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뇌경막외강에 발생한 거대한 Granular Cell Myoblastoma의 외과적 치험 : 1례 보고 A case Report
변승열,송풍호,김승래 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.2
The authors report a rare case of the large granular cell myoblastoma located in the left parietotemporooccipital epidural space. The tumor was clinically malignant and probably metastatic from the tumor on the right thigh that was well encapsulated and same in the histological findings as cranial myoblastoma. Tumors on the cranial epidural space and the right thigh were removed by complete excision.
頭部損傷 患者에서 腦脊髓腔內에 注入한 Indigo carmine의 尿中 排泄에 關한 硏究
邊承烈,宋豊鎬,金乘來 慶北大學校 醫科大學 1974 慶北醫大誌 Vol.15 No.2
急性 및 慢性 頭部損傷 患者와 對照群 患者에서 indigo carmine을 脊髓腔內에 注入한 後 尿中의 indigo carmine의 排泄量을 定量分析하여 다음과 같은 結果를 얻었다. 1. 尿中 indigo carmine의 量은 antiformin을 使用하는 色素消失 比較比色分析法으로 80μg/dl 以上에서 定量이 可能하였다. 2. 急性 頭部損傷 患者의 尿中 indigo carmine의 排泄은 慢性群과 對照群에 比하여 많았다. 3. 尿中에서 indigo carmine을 定量할 수 있었던 例에서는 indigo carmine을 注入한 後 2時間째의 尿中 에서 가장 많은 量의 indigo carmine이 測定되었으며 그후는 經時的으로 減量됨을 觀察할 수 있었다. The amount of Indigo carmine excretion in urine of the acute and chronic head injured patients after lumbar subarachnoid space injection was analyzed quantitatively for 5 hours with following results. 1. It was determined that the amount (4mg~8μg/dl) of Indigo carmine could be analyzed quantitatively in urine by the method of spectrophotometry using Antiformin as a discolorant. 2. The rate of the excretion of Indigo carmine in urine was much higher in acute cases than chronic and control cases. 3. The amount of Indigo carmine was maximally detected in the urine of two hours after injection, and the appearance of the dye in urine gradually decreased thereafter.
Effect of Tubercin - 3 - on Serum Electrophoretic Patterns in Lepromatous Leprosy
정태호,변승열,김승래 생화학분자생물학회 1985 BMB Reports Vol.11 No.4
This study was planned to determine the effect of tubercin-3, tuberculopt complex, accumulated on expense of substrate or on expense of earlier accumulated metabolite. 3 metabolites were presumed as to be phenolic compounds by diazotized sulfanilic acid test. In a typical experiment, lg of nonoylvanillylamide was dissolved in minimum amount of dimethyl-formamide and incubated in A. niger culture broth in 250γ/㎖ for 70 hours. Incubation was terminated by acidifying (pH about 3 by hydrochloric acid). After removal of mycelium with cheese cloth, the broth was extracted with ethyl acetate and worked out as usual method. 1.8g of extraction residue was obtained. The residue was applied over a silicic acid column and gradient elution system consisting of beniene and ethyl acetate was applied. Fractious of less polar metabolite were combined and removal of the solvent gave 400㎎ of crystalline compound. This compound showed the same pattern of U. V. absorption as shown by capsaicin. With comparison of NMR signals of this compound in deuterated DMSO, acetylation product in CDCl₃, and authentic nonoylvanillylamide and acetylated nonoylvanillylamide, existence of ω-hydroxy group in the metabolite was proved. Furthermore GC-mass spectral data backed up the proposad structure as 9-hydroxynonoylvanillylamide. For isolation of most polar metabolite of nonoylvanillylamide, lg of substrate was incubated for a prolonged period of time (150 hrs). After working out as usual manner 1.2g of residue obtained was applied over silicic acid column and a gradient elution with benzene and ethyl acetate gave 200㎎ of noncrystalline compund. Acidic nature was proved by bromcresol green test. Pattern of U.V. spectrum was sum,: as that of substrate. NMR spectral data and GC-mass data showed the hydroxylation on the aliphatic portion of the side chain along with ω-oxidation. Its possible structure is (화학식) We are investigating the exact position and configuration of newly introduced hydroxy group.
海綿靜?洞 瘻孔의 Surgical Direct Approach
曺守鎬,邊承烈,洪元培,宋豊鎬,金乘來 慶北大學校 醫科大學 1973 慶北醫大誌 Vol.14 No.2
Serveral methods for operation of the carotid cavernous fistula, as cervical carotid ligation, trapping, embolization, and combined method of trapping and embolization, have been used. However, there are no complete methods to be known surgically. We experienced a 16-year-old girl with traumatic carotid-cavernous fistula. Complete surgical result was obtained by clipping the just proximal and distal portion of the fistula of the cavernous internal carotid artery after exposing the cavernous sinus and final cervical-ligation.
Acetazolamide의 뇌척수액 생성에 미치는 영향
박연묵,변승열,김승래 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.2
To study, in seven men and women volunteers, the effect of acetazolamide on CSF producation, we measured the concentration and disappearance of the indigocarmine injected already into the spinal subarachnoid space by the spectrophotometer and then compaired it of control group whom acetazolamide was not given with diamox group whom acetazolamide was given intravenously in the same man. The 2㎖. CSF perfused with indigocarmine was taken at first and fifth hour after injection of indigocarmine and in diamox group, acetazolamide 5㎎./㎏. to be reported as maximum action of Maren's renal carbonic anhydrase inhibition was given intravenously 30 minutes before injection of indigocarmine into to spinal subarachnoid space. The results showed that in the man the production of CSF by acetazolamide was diminished by 8.3% and also the carbonic anhydrase system affected markedly the formation of the human CSF.