寄生蟲의 管理 및 知識에 關한 調査 : 一部農村地域의 住民을 中心으로

申蓮心,文宰奎,鄭耀翰 朝鮮大學校 醫學硏究所 1980 The Medical Journal of Chosun University Vol.- No.-

In this survey attempts were made to investigate the degree of medical knowledge and control to parasitic infections from 632 inhabitants at Om-chun Myeon and Sin-jun Myeon, Gang-jin Gun, Chonnam, Korea for a month (from 1970, August 1st to 31th). Major findings obtained from this survey can be summarized as followings : 1) Respondents who recognized all resources of parasitic infections were 8.2% (M : 12.8%, F : 4.2%), who recognized them partially 68.5% (M : 77.8%, F : 60.3%) and who recognized none 23.3% (M : 9.4%, F : 35.5%). 2) 31.8% (M : 34%, F : 29.9%) of examiness after examination of parasites were reinfected with parasites, and 68.2% (M : 66.0%, F : 70.1%) of them not reinfected. 3) Examinees who were injured severely in their health by parasitic infections were 47.0% (M : 53.9%, F : 40.9%), 27.4% (M : 21.2%, F : 32.8%) with little injuries and 25.6% (M : 24.9%, F : 26.3%) with no injuries. 4) Only 0.3% (M : 0.7%) of respondents were given a stool test once a year and 99.7% (M : 99.3%, F : 100.0%) of them were not made it. 5) 81.5% (M : 87.2%, F : 76.4%) of examinees did not believe in the results of the stool test and 4.3% (M : 2.7%, F : 5.7%) of them were not confident it and it was not known by 14.2% (M : 10.1 %, F : 17.9%) of them. 6) 3.5% (M : 6.1%, F : 1.2%) of respondents, had a suspicion about parasitic infectio-ns, had gone into the hospital or clinic for diagnosis, 88.3% (M : 90.9%, F : 86.0%) of them were administered anthelmintics, and 8.2% (M : 3.0%, F : 12.8%) of them were non- treated. 7) The respondents who were not given anthelmintics for extermintion of parasites were 94.2% (M : 93.3%, F : 94.9%), but once a year 4.4% (M : 4.8%, F : 4.2%) and twice a year 1.4% (M : 2.0%, F : 0.9%). 8) 2.4% (M : 0.7 % , F : 3.9%) of respondepts washed their hands regularly before every meal and 70.2% (M : 25.9%, F : 34.0%) of them irregularly, but 67.4% (M : 73.4%, F : 62.1%) of them did not. 9) 12.2% (M : 8.4%, F : 5.5%) of the examinees washed their hands regularly after every defecation and 37.7% (M : 43.1%, F : 32.8%) of them irregularly, but 50.2% (M : 48.5%, F : 51.6%) did not 10) 78.2% (M : 93.3%, F : 64.8%) of respondents had experienced eating an uncooked fresh-water fish, but 21.8% (M : 6.7%, F : 35.2%) of them did not. Respondents who have eaten uncooked meet were 92.4% (M : 93.6%, F : 91.3%), but 7.8% (M : 6.4%, F : 8.7%) of them do not.

寄生蟲의 管理 및 知識에 關한 調査 : 一部農村地域의 住民을 中心으로

申蓮心,文宰奎,鄭耀翰 順天鄕大學校 1980 의대논문집 Vol.5 No.-

In this survey attempts were made to investigate the degree of medical knowledge and conrrol to parasitic infections from 632 inhabitants at Om-chun Myeon and Sin-jun Myeon, Gang-jin Gun, Chonnam, Korea for a month (from 1979, August 1st to 31th). Major findings obtained from this survey can be summarized as followings : 1) Respondents who recognized all resources of parasitic infections wcre 8.2% (M : 12.8%, F:4.2%), who recognized them partially 68.5% (M : 77.8%, F : 60.3%) and who recognized none 23.3% (M : 9.4%, F : 35.5%). 2) 31.8% (M : 34%, F : 29.9%) of examiness after examination of parasites were reinfected with parasites, and 68.2% (M : 66.0%, F : 70.1%) of them not reinfected. 3) Examinees who were injured severely in their health by parasitic infections were 47.0% (M : 53.9%, F : 40.9%), 27.4% (M : 21.2%, F : 32.8%) with little injuries and 25.6% (M : 24.9%, F : 26.3%) with no injuries. 4) Only 0.3% (M : 0.7%) of respondents were given a stool test once a year and 99.7%(M : 99.3%, F : 100.0%) of thein were not made it. 5) 81.5% (M : 87.2%, F : 76.4%) of examinees did not believe in the results of the stool test and 4.3% (M : 2.7%, F : 5.7%) of them were not confident it and it was not known by 14.2% (M : 10.1%, F : 17.9%) of them. 6) 3.5% (M : 6.1%, F: 1.2%) of respondents, had a suspicion about parasitic infections, had gone into the hospital or clinic for diagnosis, 88.3% (M : 90.9%, F : 86.0%) of them were administered anthelmintics, and 8.2% (M : 3.0%, F: 12.8%) of them were non-treated. 7) The respondents who were not given anthelmintics for extermintion of parasites were 94.2% (M : 93.3%, F : 94.9%), but once a year 4.4% (M : 4.8%, F : 4.2%) and twice a year 1.4% (M : 2.0%, F : 0.9%). 8) 2.4% (M : 0.7%, F : 3.9%) of respondents washed their hands regularly before every meal and 70.2% (M : 25.9%, F : 34.0%) of them irregularly, but 67.4% (M : 73.4%, F : 62.1%) of them did not. 9) 12.2% (M : 8.4%, F : 5.5%) of the examinees washed their hands regularly after every defecation and 37.7% (M : 43.1%, F : 32.8%) of them irregularly, but 50.2% (M : 48.5%, F : 51.6%) did not. 10) 78.2% (M : 93.3%, F : 64.8%) of respondents had experienced eating an uncooked fresh-water fish, but 21.8% (M : 6.7%, F : 35.2%) of them did not. Respondents who have eaten uncooked meet were 92.4% (M : 93.6%, F : 91.3%), but 7.8% (M : 6.4%, F: 8.7%) of them do not.

급성 호흡기 증상으로 중환자실에 입원한 소아에서 호흡기 바이러스 감염의 임상적 특징

신연심 ( Youn Shim Shin ),강동수 ( Dong Soo Kang ),이건송 ( Kun Song Lee ),김재경 ( Jae Kyoung Kim ),정은희 ( Eun Hee Chung ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4

Purpose: To investigate the clinical characteristics and the risk factors for mechanical ventilator treatment and incidence of complications in children admitted to an intensive care unit (ICU) with detected respiratory viruses. Methods: Eighty-two patients who were detected respiratory viruses by multiplex real-time polymerase chain reaction from nasopharyngeal aspirates were enrolled among the 123 children admitted to ICU with acute respiratory manifestations during the study period from January 2006 to December 2012. Results: Detection rate of respiratory viruses were 66% and 13 patients (16%) had two viruses isolated. The most common respiratory virus isolated was respiratory syncytial virus (RSV) (35%) followed by rhinovirus (19%), adenovirus (13%), parainfluenza virus (11%), influenza virus (11%), human metapneumovirus (6%), and human coronavirus (5%). Pneumonia (70%) was the most common clinical diagnosis. The mean age of patient with RSV infection was the youngest and with influenza virus infection was the oldest among other viruses infection (mean±standard deviation, 5.9±10.1 months vs. 51.0±26.1 months; P=0.01). Forty Patients (49%) who had the underlying diseases were not associated with incidence of mechanical ventilator treatment and complications. Bacterial coinfection with respiratory virus was the significant risk factor of mechanical ventilator care and incidence of complications (odds ratio [OR], 50.003; 95% confidence interval [CI], 3.955.632.144; P=0.003, and OR, 15,569; 95% CI, 1.803.134.452; P=0.013). Conclusion: The significant morbidity of pediatric patient admitted to ICU with respiratory virus infection (RVI) was associated with bacterial coinfection. Furthermore, multicenter study should be performed to investigate the epidemiology of RVI in pediatric patients admitted to ICU in domestic.

급성 호흡기 증상으로 중환자실에 입원한 소아에서 호흡기 바이러스 감염의 임상적 특징

신연심 ( Youn Shim Shin ),강동수 ( Dong Soo Kang ),이건송 ( Kun Song Lee ),김재경 ( Jae Kyoung Kim ),정은희 ( Eun Hee Chung ) 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4

Purpose: To investigate the clinical characteristics and the risk factors for mechanical ventilator treatment and incidence of complications in children admitted to an intensive care unit (ICU) with detected respiratory viruses. Methods: Eighty-two patients who were detected respiratory viruses by multiplex real-time polymerase chain reaction from nasopharyngeal aspirates were enrolled among the 123 children admitted to ICU with acute respiratory manifestations during the study period from January 2006 to December 2012. Results: Detection rate of respiratory viruses were 66% and 13 patients (16%) had two viruses isolated. The most common respiratory virus isolated was respiratory syncytial virus (RSV) (35%) followed by rhinovirus (19%), adenovirus (13%), parainfluenza virus (11%), influenza virus (11%), human metapneumovirus (6%), and human coronavirus (5%). Pneumonia (70%) was the most common clinical diagnosis. The mean age of patient with RSV infection was the youngest and with influenza virus infection was the oldest among other viruses infection (mean±standard deviation, 5.9±10.1 months vs. 51.0±26.1 months; P=0.01). Forty Patients (49%) who had the underlying diseases were not associated with incidence of mechanical ventilator treatment and complications. Bacterial coinfection with respiratory virus was the significant risk factor of mechanical ventilator care and incidence of complications (odds ratio [OR], 50.003; 95% confidence interval [CI], 3.955.632.144; P=0.003, and OR, 15,569; 95% CI, 1.803.134.452; P=0.013). Conclusion: The significant morbidity of pediatric patient admitted to ICU with respiratory virus infection (RVI) was associated with bacterial coinfection. Furthermore, multicenter study should be performed to investigate the epidemiology of RVI in pediatric patients admitted to ICU in domestic. (Allergy Asthma Respir Dis 2013;1:370-376)

국내 영유아에서의 Chlamydia trachomatis 호흡기 감염

홍기배,신연심,노의정,정은희 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.7

Purpose:Chlamydia trachomatis is one of the most common sexually transmitted diseases and is also a cause of pneumonia in infants. Respiratory infections by respiratory viruses are also common for infants. The objectives of this study were to identify the clinical manifestations and to determine the prevalence of C. trachomatis respiratory infections and coinfections by respiratory viruses in infants younger than 6 months of age. Methods:For this study, we enrolled 6 months or younger infants who were admitted to the Dankook University Hospital between January 2002 and July 2007, with respiratory symptoms. Nasopharyngeal aspirates or throat swabs were collected within s d of hospitalization and C. trachomatis was detected using polymerase chain reaction (PCR). Patients who tested positive underwent multiplex PCR for respiratory viruses. Results:A total of 690 patients underwent chlamydial PCR testing and 36 (5.2%) had positive results. Of the 36, 28 (78%) were male; 30 were vaginally delivered. From the 36 patients positive for C. trachomatis, 26 underwent multiplex respiratory viral PCR; 12 were coinfected with viruses. Respiratory syncytial virus (RSV) was the most frequent pathogen that was detected in 6 patients. Increased C-reactive protein and fever were significant in patients coinfected with respiratory viruses. Conclusion:C. trachomatis can infected in infants delivered by cesarean section as well as in 6 months old or younger infants. Infant with C. trachomatis respiratory infections can also be coinfected with respiratory infection also coinfected with respiratory viruses. Further studies are needed to better understand the prevalence rates of the this infection and its coinfection rate with respiratory viruses. (Korean J Pediatr 2008;51:729-735) Purpose:Chlamydia trachomatis is one of the most common sexually transmitted diseases and is also a cause of pneumonia in infants. Respiratory infections by respiratory viruses are also common for infants. The objectives of this study were to identify the clinical manifestations and to determine the prevalence of C. trachomatis respiratory infections and coinfections by respiratory viruses in infants younger than 6 months of age. Methods:For this study, we enrolled 6 months or younger infants who were admitted to the Dankook University Hospital between January 2002 and July 2007, with respiratory symptoms. Nasopharyngeal aspirates or throat swabs were collected within s d of hospitalization and C. trachomatis was detected using polymerase chain reaction (PCR). Patients who tested positive underwent multiplex PCR for respiratory viruses. Results:A total of 690 patients underwent chlamydial PCR testing and 36 (5.2%) had positive results. Of the 36, 28 (78%) were male; 30 were vaginally delivered. From the 36 patients positive for C. trachomatis, 26 underwent multiplex respiratory viral PCR; 12 were coinfected with viruses. Respiratory syncytial virus (RSV) was the most frequent pathogen that was detected in 6 patients. Increased C-reactive protein and fever were significant in patients coinfected with respiratory viruses. Conclusion:C. trachomatis can infected in infants delivered by cesarean section as well as in 6 months old or younger infants. Infant with C. trachomatis respiratory infections can also be coinfected with respiratory infection also coinfected with respiratory viruses. Further studies are needed to better understand the prevalence rates of the this infection and its coinfection rate with respiratory viruses. (Korean J Pediatr 2008;51:729-735)

재태주령 30주 미만 미숙아에서 예방적 인공 폐 표면 활성제 투 여와 비강 양압 환기 적용

성인창,신연심,장영표 대한신생아학회 2012 Neonatal medicine Vol.19 No.4

Purpose: This study was performed to investigate the effectiveness and safety of the prophylactic administration method of surfactant,followed by rapid extubation to nasal CPAP (nCPAP) in very preterm infants. Methods: Thirty-three preterm infants with 24-29 weeks gestational age (GA) were treated with the method of prophylactic administration of surfactant by a brief intubation within 15 minutes after birth and rapid extubation to nCPAP for the treatment of respiratory distress. The variables and complications related to oxygen therapy and mechanical ventilation (MV) were compared with those of 24 historical control infants with comparable GA, treated with the rescue surfactant administration with prolonged MV for the respiratory distress syndrome (RDS). Results: Prophylactic surfactant with nCPAP did not reduce the total durations of oxygen therapy and MV, compared with the rescue surfactant with MV (P=0.622 P=122, respectively). The incidence of death and BPD at 36 weeks postmenstrual age (PMA)and other complications related to oxygen therapy and MV were not increased in the infants treated with prophylactic surfactant with nCPAP despite the lower GA and birth weight. In the subgroup analysis for infants with 27-29 weeks of GA, the total duration of MV tended to decrease in infants treated with prophylactic surfactant with nCPAP (Odd ratio, 0.93, 95% Confidence interval, 0.87,1.00, P=0.051). Conclusion: Prophylactic surfactant administration followed by rapid extubation to nCPAP tended to reduce the duration of MV in infants with GA of 27-29 weeks, compared with the rescue surfactant administration with prolonged MV for RDS. 목적: 극소 미숙아에서 예방적 인공 폐 표면 활성제 투여와 비강양압 환기를 적용하는 방법의 치료 효과와 안전성을 조사하고자 하였다. 방법: 재태주령 24-29주 미숙아 33명을 대상으로 출생 후 15분 이내에 호흡 곤란 치료를 위해 예방적 인공 폐 표면 활성제를 투여하고빠른 기관지 관 제거 후 비강 양압 환기 적용 방법으로 치료를 시행하였다. 산소 치료와 기계적 환기 치료와 관련된 변수와 합병증을 과거에 호흡 곤란 증후군으로 구조적 인공 폐 표면 활성제 투여와 지속적 기계적 환기 방법으로 치료 받았던 상응하는 재태주령의 24명의미숙아와 비교하였다. 결과: 예방적 인공 폐 표면 활성제 투여에 이은 비강 양압 환기 치료는 구조적 인공 폐 표면 활성제 투여에 이은 지속적 기계적 환기치료와 비교하여 총 산소 치료 기간과 총 기계적 환기 치료 기간을줄여주지 않았다(각각 P=0.622, P=0.122). 교정연령 36주에 사망과기관지폐 형성 이상, 산소 치료 또는 기계적 환기와 연관된 합병증들의 빈도는 대상 환아군의 낮은 재태주령과 출생 체중에도 불구하고증가하지 않았다. 재태주령 27-29주를 가진 환아를 대상으로 한 하위 집단 분석에서 총 기계적 환기 치료 기간이 예방적 인공 폐 표면활성제 투여에 이은 비강 양압 환기 치료를 받은 대상아에서 감소하는 경향을 보였다(odd ratio, 0.93, 95% confidence interval, 0.87,1.00, P=0.051). 결론: 호흡 곤란 치료를 위한 예방적 인공 폐 표면 활성제 투여에이은 비강 양압 환기 치료는 구조적 인공 폐 표면 활성제 투여에 이은 지속적 기계적 환기 치료와 비교하여 재태주령 27-29주 환아에서 기계적 환기 치료 기간을 줄여 주는 경향이 보였다.