Sodium Thipental 靜注 直後의 呼吸 및 動脈血壓 變化 觀察

權得基,金在炯,崔秉玉 최신의학사 1969 最新醫學 Vol.12 No.1

In despite of that thiobarbiturate is well known general anesthetics, the effect of the drug on the arterial pressure is not well clarified yet. The thiobarbiturate has direct constricting effect on arterial smooth muscle and has reducing action on the contractility of the myocardium. Therefore, it can raise arterial pressure in one hand and can decrease the pressure on the other hand. The present study is attempted to further elucidate the effect of rapidly administered thiopental of comparatively small dosage on the change in arterial pressure and respiratory depression immediately after the administration. Sodium thiopental was administered in does and rate of 2mg,/kg/sec. through femoral vein of experimental dog with was prior anesthetized lightly by 10 mg/kg of 2.50/, thiopental. The respiration and femoral arterial pressure were monitored through out the experiment and heart rate and arterial pH were measured before and after the administraion of the drug. The results abtained are summarized as follows: 1. Respiration was depressed pronouncely about 20 seconds after the administration of thiopental and temporary apnea was developed in about 60% of the observations. Recovery of the respiration to the control state was achieved about 20 minutes after the administration. Arterial blood pH was lowered in degree of about 1.2 by the thiopental induced respiratory depression. 2. Decrease in arterial pressure became observable 14 seconds after the administration and at 30 seconds after the thiopental, arterial pressure showed peak decrease of about 27 mmHg. Lowered pressure by thiopental recovered to control level after about 50 seconds of the administration. In about 62% of.the observation, the change of arterial pressure was biphasic, initial short rise and decrease there-after. The average degree and duration of initial rise in arterial pressure were about 18 mmHg and 4 seconds. The heart rate decreased to 90% of control rate after 1 minute of the administration of thiopental.

家兎肺 抽出液과 洗滌液의 表面活性度와 In Vitro X線照射가이에 미치는 影響

權得基,朱永恩 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.1

家兎肺에서 얻은 推出液(extracts)과 洗滌液(washings)의 肺胞表面 活性物質의 活性度와 蛋白含量을 比 較하고, 나아가서 300R, 600R 및 1,000R의 X線을 in Vitro로 照射하여 20℃에서 1,4,8,12 및 24時間에 各各 表面活性度와 蛋白含量을 測定하여 果 다음과 같은 結果를 얻었다. 1. 正常對照群의 肺洗滌液의 最大 및 最小 表面張力, 幅, S^- 및 蛋白含量은 各各 44.1dyne/cm, 8.0dyne/cm, 14.2dyne/cm, 1.38 및 115.8mg/ml이었고 肺推出液의 그것들은 各各 36.8dyne/cm, 13.6dyne/cm, 9.2dyne/cm, 0.91 및 884.7mg/ml이었다. 2. 肺洗滌液이나 肺推出液에서 모두 20℃에서 實驗 24時間까지 肺胞表面活性度나 蛋白含量은 큰 變化를 나타내지 않았다. 3. 300R의 in Vitro X線 照射로서는 各 實驗値가 對照에 比하여 큰 差異를 나타내지 않았으나, 600R 또 는 1,000R의 in Vitro對照로서는 對照群에 比하여 各實驗値에서 若干의 差異를 나타내었으며, 特히 最小 張力에서 그 傾向이 뚜렷하였다. 4. 以上의 結果로서, 肺胞表面活性度測定에는 肺推出液보다 肺洗滌液을 使用함이 더 有利하고 20℃에서 肺洗滌液을 保存하여도 그 活性度나 蛋白含量에 差異가 없음을 알 수 있다. 또한 X線 in Vitro 照射는 肺胞表面活性物質에 큰 變化를 나타내지 않는 것이라고 思料된다. The extraction method of preparing the pulmonary surfactant is crucial in determining and evaluating the surfactant activities in situ. In the present study, two most commonly used methods were compared; namely, the extracts and washings. Also, in an attempt to clarify the effect of X-irradiation on the pulmonary surfactant system, X-ray of 300R, 600R and 1,000R, respectively was irradiated to the lung extracts and lung washings obtained from the rabbit in Vitro, and the pulmonary surfactant activities as well as the protein contents of both extracts and washings were studied at 1, 4, 8, 12 and 24 hours after the irradiation at 20℃. The results obtained are summarized as follows: 1) The maximal and minimal surface tensions, width of the tension-area diagram at the surface area of 40%, stability index and protein content of the lung washings in the non-irradiated normal group was 44.1 dyne/cm, 8.0 dyne/cm, 14.2 dyne/cm, 1.38 and 115.8 mg/ml, respectively. In the lung extracts, the value was 36.8dyne/cm, 13.6dyne/cm, 9.2dyen/cm, 0.911and 884.7mg/ml, respectively. 2) In the normal group, both the lung washings and lung extracts showed no noticeable change in the pulmonary surfactant activities and protein contents upto 24 experimental hours at 20℃. 3) X-irradiation of 300R in Vitro produced no meaningful change in the surfactant activities or protein contents from the control, but 600R and 1,000R of X-irradiation showed a tendency of sligt changes in the surfactant activities from the control with the increased values of the minimal surface tensions. 4) From the above, it may be considered that the lung washings are better suited than the lung extracts for the measurement of the pulmonary surfactant activities. Also, at 20℃, the pulmonary surfactant activities as well as the protein contents do not seem to be altered greatly for at least 24 hours. Finally, X-irradiation in Vitro does not seem to produce any noticeable change in the pulmonary surfactant.

家兎肺 抽出液과 洗滌液의 表面活性度와 In Vitro X線照射가 이에 미치는 影響

權得基,朱永恩 慶北大學校 醫科大學 1975 慶北醫大雜誌 Vol.16 No.1

Reduced Glutathione 및 人蔘抽出液이 X線 全身照射를 입은 마우스 肝組織의 蛋白量에 미치는 影響

蔡洙喜,權得基,金容彦,崔聖邱 최신의학사 1974 最新醫學 Vol.17 No.9

In an attempt to clarify the radioprotective effect of reduced glutathione (GSH), and to observe a possible radioprotective effect of Ginseng extract, whole body X-irradiation of 1, 200R was administered to the mouse either independently or immediately following the injection of GSH or Ginseng extract to the mouse intraperitoneally. The protein content of the liver was measured at 30, 60 and 120 minutes, and a comparison was made with the normal. The results obtained are summarized as follows; 1) The normal value of the protein content of the mouse liver was 106.2±2.4 mg/gm wet wt. 2) The protein content of the liver did not change appreciably from the normal by the injections of Ginseng extract or reduced glutathione. 3) When 1,200R of X-irradiation was administered, the protein content of the liver increased moderately at 30 and 60 minutes, but the value returned to the normal at 120 minutes. 4) When GSH was injected prior to the X-irradiation, the liver protein increased slightly . at 30 minutes, but the value was generally within the normal limit. 5) Injection of Ginseng extract prior to the X-irradiation produced a slight increase of the protein content of the liver at 30 minutes but the value did not change greatly from the normal throughout the experiment.

半頭無腦兒의 2例

盧英夏,權得基 大韓産婦人科學會 1966 大韓産婦人科學會雜誌 Vol.9 No.8

帝王切開의 臨床的 統計觀察

徐永旭,金源培,權得基,李重吉,宋文源 최신의학사 1967 最新醫學 Vol.10 No.2

This clinical study disclosed 89 cesarean sections in 2,014 deliveries, during January 1, 1960 and October 1, 1965 at the Dept. of Ob. & Gyn., Taegu Presbyterian Hospital, Taegu, Korea. Results obtained were as follows: 1) 89 cesarean sections in total 2,014 deliveries, an operative incidence of 4.4 per cent, in 5 year and 9 month periods indicates an increase in incidence. 2) The commonest indication of the cesarean section was cephalopelvic disproportion (33.7%), and was followed by placenta previa (20.2%), eclampsia (14.6%), vaginal stricture (7.8%), ruptured uterus (6.8%), repeat section (4.5%), malpresentation (4.5%), abruptio placentae (3.4%), and so forth. 3) The predominant anesthetic method used in this study was local infiltration by I% procaine with 2.5 % pentothal sodium induction and with ether inhalation general anesthesia (73%). There was no anesthetic death. 4) The low cervical type of cesarean sectieon (73%) was the predominant operation used, while the classical cesarean section (20.2%) has not been completely abandoned yet. Cesarean hysterectomy was performed on 8 cases (9.6%). 5) Postoperative maternal morbidity was 19.1 %. 6) Maternal mortality was 2.2%, and death of these 2 cases were due to severe eclampsia per se, and not due to operation. 7) Perinatal mortality was 23.5%. 8) A comparative study of statistics and a review of literature of cesarean section were made.

난소종양의 임상병리학적 고찰

이수연(SY Lee),김원배(WB Kim),이종학(JH Lee),권득기(DK Kwon),서영욱(YU Suh) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.8

A clinico-pathological survey was made on series of 301 ovarian tumor cases operated in Presbyterian Hospital, Taegu, Korea from January, 1960 through June, 1967. 1. An icidence of ovarian tumor during this period was 13.0% of total operated cases in Obs. & Gyn. Service. 2. Age incidence of all ovarian tumor averaged at 37.5 years, and an average age incidence for the malignancy was 44.5 years. 3. As to subjective symptoms in all ovarian tumors, lower abdominal pain was noticed in 50.8% In benign ovarian tumors. lower abdominal pain was predoninating symptom appearing in 51.6% of the cases while lower abdominal mass predominates in malignant ovarian tumors and appear in 77.8% of the cases. 4. Primary sterility was noted in 16.9% of all ovarian tumors and secondary sterility, in 9.6% of the cases. 5. Menarche began at 16 years of age in 30.6% of the cases. 6. There was no great difference between incidence of benign and malignant ovarian tumor as to parity from para 0 to para 4, but he fact increasing parity parallels increasing incidence of malignant tumor corresponds with the increasing tendency of malignant tumor in the older age. 7. Occurrance of menstrual irregularity among total ovarian tumors was noted in 27.2% of the cases, and that in the benign tumors, 25.4% and 37.8%, in malignant tumors. 8. Physical finding: a) Ascites was observed in 17.9% of all ovarian tumors, 13.7% of benigh tumors and 42.2% of malignant tumors. b) Cachexia was observed in 3 cases(0.9%) c) Adhesions with the adjacent organs were observed in 30.9% d) The incidence of combination with pregnancy was observed in 11.3% e) Pedicle torsion of ovarian tumors was noted in 17.2% 9. Concerning heoglobin content level, occurrence of subnormal(below 12gm/100ml) level was noted in 45.1% of all ovarian tumor cases. 10. The incidence of benign tumors was 85.1% of all ovarian tumors while that of malignant ones, 14.9% 11. The incidences of benign and malignant tumors among all ovarian tumors were as follows: Serous cystadenoma:31.6% Cystcter atoma, benign:28.9% Pseudomucinous cystadenoma:18.6% Serous cystadenocarcinoma:22.5% Pseudomucinous cystadenocarcinoma:22.2% 12. An incidence of cystic tumors among benign tumors was 95.4% and an incidence of solid tumors among malignant tumors was 68.3% 13. As to common size of all ovarian tumors, tumor with the size of an adult`s fist occurred in 34.0% of the cases, while one with the size of a child`s head was noted in 33.3% of all malignant tumors. 14. Bilaterality was noted in 17.3% of all ovarian tumor cases, in 15.6% of benign tumors and in 26.7% of malignant tumors. 15. Bilaterality of dermoid cysts was noted in 16.1%, of serous cystadenoma, in 10.0% and of pseudomucinous cystadenoma, in 8.9%. 16. Among benign tumors the incidence of serous cystadenomas was 37.6%, that of dermoid cyst, 33.9% and that of pseudomucinous cystaden-omas, 21.4%. 17. Malignancy of pseudomucinous type was observed in 15.2%, that of serous type, in 10.3% and that of dermoid cyst, in 4.3%.

Ether 및 Methoxyflurane 전신흡입(全身吸入) 마취(麻醉)가 가토(家兎)의 혈당량(血糖量)에 미치는 영향(影響)

박노삼(Park, Ro-Sam),최성구(Choi, Sung-Ku),김용언(Kim, Yong-Eon),권득기(Kwon, Duck-Kee),김영기(Kim, Young-Ki) 대한생리학회 1974 대한생리학회지 Vol.8 No.1

정상가토(正常家兎)에 ether와 methoxyflurane으로서 흡입마취(吸入麻醉)시킨 후(後) 마취(麻醉)의 심도(深度)와 시간경과(時間經過)에 따른 각기혈당량(各其血糖量)을 측정(測定)하고 대조군(對照群)의 그것과 비교(比較)한 결과(結果) 다음의 결론(結論)을 얻었다. 1. 대조군(對照群)의 혈당량(血糖量)은 112.04±9.88 mg%이었다. 2. Ether 마취군(麻醉群)에서, 경마취시(輕麻醉時) 혈당치(血糖値)는 193.57±2.40 mg%로서 증가(增加)하였다. 심마취즉후(深麻醉卽後)에는 혈당치(血糖値)가 130.75±5.33mg%로서 다시 저하(低下)되었다. 심마취시간(深麻醉時間)의 경과(經過)에 따라 혈당치(血糖値)는 계속 상승(上昇)하여 심마취(深麻醉) 120분(分)에서는 188.61±12.33mg%에 달(達) 하였다. 3. Methoxyflurane 마취군(麻醉群)에서는 ether 마취군(麻醉群)과 유사(類似)하게 혈당치(血糖値)의 증가양상상(增加樣狀相) 보여 주었고 methoxyflurane 경마취시(輕麻醉時)의 혈당치(血糖値)는 186.89±10.90mg%였다. 심마취즉후(深麻醉卽後)에는 111.28±16.81mg%로 저하(低下)되었다가 시간(時間)의 경과(經過)에 따라 상승(上昇)하여 120분(分)에서는 208.98±7.52mg%로서 상당히 상승(上昇)하였다. 4. 이상(以上)의 결과(結果)로서 ether와 methoxyflurane 마취시(麻醉時) 혈당치(血糖値)의 변동(變動)은 시간경과(時間經過)에 따라 유사(類似)한 결과(結果)를 얻었다. In the present study, the experiment was made to observe the change of the blood sugar levels in the process of general anesthesia, subjecting the rabbits to the light or deep inhalation anesthesia with ether or methoxyflurane by the non-rebreathing system. The blood sugar level was measured by the method of Somogyi and Nelson. The results are summarized as follows; 1. The blood sugar level of the normal rabbit was 112. 04±9.88 mg%. 2. The blood sugar level in the initial stage of the light ether anesthesia was significantly increased, and slight decrease was observed in the beginning of the deep anesthesia. 3. In the ether anesthesia group, the sugar level increased gradually when deep anesthesia was induced. 4. Anesthesia with methoxyflurane produced a similar pattern of the blood sugar as in the ether group, with no significant difference between ether and methoxyflurane anesthesia.