of the INF r and maximal effect was observed at 500U/ml concentration. 3. The IIUF r treated natural killer cells did not show any significant increase in cytolytie activity as compared to that of untreated natural killer cell and the same results were obtained with monocytes. This cytolytic activity was significantly increased when INF-r treated natural killer cells were co-culturd with monoeytes. 4. The cyaolytjc activity of natural killer cells was increased at the same degree when using culture supernant of INF- treated monocytes as in the case of using