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양진향,조명옥,이가영 한국간호과학회 2012 Journal of Korean Academy of Nursing Vol.42 No.5
Purpose: This ethnography was done to explore patterns of weight management behavior among adults using obesity clinics. Methods: The participants were 12 adults who were overweight or obese and 2 family members. Data were collected from iterative fieldwork in the obesity clinics of two hospitals. Data were analyzed using text analysis and taxonomic methods. Results: Weight management behaviors among participants varied according to the recognition of the body and motivation for weight control, Participants" behavior was discussed in the socio-cultural context of obesity. Patterns of weight management behavior among participants were categorized by focus: strategic self-oriented type including managements for the body as a social asset and for health, selective neglect type, and passive group value-oriented type including type dependent on others and managements for beauty. Conclusion: Participants" weight management behavior was guided by folk concepts of body and health. and constructed within the socio-cultural context. It is necessary for health care providers to understand physical and psychological problems arising from the repeated trials, excessive control of weight, and Western cultural discourse on beauty ideals among adults who are overweight or obese. Therefore, interventions should be tailored to address individual and community needs.
광선각화증, 각화극세포종과 Bowen's병에서 p53과 p21의 표출 양상
조명구,조현득,양승하,김의한 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background The function of the p53 protein was known to regulate cell proliferation by inhibiting cells entering Sphase. So DNA damaged cell proliferation was inhibited by apoptosis. P21 is a cyclin dependent kinase inhibitor induced by wild type p53, not mutant p53. Thus p21 is thought go mediate the signal of p53 induced by DNA damaged agents to arrest the cell cycle in G1 phase. p53 and p21 were expressed in many malignant tumors, and its role in oncogenesis, tumor progression and prognosis were important. The authors analyzed immunohistochemical expression of mutant p53 and p21 protein in some skin tumors. Method Thirteen cases of actinic keratosis, 7 cases of keratoacanthoma and 8 cases of Bowen's disease were immunohistochemically stained with p53 and p21 monoclonal antibodies. Results; 1. In cases of positive p53 protein and negative p21 protein, the expressed p53 protein was suggested as mutant form. 2. Positive expression of p53 protein and p21 protein in prickle cell layer of actinic keratosis and Bowen's disease was suggesded that the composing cells of prickle cell layer were transformed into the proliferated cell. The p21 protein expression was suggested to be induced by the p53 independent pathway. 3. Negative expression of p53 protein and p21 protein in prickle cell layer of keratoacanthoma was suggested that the composing cells of prickle cell layer were completely mature cells, so the keratoacanthoma had good prognosis.