정신의학에서의 유전학

양병환,김석현,이영호 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

About 150 years have passed since genetics introduced into the psychiatric fields. Nowadays, due to the development of biological psychiatry, psychiatric genetics become a very important section of the psychiatry, contributing to the research for genetic components of psychiatric disorders. But genetic studies of psychiatric disorders have many problems. One reason of the difficulty is that psychiatric disorders do not follow Mendelian inheritance. Instead, psychiatric disorders seems that they have polygenic and multifactorial inheritance characteristics. The authors reviewed the research methods of psychiatric genetics such as family study, twin and adoption study, segregation analysis, linkage and association studies. Also the problems and issues of the research methods were discussed.

LCEC에 의한 Catecholamine 분석의 이론과 실제

楊秉煥 漢陽大學校 精神健康硏究 1985 精神健康硏究 Vol.3 No.-

스트레스와 정신신경내분비학

楊秉煥 漢陽大學校 精神健康硏究 1985 精神健康硏究 Vol.3 No.-

Methamphetamine과 Chlorpromazine이 白鼠腦의 Norepinephrine 含量에 미치는 影響에 關한 實驗的 硏究

楊秉煥 大韓神經精神醫學會 1978 신경정신의학 Vol.17 No.1

This experimental study was aimed at the effects of methamphetamine and chlorpromazine on brain norepinephrine levels and their interaction on central norepinephrine in Fischer albino rats. Drugs were injected twice daily by intraperitoneal routs to groups of rats weighing 150-250g for 5 days. Groups of rats were 25 control rats, 6 rats treated with methamphetamine in low does (3.5㎎/㎏ twice daily), 6rats treated with methamphetamine in low does(7㎎/㎏ twice daily), 13 rats treated with methamphetamine in high does(10㎎/㎏ twice daily), 15 rats treated with chlorpromazine (8㎎/㎏ twice daily) and 14 rats treated with combined drugs. The rats were sacrificed by decapitation one hour after last injection and brain levels of norepinephrine were assayed fluorometrically by the method of Bertler, Carlsson and Rosengren. The average value of norepinephrine in control rats was 0.235㎍/1g brain and had no sexual difference. Low doses methamphetamine had little or no effect on brain norepinephrine levels but norpinephrine level was depleted to 50~60% of the control level after large does of methamphetamine for 2 days. Generally, rats treated with chlorpromazine did not significantly alter norepinephrine levels. Rats treated with methamphetamine (10㎎/㎏ twice daily) and chlorpromazine (8㎎/㎏ twice daily) had higher norepinephrine level than methamphetamine-treated rats, but lower than chlorpromazine-treated rats. Norepinephrine level was depleted after combined treatment for 5 days. The results were discussed in terms of implication for several mechanisms of methamphetamine interaction with chlorpromazine, primarily mediated by cyclic AMP and calcium ion on release of central norepinephrine.

不眠에 對한 8-Chloro-6-Phenyl-4H-s-Triazolo[4.3-a][1·4]Benzodiazepine의 效果에 關한 臨床硏究

李定均,楊秉煥 大韓神經精神醫學會 1976 신경정신의학 Vol.15 No.4

In this study, authors examined the hypnotizing effect of Estazolam on patients in I.P.D & O.P.D. who visited with the chief complaint of insomnia. The number of patients selected for this study were 156. They were consisted of 78 neurotics other than depression, 66 depressive patients and 12 mild psychotic patients. Authors applied the double blind clinical method with Estazolam and placebo to the patients. They visited OPD & IPD of Psychiatric department of SNUH (Seoul National University Hospital) from October-1, 1975 to March-31, 1976. The results were as follows: 1. Estazolam had the highest sedating effect to the patients with mild psychosis and the least effect to the neurotics except depression. 2. Total duration of sleep increased approximately 20-30 minutes. 3. No difference was noticed between 2㎎ and 3㎎ administrated groups. 4. It seemed that Estazolam had no influencoe on REM sleep pattern (frequency of dream). 5. It was a most effective method to use Estazolam combined with other specific drugs to the patient who had suffered from insomnia for a long period. We applied the double blind clinical method with Estazolam and placebo to the patients who complained of insomnia. They were consisted of 78 neurotics other than depression, 66 depression patients and 12 mild psychosis. They visited OPD & IPD of psychiatric department of SNUH (Seoul National University Hospital) from October-1, 1975 to March-31, 1976. The result were as follows: 1. Estazolam had the highest sedating effect to the patients with mild psychosis and the least effect to the neurotics except depression. 2. Total duration of sleep increased approximately 20-30 minutes. 3. No difference was noticed between 2㎎ and 3㎎ administrated groups. 4. It seemed that Estazolam had no influence on REM sleep pattern (frequency of dream). 5. It was a most effective method to use Estazolam combined with other specific drugs to the patient who had suffered from insomnia for a long period.

兩耳競聽法을 이용한 精神病患者의 大腦機能側向化

金相勳,李廷南,楊秉換 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.2

Lateralized functions of the cerebral hemispheres using the dichotic listening test were surveyed in subjects who consisted of 17 schizophrenic patients (10 males, 7 females), 18 bipolar disorder patients (10 males, 8 females) and 18 normal controls (10 males, 8 females). The results were as follows; 1. As to the comparison of total correct answers, there is no significant difference among each group and between both sex. 2. As to the comparison of correct answers according to the type of test, total subjects has significantly higher scores in word test (32.4±6.82) than in digit test (23.8±5.67), (p<0.01). And also, each group has the same results (p<0.01). 3. As to the comparison of correct answers recognized through the right ear or left one, total sucjects has significanly higher scores in right ear (30.9±5.51) than in left one (25.3±6.06), (p<0.05). 4. As to the correlation between the type of test and correct answers recognized through the right ear or left one, total subjects has significantly higher scores in word test than in digit test, in which both right and left (p<0.05). 5. Although there is no evidence of definitive ear asymmetry in both psychotic groups, bipolar disorder patients show a tendency of right ear dominance in digit test but it has no statistical significance.

주정중독 환자에서의 Dexamethasone 억제검사

이수복,양병환 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.3

For the purpose of evaluating possible linkage between alcoholism and depression, dexamethasone suppression tset (DST) was performed to 15 alcoholics, 8 major depressives, and 11 non-depressive psychiatric inpatients. The alcoholics were tested twice ; in the intoxicated and recovered state. Dexamethasone suppression Test(DST) using 1 mg of dexamethasone was performed in 49 subjects, and serum cortisol concentration was determined by radioimmunoassay using the Coat-A--Count Procedure. The results were as follows; 1) Basal serum cortisol levels were higher in the major depressives and the alcoholics than in the nondepressive psychiatric inpatients. 2) Post-dexamethasone serum cortisol levels were also higher in the major depressives and the alcoholics than in the non-depressive psychiatric inpatients. 3) Basal serum cortsol levels of the intoxicated and recovered alcoholics were proved to be equally elevated, comparing with those of the non-depressive inpatients. 4) Non-suppressor of DST was detected none of the non-depressive inpatients, in 25% of the major depressives, 20% of the intoxicated alcoholics and in 33.3% of the recovered alcoholics. With the above results, the authors could suggest the possibility that there are considerable cases of primary depression among the alcoholics.

Haloperidol Decanoate치료중인 정신분열증 환자의 혈청 할로페리돌 농도에 관한 연구

양병환,고용철,김광일,강보경,이경옥,신호상 漢陽大學校 精神健康硏究 1997 精神健康硏究 Vol.16 No.-

受容體結合에 依한 向精神藥物 스크린

楊秉煥 서울대학교 의과대학 정신과학교실 1981 精神醫學報 Vol.5 No.7

관련된 정보의 수와 교재학습

양병환 창원대학교 1990 논문집 Vol.12 No.-